Clinical trials: Depression Symptom
Autism Spectrum Disorder (ASD), Anxiety
Adapted Group Therapy Compared With Usual Care for Anxiety and Depression in Adults With an Autism Diagnosis
The goal of this clinical trial is to learn whether an adapted group therapy works to treat anxiety and depression in adults with an autism diagnosis. The therapy is a form of cognitive behavioral therapy (CBT).
- Conditions
- Autism Spectrum Disorder (ASD), Anxiety, Depression
- Trial name
- CoMind (NCT07880028)
- Testing
- Autism-adapted group cognitive behavioral therapy
- Volunteers
- 154 people
- Sponsor
- Lovisenberg Diakonale Hospital
Hypercapnia, Ventilatory Depression
Effect of Selective Serotonin Reuptake Inhibitors (SSRIs) and an Opioid on Ventilation
This study is designed to evaluate the effects of the coadministration of paroxetine or escitalopram with an opioid on ventilation. Ventilation will be assessed using a rebreathing methodology.
- Trial name
- NCT05470465
- Testing
- Paroxetine and Oxycodone, Escitalopram and Oxycodone
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Food and Drug Administration (FDA)
Low Back Pain, Disability Physical
The Impact Of Fascia Thickness on Chronic Low Back Pain
This study aimed to investigate the impact of lumbar perimuscular and subcutaneous zone thickness on pain, functionality, disability, and depression in individuals with chronic low back pain (CLBP).
- Conditions
- Low Back Pain, Disability Physical, Pain, Chronic
- Trial name
- NCT06572007
- Testing
- Ultrasound
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Okan University
Depressive Symptoms, Anxiety
Living Well: A Digital ACT Intervention
Depression and anxiety are frequently comorbid and share mechanisms contributing to dysfunction. Transdiagnostic approaches, such as Acceptance and Commitment Therapy, streamline intervention and allow a broader population to…
- Conditions
- Depressive Symptoms, Anxiety, Emotional Disorders
- Trial name
- NCT04787809
- Testing
- Living Well
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Texas at Tyler
Postpartum Depression, Small for Gestational Age at Delivery
Happy Mother-Healthy Baby: An Anxiety-focused Early Prenatal Intervention
In the proposed study the investigators will develop an early prenatal preventive intervention targeting anxiety and conduct a randomized controlled trial in Pakistan to test its efficacy in reducing generalized anxiety disorder…
- Conditions
- Postpartum Depression, Small for Gestational Age at Delivery, Preterm Birth, Anxiety
- Trial name
- HMHB (NCT03880032)
- Testing
- Cognitive Behavioral Therapy Intervention for Anxiety
- Where
- Pakistan
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Depression
A Clinical Trial to Evaluate the Efficacy and Safety of Generic Escitalopram in Depression
The primary objective of this study is to evaluate the efficacy and safety of Generic Escitalopram in the treatment of Chinese patients with depression compared with Innovator Escitalopram(Lexapro®) by evaluating the change of…
- Trial name
- NCT00866593
- Testing
- Generic Escitalopram, Innovator Escitalopram
- Where
- 6 sites in China
- Volunteers
- 260 people
- Sponsor
- Shanghai Mental Health Center
COVID 19, Depression
COVID-19 : Stress Within Hospital Workers
As of December 2019, the global pandemic of COVID-19 has spread rapidly throughout the world, putting healthcare staff at the frontline.
- Conditions
- COVID 19, Depression, Stress, Psychological, Burnout
- Trial name
- NCT05037214
- Where
- France
- Volunteers
- 779 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Anxiety, Mental Health Disorder
Preventing Mental Disorders Among Women Internally Displaced by War in Ukraine: The SHAWL Trial
This study is a randomized controlled trial among 120 recently displaced women to determine the effectiveness of a single-session Acceptance and Commitment Therapy (ACT) group therapy on prevention of development of mental health…
- Conditions
- Anxiety, Mental Health Disorder, War-Related Trauma, Acceptance and Commitment Therapy
- Trial name
- SHAWL (NCT06679114)
- Testing
- Acceptance and Commitment Therapy, Attention control
- Where
- Ukraine
- Volunteers
- 120 people
- Sponsor
- Boston Medical Center
Frailty, Age-Related Macular Degeneration
Visual Frailty in Ageing
The goal of this observational study is to define visual frailty and refine monitoring for an ageing population. It involves piloting a visual frailty assessment tool in a cohort of patients aged 60 and above with a known…
- Conditions
- Frailty, Age-Related Macular Degeneration, Functional Status, Mental Health
- Trial name
- VFiA (NCT06604104)
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Amputation, Limb Loss
Self-management to Improve Function Following Amputation
Lower extremity amputations are a significant cause of morbidity, mortality, loss of function and reduced quality of life. Self-management (defined as the process by which an individual adopts an active role in managing the…
- Trial name
- VETPALS (NCT02163811)
- Testing
- VETPALS, Individual Education Support Program
- Where
- 5 sites in United States
- Volunteers
- 182 people
- Sponsor
- VA Office of Research and Development
Pain
Multicenter Perioperative Opioid Pharmacogenetic Study
The purpose of this research study is to identify factors and genes (the DNA material that determines the makeup of the human body) that may be associated with how children respond to pain medication.
- Trial name
- NCT01495611
- Where
- 15 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Post-Traumatic Stress Disorder, Mental Disorders
The Trauma Recovery and Empowerment Model for Treating Post-Traumatic Stress Disorder in Women
This study will determine the effectiveness of the Trauma Recovery and Empowerment Model in reducing the severity of post-traumatic stress disorder symptoms in women with mental disorders and who have experienced sexual or…
- Conditions
- Post-Traumatic Stress Disorder, Mental Disorders, Depression
- Trial name
- TREM (NCT00183716)
- Testing
- Trauma Recovery and Empowerment Model (TREM), Usual care
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Chronic Disease, Depressive Symptoms
Bio-psycho-social Pathways Underlying the Effects of Qigong Among Comorbid Depressed Elderly With Chronic Conditions
Depression and chronic medical conditions are common in older adults. Qigong is increasingly documented to have anti-depressive effects for older adults. Nevertheless, the scientific concepts behind qigong remain a mystery.
- Trial name
- NCT03591211
- Testing
- Qigong Training, Cognitive Training
- Where
- Hong Kong
- Volunteers
- 35 people
- Sponsor
- The Hong Kong Polytechnic University
Depressive Disorder, Depression
Magnetic Stimulation Therapy for Treating Vascular Depression
This 12-week study will evaluate the effectiveness of repetitive transcranial magnetic stimulation (rTMS) of the brain, followed by citalopram (Celexa®), for treatment of depression associated with small vascular lesions in the…
- Trial name
- rtms (NCT00044798)
- Testing
- Repetitive transcranial magnetic stimulation (rTMS), Citalopram
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- University of Iowa
Hepatitis C, Depression
VISN 20: Prophylactic Treatment of Interferon-Induced Depression in Hepatitis C Patients
The purpose of this study is to learn more about the effects of interferon and ribavirin combination therapy in people with Hepatitis C.
- Trial name
- NCT00108563
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Anxiety, Depression
Mental Health INtervention With Digital APPlications (MIND-APP): Evaluating the Effectiveness of the Tankevirus and Grubl Mental Health Apps
The MIND-APP trial is a 3-arm randomized controlled trial (1:1:1 allocation) conducted fully remotely via a bespoke smartphone research platform.
- Trial name
- MIND-APP (NCT07627204)
- Testing
- Tankevirus, Grubl
- Where
- Norway
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Akershus
COVID-19 Vaccine Adverse Reaction
Detoxification From the Lipid Tract
Apart from electroencephalogram biofeedback and electrical brain stimulation adopted for maintenance treatment, the study utilizes ultra-low frequency transcranial magnetic stimulation (ULF-TMS) for initial γ-aminobutyric acid…
- Trial name
- NCT06357104
- Testing
- electroencephalogram biofeedback, electrical brain stimulation, ultra-low frequency transcranial magnetic stimulation
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Pachankis, Yang I., M.D.
Major Depressive Disorder, Inflammation
INflammation-based Stratification for Immune-Targeted Augmentation in Major Depressive Disorder
This is a randomised, double-blind, placebo-controlled clinical trial in which patients with major depressive disorder will receive augmentation through minocycline (MCO), celecoxib (CXB) or placebo.
- Trial name
- INSTA-MD (NCT05644301)
- Testing
- Celecoxib, Minocyclin
- Where
- 3 sites in Belgium
- Volunteers
- 240 people
- Sponsor
- Universiteit Antwerpen
Depression, Mild Cognitive Impairment
Combination Treatment Study for Memory Impairment and Depression
Patients presenting with depression (DEP) and cognitive impairment (CI), represent a unique, understudied population that is difficult to diagnose, treat and estimate prognosis.
- Trial name
- DEP-CI (NCT01658228)
- Testing
- Donepezil, Citalopram, Venlafaxine
- Where
- 2 sites in United States
- Volunteers
- 86 people
- Sponsor
- New York State Psychiatric Institute
Anxiety, Depression
Effect of an Innovative Online Ayurveda Program on the Mental and Physical Health of Home-Based Adults
The overall objective of this study is to evaluate the effects, feasibility, and safety of a comprehensive online Ayurveda whole-systems (WS) intervention that targets the underlying etiological factors influencing mental and…
- Trial name
- NCT06551467
- Testing
- Online Ayurveda Program for Detox and Lifestyle
- Where
- Austria
- Volunteers
- 98 people
- Sponsor
- Maharishi International University
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