Clinical trials: Depression Symptom
Epilepsy, Cognitive Dysfunction
Investigation of the Effects of Pilates Training in Patients With Drug-Resistant Epilepsy
This study was planned to examine the effects of Pilates training in patients with drug-resistant epilepsy. It was planned to include 40 epilepsy patients in the study.
- Conditions
- Epilepsy, Cognitive Dysfunction, Seizures, Quality of Life
- Trial name
- NCT06754124
- Testing
- Pilates Group, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Older Adults (50-90 Years), Depression
Integrating Depression Care Into HIV Services for Older People With HIV Using a Stepped Care, Task-Sharing Approach.
Depression levels will be compared using PHQ-9 in the Treatment as Usual arm(TAU) VS intervention arm to see if the stepped care intervention is effective in treating depression.
- Trial name
- NCT06894680
- Testing
- Stepped care, Treatment as usual
- Where
- Nigeria
- Volunteers
- 100 people
- Sponsor
- Royal Society of Tropical Medicine and Hygiene
Depression Symptoms, Chronic Pain
Effect of Auricular Press Needle on Improvement of Patient Health Questionnaire-9 (PHQ-9) and Heart Rate Variability (HRV) Patient With Depression Symptoms in Chronic Pain
Depression is characterized by behavioral, cognitive and emotional changes. Depression can have a negative impact on decreasing quality of life because in many cases it occurs long-term.
- Trial name
- NCT06401070
- Testing
- Plesterin, Press needle acupuncture
- Volunteers
- 60 people
- Sponsor
- Universitas Indonesia
Depression
Cognitive Behavioural Couple Intervention Therapy for Chinese Couples With a Depressed Partner
Understanding depression from a relational perspective maybe more meaningful in Chinese culture due to the different values and beliefs among Chinese comparing to those of the Western cultures.
- Trial name
- NCT04590573
- Testing
- Cognitive behavioural couple therapy (CBCT), Emotion focused couple therapy (EFCT), Wait-list control (Control)
- Where
- Hong Kong
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Major Depressive Disorder
Early Versus Delayed Switch in Medication in Patients With Major Depressive Disorder
This study investigates two different approaches to the change in antidepressant treatment when an initial treatment is not effective: early intervention or delayed intervention. Two hypothesis will be tested: 1.
- Trial name
- NCT00810069
- Testing
- Duloxetine Hydrochloride, Escitalopram
- Where
- 60 sites in Denmark, France and 9 more
- Volunteers
- 840 people
- Sponsor
- Eli Lilly and Company
Major Depressive Disorder
Regulated Stimulation for Optimized Network Activity and Therapeutic Equilibrium
The objective of this study is to evaluate the safety, tolerability, and preliminary efficacy of the Motif eXternally powered Cortical Stimulation (XCS) System when used as indicated for treatment-resistant depression (TRD).
- Trial name
- RESONATE (NCT07594483)
- Testing
- Motif XCS System
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- Motif Neurotech, Inc.
Depression
Study of a Self-Help Depression Skills Program for College-Aged Youth
We propose to conduct a pilot trial of an Internet-only depression skills training program for adolescents and young adults. The intervention, MoodHelper.org already exists and has been tested in two pilots.
- Trial name
- NCT00145054
- Testing
- MoodHelper Internet program for Depression Self-Help
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Depression
To Improve Depressive Symptoms Using a Web-App
This study is being done to answer a question on whether a Web App-based Lifestyle Physical Activity Promotion Program is effective in improving depressive symptom experience of midlife Korean American women (WPAPP-K).
- Trial name
- NCT05405803
- Testing
- Web-App based Lifestyle Physical Activity Promotion Program, The Centers for Disease Control and Prevention (CDC) website on depression and physical activity guidelines
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Vanderbilt University
Depression
Pilot Feasibility Study of Psychosocial Support to Improve Well-being of Adults in Humanitarian Crises in Nepal
This is a pilot feasibility study of group problem management plus, a low-intensity psychological intervention, delivered in five sessions to adults affected by humanitarian crises.
- Trial name
- PM+ (NCT03359486)
- Testing
- Group problem management plus, Enhanced treatment as usual
- Where
- Nepal
- Volunteers
- 120 people
- Sponsor
- George Washington University
Severe Depression
Brain Changes in Severely Depressed Patients Before and After Treatment With Electroconvulsive Therapy
Electroconvulsive therapy (ECT) is a non-pharmacological treatment used in resistant depression whose effectiveness has been demonstrated. However, the brain mechanisms underlying this therapeutic effect remain unclear.
- Trial name
- ECT-IM (NCT02715986)
- Testing
- 3T MRI
- Where
- France
- Volunteers
- 17 people
- Sponsor
- University Hospital, Toulouse
Long COVID, Long COVID Syndrome
Evaluation of MicroRNAs and Vitamin B12 Expression in Subjects with Neurologic Symptoms of Depression, Anxiety and Fatigue in Long COVID-19
At the moment, the number of people with long COVID is unkown because there is still no effective diagnosis. This is why is very important to analyze the most common symptoms, which are: depression, anxiety and fatigue.
- Trial name
- NCT06864156
- Where
- Mexico
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Rehabilitacion
Major Depressive Episode, Suicidal and Self-injurious Behavior
Affective Touch, Hedonia and Suicidal Behavior
Several elements suggest that suicidal vulnerability may be associated with an alteration in the perception of affective touch. On the one hand, anhedonia, characterized by a decrease in the pleasure felt, is strongly associated…
- Trial name
- TOUCH-S (NCT05182827)
- Testing
- Tactile stimulation
- Where
- France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Montpellier
Depression Disorder, Healthy
The Neural Representation of Self in Depression Patients
To be aware of oneself as a unique entity in the world occurs early in human development and is the prerequisite of normal social functioning.
- Trial name
- NCT03551041
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Beijing Normal University
Depression
Brain Stimulation and Decision-making
Decision-making is an important process that is frequently shown to be impaired in patients with depression. While a number of preclinical and clinical studies have identified key regions involved in this process, it remains…
- Trial name
- NCT04099056
- Testing
- Neurostimulation
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Emory University
Depression, Anxiety
Adaptive Coping Skills Training to Improve Psychological Distress Among Cardiorespiratory Failure Survivors
Conditions treated in intensive care units (ICUs) such as the acute respiratory distress syndrome (ARDS), congestive heart failure, COVID pneumonia, and sepsis are common.
- Conditions
- Depression, Anxiety, Post-traumatic Stress Disorder, Stress
- Trial name
- Blueprint 2 (NCT06538246)
- Testing
- Blueprint, Education program
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Duke University
Epilepsy, Depression
A Study to Evaluate the Efficacy and Safety of Add-on Therapy of Wuling Capsule in Epilepsy Patients With Depression
The main purpose of this study is to determine the effects of add-on therapy of wuling capsule on depressive symptoms in patients with comorbidity of epilepsy and depression, to evaluate its influences on the frequency and…
- Trial name
- NCT01125241
- Testing
- wuling capsule
- Where
- 9 sites in China
- Volunteers
- 104 people
- Sponsor
- Shanghai Zhongshan Hospital
Major Depressive Disorder (MDD)
Electroencephalography-based Precise Repetitive Transcranial Magnetic Stimulation Treatment
This study will focus on the hypothesis that repetitive transcranial magnetic stimulation (TMS) based on EEG personalized modulation may be more effective in promoting symptomatic relief of major depressive disorder (MDD), and…
- Trial name
- NCT06385405
- Testing
- Individualized alpha frequency Transcranial Magnetic Stimulation (αTMS) Treatment, 10Hz-frequency TMS treatment over the left dorsolateral prefrontal cortex (DLPFC)
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Shanghai Mental Health Center
Depression, Anxiety, Healthy
Voice Biomarkers Predictive of Depression and Anxiety
The objective of this study is to collect data to improve the sensitivity and specificity of Kintsugi Voice's (formerly KiVATM) predictions on audio files.
- Conditions
- Depression, Anxiety, Healthy, Mental Health Wellness 1
- Trial name
- NCT05455905
- Testing
- Patient Health Questionnaire-9, Generalized Anxiety Disorder-7, Hamilton Depression Rating Scale
- Where
- United States
- Volunteers
- 19,533 people
- Sponsor
- Kintsugi Mindful Wellness, Inc.
Psychosis
Immune Mechanisms of Antipsychotic Treatment Response
The aim of this study is to investigate the role of the immune system in psychotic symptoms and their response to treatment. The investigators will collect blood and cerebrospinal fluid samples from participants with psychosis…
- Trial name
- IMAT (NCT06687694)
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- King's College London
Depressed
Stress Sensitivity and Reward Responsivity in Depression
The goal of this project is to learn more about the different ways in which people process information that is stressful and rewarding, and how abnormalities in these two processes are related to depression.
- Trial name
- CAN-BIND-04 (NCT02798094)
- Where
- Canada
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Dr. Kate Harkness
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