Clinical trials: Depression Diagnosis
Depression, Anxiety
Low-intensity Stepped Care for Internalizing Distress
The purpose of this study is to test the feasibility and efficacy of combining a single session intervention, COMET, with a self-help intervention, Doing what matters in times of stress. In step I, all individuals receive COMET.
- Conditions
- Depression, Anxiety, Emotion Regulation
- Trial name
- COMET-DWM (NCT05441111)
- Testing
- Common Elements Toolbox, Doing What Matters in Times of Stress: An Illustrated Guide, Guided self-help
- Where
- United States
- Volunteers
- 275 people
- Sponsor
- Indiana University
Major Depressive Disorder
Biomarkers of Social Sensitivity in Major Depression
Major depression disorder (MDD) is a frequent and disabling mental disorder with great risk of recurrence and chronicity. Interpersonal factors are among the strongest predictors of the course and duration of an episode of…
- Trial name
- SENSO (NCT02214511)
- Testing
- emotional facial stimuli, Cyberball game
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Major Depressive Disorder
The Safety and Efficacy of Psilocybin in Cancer Patients With Major Depressive Disorder
This is a Phase II, single-center, fixed dose, open label trial to explore the safety, tolerability and efficacy of a 25mg dose of psilocybin in cancer patients with MDD.
- Trial name
- NCT04593563
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Maryland Oncology Hematology, PA
Perinatal Depression, Affective Disorder
Validation of the French Version of the Perinatal Assessment of Paternal Affectivity (PAPA)
The transition to parenthood is a critical period for both the woman and her partner, and this can affect the mental health of the parents.
- Conditions
- Perinatal Depression, Affective Disorder, Fathers
- Trial name
- French-Papa (NCT06594263)
- Where
- France
- Volunteers
- 343 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Depressive Disorder
An Eight-week Study to Evaluate the Efficacy and Safety of Saredutant in Patients With Depression
The purpose of the study is to evaluate the efficacy and safety of saredutant (or SR48968C) in patients with depression. The primary objective is to evaluate the efficacy of a 100 mg dose of saredutant compared to placebo in…
- Trial name
- NCT00250614
- Testing
- Saredutant succinate (SR48968C)
- Where
- United States
- Volunteers
- 452 people
- Sponsor
- Sanofi
Major Depressive Disorder
Waitlist-Control Trial of Smartphone CBT for Major Depressive Disorder (MDD)
The investigators are testing the efficacy of Smartphone-delivered cognitive behavioral therapy (CBT) treatment for major depressive disorder (MDD).
- Trial name
- NCT04594616
- Testing
- Smartphone-delivered CBT for MDD
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Breast Cancer
Online Stress Management and Coping Skills Training for Women With Breast Cancer
Stress Management interventions have been shown to decrease cancer-related distress, foster emotional growth and improve immune functioning during treatment for breast cancer.
- Trial name
- NCT01335152
- Testing
- Coping with Breast Cancer web-based workbook
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Talaria, Inc
Trauma Injury, Depression
Therapy Dog Visits for Patients Hospitalized With Traumatic Injuries
Animal assisted therapy (AAT) with dogs has been shown to be beneficial for a wide range of patients with both acute and chronic illnesses, including spinal cord injuries, heart failure, myocardial infarctions, strokes, cancer…
- Conditions
- Trauma Injury, Depression, Anxiety, Anger
- Trial name
- NCT06812247
- Testing
- Therapy dog visits, Dog handler visits
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Boston Medical Center
Depression - Major Depressive Disorder
Enhancing Slow Wave Sleep in Depression
The goal of this pilot study is to determine if non-invasive brain stimulation during sleep can increase deep sleep in adults with depression.
- Trial name
- NCT07143838
- Testing
- Transcranial Electrical Stimulation (TES)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Wake Forest University Health Sciences
Depression
Genetic and Biochemical Markers of Interferon-Induced Depression.
The purpose of this study is to identify predictors and associated biochemical markers of interferon-induced depression. It is hypothesized that genetic variation in genes related to the serotonergic system may predict…
- Trial name
- NCT00252538
- Where
- 3 sites in United States
- Volunteers
- 133 people
- Sponsor
- US Department of Veterans Affairs
Anxiety, Depression
Mobile Mental Health Stigma Reduction Intervention Among Black Adults
Major depressive and anxiety disorders are highly prevalent in the general population and are a leading cause of disability. Black adults have a high burden of depression and anxiety.
- Conditions
- Anxiety, Depression, Health Knowledge, Attitudes, Practice, Stigmatization
- Trial name
- NCT06316804
- Testing
- Video Intervention 1, Video Intervention 2, Video Intervention 3
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Massachusetts General Hospital
Smoking Cessation, Cardiovascular Disease
What Are the Effects of Varenicline Compared With Nicotine Replacement Therapy on Long Term Smoking Cessation and Clinically Important Outcomes?
Introduction: Smoking is a major avoidable cause of ill-health and premature death. Treatments that help patients successfully quit smoking have an important effect on health and life expectancy.
- Conditions
- Smoking Cessation, Cardiovascular Disease, Respiratory Disease, Myocardial Infarction
- Trial name
- NCT02681848
- Testing
- Varenicline, Nicotine replacement therapy
- Volunteers
- 180,000 people
- Sponsor
- University of Bristol
Bipolar Depression
Memantine Augmentation of Lamotrigine Incomplete-Response in Bipolar Depression
The purpose of this study is to investigate whether addition of memantine to bipolar depression patients who have had an incomplete response to lamotrigine (Lamictal) which is frequently used to treat bipolar depression in the…
- Trial name
- NCT00305578
- Testing
- Memantine
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Indiana University
Major Depressive Disorder
A Study in the Treatment of Children and Adolescents With Major Depressive Disorder
The purpose of this study is to assess whether duloxetine is superior to placebo in the treatment of children and adolescents with major depressive disorder (MDD)
- Trial name
- NCT00849693
- Testing
- fluoxetine, duloxetine
- Where
- 56 sites in United States, Argentina and 2 more
- Volunteers
- 463 people
- Sponsor
- Eli Lilly and Company
Major Depressive Disorder, Recurrent
Mechanisms of Mindfulness-Based Cognitive Therapy in the Treatment of Recurrent Major Depressive Disorder
The primary purpose of this study is to investigate neural mechanisms and predictors of treatment outcome in Mindfulness-Based Cognitive Therapy (MBCT) for recurrent Major Depressive Disorder.
- Trial name
- NCT03353493
- Testing
- MBCT, TAU
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- University of Aarhus
Diabetes, Depression
e-Pharmacovigilance II - Surveillance for Safety and Effectiveness - Calling for Earlier Detection of Adverse Reactions
Specific Aim 1: To develop a patient-reported, EHR-integrated system to actively monitor the safety and effectiveness of treatment for patients taking FDA-approved medications for one of four common chronic conditions (diabetes…
- Conditions
- Diabetes, Depression, Insomnia, Hypertension
- Trial name
- CEDAR (NCT02087293)
- Testing
- Intervention arm - automated call and phone-based pharmacist counseling
- Where
- United States
- Volunteers
- 38,400 people
- Sponsor
- Brigham and Women's Hospital
Acoustic Stimulation
Acoustic Stimulation, Sleep, and Cognitive-Emotional Processes in Young Adults With Anxiety and Depression Symptoms
In this study, the investigators will recruit young adults (ages 18-25 years) with elevated anxiety/depression symptoms and sleep disturbance. Participants will complete two overnights in a sleep lab.
- Trial name
- SERS (NCT05802004)
- Testing
- Acoustic Stimulation (STIM), Daily acoustic stimulation (STIM2)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Michelle Stepan
Stress Disorders, Post-Traumatic
Train Your Brain: Neurofeedback Intervention for PTSD
The investigator's aim is to evaluate the efficacy of two types of neurofeedback treatments for PTSD symptoms reduction. Half of the participants will receive the current standard for PTSD neurofeedback care undergoing…
- Trial name
- NCT03858933
- Testing
- eBrainFit Platform
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Southern California
Inpatient Facility Diagnoses, Psychiatric Disorders
Behavioral Activation - From Inpatient to Outpatient Services
The purpose of this study is to compare the effectiveness of Behavioral Activation and Supportive Therapy added to the standard acute psychiatric inpatient care.
- Conditions
- Inpatient Facility Diagnoses, Psychiatric Disorders, Depressive Symptoms
- Trial name
- NCT01786733
- Testing
- Behavioral Activation, Supportive Therapy
- Volunteers
- 64 people
- Sponsor
- Uppsala University
Depression - Major Depressive Disorder, Mental Distress
The Effect of Digital Markers in the Self-management of Depressive Symptoms
The purpose of the MENTINA trial is to investigate the effect of using the smartphone-based MENTINA app for self-monitoring of depressive symptoms and rule-based feedback in individuals with current or previous depression…
- Trial name
- MENTINA (NCT06919133)
- Testing
- The MENTINA app, Control
- Where
- 3 sites in Denmark, Germany and 1 more
- Volunteers
- 660 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
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