Clinical trials: Depression Mild
Mild-to-moderate Depression
Treating Depression With Transcutaneous Electrical Cranial-auricular Acupoint Stimulation (TECAS).
One multi-center, randomized controlled clinical trial is designed to examine whether transcutaneous electrical cranial-auricular acupoint stimulation (TECAS) is non-inferior to the antidepressant drug (Escitalopram) in treating…
- Trial name
- TECAS (NCT03909217)
- Testing
- TECAS Procedure, Escitalopram, Insomnia medication
- Where
- 6 sites in China
- Volunteers
- 470 people
- Sponsor
- The University of Hong Kong
Concussion (Diagnosis), Concussion, Mild Traumatic Brain Injury
Multidimensional Sleep Health Intervention to Optimize Concussion Recovery
Following adolescent concussion, poor sleep health is common and relates to the development of persisting post-concussion symptoms, and uninjured adolescents (independent of concussion) also commonly experience sleep…
- Conditions
- Concussion (Diagnosis), Concussion, Mild Traumatic Brain Injury, Treatment, Sleep Health
- Trial name
- SCORE (NCT07082218)
- Testing
- Sleep Intervention
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Colorado, Denver
Mild-moderate Unipolar Depression; Persistent Negative Affect
Dismantling Mindfulness: Contributions of Attention vs. Acceptance
This study addresses NCCAM's request for research that investigates the neuropsychological mechanisms underlying mind-body therapies, and for precise criteria and better delineation of meditation practices.
- Trial name
- NCT01831362
- Testing
- Mindfulness-Based Cognitive Therapy, Focused Attention (FA), Open- Monitoring
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Brown University
Mild Cognitive Impairment
A Retrospective Analysis of Cerefolin NAC® in Cognitively Impaired Patients
This retrospective analysis of de-identified data from 700 charts of consecutive patients from this patient population is to investigate the prevalence of hyperhomocysteinemia and associated metabolic abnormalities in this…
- Trial name
- NCT01594541
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Pamlab, Inc.
Mild to Moderate Depressive Symptoms
Effectiveness of Internet-based Depression Treatment
Care for people suffering from depressive symptoms should be given in a step-wise approach. One first step can be the provision of self-help material. Online self-help is an innovative way of providing self-help.
- Trial name
- EVIDENT (NCT01636752)
- Testing
- Deprexis
- Where
- 4 sites in Germany
- Volunteers
- 1,013 people
- Sponsor
- University of Luebeck
Depression, Dementia
Longitudinal Observational Biomarker Study
The purpose of this study is to test whether treatment-resistant late life depression is associated with declines in memory and attention and brain structure and function.
- Conditions
- Depression, Dementia, Mild Cognitive Impairment
- Trial name
- OPT-Neuro (NCT05204940)
- Testing
- Mechanisms of Late life depression (LLD)-dementia through functional Magnetic Resonance Imaging (fMRI), Neuropsychological Data, Clinical Scales
- Where
- 5 sites in United States, Canada
- Volunteers
- 506 people
- Sponsor
- Centre for Addiction and Mental Health
Dementia
Computerized Cognitive Training Program for Older Persons With Mild Dementia
Little is known about the effects of computerized cognitive training programs on mild dementia patients' health. The purpose of this study was to examine the effects of a community-based computerized cognitive training program.
- Trial name
- NCT02671630
- Testing
- A community-based computerized cognitive training program
- Volunteers
- 30 people
- Sponsor
- Far Eastern Memorial Hospital
Depression
Effects of Saffron and Chamomile in Mild to Moderate Depression
Diabetes characterized by decreased production, or resistance to the action of insulin or both. The reduced production or action alters many important body functions namely glucose absorption and utilization in the body.
- Trial name
- NCT04935671
- Testing
- chamomile tea n saffron
- Where
- Pakistan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Dr Saara (Ahmad) Muddasir Khan
Hepatic Impairment
Pharmacokinetics of AGO178 in Participants With Liver Impairment
AGO178 was developed for the treatment of depression. A new formulation is being tested in the present study: a tablet to be placed and dissolved under the tongue (sublingual tablet).
- Trial name
- NCT01531309
- Testing
- AGO178
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Low Mood, Mild Depression
Feasibility Study of an Online Physical Activity Intervention for Youth With Depression
Physical activity (PA) has recently been established as both a primary intervention for mild to moderate, and a secondary therapy for moderate to severe Major Depressive Disorder (MDD; Fortier et al., 2020).
- Conditions
- Low Mood, Mild Depression, Moderate Depression, Inactivity, Physical
- Trial name
- NCT05386745
- Testing
- physical activity
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Victoria
Mild Traumatic Brain Injury, Internet-Delivered Cognitive Behavioural Therapy
Internet Delivered Cognitive Behavioural Therapy for Persons With Mild Traumatic Brain Injury
Background: Individuals with neurological conditions (stemming from brain injury or stroke) can experience high levels of emotional distress leading to decreased quality of life and increased health care costs.
- Conditions
- Mild Traumatic Brain Injury, Internet-Delivered Cognitive Behavioural Therapy, Depression, Anxiety
- Trial name
- NCT04561011
- Testing
- Internet-delivered Cognitive Behavioural Therapy(ICBT)
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Mild Cognitive Impairment, Depressive Symptoms
HEPPI: Efficacy of a Cognitive-Emotional Intervention for Homebound Older Adults
The main goal of this research is to assess the efficacy of a 10-week home-delivered cognitive-emotional intervention program for homebound older adults presenting Mild Cognitive Impairment (MCI) and depressive and/or anxiety…
- Conditions
- Mild Cognitive Impairment, Depressive Symptoms, Anxiety State
- Trial name
- HEPPI (NCT05499767)
- Testing
- HEPPI
- Where
- Portugal
- Volunteers
- 199 people
- Sponsor
- University of Coimbra
Alzheimer s Disease, Major Depressive Disorder (MDD)
VR Pupillometry in Cognitive Impairment
With disease-modifying therapies emerging for dementia and related conditions, identifying cognitive decline as early as possible is increasingly important.
- Conditions
- Alzheimer s Disease, Major Depressive Disorder (MDD), Mild Cognitive Impairment, Dementia
- Trial name
- NCT07402356
- Where
- Germany
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Max-Planck-Institute of Psychiatry
Anxiety, Anxiety Disorders
A Feasibility Study of Nature-based Health Interventions for People With Mild to Moderate Anxiety, Depression and Stress
Background and aimThe increased burden on mental health both globally and nationally is a serious challenge that requires attention and action from healthcare professionals, politicians, and decision-makers.
- Conditions
- Anxiety, Anxiety Disorders, Depression - Major Depressive Disorder, Depressive Disorder
- Trial name
- NCT06981000
- Testing
- Locally adapted nature-based health intervention
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- University of Copenhagen
Depression Mild, Depression Moderate
Treatment of Depression Using a Mobile Application in the Dominican Republic
The overall objective of this study is to develop a feasible and acceptable mental health app which delivers Cognitive Behavioral Therapy (CBT) for depressed patients in the Dominican Republic.
- Trial name
- NCT04948996
- Testing
- El Buen Consejo Móvil- Group (EBCM-G), El Buen Consejo Móvil- Individual (EBCM-I)
- Where
- 2 sites in United States, Dominican Republic
- Volunteers
- 27 people
- Sponsor
- Northern Illinois University
Anxiety, Mild to Moderate Depression
Guided Internet-based Interventions in Primary Care Effectiveness-implementation Randomized Controlled Trial
Internet-based cognitive behavioral therapy for anxiety and depression have far-reaching potential to overcome common barriers to accessing evidence-based treatment, such as waiting lists, travel distance and costs.
- Trial name
- INTERMENTAL (NCT05118828)
- Testing
- Guided internet-based cognitive behavioural therapy, Treatment as usual in Prompt Mental Health Care (TAU-PMHC)
- Where
- 6 sites in Norway
- Volunteers
- 1,000 people
- Sponsor
- Norwegian Institute of Public Health
Neurocognitive Disorders, Mild, Cognitive Impairment, Mild
Effects of Personalized Digital Reminiscence Therapy on Patients With Neurocognitive Disorders
This study aims to observe the effects of daily personalized digital reminiscence sessions, conducted with the help of a digital conversational agent, and to determine whether these sessions lead to improvements in symptoms such…
- Conditions
- Neurocognitive Disorders, Mild, Cognitive Impairment, Mild, Depression Mild, Apathy
- Trial name
- NCT07237009
- Where
- 5 sites in France
- Volunteers
- 80 people
- Sponsor
- KompanionCare SAS
Depression Mild, Depression, Anxiety
Habits of Gamers Study
Rationale: Mindfulness is a popular therapeutic strategy that has a growing body of evidence suggesting it can improve a wide range of physical and psychological symptoms.
- Conditions
- Depression Mild, Depression, Anxiety, Anxiety, Attention Concentration Difficulty
- Trial name
- GAMES (NCT04551976)
- Testing
- Mindfulness
- Where
- United States
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Depression Mild, Depression Moderate
An Online Intervention Targeting Depression and Low Reward Sensitivity
This study aims to evaluate and compare the effectiveness of different online interventions targeting reward sensitivity and depressive symptoms.
- Trial name
- NCT05402150
- Testing
- Behavioral Activation, Mindulness and Gratitude, Combination of Behavioral Activation and Mindfulness and Gratitude
- Where
- Germany
- Volunteers
- 224 people
- Sponsor
- Philipps University Marburg
Depression
Psychotherapy for Young Adults With Mild-to-moderate Depression: Does Virtual Reality Increase Its Efficacy
Cognitive Behavioral Therapy (CBT) is the most prestigious psychological treatment for depression. However, not only do we need to increase its efficacy but also to widen the repertoire of evidence-based psychotherapeutic…
- Trial name
- PSYADEP (NCT04321525)
- Testing
- Cognitive-behavioral therapy, Personal Construct Therapy, Personal Construct Therapy with virtual reality
- Where
- 2 sites in Spain
- Volunteers
- 12 people
- Sponsor
- University of Barcelona