Clinical trials: Depression, suspended
Post Traumatic Stress Disorder
Early Prevention of PTSD in Patients Within One Week of Acute Physical Trauma
The objective of this study is to assess the feasibility and effectiveness of AEPET plus Resilience Based Therapy (RBT) versus RBT alone for the prevention of PTSD and depression in trauma patients.
- Trial name
- NCT02915497
- Testing
- Abbreviated Early Prolonged Exposure Therapy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Sunnybrook Health Sciences Centre
Major Depressive Disorder, Mild Neurocognitive Disorder
Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disorder (MND) in Persons With HIV
A phase II, randomized, open-label, two-arm clinical trial evaluating the safety and efficacy of pramipexole extended release (ER) versus escitalopram for the treatment of major depressive disorder (MDD) and comorbid MDD with…
- Conditions
- Major Depressive Disorder, Mild Neurocognitive Disorder, HIV
- Trial name
- NCT06705478
- Testing
- Pramipexole ER, Escitalopram
- Where
- 41 sites in United States, Botswana and 12 more
- Volunteers
- 186 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Anxiety Depression, Alcohol Abuse
CBD Oil for Reducing Emotional Impact of COVID-19
Our purpose is to conduct a 4-arm placebo-controlled clinical trial to investigate the relative clinical efficacy of 300 mg. of pure hemp-derived CBD isolate, 300 mg. of full spectrum CBD oil, 300 mg.
- Conditions
- Anxiety Depression, Alcohol Abuse, Substance Abuse, Anger
- Trial name
- CBDOIL (NCT04603781)
- Testing
- CBD Isolate, Full Spectrum CBD Oil, Broad-Spectrum CBD Oil
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Type 2 Diabetes, Psychological Distress
Psychological Distress and Type 2 Diabetes
Increasing evidence suggests that psychological disorders play an important role in the development and worsening of type 2 diabetes (T2D).
- Trial name
- COPEST (NCT01870141)
- Testing
- Cognitive-Behavioral Intervention
- Where
- Italy
- Volunteers
- 61 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Depressive Symptoms
Syrenity App for Depression
The goal of this clinical trial is to learn if the Syrenity mental health app reduces depressive symptoms when compared to a control condition.
- Trial name
- SYRA (NCT06408025)
- Testing
- Syrenity App
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Indiana University
Depressive Disorder, Major, Bipolar Depression
Ketamine Versus Electroconvulsive Therapy in Depression
While there are effective treatments for depression available, some patients do not see results with these options. Often, these patients are referred to electroconvulsive therapy (ECT) which has drawbacks such as adverse side…
- Trial name
- NCT03674671
- Testing
- Intravenous Ketamine, Electroconvulsive Therapy
- Where
- 4 sites in Canada
- Volunteers
- 240 people
- Sponsor
- University of Ottawa
Major Depressive Disorder, Treatment Resistant Depression
Low-Intensity Focused Ultrasound for Treatment-Resistant Depression
The Investigators are proposing to demonstrate safety and efficacy of LIFUP for treatment resistant major depressive disorder in a ten-patient pilot study.
- Trial name
- NCT06013384
- Testing
- Low-Intensity Focused Ultrasound Pulsation
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Medical University of South Carolina
Depressive Disorder, Major
Predictors of Treatment Response in Late-onset Major Depressive Disorder
Depression is a common disorder, especially in old age, where it is associated with significant morbidity and mortality. This study will investigate whether there are features of individual patients with major depression that may…
- Trial name
- NCT02546024
- Testing
- Standard care
- Volunteers
- 40 people
- Sponsor
- King's College London
Alcoholism, Alcohol Drinking
Amplification of Positivity for Alcohol Use Disorder Co-Occurring With Anxiety or Depression
The purpose of this study is to examine the feasibility of a protocol in which individuals with comorbid depression or anxiety disorders and alcohol use disorder will be randomized to complete Amplification of Positivity for…
- Conditions
- Alcoholism, Alcohol Drinking, Drinking Behavior, Alcohol-Related Disorders
- Trial name
- NCT04934553
- Testing
- Amplification of Positivity Training, Cognitive-behavioral Therapy
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Charles Taylor
Depression Disorder
The Effects of Chiropractic on Adults With Depression
The goal of this clinical trial is to evaluate the feasibility of the study design in preparation for a future clinical trial examining chiropractic care for adults with mild to moderate depression.
- Trial name
- DEP (NCT07260045)
- Testing
- Chiropractic Care
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Life University
Major Depressive Disorder, Breast Cancer
Feasibility Trial of Tele-IPT and Tele-Pharmacotherapy for Patients With Depression and Non-Metastatic Breast Cancer
Cancer and depression commonly occur together, and each worsens the other. We conducted a large psychotherapy study treating depression in breast cancer patients, showing that psychotherapy lowers symptoms.
- Conditions
- Major Depressive Disorder, Breast Cancer, Venlafaxine
- Trial name
- IPT (NCT04973930)
- Testing
- Interpersonal Psychotherapy, Venlafaxine HCl ER
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- New York State Psychiatric Institute
Chronic Pain, Anxiety
Phase II Trial of Nu-V3 Non-Invasive Nerve Stimulation Device for Chronic Pain, Anxiety, Depression, Sleeplessness
This Nu-V3 clinical study is a randomized, phase II, open-label study evaluating the Nu-V3 cranial nerve stimulation treatment device in patients with chronic pain, anxiety, depression, and/or sleeplessness.
- Conditions
- Chronic Pain, Anxiety, Depression, Sleeplessness
- Trial name
- Nu-V3P2RCT (NCT05394545)
- Testing
- Nu-V3
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Nu-Life Solutions
Bipolar Depression, Unipolar Depression
Low Field Magnetic Stimulation (LFMS) in Mood Disorders: 6 Treatments
To demonstrate the efficacy of multiple applications of Low Field Magnetic Stimulation (LFMS) as an antidepressant treatment in subjects with mood disorders.
- Trial name
- LFMS6tx (NCT01557192)
- Testing
- Low Field Magnetic Stimulation Device
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Mclean Hospital
Major Depressive Disorder, Suicide
Identifying the Neural Basis of Capability for Suicide
Since capability for suicide involves overriding potential pain, and the opioid system plays a strong role in controlling pain perception, it follows that capability for suicide may be impacted by the opioid system.
- Conditions
- Major Depressive Disorder, Suicide, Suicidal Ideation, Psychiatric Illness
- Trial name
- NCT03327129
- Testing
- fMRI
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Idiopathic Parkinson's Disease, Parkinson Disease
Exploring Mechanisms for Neuropsychiatric Symptoms of Parkinson Disease Using Transcranial Direct Current Stimulation
This study evaluates the effect of transcranial direct current stimulation (tDCS) on non-motor symptoms of Parkinson's disease, including depression and cognitive symptoms.
- Conditions
- Idiopathic Parkinson's Disease, Parkinson Disease, Depression
- Trial name
- NCT03074812
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Johns Hopkins University
Moderate Depression, Major Depressive Disorder
Neuromodulation of Different Doses to Treat TRD Guided by pBFS Technique
The aim of this study is to explore the effectiveness and safety of different doses of neural regulation under the guidance of pBFS technology in improving symptoms in patients with moderate to severe depressive disorders.
- Conditions
- Moderate Depression, Major Depressive Disorder, Severe Depression
- Trial name
- NCT06112652
- Testing
- 4 session rTMS, 6 session rTMS, 8 session rTMS
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Changping Laboratory
Major Depression
Selenium as Augmentation Treatment for Sertraline Resistant Major Depression
The main goals of antidepressant treatments are to achieve remission of depressive episodes and prevent recurrences. However, clinical trials designed to approve antidepressants targets a response rate of at least 50%, which is…
- Trial name
- NCT02890212
- Testing
- selenium supplementation
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Anhedonia, Virtual Reality
Mobile Virtual Positive Experiences for Anhedonia
Anhedonia is a symptom dimension that characterizes many individuals suffering from depression, as well as some types of anxiety, psychosis, and substance use.
- Conditions
- Anhedonia, Virtual Reality, Depression, Mood Disorders
- Trial name
- MVR (NCT03715400)
- Testing
- Positive Virtual Reality Training
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of California, Los Angeles
Depression Anxiety Disorder
Alternative Treatments To Prevent Cognitive Decline in Older Adults With Depression and Anxiety
Major depression and anxiety disorders are leading causes of disability worldwide. These mental disorders deeply impact social functioning and physical health in more than 300,000-600,000 Canadians over the age of 60.
- Trial name
- NCT03607708
- Testing
- Mindfulness-Based Cognitive Therapy (MBCT), Health Enhancement Program (HEP)
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Lady Davis Institute
Disorder, Major Depressive
Smartphone-enabled Health Coaching Intervention for Youth Diagnosed With Major Depressive Disorders
Randomized controlled trial (RCT) comparing youth diagnosed with major depressive disorder treated with online mindfulness-based cognitive behavioural therapy vs. standard psychiatric care (as wait-list controls).
- Trial name
- NCT03406052
- Testing
- Smartphone-Assisted MB-CBT
- Where
- Canada
- Volunteers
- 168 people
- Sponsor
- York University