Clinical trials: Depression Moderate, open to volunteers
Depression, Depression Disorder
GynMDD Add-On to Supportive Psychotherapy in Mild to Moderate Depression
The goal of this clinical trial is to learn whether the dietary supplement GynMDD, when taken as an add-on to supportive psychotherapy, can improve symptoms of mild to moderate depression in adults aged 18 to 65.
- Conditions
- Depression, Depression Disorder, Depression in Adults
- Trial name
- SWING (NCT07416747)
- Testing
- GynMDD
- Where
- France
- Volunteers
- 168 people
- Sponsor
- Fondation FondaMental
Depression
Neuroscience of Psychotherapy for Depression
The goal of this study is to learn the extent to which client-therapist brain activity may synchronize during a psychosocial intervention for depression symptoms.
- Trial name
- NCT06696001
- Testing
- Psychoeducation, Behavioral Activation
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of North Carolina, Chapel Hill
Working Memory, Mild to Moderate Depression
Cross-over Study on the Influence of Fampridine on Working Memory in Mild to Moderate Depression
Cognitive deficits, including working memory deficits, are often present in depression and there are currently no effective pharmacological treatments targeting working memory deficits. Papassotiropoulos et al.
- Trial name
- FamD_2025 (NCT06751784)
- Testing
- Fampridine SR
- Where
- Switzerland
- Volunteers
- 38 people
- Sponsor
- University of Basel
Major Depression Moderate, Feasibility Studies
rTMS for Youth Inpatients With Depression
Youth aged 15-24 are likelier to have depression than all age groups in Canada. One-third of depressed youth do not respond to psychotherapy and/or antidepressant medications.
- Trial name
- NCT07140575
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Sunnybrook Health Sciences Centre
Severe Depression, Moderate Depression
Nebulized Ketamine for the Treatment of Major Depressive Disorder
This is a double-blind active placebo controlled clinical trial for individuals with moderate to severe depression. The purpose of this study is to assess if nebulized ketamine can reduce depressive symptoms.
- Conditions
- Severe Depression, Moderate Depression, Ketamine, Midazolam
- Trial name
- NCT06752759
- Testing
- nebulized ketamine, nebulized midazolam
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Theresa Jacob, PhD, MPH
Depression
A Study of the Effectiveness and Safety of JS1-1-01 Tablet in Patients With Moderate to Severe Depression
The purpose of this study is to evaluate the Effectiveness and Safety of JS1-1-01 Tablet in Patients With Moderate to Severe Depression
- Trial name
- NCT07485595
- Testing
- JS1-1-01 low-dose group, JS1-1-01 high-dose group
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Tasly Pharmaceutical Group Co., Ltd
Attention-Deficit/Hyperactivity Disorder (ADHD), Depression - Major Depressive Disorder
Clinical Trial to Investigate the Safety and Efficacy of Two Dexamfetamine Sulfate Formulations in Adults With ADHD and Moderate to Severe Depression
The indication of attention-deficit/hyperactivity disorder (ADHD) to be examined often occurs with other psychiatric disorders, and the majority of adults with ADHD have at least one psychiatric comorbidity in their lives.
- Trial name
- DEXAD (NCT06967857)
- Testing
- DEX IR tablets, DEX XL
- Where
- 5 sites in Germany
- Volunteers
- 105 people
- Sponsor
- Prof. Dr. Frank Behrens
Mild to Moderate Anxiety and Depression
Digital Positive Affect Intervention Study
Anxiety and depression are highly prevalent mental health disorders that impose a significant burden on individuals and public health systems worldwide (GBD 2019 Mental Disorders Collaborators, 2022).
- Trial name
- NCT06978257
- Testing
- Digital positive affect intervention (PAI), Self-monitoring intervention
- Where
- Singapore
- Volunteers
- 2,400 people
- Sponsor
- National University of Singapore