Clinical trials: Depression Severe
Major Depressive Disorder, Neuroticism
Predictors of Cognitive Outcomes in Geriatric Depression
This study will focus on examining effects of stress on long-term mood and cognitive outcomes of late-life depression. It will also example the neural underpinnings of these changes using structural and functional brain imaging.
- Conditions
- Major Depressive Disorder, Neuroticism, Cognitive Change, Stress
- Trial name
- NBOLD (NCT05273996)
- Testing
- Sertraline, bupropion, desvenlafaxine
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- David Steffens
Sleep Initiation and Maintenance Disorders, Depression
Self-help Smartphone-delivered Cognitive Behavioral Therapy for Insomnia in People With Depression and Insomnia
This randomized controlled trial aims to examine the effectiveness of a self-help smartphone-delivered cognitive behavioral therapy for insomnia, compared to a waitlist control, in treating people with major depression and…
- Trial name
- NCT04228146
- Testing
- Cognitive Behavioral Therapy for Insomnia, Waitlist Control
- Where
- China
- Volunteers
- 285 people
- Sponsor
- The University of Hong Kong
Major Depressive Disorder
Measuring Psychomotor Response to L-DOPA Challenge As a Biomarker for Outcomes in Late-Life Depression: a Pilot Feasibility Trial
Background Adults over the age of 60 with symptoms of major depressive disorder are said to have late-life depression (LLD), a condition that usually decreases a person's quality of life and is associated with other risks like…
- Trial name
- LLDOPA (NCT06626152)
- Testing
- Apo-levocarb
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of British Columbia
Major Depressive Disorder
Efficacy and Safety Study of SPD489 in Combination With an Antidepressant in the Treatment of Adults With Major Depressive Disorder
This study will examine SPD489 in subjects aged 18-65 with major depressive disorder (MDD) who are taking certain types of antidepressants but continue to have residual depression symptoms.
- Trial name
- NCT01436149
- Testing
- SPD489 (Lisdexamfetamine dimesylate )
- Where
- 85 sites in United States, Canada and 4 more
- Volunteers
- 1,262 people
- Sponsor
- Shire
Depressive Disorder, Major
An 8 Week Study Of Adults Diagnosed With Major Depressive Disorder
A Placebo Controlled Study Evaluating Efficacy, Safety and Tolerability of Medication in Patients with Major Depressive Disorder (MDD)
- Trial name
- NCT00057226
- Testing
- Radafaxine
- Where
- 21 sites in United States
- Volunteers
- 365 people
- Sponsor
- GlaxoSmithKline
Depression, Major Depressive Disorder
Incomplete Response in Late-Life Depression: Getting to Remission With Buprenorphine
The purposes of this project are to examine the feasibility, safety, tolerability and clinical effect of low-dose buprenorphine as a novel treatment for late-life treatment-resistant depression and to develop preliminary data…
- Trial name
- IRLGREY-B (NCT02176291)
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Jordan F. Karp
Major Depressive Disorder, Pregnancy
Light Therapy for Depression During Pregnancy
The purpose of this study is to determine whether morning bright light therapy is an effective treatment for major depression during pregnancy compared with low-intensity placebo light therapy, when administered 60 minutes daily…
- Trial name
- NCT01043289
- Testing
- Light therapy
- Where
- Switzerland
- Volunteers
- 46 people
- Sponsor
- Psychiatric Hospital of the University of Basel
Major Depressive Disorder
Transcranial Direct Current Stimulation to Treat Major Depressive Disorder
The investigators purpose is to offer active Transcranial Direct Current Stimulation (tDCS) in patients of the investigators previous study who received either placebo or sertraline and have not responded.
- Trial name
- NCT01149889
- Testing
- transcranial direct current stimulation
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Major Depression
Inflammatory Markers and Cognitive Function in Major Depression
Major depression is accompanied by cognitive changes as well as alterations in multiple physical functions. The inflammatory system is altered generally toward a pro-inflammatory state.
- Trial name
- NCT01391221
- Testing
- Duloxetine
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire en santé Mentale de Montréal
Depressive Disorder, Major
Study on the Influence of Electroconvulsive Therapy (ECT) on Homocysteine Levels
Elevated homocysteine levels are associated with depression and cognitive impairment. When depression ameliorates due to treatment, homocysteine serum levels often normalize.
- Trial name
- NCT00370058
- Testing
- ECT treatment
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Major Depressive Disorder (MDD, Anxiety Disorder, Generalized
Serotonin Variants & Gut Microbiota in Mental Health
This observational pilot study investigates whether a broad panel of genetic variants relevant to the serotonin pathway (including serotonergic system, methylation cycle, intestinal barrier integrity, and inflammatory response…
- Conditions
- Major Depressive Disorder (MDD, Anxiety Disorder, Generalized, Stress Disorders, Post-Traumatic, Panic Disorder
- Trial name
- NCT07634458
- Testing
- SNP Genotyping and Gut Metagenomics
- Volunteers
- 30 people
- Sponsor
- Neurobiologix
Major Depressive Disorder
Open-label Safety Extension Study of 15 and 20 mg of Vortioxetine (Lu AA21004) in Long-term Treatment of Major Depressive Disorder in Adults
To evaluate the long-term safety and tolerability of flexible doses, 15 and 20 mg/day, of Vortioxetine over a period of 52 weeks in patients with Major Depressive Disorder (MDD)
- Trial name
- NCT01323478
- Testing
- Vortioxetine (Lu AA21004)
- Volunteers
- 71 people
- Sponsor
- H. Lundbeck A/S
Depressive Disorder, Major
A Study to Evaluate the Efficacy of Sage-217 in the Treatment of Adult Participants With Major Depressive Disorder (MDD)
The purpose of this study to evaluate the efficacy of SAGE-217 in the treatment of participants with MDD.
- Trial name
- NCT04442490
- Testing
- SAGE-217
- Where
- 39 sites in United States
- Volunteers
- 543 people
- Sponsor
- Biogen
Psychosis, Psychosis Nos/Other
EPI-MINN: Targeting Cognition and Motivation - National
The purpose of this study is to perform a practice-based research project designed to assess whether cognition and motivated behavior in early psychosis can be addressed as key treatment goals within real-world settings by using…
- Conditions
- Psychosis, Psychosis Nos/Other, Schizophrenia, Schizo Affective Disorder
- Trial name
- NCT05877716
- Testing
- Cognitive and Social Cognitive Training, Personalized Real-Time Intervention for Motivational Enhancement (PRIME) App, Early Psychosis Coordinated Specialty Care
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Minnesota
Treatment-Resistant Major Depressive Disorder
The Effects of Psilocybin on Self-Focus and Self-Related Processing in Treatment Resistant MDD
This open-label fMRI study will assess the effects of a single dose of psilocybin on rumination and the neural correlates of rumination in individuals with treatment-resistant major depressive disorder.
- Trial name
- NCT05381974
- Testing
- Psilocybin
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Major Depressive Disorder (MDD)
Evaluating Conversational Artificial Intelligence for Depression Management
The goal of this clinical trial is to evaluate how a conversational method of collecting medical history affects patients' perceptions and experiences compared to clinical care as usual.
- Trial name
- NCT07105397
- Testing
- Conversational AI system vs Usual Care
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- George Mason University
Depressive Disorder, Major
A Study of Lumateperone Versus Placebo in Participants With Major Depressive Disorder
The purpose of the study is to assess how well each dose of lumateperone (Dose 1 and 2) works when given alone as compared to placebo in participants with major depressive disorder (MDD; a medical condition characterized by a…
- Trial name
- CANDLE (NCT07747389)
- Testing
- Lumateperone
- Volunteers
- 585 people
- Sponsor
- Intra-Cellular Therapies, Inc.
Depressive Episode, Bipolar 1 Depression
A Clinical Study to Test the Effectiveness of an Investigational Drug to Treat People That Have Major Depressive Episodes When They Have Bipolar 1 Depression
A clinical study to test the effectiveness of an investigational drug to treat people that have major depressive episodes when they have Bipolar 1 Depression
- Trial name
- NCT03543410
- Testing
- SEP-4199 200 mg, SEP-4199 400 mg
- Where
- 87 sites in United States, Bulgaria and 6 more
- Volunteers
- 344 people
- Sponsor
- Sumitomo Pharma America, Inc.
Major Depression
Antidepressant Effect of Theta-Burst rTMS
The aim of this study is to evaluate the safety and efficacy of theta-burst rTMS in patients with major depression. Patients will be randomized to receive ether left-sided intermittent theta-burst rTMS or rigt-sided continuous…
- Trial name
- NCT00515658
- Testing
- theta-burst rTMS
- Where
- Israel
- Sponsor
- Rambam Health Care Campus
Loneliness, Well-Being, Psychological
A Randomized Controlled Trial of Robotic Support for Enhanced Later Life (RoSELL)
The purpose of this study is to compare the efficacy of a personalized, co-designed robot interaction against a standardized, fixed robot interaction for reducing loneliness, depression, as well as improving self-agency and…
- Conditions
- Loneliness, Well-Being, Psychological, Depression - Major Depressive Disorder
- Trial name
- RoSELL (NCT07102017)
- Testing
- Co-Design LOVOT Intervention, Standard LOVOT Intervention
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine