Clinical trials: Depression; Bipolar Disorder
Bipolar Disorder, Bipolar Depression
Cannabidiol as an Adjunctive Treatment for Bipolar Depression
Depressive symptoms are associated with significant psychosocial impairment. However, current treatments of bipolar depression are only partially effective.
- Conditions
- Bipolar Disorder, Bipolar Depression, Bipolar Affective Disorder
- Trial name
- CBDBD (NCT03310593)
- Testing
- Cannabidiol
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Bipolar Disorder, Anxiety
Quetiapine Extended Release (XR) in Bipolar Patients With Comorbid Generalized Anxiety Disorder (GAD)
The primary objective is to test the hypothesis that Quetiapine XR (Extended Release) monotherapy and adjunctive therapy is effective in the acute treatment of bipolar depression and comorbid generalized anxiety disorder in…
- Conditions
- Bipolar Disorder, Anxiety, Anxiety Disorders, Substance Use Disorders
- Trial name
- NCT00671853
- Testing
- Quetiapine XR
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University Hospitals Cleveland Medical Center
Schizophrenia, Bipolar Disorder
EMR Data to Assess Monitoring of Patients Treated With Quetiapine
A study to evaluate the effectiveness of an update of educational materials with respect to evaluation of monitoring of metabolic parameters
- Conditions
- Schizophrenia, Bipolar Disorder, Major Depressive Disorder
- Trial name
- NCT01793324
- Volunteers
- 6,153 people
- Sponsor
- AstraZeneca
Bipolar I Disorder
Emotion Regulation Group Therapy for Bipolar Disorder
Psychoeducation has been the only group treatment developed for bipolar disorder thus far. Deficits in emotion regulation, a core impairment among patients with bipolar disorder, are not directly addressed in this treatment.
- Trial name
- NCT01207505
- Testing
- Enhancing Emotion Regulation
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Massachusetts General Hospital
Depressive Disorder, Bipolar Disorder
EVALUATION OF BLOOD BIOMARKER-BASED DIAGNOSTIC AID IN OUTPATIENTS SUFFERING FROM DEPRESSION
This is an observational (non-interventional) study, carried out in an outpatient setting, which involves a blood sampling. The primary objective of this study is to confirm the association between the EDIT-B® editing signature…
- Conditions
- Depressive Disorder, Bipolar Disorder, Bipolar Depression
- Trial name
- NCT06369805
- Testing
- there is no intervention
- Where
- Switzerland
- Volunteers
- 307 people
- Sponsor
- Les Toises - Psychiatry and Psychotherapy Center
Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse), Schizophrenia
INCLUDE: Using Lived Experience to Improve Mental Health Diagnosis v1
The focus of this study is not about what it is like to have a mental disorder, but instead the diagnostic experience. Some people find diagnoses helpful, but some find them upsetting and harmful.
- Conditions
- Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse), Schizophrenia, Generalised Anxiety Disorder, Bipolar Disorder
- Trial name
- INCLUDE (NCT03131505)
- Where
- United Kingdom
- Volunteers
- 59 people
- Sponsor
- Norfolk and Suffolk NHS Foundation Trust
Bipolar Disorder
Understanding Treatment Adherence Among Individuals With Rapid Cycling Bipolar Disorder
This study will examine how various factors, such as psychiatric symptoms, gender, quality of life, and attitudes toward medication, affect treatment adherence in individuals with rapid cycling bipolar disorder.
- Trial name
- NCT00183703
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Case Western Reserve University
Bipolar Depression, Bipolar Disorder
Theta-Burst Stimulation for Bipolar Depression
The purpose of this trial is to determine if intermittent theta-burst stimulation (iTBS) can reduce the symptoms of depression in treatment-resistant bipolar disorder.
- Conditions
- Bipolar Depression, Bipolar Disorder, Treatment- Resistant Bipolar Disorder, Type 2 Bipolar Disorder
- Trial name
- TRIBE (NCT06370988)
- Testing
- iTBS Stimulation
- Where
- 2 sites in Canada
- Volunteers
- 124 people
- Sponsor
- Centre for Addiction and Mental Health
Bipolar Depression
Safety and Efficacy of Fecal Microbiota Transplantation in a Population With Bipolar Disorder
Every human harbors complex microbial communities (collectively, the human 'microbiome') that cover the skin and the body's mucosal surfaces.
- Trial name
- NCT03279224
- Testing
- Allogenic FMT, Autologous FMT
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- Valerie Taylor
Bipolar Disorder
Efficacy of Adjunctive Tianeptine in the Treatment of Bipolar Depression
One of the main challenges in the treatment of Bipolar Disorder (BD) is to achieve better functioning outcomes after syndromal recovery.
- Trial name
- NCT00879372
- Testing
- tianeptine
- Where
- Brazil
- Volunteers
- 13 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Bipolar Disorder, Depression, Bipolar
Study of the Effectiveness of Vestibular Stimulation Treatment in the Depressive Phase of Bipolar Disorder
Vestibular stimulation has been shown to be a very effective noninvasive treatment for major depression. Bipolar disorder is a mental illness that presents cyclic sequences of depressive and euphoric states.
- Trial name
- NCT02778256
- Testing
- Vestibular stimulation
- Where
- Chile
- Volunteers
- 120 people
- Sponsor
- Vest Brain,Centro de Estudios Neurovestibulares
Bipolar Disorder (BD), Bipolar 1 Depression
Neuromodulation of Mood Switch Circuitry in Bipolar Disorder
This study is exploring a new approach to treating depression in people with bipolar disorder (BD). Investigators are testing whether a non-invasive form of brain stimulation can help us understand depressed-to-euthymic mood…
- Conditions
- Bipolar Disorder (BD), Bipolar 1 Depression, rTMS, fMRI
- Trial name
- CircuitBD (NCT07680153)
- Testing
- MagVenture MagPro TMS system
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Weill Medical College of Cornell University
Severe Mental Disorder, Schizophrenia
Community-based Mental Health Care for People With Severe and Enduring Mental Ill Health (RECOVER-E) Croatia
To contribute to improving the level of functioning and quality of life and mental health outcomes for people with severe and enduring mental ill health (SMI) (schizophrenia, bipolar disorder, depression) by adapting and up…
- Conditions
- Severe Mental Disorder, Schizophrenia, Bipolar Disorder, Severe Depression
- Trial name
- RECOVER-E (NCT03862209)
- Testing
- Community mental health team
- Where
- Croatia
- Volunteers
- 200 people
- Sponsor
- Klinički Bolnički Centar Zagreb
Bipolar Disorder
Ropinirole in the Treatment of Bipolar Depression
To demonstrate efficacy and safety of Requip in in treating bipolar depression.
- Trial name
- NCT00314821
- Testing
- ropinirole
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Cambridge Health Alliance
Bipolar Disorder
Clinical Trial of Pramipexole in Bipolar Depression
The purpose of this study is to examine the safety and effectiveness of the drug pramipexole given in combination with lithium or divalproex for the short-term treatment of acute depression in patients with bipolar disorder.
- Trial name
- NCT00025792
- Testing
- Pramipexole
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Treatment Resistant Depression
Effect of Lithium Versus Placebo in Adults With Treatment-Resistant Depression Who Are Receiving Ketamine
The purpose of this research study is to compare the antidepressant effect of lithium versus placebo in adults receiving ketamine.
- Trial name
- NCT03290963
- Testing
- Lithium, Ketamine
- Where
- United States
- Sponsor
- William V. Bobo, M.D.
Schizophrenia, Bipolar Disorder
Person-Centered Versus Measurement-Based Care in Mental Health
Fifteen minutes is the typical length of an outpatient medication management appointment for people with serious mental health conditions.
- Conditions
- Schizophrenia, Bipolar Disorder, Major Depression
- Trial name
- PCORI-SDM (NCT02507349)
- Testing
- Person-Centered Care, Measurement-Based Care
- Where
- 2 sites in United States
- Volunteers
- 2,443 people
- Sponsor
- University of Pittsburgh
Bipolar Depression, Major Depressive Disorder
Clinical Trial Evaluating Lumateperone Monotherapy in the Treatment of Bipolar Depression or Major Depressive Disorder
This is a randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of lumateperone monotherapy in the treatment of patients with major depressive episodes associated with Bipolar I or…
- Trial name
- NCT04285515
- Testing
- Lumateperone
- Where
- 42 sites in United States, Bulgaria and 3 more
- Volunteers
- 488 people
- Sponsor
- Intra-Cellular Therapies, Inc.
Schizophrenia, Schizoaffective Disorder
Self-Management Training and Automated Telehealth to Improve SMI Health Outcomes
This randomized clinical trial (RCT) of 300 persons with serious mental illness (SMI) and medical comorbidity will evaluate outcomes for n=100 in a Community Based Health Home alone (CBHH), compared to n=100 also receiving…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Depression
- Trial name
- NCT02188732
- Testing
- CBHH+AT, CBHH+SMT, CBHH
- Where
- 2 sites in United States
- Volunteers
- 301 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Schizophrenia, Bipolar Disorder
Physician Survey on Monitoring of Patients Treated With Quetiapine
A physician survey to document receipt of metabolic educational materials and assess behavior of physicians in following messages communicated through the educational materials
- Conditions
- Schizophrenia, Bipolar Disorder, Major Depressive Disorder
- Trial name
- NCT01795326
- Volunteers
- 800 people
- Sponsor
- AstraZeneca