Clinical trials: Depression Chronic, open to volunteers
Cirrhosis
Chronic Pain Optimization and Management for Relief and Functionality With TEA in Cirrhosis
This study is being done to better understand how the study team can treat pain for people with cirrhosis and depression. Enrolled participants on this feasibility study will be randomized to Transcutaneous Electrical…
- Trial name
- COMFORT (NCT07820917)
- Testing
- Transcutaneous Electrical Acustimulation (TEA)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Michigan
Insomnia Chronic
Aerobic Exercise Versus Digital Cognitive Behavioral Therapy for Insomnia
The purpose of this study is to compare the effects of aerobic exercise versus digital CBT-I in university students with insomnia complaints. This is a clinical trial.
- Trial name
- NCT06636006
- Testing
- Aerobic Exercise, Cognitive Behavioral Therapy for Insomnia
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Universidade Federal de Goias
Cognition, Affect (Mental Function)
ETASCAN Project: ETAS Project 2
This study aims to investigate the chronic effects of ETAS® on cognitive, affective and neural outcomes in healthy adults aged 60-80 years with mild to moderate subjective cognitive complaints.
- Conditions
- Cognition, Affect (Mental Function), Sleep, MRI
- Trial name
- ETASCAN (NCT07550140)
- Testing
- ETAS®
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Reading
Depression - Major Depressive Disorder, Depression Disorder
Virtual Reality-Based Mindfulness as an Adjunct to Treatment as Usual in Treatment-Resistant Depression
The primary aim of this study is to evaluate the efficacy and tolerability of a combined Virtual Reality (VR)-based mindfulness intervention and pharmacological treatment compared with pharmacological treatment alone in reducing…
- Conditions
- Depression - Major Depressive Disorder, Depression Disorder, Depression Chronic, Treatment-Resistant Major Depressive Disorder
- Trial name
- NCT07422519
- Testing
- Virtual-Reality-based mindfulness intervention, Esketamine Treatment as Usual (ESK)
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Chronic Kidney Disease(CKD), Depression
Pharmacogenomics of Mood Disorder in Chronic Kidney Disease Patients
By using genetic information we could predict the prevalence of mood disorder and response to treatment.
- Trial name
- CKD (NCT06675396)
- Testing
- Antidepressants
- Volunteers
- 300 people
- Sponsor
- Wonju Severance Christian Hospital
Chronic Low-back Pain
Integrative Mindfulness-Based Predictive Approach for Chronic Low Back Pain Treatment
This study will identify unique signatures that people have which can cause pain by evaluating biological, psychological, and social markers using artificial intelligence.
- Trial name
- IMPACT (NCT06106191)
- Testing
- Mindfulness meditation, Perspectives on pain, Discussion
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Boston Medical Center
Chronic and Episodic Headache, Headache Disorders
PERSONOLOGICAL STRUCTURE, COGNITIVE FUNCTIONS AND CENTRAL SENSITIZATION IN HEADACHE
Headache, in its episodic and chronic forms, cannot be considered solely as an isolated neurological symptom, but as a complex condition of a bio-psycho-social nature.
- Trial name
- AURA (NCT07268768)
- Testing
- Neuropsychological assessment
- Where
- Italy
- Volunteers
- 64 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Long Covid-19, Emotional Disorder
Effectiveness and Acceptability of the Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders in People With Long COVID-19.
This Randomized Controlled Trial (RCT) aims to assess the effectiveness and acceptability of the Unified Protocol (UP) in an online group format for the treatment of emotional disorders in adults.
- Conditions
- Long Covid-19, Emotional Disorder, Anxiety, Depression Disorders
- Trial name
- UP-LONGCOVID-R (NCT06928480)
- Testing
- Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders, Treatment as Usual (TAU)
- Where
- 2 sites in Spain
- Volunteers
- 90 people
- Sponsor
- Instituto de Investigación Sanitaria Aragón
Obesity, Hyperlipidemias
Lifestyle Medicine: Establishing Clinical Approaches to Chronic Disease for Rural Patients
Developed nations worldwide are currently enduring a health crisis, as chronic diseases continue to decrease quality of life and promote additional disease states or even death for much of the population.
- Conditions
- Obesity, Hyperlipidemias, Polycystic Ovary Syndrome, Hypertension
- Trial name
- NCT06049420
- Testing
- Lifestyle counseling and coaching
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- West Virginia School of Osteopathic Medicine
Pancreatic Tumor, Benign, Pancreatic Cancer, Adult
Association Between Chronic Psychological Stress and Disease Course Outcomes in Pancreatic Cancer
This is a prospective, observational cohort study (MIND-PANC) to explore the associations of chronic psychological stress with disease progression, treatment outcomes, and prognosis of pancreatic cancer.
- Conditions
- Pancreatic Tumor, Benign, Pancreatic Cancer, Adult, Pancreatic Cancer Resectable
- Trial name
- MIND-PANC (NCT07529626)
- Where
- 3 sites in China
- Volunteers
- 320 people
- Sponsor
- Shanghai Zhongshan Hospital
Traumatic Brain Injury (TBI)
Allopregnanolone in Chronic Complex Traumatic Brain Injury
This study will determine if allopregnanolone (ALLO) improves depression and pain symptoms in patients who have a history of mild traumatic brain injury (TBI) [primary endpoints].
- Trial name
- ALLO (NCT04003285)
- Testing
- Allopregnanolone
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- VA Office of Research and Development
Cognitive Dysfunction, Stroke
Vascular mEchanisms in, Stroke, dePression, dementiA, and deliRum: The VESPAR Project
The goal of this observational study is to determine the feasibility of using integrated Transcranial Doppler Ultrasonography or Near Infrared Spectroscopy to detect changes in cerebral autoregulation and neurovascular coupling…
- Conditions
- Cognitive Dysfunction, Stroke, Dementia, Depression
- Trial name
- VESPAR (NCT05649800)
- Where
- 2 sites in United Kingdom
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Late Life Depression
Chronic Anergic Depression IDentification - Magnetic Resonance Imaging Exploration in the Elderly of Traits Related to Onset
Depression in the elderly, or "late life depression" (LLD), is often considered to be homogeneous, legitimizing standardized treatment.
- Trial name
- CAnD'ID-METRO (NCT06663891)
- Testing
- Functional MRI with EEG per MRI
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Coccydynia, Chronic Pain
Alexithymia, Pain Intensity, Quality of Life, and Psychological Symptoms in Chronic Coccydynia Patients Scheduled for Ganglion Impar Block
Chronic coccydynia is characterized by pain localized to the coccygeal region that typically worsens with sitting, leading to notable impairments in functional performance and health-related quality of life.
- Conditions
- Coccydynia, Chronic Pain, Alexithymia
- Trial name
- NCT07828145
- Testing
- Psychometric and Clinical Survey Battery
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Marmara University
Episodic Migraine, Chronic Migraine
CGRP Inhibition, Autonomic Function, and Migraine
The purpose of this clinical study is to better understand the function of the autonomic nervous system in patients with migraine. We aim to understand whether the autonomic functions change depending on the migraine status (i.e.
- Trial name
- CGRP-1 (NCT04628429)
- Testing
- Erenumab, Galcanezumab, Fremanezumab
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Chronic Pain
Application of Meaning-Based Psychotherapy to a Sample of Patients With Chronic Pain
The aimes of this study is to determine whether Meaning-Based Psychotherapy (MBP) is an effective therapy for improving sense of purpose, reducing depression, and improving quality of life in people with chronic pain and to…
- Trial name
- DOLORSENT (NCT07915440)
- Testing
- Meaning Based Group Psychotherapy, Cognitive Behavioural Psychotherapy
- Where
- Spain
- Volunteers
- 118 people
- Sponsor
- Hospital Clinico Universitario San Cecilio
Spinal Cord Injuries (SCI), Chronic Pain
Virtual Reality-Based Hypnotherapy for Pain, Sleep, and Mood in Spinal Cord Injury
The goal of this clinical trial is to learn whether virtual reality (VR)-based hypnotherapy, added to conventional physiotherapy, improves pain, sleep, mood, and quality of life in adults with chronic spinal cord injury.
- Conditions
- Spinal Cord Injuries (SCI), Chronic Pain, Neuropathic Pain, Sleep Disturbance
- Trial name
- HypnoVR-SCI (NCT07846410)
- Testing
- Virtual Reality-Based Hypnotherapy, Conventional Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Chronic Low Back Pain, Depression
Ketamine-assisted Integrative Treatment for Veterans With Chronic Low Back Pain and Comorbid Depression
This is a pilot study to evaluate the feasibility, acceptability, and safety of ketamine infusions followed by a brief behavioral intervention in Veterans with chronic low back pain and depression.
- Trial name
- NCT06419439
- Testing
- Ketamine hydrochloride, Minimally Enhanced Usual Care, Brief narrative intervention
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- VA Office of Research and Development
Long COVID
Evaluating the Effects of a Fermented Diet on Microbiome Diversity in Individuals With Long COVID
The purpose of this study is to evaluate the effects of fermented foods on bacterial gut microbiome diversity of long-COVID subjects.
- Trial name
- NCT06560554
- Testing
- Fermented foods, Control
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Deprescribing, Antidepressant
General Practitioner & Pharmacist Support for Discontinuing Long-term Antidepressants in Clinically Stable Patients
In Belgium, many adults who have suffered from depression keep using antidepressants on a daily basis for years afterwards, sometimes longer than guidelines recommend.
- Conditions
- Deprescribing, Antidepressant, Depression Disorder, Discontinuation
- Trial name
- GPS-AD (NCT07398053)
- Testing
- GPS-AD intervention
- Volunteers
- 324 people
- Sponsor
- University Ghent