Clinical trials: Depression Symptom
Mood Disorders
Effects of Erythropoietin on Depressive Symptoms and Neurocognitive Deficits in Depression and Bipolar Disorder
Depression and bipolar disorder (mania and depression) may be related to problems with nerve cells not being regenerated as fast as normal and are accompanied by cognitive difficulties including memory, attention and planning…
- Trial name
- NCT00916552
- Testing
- Erythropoietin
- Where
- Denmark
- Volunteers
- 83 people
- Sponsor
- Lars Vedel Kessing, professor, MD, DMSc.
Depression, Unipolar Depression
Confirmatory Efficacy and Safety Trial of Magnetic Seizure Therapy for Depression
This trial aims to assess the efficacy and tolerability of Magnetic Seizure Therapy (MST) as an alternative to electroconvulsive therapy (ECT) for depression.
- Conditions
- Depression, Unipolar Depression, Treatment Resistant Depression
- Trial name
- CREST-MST (NCT03191058)
- Testing
- Magnetic Seizure Therapy, Electroconvulsive Therapy
- Where
- 3 sites in United States, Canada
- Volunteers
- 239 people
- Sponsor
- University of Texas Southwestern Medical Center
Insomnia
Preventing Insomnia With Virtual Oneshot Therapy (PIVOT)
This study is intended to assess the efficacy of preventative Cognitive Behavioral Therapy for Insomnia (pCBT-I) on reducing the severity and stopping the progression of acute insomnia and depression.
- Trial name
- NCT05523726
- Testing
- pCBT-I
- Where
- United States
- Volunteers
- 167 people
- Sponsor
- Henry Ford Health System
Depression, Diabetes
Effectiveness of a mHealth Intervention for the Treatment of Depression in People With Diabetes or Hypertension in Peru
Background: Depression is a common comorbidity of physical chronic diseases such as diabetes and/or hypertension and constitutes an important public health problem.
- Conditions
- Depression, Diabetes, Hypertension
- Trial name
- LATIN-MHPeru (NCT03026426)
- Testing
- CONEMO
- Where
- 8 sites in Peru
- Volunteers
- 432 people
- Sponsor
- Universidad Peruana Cayetano Heredia
MDD, PMDD
Stress, Inflammation and Neuroimaging in Major Depressive Disorder as Compared to Premenstrual Dysphoric Disorder
Premenstrual dysphoric disorder (PMDD) is a sex-specific depressive disorder where depressive symptom severity drastically changes in relation to menstrual cycle phase.
- Trial name
- NCT06130371
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Anxiety Disorders and Symptoms, Depression
Novel Behavioral Intervention to Enhance Social Connections in Anxiety and Depression
The overall goal of this project is to develop a novel transdiagnostic behavioral treatment -- social approach training -- intended to enhance positive social connections in individuals with elevated anxiety and/or depression.
- Trial name
- NCT03196544
- Testing
- Social Approach Training (5 sessions), Social Approach Training (10 sessions)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of California, San Diego
Major Depressive Disorder, Anhedonia
Dopamine Neurotransmission in Major Depression
The overall aim of this study is to utilize an integrative research model in order to dynamically assess reward-related dopamine (DA) transmission in major depressive disorder (MDD) and test the role of dysfunctional DA release…
- Trial name
- NCT01659814
- Where
- 2 sites in United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Breast Cancer
Design and Evaluation of the Effects of a Physical Therapy Program With Digital Support in Patients With Breast Cancer
Breast cancer surgery usually results in reduced range of motion of the shoulder joint, weakness of the musculature and altered scapular kinematics during movement.
- Trial name
- NCT04837248
- Testing
- Active Comparator: Group 1. Conventional treatment, Experimental: Group 2. Experimental treatment.
- Where
- Spain
- Volunteers
- 92 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Parenting, Parent-Child Relations
Parenting Young Children Study
Opioid use is rising at unprecedented levels and has reached epidemic proportions in some areas of the country, particularly rural areas.
- Conditions
- Parenting, Parent-Child Relations, Opioid Misuse, Opioid Use Disorder
- Trial name
- NCT05180487
- Testing
- Family Check-Up
- Where
- United States
- Volunteers
- 356 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Depressive Symptoms, Anxiety
Expressive Writing on Minority Stressors Among Sexual Minority Veterans
Sexual minority stressors (e.g., sexual minority identity-based discrimination) contribute to greater risk for and severity of depression, anxiety, substance use disorders and suicide among sexual minority Veterans.
- Trial name
- EWMS (NCT05897021)
- Testing
- Expressive Writing on Minority Stressors, Neutral Writing
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- VA Office of Research and Development
Mental Health Care, Mental Health
Mental Health CPR for Cancer Survivors
This is a parallel, two-arm interventional study comparing the Mental Health CPR behavioral intervention to standard community health education.
- Conditions
- Mental Health Care, Mental Health, Depression Anxiety Disorder
- Trial name
- MH-CPR CaS (NCT07219264)
- Testing
- Mental Health CPR, Standard Community Health Education
- Where
- Puerto Rico
- Volunteers
- 1,260 people, healthy volunteers welcome
- Sponsor
- Ponce Medical School Foundation, Inc.
Mental Health Disorder, Post-Traumatic Stress Disorder in Adolescence
Promoting Asylum-seeking and Refugee Children's Coping With Trauma
A short term trauma-focused cognitive- behavioral program to reduce trauma-related mental health problems among asylum-seeking and refugee children.
- Conditions
- Mental Health Disorder, Post-Traumatic Stress Disorder in Adolescence, Depression, Social Anxiety
- Trial name
- NCT03822598
- Testing
- Teaching Recovery Techniques, TRT
- Where
- 16 sites in Norway
- Volunteers
- 170 people
- Sponsor
- Norwegian Institute of Public Health
Fibromyalgia, Psychological Trauma
Augmentation of EMDR With tDCS in the Treatment of Fibromyalgia
Fibromyalgia (FM) is a generalized, widespread chronic pain disorder and has an estimated prevalence of 2%-4% in the general population.
- Conditions
- Fibromyalgia, Psychological Trauma, Depressive Symptoms, Anxiety
- Trial name
- NCT04084795
- Testing
- Eye Movement Desensitization and Reprocessing therapy, transcranial Direct Current Stimulation
- Where
- Spain
- Volunteers
- 96 people
- Sponsor
- Parc de Salut Mar
Mild to Moderate Anxiety and Depression
Digital Positive Affect Intervention Study
Anxiety and depression are highly prevalent mental health disorders that impose a significant burden on individuals and public health systems worldwide (GBD 2019 Mental Disorders Collaborators, 2022).
- Trial name
- NCT06978257
- Testing
- Digital positive affect intervention (PAI), Self-monitoring intervention
- Where
- Singapore
- Volunteers
- 2,400 people
- Sponsor
- National University of Singapore
Hazardous Alcohol Use
PrEP and Alcohol - Enhancing HIV Pre-Exposure Prophylaxis (PrEP)
The present investigation entails a pilot randomized controlled trial to explore whether a stand-alone, alcohol-reduction, brief intervention (with a module on substance use and depression) would be feasible, acceptable, and…
- Trial name
- NCT05097430
- Testing
- Alcohol-focused brief intervention
- Where
- 3 sites in Canada
- Volunteers
- 122 people
- Sponsor
- Centre for Addiction and Mental Health
Depression
Predicting Effectiveness of Light Treatment for Winter Seasonal Affective Disorder
This study will evaluate a possible tool for predicting future effectiveness of bright light in treating seasonal affective disorder, winter subtype, and will examine secondary effects of bright light on cardiovascular risk…
- Trial name
- NCT00742365
- Testing
- Bright light
- Volunteers
- 41 people
- Sponsor
- University of Maryland, Baltimore
Depression
Evaluation of the H1-Coil TMS- Double Blind Placebo Controlled Study in Adolescent Patients Suffering From Major Depression
This study is a randomized double blind placebo controlled EEG monitored study of deep rTMS treatment to treat adolescent depression.
- Trial name
- NCT03541707
- Testing
- Deep TMS Brainsway's H coil
- Where
- Israel
- Volunteers
- 52 people
- Sponsor
- Shalvata Mental Health Center
Stem Cell Transplantation, Fatigue
Severe Fatigue in Stem Cell Transplantation
Fatigue is a common symptom during allogeneic-hematopoietic stem cell transplantation (allo-HSCT). However, effects of severe fatigue on pulmonary functions, blood cells, dyspnea, muscle strength, exercise capacity, depression…
- Trial name
- NCT03448471
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people
- Sponsor
- Gazi University
Major Depressive Disorder, Vasomotor Symptoms
Desvenlafaxine Succinate (Pristiq): Postmarketing Surveillance Study Among Filipino Patients
This is a non-interventional study to review safety data on administration of desvenlafaxine succinate among Filipino patients with MDD and VMS per usual clinical practice within the first three years post commercial distribution.
- Trial name
- NCT01353963
- Testing
- desvenlafaxine succinate
- Where
- 3 sites in Philippines
- Volunteers
- 13 people
- Sponsor
- Pfizer
Depressive Symptoms, Anxiety
School-based Group Acceptance and Commitment Therapy for Adolescents
The objective of the investigators' mental health promotion intervention premised on the Acceptance and Commitment Therapy (ACT) framework in secondary school settings aims to enhance young people's psychological flexibility and…
- Conditions
- Depressive Symptoms, Anxiety, Stress
- Trial name
- NCT06039228
- Testing
- Acceptance and commitment therapy
- Where
- Hong Kong
- Volunteers
- 61 people
- Sponsor
- Chinese University of Hong Kong
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