Clinical trials: Depression Disorders, open to volunteers
Major Depressive Disorder (MDD)
Mechanisms of Repeated Real-time Biofeedback With 7-Tesla MRI in Depression
Previous work demonstrated that individuals are able to self-regulate their ventral tegmental area (VTA) activity using real-time biofeedback.
- Trial name
- NCT07694076
- Testing
- Active Biofeedback
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Oxford
Depressive Disorder, Major
A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder
This study evaluates the safety and efficacy of brenipatide when administered with standard of care (SoC) compared to placebo plus SoC in delaying the return of major depressive symptoms.
- Trial name
- RENEW-MDD- 2 (NCT07775300)
- Testing
- Brenipatide
- Where
- 170 sites in United States, Australia and 13 more
- Volunteers
- 1,000 people
- Sponsor
- Eli Lilly and Company
Antenatal Depression
Single Session Personalized Aperiodic Transcranial Alternating Current Stimulation (PandA-tACS) for Antenatal Depression
The purpose of this pilot trial is to primarily assess safety, feasibility, and tolerability of PandA-tACS in antenatal depression and determine whether a single PandA-tACS session produces greater left dlPFC aperiodic slope…
- Trial name
- PandA (NCT07799480)
- Testing
- IAF-tACS, PandA-tACS
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of North Carolina, Chapel Hill
Spinal Cord Injuries (SCI), Chronic Pain
Virtual Reality-Based Hypnotherapy for Pain, Sleep, and Mood in Spinal Cord Injury
The goal of this clinical trial is to learn whether virtual reality (VR)-based hypnotherapy, added to conventional physiotherapy, improves pain, sleep, mood, and quality of life in adults with chronic spinal cord injury.
- Conditions
- Spinal Cord Injuries (SCI), Chronic Pain, Neuropathic Pain, Sleep Disturbance
- Trial name
- HypnoVR-SCI (NCT07846410)
- Testing
- Virtual Reality-Based Hypnotherapy, Conventional Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Major Depressive Disorder (MDD), Treatment Resistant Depression
EEG-Guided Transcranial Magnetic Stimulation for Adults With Depression
The purpose of this research is to see if an experimental treatment for depression called intermittent theta burst stimulation (iTBS), a form of transcranial magnetic stimulation (TMS) can be improved for better results using…
- Conditions
- Major Depressive Disorder (MDD), Treatment Resistant Depression, Major Depression
- Trial name
- CLEOPATRA (NCT07862205)
- Testing
- MagVenture TMS Therapy System with Localite Navigation System and actiCHamp EEG
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Chronic Pain, Neuropathic Pain
Transcranial Direct Current Stimulation for Chemotherapy-Related Chronic Pain in Cancer Survivors
The goal of this clinical trial is to learn if transcranial direct current stimulation (tDCS) combined with a working-memory task can treat chronic pain and related emotional and cognitive problems after chemotherapy in adult…
- Conditions
- Chronic Pain, Neuropathic Pain, Cancer Survivors, Anxiety
- Trial name
- ONCOSTIM (NCT07912775)
- Testing
- Active tDCS with Sternberg task
- Where
- 2 sites in Spain
- Volunteers
- 60 people
- Sponsor
- Instituto de investigación e innovación biomédica de Cádiz
Major Depressive Disorder (MDD), Depression in Adults
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
The purpose of this study is to determine the efficacy, safety and tolerability of CYB003 compared to matching placebo as adjunctive treatment in patients with MDD.
- Conditions
- Major Depressive Disorder (MDD), Depression in Adults, Depression - Major Depressive Disorder, Depression Disorders
- Trial name
- EMBRACE (NCT06793397)
- Testing
- CYB003, Psychological Support
- Where
- 79 sites in United States, Australia and 6 more
- Volunteers
- 330 people
- Sponsor
- Cybin IRL Limited
Major Depressive Disorder
Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
This study will evaluate the long-term safety and tolerability of NBI-1065845 as an adjunctive treatment in participants with MDD.
- Trial name
- NCT06966401
- Testing
- NBI-1065845
- Where
- 120 sites in United States, Australia and 21 more
- Volunteers
- 850 people
- Sponsor
- Neurocrine Biosciences
HIV, HIV - Human Immunodeficiency Virus
Intervention to Reduce HIV Related Stigma Among Pregnant and Postpartum Women
Purpose of this Study: The main purpose of this study is to adapt an existing evidence-based intervention, Project Accept Post-Test Support Services (PTSS) Module 3, specifically for pregnant and postpartum women living with HIV…
- Conditions
- HIV, HIV - Human Immunodeficiency Virus, Postpartum, Pregnancy
- Trial name
- WAT (NCT07064928)
- Testing
- Adapted Project Accept's Post-Test Support Services (PTSS) Module 3
- Where
- Ghana
- Volunteers
- 163 people
- Sponsor
- University of California, San Francisco
Treatment Resistant Depression
Vagus Nerve Stimulation (VNS) Electroencephalogram (EEG) Protocol Supplement
The study will examine the autonomic, physiologic and neurophysiologic effects of implanted Vagus Nerve Stimulation (VNS) in treatment-resistant depression patients.
- Trial name
- NCT07310381
- Testing
- Vagus Nerve Stimulation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Stanford University
Major Depressive Disorder
Regulated Stimulation for Optimized Network Activity and Therapeutic Equilibrium
The objective of this study is to evaluate the safety, tolerability, and preliminary efficacy of the Motif eXternally powered Cortical Stimulation (XCS) System when used as indicated for treatment-resistant depression (TRD).
- Trial name
- RESONATE (NCT07594483)
- Testing
- Motif XCS System
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- Motif Neurotech, Inc.
Anxiety, Depression
Metacognitive Bibliotherapy for Anxiety, Depression, and Metacognitions in University Students
This study tests whether reading a structured self-help book (bibliotherapy) can reduce anxiety, depression and stress and change unhelpful thinking patterns in medical and health-sciences students.
- Conditions
- Anxiety, Depression, Stress (Psychology)
- Trial name
- NCT07627139
- Testing
- Zihninde Çok Kuran İnsanlar için Salma Rehberi, Çapa Atmak
- Where
- Turkey (Türkiye)
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Istanbul Nisantasi University
Depression - Major Depressive Disorder, Generalised Anxiety Disorder
Effectiveness of Internet-based Unified Protocol (iUP) for Emotional Problems: A Randomized Controlled Trial
The goal of this clinical trial is to learn if an internet-based Unified Protocol (iUP) intervention is effective for treating depression and anxiety disorders in Hong Kong young adults aged 18-29 years.
- Conditions
- Depression - Major Depressive Disorder, Generalised Anxiety Disorder, Anxiety Disorder (Panic Disorder or GAD), Depressive and Anxiety Disorders
- Trial name
- NCT07908628
- Testing
- Internet-based Unified Protocol (iUP), Waitlist Control Group
- Where
- Hong Kong
- Volunteers
- 78 people
- Sponsor
- New Life Psychiatric Rehabilitation Association
Early-stage Breast Cancer, Fear of Cancer Recurrence
Psilocybin FCR Early-Stage Breast Cancer
This trial is designed to evaluate efficacy and psychological mechanisms of single-dose psilocybin-assisted psychotherapy (PAP) to treat fear of cancer recurrence (FCR), psychiatric (anxiety, depression) distress and…
- Conditions
- Early-stage Breast Cancer, Fear of Cancer Recurrence, Anxiety, Depression
- Trial name
- NCT07909408
- Testing
- Psilocybin 25 mg, Psilocybin 5 mg
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- NYU Langone Health
Stress, Anxiety
Psychological and Physiological Effects of Three-Minute Breathing Space Meditation in UPM Postgraduate Students
Postgraduate students often experience psychological distress linked to academic demands, deadlines, research uncertainty, and financial or social pressures, and international students may face additional adjustment challenges.
- Conditions
- Stress, Anxiety, Depression
- Trial name
- NCT07911020
- Testing
- Three-Minute Breathing Space Meditation, Neutral Audio Attention-Control Activity
- Where
- Malaysia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- ZIRUI LIU
Depression, Major Depressive Disorder
Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression
Background: Most drugs that treat mood disorders take a long time to work. Ketamine works within hours. A dose can last for a week or more. Certain receptors in the brain might help ketamine work.
- Conditions
- Depression, Major Depressive Disorder, Major Depression
- Trial name
- NCT03973268
- Testing
- Arm 1, 2, 3 device interventions, Arm 2 Interventions, Arm 1, 2, 3 drug Interventions
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- National Institute of Mental Health (NIMH)
Transdiagnostic, Depression - Major Depressive Disorder
Open-Label Psilocybin Study in Transdiagnostic Population
The primary objective of this study is to investigate the safety, feasibility, and tolerability of psilocybin treatment in individuals with functional impairment due to psychiatric symptoms.
- Conditions
- Transdiagnostic, Depression - Major Depressive Disorder, Anxiety, PTSD Symptoms
- Trial name
- NCT06442423
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yale University
Physical Activity, Depression Disorder
Organizational Strategies and Psychosocial Skills for Maintaining Physical Activity After a Depressive Episode: a 3-month Post-rehabilitation Study.
With nearly 280 million people affected worldwide (2022), the management of depression represents a major public health issue. The study titled "Organizational Strategies and Psychosocial Skills to Maintain Physical Activity…
- Conditions
- Physical Activity, Depression Disorder, Rehabilitation, Organizational Behavior
- Trial name
- AP&Depression (NCT07129928)
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Hopital La Musse
Major Depression, Healthy Participants
Synaptic Mechanisms of Intermittent Theta Burst Stimulation for Major Depressive Disorder
Many people with depression do not get better with standard treatments like medications or talk therapy. Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation treatment that uses magnetic pulses to stimulate…
- Trial name
- NCT07593222
- Testing
- TMS, D-cycloserine, Dextromethophan
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Major Depressive Episode (MDE), Major Depressive Disorder (MDD)
A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
The goal of this clinical trial is to learn if a drug called TNX-102 SL works to treat moderate to severe major depressive disorder in adults. It will also learn about the safety of TNX-102 SL.
- Conditions
- Major Depressive Episode (MDE), Major Depressive Disorder (MDD), Depression
- Trial name
- HORIZON (NCT07621237)
- Testing
- TNX-102 SL
- Where
- 27 sites in United States
- Volunteers
- 360 people
- Sponsor
- Tonix Pharmaceuticals, Inc.