Clinical trials: Depression Disorders
Stroke, Depression
Improving Quality of Life for Veterans With Stroke and Psychological Distress
The study will create a treatment to improves mobility, physical activity, engagement in activities with family and friends and overall satisfaction with life for Veterans who have depression and anxiety after having a stroke.
- Conditions
- Stroke, Depression, Anxiety
- Trial name
- NCT03645759
- Testing
- I'm Whole, Education + usual care
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- VA Office of Research and Development
Alcohol Abuse, Schizophrenia
Contingency Management of Alcohol Abuse in the Severely Mentally ILL
The investigators will evaluate the efficacy of a comprehensive 12-week contingency management intervention for treating alcohol dependence for persons with severe mental illness who are seen within the context of a community…
- Conditions
- Alcohol Abuse, Schizophrenia, Bipolar Disorder, Major Depressive Disorder
- Trial name
- CMETG (NCT01567943)
- Testing
- Contingency Management
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- University of Washington
Anxiety, Depression
Improving Adherence to Homework During Therapy
The purpose of this study is to expand Adhere.ly- a simple, HIPAA-compliant, web-based platform to help therapists engage clients in practicing therapeutic skills between sessions (homework) during mental health treatment by…
- Conditions
- Anxiety, Depression, Depression/Anxiety
- Trial name
- Adherely STTR (NCT05866185)
- Testing
- Therapy, Therapy + Adhere.ly
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- University of South Florida
Type 2 Diabetes Mellitus, Diabetes-related Distress
COMRADE: Collaborative Care Management for Distress and Depression in Rural Diabetes
The study will implement and evaluate, using a pragmatic comparative effectiveness trial, a unique collaborative, stepped-care intervention for patients with uncontrolled Type 2 diabetes and co-morbid distress and/or depression.
- Conditions
- Type 2 Diabetes Mellitus, Diabetes-related Distress, Depression
- Trial name
- COMRADE (NCT02863523)
- Testing
- Integrated Behavioral Care
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- East Carolina University
Major Depression, Bipolar Depression
The Use of Galantamine HBr (Reminyl) in Electroconvulsive Therapy: Impact on Mood and Cognitive Functioning
The purpose of the study is to see if galantamine HBr (Razadyne) is safe and can help treat problems with thinking and memory caused by electroconvulsive therapy (ECT).
- Conditions
- Major Depression, Bipolar Depression, Schizoaffective Disorder
- Trial name
- Galantamine (NCT00566735)
- Testing
- Razadyne
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Massachusetts General Hospital
Major Depressive Disorder
Omega-3 Fatty Acids as Adjunct Treatment for Major Depressive Disorder
The primary objective of the study was to determine the effects of 10-week adjunctive supplementation with 2 doses of LCn-3 fatty acids (fish oil) on cortical functional activity and biochemistry in adolescents with MDD.
- Trial name
- NCT00511810
- Testing
- Low Dose Fish Oil, High Dose Fish Oil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Cincinnati
Major Depressive Disorder
A Study to Assess the Safety and Effect of TC-5214 in Patients With Major Depressive Disorder.
The purpose of this study is to assess the safety and effect of TC-5214 as a single therapy in patients with major depressive disorder who exhibit inadequate response to antidepressants.
- Trial name
- NCT01288079
- Testing
- TC-5214, Duloxetine
- Where
- 63 sites in United States, Estonia and 3 more
- Volunteers
- 145 people
- Sponsor
- AstraZeneca
Drug Use Disorders, Drug Abuse
Evaluation of a Health Plan Initiative to Mitigate Chronic Opioid Therapy Risks
Background: Sixty million American adults suffer from moderate to severe chronic pain. Of these, 5 to 8 million currently use opioids long-term.
- Conditions
- Drug Use Disorders, Drug Abuse, Drug Addiction, Drug Dependence
- Trial name
- CARE (NCT02224508)
- Volunteers
- 1,588 people
- Sponsor
- Kaiser Permanente
Posttraumatic Stress Disorder, Major Depressive Disorder
rTMS for PTSD Comorbid With Major Depressive Disorder
The purpose of this study is to see how well a treatment called "Repetitive Transcranial Magnetic Stimulation" works for patients who struggle with symptoms of both posttraumatic stress disorder and major depressive disorder.
- Conditions
- Posttraumatic Stress Disorder, Major Depressive Disorder, Transcranial Magnetic Stimulation, Repetitive
- Trial name
- NCT02273063
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Butler Hospital
Major Depressive Disorder
Beat the Blues in Pregnancy Study - Transcranial Magnetic Stimulation
The purpose of this study is to determine if repetitive transcranial magnetic stimulation (TMS) will alleviate symptoms of major depressive disorder (MDD) in pregnant women.
- Trial name
- TMS (NCT01492309)
- Testing
- Active Transcranial Magnetic Simulation
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Pennsylvania
Randomized Controlled Trial
Exploring the Effect of Rumination-Focused Cognitive Behaviour Therapy in Patients With Schizophrenia
This study will explore the effect of Rumination-Focused Cognitive Behaviour Therapy on depressive symptoms in patients with schizophrenia for three months.
- Trial name
- NCT04442893
- Testing
- Rumination-Focused Cognitive Behaviour Therapy, Health Education programme
- Where
- Taiwan
- Volunteers
- 85 people
- Sponsor
- National Yang Ming Chiao Tung University
Anxiety Disorders, Complex Regional Pain Syndrome Type II
Regional Anesthesia Military Battlefield Pain Outcomes Study
The purpose of this study is to examine the short and long-term benefits of implementing early regional anesthesia techniques for pain control after a major traumatic injury to one or more extremities during combat in the…
- Conditions
- Anxiety Disorders, Complex Regional Pain Syndrome Type II, Depressive Disorders, Post-Traumatic Stress Disorder
- Trial name
- RAMBPOS (NCT00431847)
- Testing
- Regional Anesthesia, Standard Pain Management Protocol
- Where
- 3 sites in United States
- Volunteers
- 386 people
- Sponsor
- VA Office of Research and Development
Depressive Disorder, Major
Study of Adjunctive or Monotherapy Rapastinel Treatment in Patients With Major Depressive Disorder (MDD)
Multicenter, open-label, long-term extended access treatment protocol in adult patients with a primary diagnosis of MDD.
- Trial name
- NCT03668600
- Testing
- Rapastinel
- Where
- 74 sites in United States
- Volunteers
- 230 people
- Sponsor
- Naurex, Inc, an affiliate of Allergan plc
Major Depressive Disorder
Pilot Study of Duloxetine in Psychological Resilience
The purpose of this study is to explore benefits of duloxetine in enhancing psychological resilience and to understand the relevance of inhibiting of both serotonin (5HT) and norepinephrine (NE)to therapeutic responses.
- Trial name
- NCT00331799
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Duke University
Opioid-use Disorder, Medication Assisted Treatment
Minds and Mentors Program (MiMP)- R61
The proposed research effort will: The purpose of this study is as follows: 1. Test the feasibility and acceptability of a twelve- week mindfulness based relapse prevention protocol in combination with peer mentoring in…
- Conditions
- Opioid-use Disorder, Medication Assisted Treatment, Substance Use Disorders
- Trial name
- MiMP (NCT04233671)
- Testing
- Mindfulness based relapse prevention and peer mentoring
- Where
- 2 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Alabama, Tuscaloosa
Depression
Ketamine Plus Lithium in Treatment-Resistant Depression
The purpose of this study is to test the antidepressant effect of ketamine when given repeatedly over a period of 1 week, as well as the use of Lithium as a relapse-prevention strategy for patients with treatment-resistant…
- Trial name
- NCT01880593
- Testing
- Lithium, Ketamine
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Delirium, Cognitive Impairment
Preventing Post-Operative Delirium in Patients Undergoing a Pneumonectomy, Esophagectomy or Thoracotomy
The purpose of this study is to investigate the effectiveness of a preventative low-dose of Haloperidol to prevent delirium in patients undergoing a esophagectomy, pneumonectomy or thoracotomy.
- Conditions
- Delirium, Cognitive Impairment, Post-traumatic Stress Disorder, Depression
- Trial name
- PE-POD (NCT02213900)
- Testing
- Haloperidol
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- Indiana University
Treatment Resistant Depression
A Randomized, Placebo-Controlled, Double-Blind Study to Assess Safety and Efficacy of PCN-101 in TRD
This is a double-blind, randomized, placebo-controlled, multicenter study comprised of 3 phases:screening (up to 2 weeks [Day -15 to Day -2]), In-Clinic Treatment (Day -1 to Day 2; including double-blind treatment [Day 1]), and…
- Trial name
- NCT05414422
- Testing
- PCN-101
- Where
- 21 sites in United States, Germany and 1 more
- Volunteers
- 102 people
- Sponsor
- Perception Neuroscience
Depressive Symptoms, Multiple Chronic Conditions
Resourcefulness Intervention With Parents of Technology-Dependent Children
Technology-dependent children, those who live at home but rely on medical equipment such as mechanical ventilation or feeding tubes, require complex care for their chronic condition.
- Conditions
- Depressive Symptoms, Multiple Chronic Conditions, Family Caregivers
- Trial name
- NCT03301831
- Testing
- Resourcefulness Training
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Depressive Disorder, Treatment-Resistant
Proof of Concept Study Evaluating the Efficacy and Safety of MIJ821 in Patients With Treatment-resistant Depression
This study evaluated the efficacy and safety of the compound MIJ821 compared to placebo in patients aged from 18 to 65 years diagnosed with treatment-resistant depression. The study was conducted in the US and in Europe (Spain).
- Trial name
- NCT03756129
- Testing
- MIJ821, Ketamine
- Where
- 12 sites in United States, Spain
- Volunteers
- 70 people
- Sponsor
- Novartis Pharmaceuticals