Clinical trials: Depression / Major Depressive Disorder
Suicidal Ideation, Major Depressive Disorder (MDD)
Understanding and Treating Suicidal Ideation With Ketamine
The goal of this clinical trial is to treat active suicidal ideation in individuals with Major Depressive Disorder (MDD) using ketamine and to understand suicidal ideation by examining biological mechanisms using magnetic…
- Trial name
- NCT06891300
- Testing
- ketamine hydrochloride
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- The Royal's Institute of Mental Health Research
Major Depression
Serum Markers as a Bioassay for Unipolar Depression
The goal of the study is to validate a biomarker assay for unipolar depression based on serum proteins involved in inflammation, metabolism, and stress response.
- Trial name
- NCT00825799
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Steward St. Elizabeth's Medical Center of Boston, Inc.
Major Depressive Disorder
Characterization of Microbial, Immune and Epigenetic Biomarkers for Major Depressive Disorder and ECT Treatment
The investigators aim to characterize fecal microbial biomarkers as well as blood cytokine levels in MDD patients vs. healthy controls.
- Trial name
- NCT03703414
- Testing
- Fecal microbiota composition analysis and blood cytokine level analysis
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ziv Hospital
Major Depressive Disorder
Trial of Centanafadine Efficacy and Safety as Monotherapy or as Adjunct to SSRI in Adults With Major Depressive Disorder
This is a phase 2, multicenter, randomized, double-blind, placebo-controlled, parallel-arm trial to assess the efficacy, safety, and tolerability of centanafadine once-daily (QD) extended-release (XR) capsules for the treatment…
- Trial name
- JUNIPER (NCT05536414)
- Testing
- Centanafadine, Escitalopram
- Where
- 62 sites in United States
- Volunteers
- 337 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Major Depressive Disorder
Open-label Safety Extension Study of 5 and 10 mg of Vortioxetine (Lu AA21004) in Long-term Treatment of Major Depressive Disorder in Adults
The purpose of the study is to evaluate long-term safety and tolerability of Vortioxetine over a period of 52 weeks in patients with Major Depressive Disorder (MDD) having completed 6-week acute treatment in study NCT00839423 /…
- Trial name
- NCT00761306
- Testing
- Vortioxetine (Lu AA21004)
- Volunteers
- 74 people
- Sponsor
- H. Lundbeck A/S
Major Depression
Trial of Transcranial Direct Current Stimulation (tDCS)
Among antidepressant treatments, ECT stands as the most effective in treating acute depression. However, patient concerns with the cognitive side effects of ECT have encouraged the development of new and more focal forms of brain…
- Trial name
- NCT01346306
- Testing
- Eldith Company - direct current stimulator
- Where
- 2 sites in Australia, Singapore
- Volunteers
- 24 people
- Sponsor
- The University of New South Wales
Treatment Resistant Depression, Bipolar Depression
A Naturalistic Study of Ketamine for Treatment Resistant Mood Disorders
This study aims to openly test the long-term safety, tolerability and effectiveness of repeated administration of IV, nasal spray and oral ketamine for treatment-resistant mood disorders.
- Conditions
- Treatment Resistant Depression, Bipolar Depression, Ketamine, Major Depressive Disorder
- Trial name
- GDKet (NCT04226963)
- Testing
- Ketamine
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Medical University of Gdansk
Major Depressive Disorder
Behavioral and Electrophysiological Effects of Ketamine in Treatment-Resistant Depression
The overarching goal of the present study is to evaluate the effect of a subanesthetic dose of ketamine 24-hour post-injection on resting state functional connectivity, cognitive control, and reward learning.
- Trial name
- NCT04239963
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Unipolar Depression, Bipolar Depression
Ketamine as an Augmentation Strategy for Electroconvulsive Therapy (ECT) in Depression
The study aims to compare outcomes of Electroconvulsive Therapy (ECT) using ketamine versus methohexital anesthesia in depressed patients.
- Trial name
- NCT01881763
- Testing
- Ketamine, Methohexital
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Northwell Health
Depressive Episodes, Bipolar I Depression
A Clinical Trial to Determine the Long-term Safety and Tolerability of an Investigational Drug in People With Major Depressive Episode Associated With Bipolar I Disorder (Bipolar I Depression).
This is a clinical trial to determine the long-term safety and tolerability of an investigational drug in people with Major Depressive Episode Associated with Bipolar I Disorder (Bipolar I Depression).
- Trial name
- NCT05227209
- Testing
- SEP-4199 CR
- Where
- 69 sites in United States, Bulgaria and 1 more
- Volunteers
- 64 people
- Sponsor
- Sumitomo Pharma America, Inc.
Major Depressive Disorder, Excessive Sleepiness
Safety and Tolerability of Single and Multiple Ascending Doses of GATE-101 in Normal Human Volunteers
To evaluate the safety, tolerability, and pharmacokinetics of single and multiple ascending doses of GATE-101 in normal human volunteers
- Trial name
- NCT04618263
- Testing
- GATE-101
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Syndeio Biosciences, Inc
Major Depressive Disorders
Efficacy of Transcranial Direct Current Stimulation (tDCS) for the Treatment of Major Depressive Disorder
The aim of this study is to assess the efficacy of Transcranial Direct Current Stimulation (tDCS) as an Add-on Treatment for the drug-naïve Major depressive disorder.
- Trial name
- NCT04497493
- Testing
- Transcranial Direct Current Stimulation (tDCS)-active
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Tianjin Anding Hospital
Major Depressive Disorder
Quantitative EEG (QEEG) as a Predictor of Treatment Outcome in Depression
The purpose of the study is to try to see if antidepressant medications cause changes in QEEG measurements in the brain. QEEG is a mathematical analysis of electrical currents in the brain using electrodes placed on the scalp.
- Trial name
- NCT00157547
- Testing
- Selective serotonin reuptake inhibitors (SSRI)
- Volunteers
- 95 people
- Sponsor
- Massachusetts General Hospital
Treatment Resistant Depression
Coupling Repetitive Transcranial Magnetic Stimulation With a Neuronavigation System in Treatment Resistant Depression
Repetitive Transcranial Magnetic Stimulation (rTMS) is a non invasive technique which was shown to be effective in the treatment of major depression.
- Trial name
- TMS (NCT01677078)
- Testing
- Neuronavigation system, Standard localisation method
- Where
- 5 sites in France
- Volunteers
- 107 people
- Sponsor
- Rennes University Hospital
Depression
Study Evaluating Effexor XR in Elderly Patients With Major Depression.
Phase III study evaluating Effexor XR in elderly patients with major depression.
- Trial name
- NCT00225485
- Testing
- Effexor XR
- Where
- 37 sites in Japan
- Volunteers
- 100 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Depression, Major Depressive Disorder
Hyperthermic Yoga for Depressive Symptoms
Study is a randomized controlled trial to assess the feasibility, acceptability, efficacy, and mechanisms of action of hyperthermic yoga versus a waitlist control for 80 medically healthy adults with mild to moderate depressive…
- Trial name
- NCT02607514
- Testing
- hyperthermic yoga
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Major Depressive Disorder
Synchronized Transcranial Magnetic Stimulation (sTMS) in Major Depressive Disorder
This study is designed to evaluate the safety and efficacy of synchronized transcranial magnetic stimulation (sTMS) using the NeoSync EEG Synchronized TMS device (NEST) in subjects with Major Depressive Disorder.
- Trial name
- NEST-MDD (NCT01370733)
- Testing
- NEST-1 (NeoSync EEG Synchronized TMS)
- Where
- 18 sites in United States
- Volunteers
- 202 people
- Sponsor
- Wave Neuroscience
Partner Assisted Interpersonal Psychotherapy, Treatment as Usual
Partner-Assisted Interpersonal Psychotherapy or Antidepressant Medication for Antenatal Depression
Purpose: To compare a novel psychotherapy, Partner-Assisted Interpersonal Psychotherapy (PA-IPT), with treatment as usual (TAU) in a sample of pregnant women seeking treatment for Major Depressive Disorder (MDD) at the University…
- Trial name
- NCT01732055
- Testing
- Partner-Assisted Interpersonal Psychotherapy, Treatment as Usual
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Depressed Mood
ATLAS-1: Advanced Trial for Longitudinal Assessment in Salma 1
This study will evaluate the feasibility and clinical utility of developing predictive models of treatment response for patients with depressed mood using multimodal clinical data collected in real-world clinical settings.
- Trial name
- ATLAS-1 (NCT07528014)
- Where
- 2 sites in United States
- Volunteers
- 5,000 people
- Sponsor
- Salma Health, Inc.
Major Depressive Disorder
Patient Stratification and Treatment Response Prediction in Neuropharmacotherapy Using Hybrid Positron Emmission Tomography/Magnetic Resconance Imaging (PET/MR)
Selective serotonin reuptake inhibitors (SSRIs) raise serotonin (5-HT) in the synaptic cleft and are the current first line of pharmacological antidepressive treatment.
- Trial name
- NCT02711215
- Testing
- PET/MR [11C]DASB, Citalopram, Escitalopram (Mirtazapine/Duloxetine/Venlafaxine)
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna