Clinical trials: Depression; Bipolar Disorder
Schizophrenia, Schizoaffective Disorder
Study of the Effectiveness of Valbenazine on Patient- and Clinician-Reported Outcomes in Participants With Tardive Dyskinesia
This study will evaluate the effectiveness of valbenazine on patient- and clinician-reported outcomes assessing health-related quality of life, functioning, and treatment effect in participants with tardive dyskinesia (TD) who…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depressive Disorder
- Trial name
- NCT05859698
- Testing
- Valbenazine
- Where
- 18 sites in United States
- Volunteers
- 59 people
- Sponsor
- Neurocrine Biosciences
Depression, Bipolar Disorder
Augmenting Hospitalization for Serious Mental Illness: Cognitive Bias Modification
Approximately 4.1% of the adult US population meets the criteria for SMI, a mental disorder associated with significant functional impairment.
- Conditions
- Depression, Bipolar Disorder, Anxiety Disorders, Psychiatric Disorder
- Trial name
- NCT03509181
- Testing
- I-Change, Symptom Tracking
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Mclean Hospital
Bipolar Disorder, Depression
Study of the Efficacy of a Fixed-dose Regimen of Cariprazine Compared to Placebo for Treatment of the Depressive Episode in Participants With Bipolar I Disorder
This study is designed to prospectively confirm the efficacy of a fixed-dose regimen of cariprazine 1.5 milligrams (mg)/day or 3 mg/day compared to placebo for treatment of the depressive episode in participants with bipolar I…
- Trial name
- NCT02670538
- Testing
- Cariprazine
- Where
- 89 sites in United States, Bulgaria and 6 more
- Volunteers
- 493 people
- Sponsor
- Forest Laboratories
Diabetes Mellitus, Bipolar Disorder
Improving Outcomes for Individuals With Serious Mental Illness and Diabetes
This project tests a model for improving illness self-management among persons who have both serious mental illness and diabetes and will be performed within a primary care setting at a safety net hospital system.
- Conditions
- Diabetes Mellitus, Bipolar Disorder, Depression, Psychotic Disorders
- Trial name
- TTIM (NCT01410357)
- Testing
- Targeted Training in Illness Management (TTIM)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Case Western Reserve University
Unipolar Depression, Bipolar Depression
Ketamine as an Augmentation Strategy for Electroconvulsive Therapy (ECT) in Depression
The study aims to compare outcomes of Electroconvulsive Therapy (ECT) using ketamine versus methohexital anesthesia in depressed patients.
- Trial name
- NCT01881763
- Testing
- Ketamine, Methohexital
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Northwell Health
Amphetamine Abuse, Amphetamine Dependence
A Pilot Study of Citicoline add-on Therapy in Patients With Bipolar Disorder or Major Depressive Disorder and Amphetamine Abuse or Dependence
Bipolar disorder (BD) is a common and severe psychiatric illness. Drug and alcohol abuse are very common in people with BD and other mood disorders and are associated with increased rates of hospitalization, violence towards self…
- Conditions
- Amphetamine Abuse, Amphetamine Dependence, Bipolar Disorder, Major Depressive Disorder
- Trial name
- NCT00377299
- Testing
- Citicoline
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Depressive Disorder, Bipolar Disorder
Nonconvulsive Electrotherapy: a Proof-of-concept Trial
This study involves pilot testing of a modified version of a proven treatment for mental illness. The treatment, electroconvulsive therapy (ECT) is used to treat more than 100,000 Americans yearly.
- Conditions
- Depressive Disorder, Bipolar Disorder, Schizoaffective Disorder
- Trial name
- NCT01065597
- Testing
- Nonconvulsive electrotherapy
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Maryland, College Park
Bipolar Disorder
Simvastatin Augmentation of Lithium Treatment in Bipolar Depression
Primary Aim: To estimate the antidepressant efficacy of simvastatin versus placebo as an adjunct to lithium, valproate, and/or other atypical antipsychotic therapy among individuals with bipolar I disorder in a nonpsychotic major…
- Trial name
- NCT01665950
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Massachusetts General Hospital
Bipolar Depression, Major Depressive Disorder
Clinical Trial Evaluating Lumateperone Monotherapy in the Treatment of Bipolar Depression or Major Depressive Disorder
This is a randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of lumateperone monotherapy in the treatment of patients with major depressive episodes associated with Bipolar I or…
- Trial name
- NCT04285515
- Testing
- Lumateperone
- Where
- 42 sites in United States, Bulgaria and 3 more
- Volunteers
- 488 people
- Sponsor
- Intra-Cellular Therapies, Inc.
Bipolar Disorder, Major Depressive Disorder
Reducing Suicide Risk in Adolescents and Young Adults Via a Psychobehavioral Intervention to Regularize Daily Rhythms
The purpose of this study is to advance a non-pharmacologic suicide preventive intervention with wide dissemination potential as an innovative high-yield solution to reduce suicide rates.
- Conditions
- Bipolar Disorder, Major Depressive Disorder, Mood Disorders, Suicide
- Trial name
- NCT05317481
- Testing
- BE-SMART-DR, psychoeducational control comparator condition (CC)
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- Yale University
Cigarette Smoking, Schizophrenia
Integrated Smoking Cessation Treatment for Smokers With Serious Mental Illness
The overall aim of this study is to test the effect of academic detailing (i.e. provider-level educational intervention focused on evidence-based smoking cessation treatment for those with psychiatric illness) and community…
- Conditions
- Cigarette Smoking, Schizophrenia, Bipolar Disorder, Depressive Disorder, Major
- Trial name
- NCT02845440
- Testing
- Academic Detailing, Community Health Worker, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 1,165 people
- Sponsor
- Massachusetts General Hospital
Treatment Resistant Depression
Pilot Accelerated Theta Burst in Treatment-Resistant Bipolar Depression
This study evaluates an accelerated schedule of theta-burst stimulation using a transcranial magnetic stimulation device for treatment-resistant bipolar depression.
- Trial name
- NCT03953417
- Testing
- Accelerated intermittent theta-burst treatment
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Stanford University
Bipolar Depression
Multiple Treatment Study Using Low Field Magnetic Stimulation for Bipolar Depression
Objectives: To demonstrate the duration of the antidepressant effect of Low Field Magnetic Stimulation (LFMS)in subjects with bipolar depression.
- Trial name
- LFMS (NCT01929681)
- Testing
- Low Field Magnetic Stimulation
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Mclean Hospital
Bipolar Disorder
Radiosurgical Neuromodulation for Refractory Depression
This study is designed to evaluate the safety and effectiveness of an investigational procedure for treating people with treatment resistant bipolar depression (TRD).
- Trial name
- NCT01403441
- Testing
- Radiosurgical Neuromodulation using the Cyberknife
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Stanford University
Major Depressive Disorder, Bipolar Disorder
Brain Mechanisms of Human Motivation
This study aims to investigate reward learning across the mood disorder spectrum and to investigate the predictive validity of reward learning for subsequent symptom severity.
- Trial name
- NCT01976975
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Bipolar Disorder
A Study of JNJ-55308942 in the Treatment of Bipolar Depression
The purpose of this study is to evaluate the efficacy of JNJ-55308942 compared to placebo on symptoms of depression in participants with bipolar disorder (BD) in a major depressive episode (MDE) at Week 6.
- Trial name
- NCT05328297
- Testing
- JNJ-55308942
- Where
- 44 sites in United States, Canada and 2 more
- Volunteers
- 116 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Schizophrenia, Schizoaffective Disorder
Decreasing Risk of Coronary Artery Disease in Schizophrenia by Omega-3 Fatty Acid Supplementation
The purpose of this study is to determine whether the administration of omega-3 polyunsaturated fatty acids, particularly eicosapentaenoic acid (EPA), can be useful both to reduce coronary artery disease (CAD) risk and illness…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Major Depression, Bipolar Disorder
- Trial name
- CAD (NCT00167310)
- Testing
- Eicosapentaenoic acid (omega-3 fatty acid)
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Pittsburgh
Mental Disorder, Schizophrenia
A Trial to Assess a Wearable Patch's Functioning to Detect Medication Ingestion
The primary purpose of the study is to evaluate the positive detection accuracy (PDA) and detection latency measures of the D-Tect patch.
- Conditions
- Mental Disorder, Schizophrenia, Major Depressive Disorder, Bipolar I Disorder
- Trial name
- NCT06372210
- Testing
- Abilify MyCite®, D-Tect Patch
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Mood Disorder, Bipolar Disorder
A Pilot Study on Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment of Bipolar Depression
This is a pilot project to study if repetitive Transcranial Magnetic Stimulation (rTMS) will benefit patients with bipolar depression safely.
- Conditions
- Mood Disorder, Bipolar Disorder, Major Depression, Depression
- Trial name
- TMS-BD (NCT00699218)
- Testing
- Magnetic Stimulator Rapid2 made by Magstim Company Ltd. U.K.
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of California, Davis
Bipolar Disorder, Depression
Maintenance Treatment of Bipolar Depression
This study will compare two different antidepressant treatment regimens to determine which is more effective in reducing symptoms of bipolar depression.
- Trial name
- NCT00183469
- Testing
- Lamotrigine, Divalproex (DIV) ER
- Volunteers
- 86 people
- Sponsor
- The University of Texas Health Science Center at San Antonio