Clinical trials: Depression Symptom
Posttraumatic Stress Disorder, Depression
Examining Changes in Microbiota Over the Course of PTSD Treatment
The overall goals of this project are to evaluate the use of 5-day intensively-delivered Cognitive Processing Therapy to treat PTSD and to determine the associations between the microbiome, salivary cytokines, and the presence of…
- Trial name
- NCT04109196
- Testing
- Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Rush University Medical Center
Fatigue, Unspecified Adult Solid Tumor, Protocol Specific
Levocarnitine in Treating Fatigue in Cancer Patients
RATIONALE: Levocarnitine may help improve energy levels in cancer patients. PURPOSE: This randomized phase III trial is studying how well levocarnitine works compared to a placebo in treating fatigue in cancer patients.
- Trial name
- NCT00091169
- Testing
- levocarnitine
- Where
- 116 sites in United States
- Volunteers
- 376 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Depression
The Effect of Duloxetine on Mood, Quality of Life and Cognitive Functioning in Glioblastoma Patients
Primary tumor glioblastoma is the most common malignant brain. Standard treatment includes biopsy or excision of the tumor in order to obtain a pathological diagnosis, and tumor mass reduction.
- Trial name
- NCT02443194
- Testing
- duloxetine
- Volunteers
- 50 people
- Sponsor
- michal roll
Depressive Disorder, Major
Major Depressive Disorder In The Elderly
This is a placebo-controlled study evaluating the effectiveness of medication in elderly subjects with Major Depressive Disorder (MDD).
- Trial name
- NCT00093288
- Testing
- bupropion XL
- Where
- 16 sites in Australia, Belgium and 4 more
- Volunteers
- 364 people
- Sponsor
- GlaxoSmithKline
Perinatal Depression, Post Partum Depression
Characterizing the Neural Substrates of Irritability in Women: an Experimental Neuroendocrine Model
The proposed study involves experimentally manipulating reproductive hormones in nonpregnant, euthymic women to create a scaled down version of the changes that occur during pregnancy and the postpartum period.
- Conditions
- Perinatal Depression, Post Partum Depression, Depression, Postpartum, Depression
- Trial name
- NCT04051320
- Testing
- Leuprolide Acetate 3.75 MG/ML, Estradiol 2 Mg tablet, Micronized progesterone
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Depression, Anxiety
Improving Women's Mental Health Through Tele-based Wellbeing Centres in Bangladesh.
1. Burden: Women in Bangladesh face a high mental health burden, with 22% experiencing mental disorders compared to 16% of men. Access to face to face psychological care is limited by stigma, financial barriers, restricted…
- Trial name
- NCT07890896
- Testing
- Tele-counselling, In-person counselling
- Where
- 2 sites in Bangladesh
- Volunteers
- 1,200 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Social Skills, Self-Criticism
Development and Pilot Trial of an Intervention to Reduce Disclosure Recipients Negative Social Reactions and Victims Psychological Distress and Problem Drinking
The purpose of this randomized controlled trial is to evaluate an intervention, Supporting Survivors and Self: An Intervention for Social Supports of Survivors of Partner Abuse and Sexual Aggression (SSS).
- Conditions
- Social Skills, Self-Criticism, Post-traumatic Stress Disorder, Depression
- Trial name
- NCT03488927
- Testing
- Supporting Survivors and Self: An Intervention for Social Supports of Survivors of Partner Abuse and Sexual Aggression (SSS)
- Where
- United States
- Volunteers
- 1,268 people, healthy volunteers welcome
- Sponsor
- University of New Hampshire
Depression
Developing the Precision Nursing Education Program to Young Colorectal Cancer Survivors
This study is aimed to demonstrate the long-term effectiveness of 8-week precision nursing education program through the e-flipped classroom model for YCC survivors and provide a compliant strategy to improve quality of life and…
- Trial name
- NCT06337773
- Testing
- 8-weeks's on-line precision nursing education program
- Where
- Taiwan
- Volunteers
- 110 people
- Sponsor
- Fooyin University
Mental Health Issue, Depressive Symptoms
Piloting +Connection is Medicine / The Healing Spirits Program
This study aims to assess what benefit, if any, an individualized coping plan and facilitating connections to care through referral coordination in conjunction with culturally tailored caring messages, (herein called the…
- Conditions
- Mental Health Issue, Depressive Symptoms, Anxiety
- Trial name
- NCT05424679
- Testing
- Safety Planning Intervention, Caring Contacts
- Where
- 4 sites in United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Depressive Symptoms, Parkinson's Disease
Rasagiline in Cognitive-impairment Related Depression: AzileCt in COgnitive-impairment Related DepressiOn
The primary endpoint for this study is the clinical response after 12 weeks of treatment, defined as a change in total score from baseline depressive symptoms as measured by the Beck Depression Inventory-Amended (BDI-IA) total…
- Trial name
- ACCORDO (NCT01055379)
- Testing
- Rasagiline
- Where
- 12 sites in Italy
- Volunteers
- 121 people
- Sponsor
- Lundbeck Italia S.p.A.
Treatment Resistant Depression, Major Depressive Disorder
Clinical Study of GH001 in Depression
The aim of the study is to investigate the safety of GH001 (containing 5-methoxy-dimethyltryptamine; 5-MeO-DMT), and to investigate its effects on severity of depressive symptoms, and its dose-related psychoactive effects in…
- Conditions
- Treatment Resistant Depression, Major Depressive Disorder, Depression
- Trial name
- NCT04698603
- Testing
- 5 Methoxy N,N Dimethyltryptamine
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- GH Research Ireland Limited
Burnout, Emotional Disturbances
Mindfulness-based Therapy Versus Relaxation in Prevention of Burnout in Medical Students
A recent survey exploring mental health in a large cohort of French medical students and young graduates (N = 21.768), observed that 68.2% of participants showed pathologic anxiety.
- Conditions
- Burnout, Emotional Disturbances, Depression
- Trial name
- MUSTPrevent (NCT04026594)
- Testing
- Mindfulness Based Stress Reduction, Relaxation group
- Where
- France
- Volunteers
- 612 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Crohn Disease, Ulcerative Colitis
Digital Behavioral Interventions in Inflammatory Bowel Disease
Given the bidirectionality between psychological distress and disease activity in inflammatory bowel disease (IBD), whereby increased psychological distress exacerbates disease activity and vice versa, psychosocial aspects of IBD…
- Conditions
- Crohn Disease, Ulcerative Colitis, Inflammatory Bowel Diseases, Stress, Psychological
- Trial name
- NCT04861597
- Testing
- Internet based cognitive behavioral therapy, Digital mood tracking
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Montefiore Medical Center
Major Depression
Multicenter Comparative Study of the Activity of the Medial Prefrontal Cortex in Vulnerability to Depression
To examine whether the medial prefrontal cortex displays an increased activity during self-referential processing among remitted depressed patients compared to healthy controls
- Trial name
- CORVAD (NCT02171923)
- Where
- France
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Scheduled Surgery, Healthy Volunteers
Validation of the French Version of the Pain Sensitivity Questionnaire
The Pain Sensitivity Questionnaire (PSQ) is a tool created in 2009 by Dr. R. Ruscheweyh in Germany. It aims at identifying the natural sensitivity to pain, through a set of 17 simple questions.
- Trial name
- PSQ-F (NCT03113903)
- Testing
- Psychophysical exploration
- Where
- France
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Healthy
A Multiple Ascending Dose Study of BCI-838 in Healthy Volunteers
This study will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of BCI-838 and its metabolite BCI-632 in healthy male and female subjects.
- Trial name
- NCT01548703
- Testing
- BCI-838
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- BrainCells Inc.
Depressive Disorder, Major, Postpartum Depression
Mommy-Baby Treatment for Perinatal Depression
Perinatal depression is a major public health problem, affecting 15% of women during pregnancy through the postpartum period, with adverse consequences for the mother, the fetus, the infant, and the family.
- Trial name
- NCT01744041
- Testing
- Dyadic Interpersonal Psychotherapy, Enhanced Treatment as Usual
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Washington University School of Medicine
Depression
Exercise Training Versus Drug Therapy for Treating Depression in Older Adults
This study will evaluate the effectiveness of both center-based and home-based exercise versus the antidepressant drug sertraline in treating depression in middle-aged and older adults.
- Trial name
- NCT00331305
- Testing
- Supervised Exercise, Home-Based Exercise, Sertraline (Zoloft)
- Where
- United States
- Volunteers
- 457 people
- Sponsor
- Duke University
Epilepsy, Depressive Symptoms
Electrophysiologic Mechanisms of Ketamine Antidepressant Response
This study aims to identify electrophysiologic biomarkers associated with antidepressant response to ketamine in adults with epilepsy undergoing clinically indicated stereo-electroencephalography (sEEG) monitoring who have at…
- Trial name
- Ketamine-sEEG (NCT07768618)
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Emory University
Ventricular Tachycardia
Exercise Training in ICD Recipients; Effect on Therapy Delivered, Depression and Anxiety
Interventional study in patients with ICD. Controlled, open intervention with exercise training. Assessment of changes in physiological and psychological parameters.
- Trial name
- ETHIC (NCT01038960)
- Testing
- Exercise training
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- Helse Stavanger HF
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