Clinical trials: Depression Diagnosis
Major Depression
Study of Depression-Ketamine-Brain Function
Targeting the glutamatergic system to treat depression is a new and promising strategy based on studies at the molecular, synaptic, and neuronal level but also on results of studies conducted in animal models and first clinical…
- Trial name
- NCT01135758
- Testing
- Ketamine
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- Markus KOSEL
Burnout, Professional, Stress, Psychological
Improving the Mental Health of Resident Physicians and Fellows Through Transcendental Meditation
This proposal aims to optimize resident physician and fellow wellness and performance at Banner University Medical Center through an evidence-based stress reduction program, Transcendental Meditation (TM).
- Conditions
- Burnout, Professional, Stress, Psychological, Depression, Job Stress
- Trial name
- NCT04586309
- Testing
- Transcendental meditation
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Arizona
Depression, Ketosis
Ketogenic Intervention in Depression
The goal of this study is to examine whether a well-formulated ketogenic diet (KD) can be implemented into a university counseling treatment program for major depression and to test whether such a program has any benefit on…
- Trial name
- KIND (NCT06080932)
- Testing
- Ketogenic Diet, NIH Toolbox, gradCPT
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Depression, Postpartum
Repetitive Transcranial Magnetic Stimulation in Postpartum Depression
Several factors characterize repetitive transcranial magnetic stimulation (rTMS) as a strategic aid in the treatment of postpartum depression.
- Trial name
- rTMSPPD (NCT01452321)
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- Brazil
- Volunteers
- 14 people
- Sponsor
- University of Sao Paulo General Hospital
Major Depressive Disorder
A Study for Participants With Major Depression
This is a study to assess the safety and effectiveness of LY2216684 compared to placebo in treating adults with major depressive disorder.
- Trial name
- NCT00420004
- Testing
- LY2216684, Escitalopram
- Where
- 7 sites in United States, Romania
- Volunteers
- 469 people
- Sponsor
- Eli Lilly and Company
Major Depressive Disorder (MDD, Anxiety Disorder, Generalized
Serotonin Variants & Gut Microbiota in Mental Health
This observational pilot study investigates whether a broad panel of genetic variants relevant to the serotonin pathway (including serotonergic system, methylation cycle, intestinal barrier integrity, and inflammatory response…
- Conditions
- Major Depressive Disorder (MDD, Anxiety Disorder, Generalized, Stress Disorders, Post-Traumatic, Panic Disorder
- Trial name
- NCT07634458
- Testing
- SNP Genotyping and Gut Metagenomics
- Volunteers
- 30 people
- Sponsor
- Neurobiologix
Memory Deficits, Electroconvulsive Therapy
Cognitive Training for Memory Deficits Associated With Electroconvulsive Therapy
Although electroconvulsive therapy (ECT) remains the most effective treatment for people with severe depression, patients may experience a significant degree of persistent and/or permanent memory problems following ECT.
- Trial name
- NCT01876758
- Testing
- Cognitive Intervention: Memory Training, Comparable general mental stimulation
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- New York State Psychiatric Institute
Treatment Resistant Depression
Comparison of Antidepressant Augmentation With Amantadine vs Pramipexole vs Quetiapine in Treatment Resistant Depression
The present study has been designed to compare the efficacy and safety of augmentation of SSRIs with Amantadine vs Pramipexole vs the recommended Quetiapine augmentation in Treatment-Resistant Depression (TRD) and correlate the…
- Trial name
- APQ-TRD (NCT04936126)
- Testing
- Quetiapine, Amantadine, Pramipexole
- Where
- India
- Volunteers
- 150 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
BIPOLAR DISORDER
Brain Derived Neurotrophic Factor as a Predictor of Response to Treatment in Bipolar Depression and Mania
There is sound evidence that quetiapine is effective in the treatment of manic and depressive episodes associated with Bipolar Disorder (BD) (Yatham et al 2006).
- Trial name
- NCT00879632
- Where
- Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Major Depression
Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression
The purpose of this multi-site randomized controlled trial is to evaluate the efficacy and risks of psilocybin for the treatment of depression in U.S.
- Trial name
- PIVOT (NCT07226232)
- Testing
- Psilocybin
- Where
- 5 sites in United States
- Volunteers
- 240 people
- Sponsor
- VA Office of Research and Development
Depression
Effectiveness of Telephone Versus Face-to-Face CBT in Treating People With Depression
This study will compare the effectiveness of telephone versus face-to-face administration of cognitive behavioral therapy in treating people with depression.
- Trial name
- NCT00498706
- Testing
- Telephone-administered cognitive behavioral therapy (T-CBT), Face-to-face administered CBT (FtF-CBT)
- Where
- United States
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Anorexia Nervosa
Nutritional Supplements in Patients with Anorexia Nervosa
Anorexia nervosa causes gastroparesis, constipation, and can lead to elevated liver enzymes. It is often necessary to supplement the diet of patients with nutritional formulas.
- Trial name
- PEPTIDICAN21 (NCT05184738)
- Testing
- Experimental Treatment, Oligomeric nutritional formula, Control Treatment
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Major Depression
Psilocybin for Depression in Veterans
More efficacious treatments for Major Depressive Disorder (MDD) in Veterans are urgently needed. Psilocybin is a promising novel treatment that is likely to be the first FDA-approved psychedelic, but its safety and efficacy…
- Trial name
- PACT (NCT07895134)
- Testing
- Psilocybin, modafinil, zolpidem
- Where
- 4 sites in United States
- Volunteers
- 150 people
- Sponsor
- VA Office of Research and Development
Postpartum Depression, Postpartum Anxiety
Online MBI for Families Affected by PPDA
The aim of this study is to explore the feasibility of delivering clinical mindfulness groups for families affected with postpartum depression and anxiety (PPDA).
- Trial name
- NCT04617132
- Testing
- MBCT/MBSR
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- British Columbia Children's Hospital
Depression Disorders, Fatigue Symptom
AI Platform for Fatigue and Depression Detection
This study evaluates the accuracy of the Okaya AI platform in detecting fatigue and depression in cardiology patients, comparing its assessments to PHQ-9 and Fatigue Assessment Scale scores.
- Conditions
- Depression Disorders, Fatigue Symptom, Cardiovascular
- Trial name
- NCT07218263
- Testing
- AI-enabled Okaya platform
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Brijesh Patel
Depression - Major Depressive Disorder, Childhood Traumas
Resolving Early Life Stress: Psychotherapy Outcomes and Neurobiology in Complex Depression
The RESPOND trial explores the link between early life adversity and later life depressive symptoms. The investigators have designed a new psychological therapy tailored to address the symptoms that can be caused by difficult…
- Trial name
- RESPOND (NCT07250893)
- Testing
- Psychotherapy
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Parkinson Disease, Pilates
Effect of Pilates Application on Abdominal Muscle Function, Core Stability, Musculoskeletal Pain, Quality of Life, Anxiety and Depression in Parkinson's Patients
In this study, it is aimed to investigate the effect of Pilates application on abdominal muscle function, core stability, musculoskeletal pain, quality of life, anxiety and depression in Parkinson's Patients.
- Conditions
- Parkinson Disease, Pilates, Muscle Function
- Trial name
- NCT04619784
- Testing
- Pilates Exercises, control
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Dokuz Eylul University
PTSD
Prevention of Combat-related PTSD Using Attention Bias Modification (ABM): A Randomized Controlled Trial
Military deployment to combat zones involves exposure to trauma at a higher than average rate and therefore presents a unique opportunity to study predisposing factors to posttraumatic stress reactions and test strategies…
- Trial name
- NCT01723215
- Testing
- Active ABMT8, Active ABMT4
- Where
- Israel
- Volunteers
- 862 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
Human Immunodeficiency Virus, Depression
Our Family Our Future: A Resilience-oriented Family Intervention to Prevent Adolescent HIV/STI Infection and Depression in South Africa
The purpose of this study is to test the efficacy of Our Family Our Future, an integrated intervention for preventing HIV and depression onset among adolescents.
- Conditions
- Human Immunodeficiency Virus, Depression, Sexually Transmitted Diseases
- Trial name
- NCT03231358
- Testing
- Our Family Our Future
- Where
- South Africa
- Volunteers
- 1,758 people, healthy volunteers welcome
- Sponsor
- Brown University
Depression - Major Depressive Disorder, Depression Disorders
Racial Disparities in Antidepressant Treatment After a Psychiatric Consultation
Patients from black, indigenous, and people of color (BIPOC) communities are reported to have lower rates of antidepressant adherence and response. The investigators have a limited understanding of why this disparity exists.
- Trial name
- RITA-PC (NCT06799078)
- Testing
- Observation while participants receive treatment by their primary care provider
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Centre for Addiction and Mental Health
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