Clinical trials: Depression Diagnosis
Anxiety, Depression
Difficulties in Emotion-regulation and Interpersonal Problems During and After the COVID-19 Pandemic
Central indicators of psychological functioning such as difficulties in emotion regulation and habitual problems in one's relating to others are likely to have been substantially impacted by the COVID-19 amelioration measures of…
- Conditions
- Anxiety, Depression, Interpersonal Problem, Emotion Regulation
- Trial name
- NCT04442282
- Volunteers
- 5,041 people
- Sponsor
- University of Oslo
Obsessive-compulsive Disorder, Depression
Rechargeable Neurostimulators in Deep Brain Stimulation for Psychiatric Disorders
From 1999 onwards, Deep Brain Stimulation [DBS] has been proposed as an alternative to capsulotomy in refractory cases of Obsessive-Compulsive Disorder [OCD].
- Trial name
- NCT02685280
- Testing
- Medtronic Restore Advanced 37713
- Volunteers
- 12 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Mental Health Issue, Depression
Developing and Implementing E-psychotherapy Program for Mental Health Challenges in Oncology and Palliative Care
The demand for mental health problems, particularly depression and anxiety, is three times greater in Oncology and Palliative Care Centres than in the general population.
- Conditions
- Mental Health Issue, Depression, Anxiety, Palliative Care
- Trial name
- NCT04664270
- Testing
- e-CBT
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Dr. Nazanin Alavi
Diabetes Mellitus, Depression
CBT for Adherence and Depression in Diabetes
This study will evaluate the effectiveness of cognitive behavioral therapy (CBT) in treating people with depression and type 2 diabetes.
- Trial name
- NCT00564070
- Testing
- Enhanced treatment as usual plus adherence training, Enhanced treatment as usual plus CBT-AD
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Massachusetts General Hospital
Major Depressive Disorder
Closed-Loop Deep Brain Stimulation for Major Depression
Neurons are specialized types of cells that are responsible for carrying out the functions of the brain. Neurons communicate with electrical signals. In diseases such as major depression this electrical communication can go awry.
- Trial name
- PReSiDio (NCT04004169)
- Testing
- Stimulation-ON, Stimulation-OFF, Stimulation-ON Active Control
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Andrew Krystal
Major Depressive Disorder
Mindfulness-Based Cognitive Therapy for Depressed IAPT Non-Responders
If not treated sufficiently, Major Depression tends to take a recurrent or chronic lifetime course that is associated with a significantly increased risk for physical and neurodegenerative disorders.
- Trial name
- NCT05236959
- Testing
- Mindfulness-Based Cognitive Therapy, Treatment as Usual
- Where
- 4 sites in United Kingdom
- Volunteers
- 234 people
- Sponsor
- Sussex Partnership NHS Foundation Trust
Stroke, Depression, Anxiety
Promoting Resilience in Stroke Survivor-carepartner Dyads (ReStoreD)
Affecting nearly 800,000 people in the US every year, stroke is a leading cause of long-term disability, and has serious consequences for stroke survivors and their carepartners.
- Conditions
- Stroke, Depression, Anxiety, Coping Skills, Couples
- Trial name
- ReStoreD (NCT04845542)
- Testing
- ReStoreD
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Utah
Depression, Anxiety, Alcohol Abuse
Cognitive-Behavioral Therapy for Young Adult Lesbian, Gay and Bisexual: Transdiagnostic Minority Stress Approach
Background: LGB people experience a large number of anxiety and mood disorders, and risk behaviors than heterosexual (Marshall et al., 2011).
- Conditions
- Depression, Anxiety, Alcohol Abuse, Sexual Compulsivity, Unsafe Sex
- Trial name
- NCT03980873
- Testing
- ESTEEM (Effective Sikills to Empower Effective Men)
- Where
- Spain
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of the Basque Country (UPV/EHU)
Anxiety, Depression
Pilot Effectiveness Trial of an ACT Self-help Workbook Tailored Specifically for Prisons
The goal of this research study is to adapt an ACT-self-help workbook to the prison setting and determine the feasibility acceptability, and effectiveness of this workbook. Participants can expect to be in the study for 13 weeks.
- Conditions
- Anxiety, Depression, Depression, Anxiety, Anxiety Disorders
- Trial name
- NCT06162624
- Testing
- Acceptance and Commitment Therapy (ACT), Reflective Journaling
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of Wisconsin, Madison
Treatment-Resistant Depression
Functional and Neurochemical Correlates of Treatment Response in Major Depressive Disorder
This is an ancillary study to a clinical trial that is being conducted at Massachusetts General Hospital. Investigators at MGH are conducting a clinical trial to test the efficacy of ziprasidone together with escitalopram for…
- Trial name
- NCT01598324
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mclean Hospital
Major Depressive Disorder (MDD)
Theta-Burst Stimulation to Treat Depression
The goal of this clinical trial is to explore the effects of non-invasive brain stimulation protocols using intermittent theta-burst stimulation (iTBS) on brain plasticity and depression severity in depressed individuals aged 18…
- Trial name
- INSPiRE-D (NCT07033780)
- Testing
- Spaced iTBS, Compressed iTBS
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- Centre for Addiction and Mental Health
Postpartum Depression
Effect of Exercise and Wellness Interventions on Preventing Postpartum Depression
The purpose of this study is to examine the efficacy of the active interventions (exercise or wellness/support intervention) compared to usual care on the prevention of postpartum depression among women at risk for depression.
- Trial name
- HM2 (NCT01883479)
- Testing
- Exercise, Wellness/Support
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Mental Health Wellness 1, Stress, Psychological
Heartfulness Meditation to Improve Resilience Among Health Care Students: A 90 Day Program
This investigation will examine the feasibility of delivery and effect on resilience, depression and anxiety of a 90-day Heartfulness Practice delivered virtually for health care students.
- Conditions
- Mental Health Wellness 1, Stress, Psychological, Depression, Anxiety
- Trial name
- HEART (NCT04790162)
- Testing
- Heartfulness Meditation
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Schizophrenia, Schizophreniform Disorder
Integrated Care in Psychotic Disorders With Severe Mental Illness
The study examine the effectiveness of an integrated care program including therapeutic assertive community treatment (ACT) for people with psychotic disorders fulfilling severe and persistent mental illness (SPMI, ACCESS-II…
- Conditions
- Schizophrenia, Schizophreniform Disorder, Schizoaffective Disorder, Delusional Disorder
- Trial name
- ACCESS-II (NCT01888627)
- Testing
- Integrated care
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Depression, Major Depressive Disorder
Effects of Low Dose Ketamine Given at Induction of Anesthesia on Postoperative Mood in Patients With Depressive Symptoms
Ketamine has been shown to have an antidepressant effect when given intravenously in doses of 2mg/kg. Ketamine is used as a standard induction drug during general anesthesia.
- Trial name
- NCT02422303
- Testing
- ketamine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Breast Cancer, Depression
Study of Health Promotion in Patients With Early-Stage Breast or Prostate Cancer
RATIONALE: Telephone counseling by a nutritionist and a personal trainer may improve physical function and quality of life in patients who have early-stage breast cancer or prostate cancer.
- Conditions
- Breast Cancer, Depression, Fatigue, Malnutrition
- Trial name
- NCT00037024
- Testing
- fatigue assessment and management, nutritional support, physical therapy
- Where
- United States
- Sponsor
- Duke University
Major Depressive Disorder
An Open Prospective Trial of IV Ketamine in Suicidal Adolescents
1. Investigate the safety and effectiveness of a single dose of IV Ketamine for adolescents with suicidal ideation and depression.
- Trial name
- NCT02048423
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Nationwide Children's Hospital
Addiction, Depression/Anxiety
Healing Lodge First Face Training Evaluation Study
The purpose of this study is to evaluate a culturally grounded training program, xaʔtus (meaning First Face) for Mental Health. This program will train community members in how to recognize and respond to youth and adults…
- Conditions
- Addiction, Depression/Anxiety, Trauma, Psychological, Self-harm
- Trial name
- NCT06290180
- Testing
- First Face for Mental Heatlh
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Cambridge Health Alliance
Major Depressive Disorder
HypErthermia as an Additional Treatment for the Biology and Experience of Depression
This single-arm feasibility trial administered up to 8 weekly (early phase) or 4 bi-weekly (later phase) whole-body hyperthermia (WBH) sessions and 8 weekly cognitive behavioral therapy (CBT) sessions to adults aged 18 years or…
- Trial name
- HEATBED (NCT05041361)
- Testing
- Cognitive Behavioral Therapy (CBT), Whole-Body Hyperthermia (WBH)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of California, San Francisco
Suicide Risk, Major Depressive Disorder (MDD)
Orexin Antagonism for Suicide Risk: A Proof-of-Concept Clinical Trial
The goal of this proof-of-concept clinical trial is to evaluate the initial safety, feasibility, and tolerability of the orexin mixed antagonist suvorexant in a sample of veteran adults with Major Depressive Disorder and elevated…
- Trial name
- NCT06854224
- Testing
- Suvorexant (dual orexin receptor antagonist)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Marianne Goodman
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