Clinical trials: Depression Chronic
Depression, Anxiety Disorders
MINDFUL-PC for Portuguese Speakers Pilot Study 2020
The study evaluates the effects of the Mindfulness Training for Primary Care (MTPC) Portuguese-adapted version on heart rate variability during a demanding cognitive task.
- Conditions
- Depression, Anxiety Disorders, Stress Related Disorder, Adjustment Disorders
- Trial name
- NCT04268355
- Testing
- Mindfulness Training for Primary Care
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Cambridge Health Alliance
Treatment Resistant Depression
SAINT for Treatment of Preoperative Depression to Reduce Opioid Use Following Arthroplasty
This study evaluates an accelerated schedule of theta-burst stimulation using a transcranial magnetic stimulation device for treatment-resistant depression.
- Trial name
- NCT04195308
- Testing
- Active TBS-DLPFC, Open label TBS-DLPFC
- Where
- United States
- Sponsor
- Stanford University
Long Covid, Depression
Development of an Accessible Cognitive Behavioral Therapy Digital Therapeutic for Individuals With Long COVID
This study will evaluate Toivoa-004 as an experimental digital therapeutic for persons with Long COVID suffering from anxiety or depression.
- Conditions
- Long Covid, Depression, Anxiety
- Trial name
- NCT07714889
- Testing
- Rauha® Digital Therapeutic Platform (Toivoa-004)
- Sponsor
- Toivoa Inc
Low Back Pain, Disability Physical
Psychological Predictors of Pain and Disability in Patients With Chronic Low Back Pain After Manual Therapy
Low back pain has been reported to cause more disability than any other musculoskeletal health condition worldwide. About eight out of ten people will experience back pain at least once in their lifetime.
- Conditions
- Low Back Pain, Disability Physical, Manual Theapy
- Trial name
- NCT07306312
- Testing
- Manual therapy, Manual therapy plus Pain Neuroscience Education
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- University of Thessaly
Chronic Neck Pain, Disability
Association Between Neck Pain and Quality of Sleep
A prospective study to assess the association between the change in quality of sleep and the change in intensity of pain in Spanish patients seen for subacute or chronic neck pain.
- Trial name
- NCT00907049
- Where
- 2 sites in Spain
- Volunteers
- 424 people
- Sponsor
- Kovacs Foundation
Chronic Musculoskeletal Pain, Anxiety
Screening and Referral Practices for Anxiety and Depression Among Patients With Chronic Neck, Shoulder and Low Back Pain Within Physiotherapy Practices
The goal of this cross-sectional, qualitative study is to investigate whether physiotherapists screen for symptoms of anxiety and depression in patients with chronic musculoskeletal pain and to explore the facilitators and…
- Conditions
- Chronic Musculoskeletal Pain, Anxiety, Depression
- Trial name
- NCT07177547
- Testing
- Mental health screening and referral practices in physiotherapy
- Where
- Belgium
- Volunteers
- 18 people
- Sponsor
- Ana Catarina Navarro Ramalho
Other Chronic Postoperative Pain
High Pain Intervention in Cesarean Sections
In previous studies the investigators have seen that the severity of pain one day after cesarean delivery can predict the presence of pain and depression 2 months later.
- Trial name
- NCT01298778
- Testing
- Duramorph 150, Acetaminophen, Duramorph 300
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Wake Forest University Health Sciences
Mental Health, Depression and Burden in Caregivers
SOS for Caregiver Wellbeing
Parents and caregivers of children who have a chronic condition carry a large care burden and are at higher risk of having mental health symptoms.
- Conditions
- Mental Health, Depression and Burden in Caregivers, Anxiety Depression, Stress
- Trial name
- SOS (NCT07136584)
- Testing
- Screening, Outcomes and Referral Pathways
- Where
- Australia
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Murdoch Childrens Research Institute
Chronic Pain
Lidocaine and Ketamine Levels in Plasma After Simultaneous Lidocaine/Ketamine Infusions
The aim of this monocentric observational pilot study is to measure the lidocaine plasma level in a limited number of patients to generate explorative data on inter- and intrapersonal stability and safety of drug plasma levels…
- Trial name
- NCT05906121
- Testing
- lidocaine-ketamine infusions
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- University Hospital, Basel, Switzerland
Major Depressive Disorder, Chronic Major Depression, Recurrent
Establishing Multimodal Brain Biomarkers for Treatment Selection in Depression
The purpose of the study is to identify brain biomarkers and characteristics that predict individual responses to treatment of major depression with the antidepressant drug sertraline (tradename Zoloft), a common selective…
- Trial name
- Re-EMBARC (NCT05892744)
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Texas at Austin
Chronic Obstructive Pulmonary Disease (COPD), Chronic Obstructive Lung Disease
Mindfulness-based Cognitive Therapy for Chronic Obstructive Pulmonary Disease
The purpose of the study is to determine the efficacy of mindfulness-based cognitive therapy (MBCT) as an add-on to pulmonary rehabilitation (treatment as usual, TAU) in chronic obstructive pulmonary disease (COPD).
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Chronic Obstructive Lung Disease, Chronic Obstructive Airway Disease, Chronic Bronchitis
- Trial name
- NCT02042976
- Testing
- Mindfulness-based cognitive therapy, Pulmonary rehabilitation
- Where
- Denmark
- Volunteers
- 84 people
- Sponsor
- University of Aarhus
Posttraumatic Stress Disorder
Use of Repetitive Transcranial Magnetic Stimulation (rTMS) in Chronic Posttraumatic Stress Disorder (PTSD)
Posttraumatic stress disorder occurs in patients who have experienced, witnessed or have been confronted with an event involving actual death or the threat of death, serious injury, or the threat to physical health and felt fear…
- Trial name
- NCT00001657
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Mental Health (NIMH)
Quality of Life, Self Efficacy
What Concept of Manual Therapy is More Effective?
The aim of the study will be to find out which manual therapy approach is most effective for the improvement of symptoms (sensory, cognitive, emotional and social) in people with Fibromyalgia.
- Conditions
- Quality of Life, Self Efficacy, Kinesiophobia, Catastrophizing
- Trial name
- NCT05559021
- Testing
- Myofascial Therapy Treatments, Passive Mobilizations Approach
- Where
- 2 sites in Spain
- Volunteers
- 52 people
- Sponsor
- Universidad Europea de Madrid
Chronic Low Back Pain, Degenerative Disc Disease
Opioid Treatment for Chronic Low Back Pain and the Impact of Mood Symptoms
Opioids are frequently prescribed for chronic low back pain (CLBP). Psychiatric illness, such as high levels of depression and anxiety symptoms, is a common co-occurrence in chronic pain patients (and is termed comorbid negative…
- Conditions
- Chronic Low Back Pain, Degenerative Disc Disease, Depression, Anxiety
- Trial name
- NCT01502644
- Testing
- Oxycodone, Morphine
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Brigham and Women's Hospital
Depressive Symptoms, Allostatic Load
Rise & Thrive: Community-Engagement Intervention for Stress and Depression in Youth.
American youth and young adults face persistent and chronic stressors, which have contributed to a mental health crisis in the United States.
- Conditions
- Depressive Symptoms, Allostatic Load, Metabolic Syndrome
- Trial name
- R&T (NCT07554326)
- Testing
- Rise Together: Community Engagement Intervention, Adulting 101: Life Skills
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Asthma, Atrial Fibrillation
The Living With a Long-Term Condition Study
Psychological distress (anxiety and depression) is common in and experienced differently by people living with long-term health conditions (LTCs).
- Conditions
- Asthma, Atrial Fibrillation, Cancer, Cerebrovascular Disorders
- Trial name
- LTC (NCT06072287)
- Testing
- Living with LTC Questionnaire
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- King's College London
Spinal Cord Injuries, Anxiety Disorders
UK Prevalence of Mental Health After SCI
Mental health decline after Spinal Cord Injury (SCI) is commonly reported but minimally investigated in the United Kingdom. The current study aims to explore the prevalence and impact of mental health challenges after SCI to…
- Conditions
- Spinal Cord Injuries, Anxiety Disorders, Depression, PTSD
- Trial name
- NCT06618404
- Testing
- No intervention - cross-sectional cohort analysis
- Where
- United Kingdom
- Volunteers
- 318 people
- Sponsor
- University of Reading
Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Interoceptive Awareness
Interoception and Symptom Perception in Acute COPD Exacerbation
Interoception refers to the process of perceiving and interpreting internal physiological signals and plays a central role in symptom perception.
- Trial name
- NCT07719231
- Testing
- No Intervention: Observational Cohort
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Saglik Bilimleri Universitesi
Depression, Chronic Liver Disease
Vitamin D Improves Depression in Liver Patients
This study evaluates the efficacy of vitamin D replacement therapy in reducing depressive symptoms in patients with chronic liver disease and vitamin D deficiency.
- Trial name
- CLDVitD (NCT02359266)
- Testing
- Vitamin D
- Where
- Germany
- Volunteers
- 111 people
- Sponsor
- Universität des Saarlandes
Major Depressive Disorder, Dysthymic Disorder
Mindfulness Based Cognitive Therapy for Chronic Pain and Comorbid Unipolar Depression
The primary aim of this study is to test the feasibility and efficacy of Mindfulness Based Cognitive Therapy (MBCT) training for the treatment of depressive symptoms in patients with chronic pain.
- Conditions
- Major Depressive Disorder, Dysthymic Disorder, Depressive Disorder NOS, Chronic Pain
- Trial name
- NCT01473615
- Testing
- Mindfulness Based Cognitive Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital