Clinical trials: Depression NOS
Cardiovascular Diseases, Mood Disorders
Evaluating the Effects of Omega-3 Fatty Acids on Heart Disease and Behavior
Omega-3 fatty acids are a certain kind of fish fat that has recently been shown to have health benefits. This study will examine the effectiveness of fish oil supplementation for reducing the early signs of heart disease risk and…
- Conditions
- Cardiovascular Diseases, Mood Disorders, Inflammation
- Trial name
- NCT00663871
- Testing
- Fish Oil
- Where
- United States
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Depression
Ketamine for Depression Relapse Prevention Following ECT
Depression affects up to 20% of people in their lifetime and can be a severe debilitating illness. Indeed, the World Health Organisation has estimated that depression will soon be the second leading contributor to the burden of…
- Trial name
- KEEP-WELL (NCT02414932)
- Testing
- Ketamine, Midazolam
- Where
- Ireland
- Volunteers
- 6 people
- Sponsor
- St Patrick's Hospital, Ireland
Bipolar Disorder, Bipolar Depression
Safety Study of Ziprasidone (Geodon) for the Depressive Mixed State
Mixed states in bipolar disorder have long been recognized. Over a century ago, it was argued that mixed states were the most common episodes in manic-depressive illness.
- Conditions
- Bipolar Disorder, Bipolar Depression, Depression
- Trial name
- NCT00490542
- Testing
- ziprasidone (Geodon)
- Where
- 4 sites in United States
- Volunteers
- 73 people
- Sponsor
- Tufts Medical Center
Premenstrual Syndrome, Menstruation Disturbances
A Treatment Study for Premenstrual Syndrome (PMS)
This study examines the effects of estrogen and progesterone on mood, the stress response, and brain function and behavior in women with premenstrual syndrome.
- Trial name
- NCT00001259
- Testing
- Leuprolide, Estradiol Patches, Progesterone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Mental Health (NIMH)
Cognitive Impairment, Mild, Depressive Symptoms
Brain Stimulation and Enhancing Cognition in Older Adults
The aim of the current research is to evaluate the efficacy of a combination of Mindfulness-Based Stress Reduction (MBSR) and transcranial direct current stimulation (tDCS) to improve cognitive function in individuals with…
- Conditions
- Cognitive Impairment, Mild, Depressive Symptoms, Anxiety
- Trial name
- NCT03653351
- Testing
- Active Transcranial Direct Current Stimulation (tDCS)
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Washington University School of Medicine
Depression, Anxiety
IntelliCare Study: Artificial Intelligence in a Mobile (AIM) Intervention for Depression
This study will evaluate and compare a smartphone intervention for depression and anxiety that uses machine learning to tailor treatment for participants with the same intervention without the machine learning component.
- Trial name
- AIM (NCT02801877)
- Testing
- IntelliCare, Hub App with the Recommender System, Coaching
- Where
- United States
- Volunteers
- 301 people
- Sponsor
- Northwestern University
Major Depressive Disorder
Riluzole Augmentation Pilot in Depression (RAPID) Trial
The investigators are doing a research study to find out if riluzole, when taken along with a standard antidepressant (sertraline) can help people with major depression.
- Trial name
- RAPID (NCT01703039)
- Testing
- Riluzole, Sertraline
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Pain, Insomnia
Effect of Medical Marijuana on Neurocognition and Escalation of Use
This study will use a randomized controlled design to test whether patients who use medical marijuana, compared to a waitlist control group, experience a change in health outcomes (relief of symptoms, or adverse health outcomes…
- Conditions
- Pain, Insomnia, Depression, Anxiety
- Trial name
- MMNE (NCT03224468)
- Testing
- Medical Marijuana
- Where
- United States
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Major Depressive Disorder
Focal Electroconvulsive Therapy for Depression
This pilot, open label investigation evaluates the safety and efficacy of a new form of electroconvulsive therapy (ECT). Both the efficacy and adverse cognitive effects of ECT are highly contingent on the intracerebral current…
- Trial name
- FEAST (NCT01589315)
- Testing
- focal ECT
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Medical University of South Carolina
Depressive Disorder
A Randomised, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of Orvepitant in Subjects With Major Depressive Disorder
This is a 6-week, randomised, multicenter, double-blind, placebo controlled, fixed dose parallel group study to assess the efficacy and safety of orvepitant (30 and 60 mg/day) versus placebo in subjects with a diagnosis of a…
- Trial name
- Orvepitant MDD (NCT00880048)
- Testing
- orvepitant
- Where
- 32 sites in United States, Canada
- Volunteers
- 343 people
- Sponsor
- GlaxoSmithKline
Depression
Adapting Behavioral Activation to Technology Platform
This project aims to use an asynchronous remote communities (ARC) approach both to discover the design requirements for adapting Behavioral Activation (BA) to ARC as well as design/build an ARC platform for administering BA.
- Trial name
- NCT03783533
- Testing
- Behavioral Activation
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Washington
Depression
Maternal Depression Treatment in HIV
Cluster randomized controlled trial to compare the effects of task-shifted, evidence-based depression care vs. usual care on adherence to each step of the prevention of mother-to-child-transmission (PMTCT) care cascade at 8…
- Trial name
- M-DEPTH (NCT03892915)
- Testing
- evidence-based depression treatment
- Where
- Uganda
- Volunteers
- 391 people
- Sponsor
- RAND
Depression, Depressive Disorder
Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) Versus Placebo in Peri- and Postmenopausal Women
Desvenlafaxine succinate (DVS) is a potent and selective serotonin and norepinephrine reuptake inhibitor (SNRI). The sustained-release (SR) formulation, DVS SR, is being studied in the development program for the treatment of…
- Conditions
- Depression, Depressive Disorder, Depressive Disorder, Major
- Trial name
- NCT00369343
- Testing
- Desvenlafaxine administered as a succinate salt in a sustained-release form (DVS SR)
- Where
- 37 sites in United States
- Volunteers
- 381 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Major Depressive Disorder
A Study for Participants With Major Depression
This is a study to assess the safety and effectiveness of LY2216684 compared to placebo in treating adults with major depressive disorder.
- Trial name
- NCT00420004
- Testing
- LY2216684, Escitalopram
- Where
- 7 sites in United States, Romania
- Volunteers
- 469 people
- Sponsor
- Eli Lilly and Company
Depression
Effectiveness of Telephone Versus Face-to-Face CBT in Treating People With Depression
This study will compare the effectiveness of telephone versus face-to-face administration of cognitive behavioral therapy in treating people with depression.
- Trial name
- NCT00498706
- Testing
- Telephone-administered cognitive behavioral therapy (T-CBT), Face-to-face administered CBT (FtF-CBT)
- Where
- United States
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Human Immunodeficiency Virus, Depression
Our Family Our Future: A Resilience-oriented Family Intervention to Prevent Adolescent HIV/STI Infection and Depression in South Africa
The purpose of this study is to test the efficacy of Our Family Our Future, an integrated intervention for preventing HIV and depression onset among adolescents.
- Conditions
- Human Immunodeficiency Virus, Depression, Sexually Transmitted Diseases
- Trial name
- NCT03231358
- Testing
- Our Family Our Future
- Where
- South Africa
- Volunteers
- 1,758 people, healthy volunteers welcome
- Sponsor
- Brown University
Stroke, Stroke Sequelae
Mindfulness Based Stress Reduction and Post-Stroke Cognition
The investigators don't fully understand how, regardless of the size or location in the brain, minor strokes can result in significant problems with focus, attention, and multi-tasking that prevent individuals from returning to…
- Conditions
- Stroke, Stroke Sequelae, Depression, Cognitive Impairment
- Trial name
- NCT04302493
- Testing
- Mindfulness Based Stress Reduction (MBSR), Stroke Support Group (SSG)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
TBI, Anxiety
Cranial Electrotherapy Stimulation (CES) Therapy
The primary aim of this proposed study is to gather preliminary data for CES use in treating PTSD and anxiety symptoms in OEF/OIF Veterans with PTSD and a history of TBI.
- Conditions
- TBI, Anxiety, PTSD, Depression
- Trial name
- CES (NCT02453347)
- Testing
- CES Therapy
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Breast Cancer, Gynecologic Cancer
Prasterone (Dehydroepiandrosterone) in Treating Postmenopausal Cancer Survivors With Vaginal Symptoms
RATIONALE: Dehydroepiandrosterone (DHEA) may help relieve vaginal symptoms in female cancer survivors. PURPOSE: This randomized phase III trial studies DHEA to see how well it works compared to placebo in treating postmenopausal…
- Trial name
- NCT01376349
- Testing
- prasterone
- Where
- 280 sites in United States
- Volunteers
- 464 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Major Depressive Disorder, Alcohol Abuse
Acamprosate Added to Escitalopram and Behavioral Treatment for Comorbid Depression and Alcoholism
This is a study about treatment for people who suffer from both major depression and alcohol abuse or dependence. The study will examine whether the addition of acamprosate to escitalopram and behavioral interventions will…
- Conditions
- Major Depressive Disorder, Alcohol Abuse, Alcohol Dependence
- Trial name
- NCT00452543
- Testing
- acamprosate, escitalopram, Medical management
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Massachusetts General Hospital
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