Clinical trials: Depression Symptom
Transgender, Depression
Mental Health Support for Transgender and Gender-expansive Individuals
This study will evaluate an intervention's feasibility, acceptability and efficacy potential in a one-arm trial with Romanian transgender and gender diverse (e.g., gender non-binary) (TGD) individuals who report depression or…
- Conditions
- Transgender, Depression, Anxiety, Suicidality
- Trial name
- NCT06229132
- Testing
- LGBTQ-affirmative CBT for transgender individuals
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Columbia University
Distress, Depression
Psilocybin-assisted Group Therapy for Demoralization in Long-term AIDS Survivors
The purpose of this study is to determine whether psilocybin-assisted group psychotherapy is a safe and feasible treatment for demoralization in long-term AIDS survivors (LTAS).
- Conditions
- Distress, Depression, Grief
- Trial name
- NCT02950467
- Testing
- Psilocybin, Modified brief Supportive Expressive Group Therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Joshua Woolley
Major Depressive Disorder With Mixed Features
Major Depressive Disorder (MDD) With Mixed Features - Flexible Dose
Lurasidone HCl is a compound that is a candidate for the treatment of major depressive with mixed features.This clinical study is designed to test how well Lurasidone works to treat major depressive disorder with mixed features.
- Trial name
- RESOLVE 1 (NCT01421134)
- Testing
- Lurasidone
- Where
- 43 sites in United States, Russia and 3 more
- Volunteers
- 211 people
- Sponsor
- Sumitomo Pharma America, Inc.
Bipolar Disorder
FMRI Study of Brain Response Before and After Lithium Treatment in People With Bipolar Disorder
This study will assess the effects of bipolar disorder on brain activity and will determine if medication changes the brain activity in people with bipolar disorder.
- Trial name
- NCT00596622
- Testing
- Lithium
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Indiana University
Major Depression
Antidepressant Effects of Ayahuasca: a Randomized Placebo Controlled Trial in Treatment Resistant Depression
The purpose of the present trial is to test the efficacy of Ayahuasca in treatment-resistant depression. Ayahuasca is a decoction of two plants, long used by Amazonian Amerindians.
- Trial name
- NCT02914769
- Testing
- Ayahuasca
- Where
- Brazil
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio Grande do Norte
Breast Cancer, Depression
Yoga or Educational Wellness Class for Women With Stage I, Stage II, or Stage III Breast Cancer Undergoing Chemotherapy
RATIONALE: Yoga and wellness classes may reduce fatigue and improve mood, sleep, and quality of life in women receiving chemotherapy for breast cancer.
- Conditions
- Breast Cancer, Depression, Fatigue, Sleep Disorders
- Trial name
- NCT00994279
- Testing
- Yoga, Education
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Wake Forest University Health Sciences
Bipolar Disorder
Does Risperidone Consta Reduce Relapse and Rehospitalization in Bipolar Disorder?
This study will evaluate the relative effectiveness of risperidone Consta injections occurring every 2 weeks in contrast to treatment as usual in preventing symptomatic relapse and rates of rehospitalization or admission into…
- Trial name
- Consta (NCT00571688)
- Testing
- Risperdal (risperidone) Consta, Treatment as usual
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Vanderbilt University
Depression, Insomnia
PracticeGround: Transforming Training and Delivery of Mental Health EBPs
The ultimate goal is to facilitate the delivery of empirically supported treatments (ESTs) for mental disorders and to improve client mental health outcomes.
- Conditions
- Depression, Insomnia, Suicide
- Trial name
- NCT02314624
- Testing
- Behavioral Activation for Depression, Cognitive Behavior Therapy for Insomnia, Collaborative Assessment and Management of Suicidality, Care-as-Usual Psychotherapy
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- Evidence-Based Practice Institute, Seattle, WA
Pain, Chronic Disease
Improving Chronic Pain Treatment in Primary Care
The primary objective of this study is to determine to what extent a collaborative intervention improves chronic pain-related outcomes in a VA primary care setting.
- Conditions
- Pain, Chronic Disease, Depression
- Trial name
- SEACAP (NCT00129480)
- Testing
- Assistance with Pain treatment
- Where
- United States
- Volunteers
- 401 people
- Sponsor
- VA Office of Research and Development
Xerostomia, Depression
Drug-induced Xerostomia. Evaluation of Malic Acid 1%, Salivary Mucins and Buffering Capacity
The aim of our study was to evaluate the clinical efficacy of a topical sialogogue spray containing 1% malic acid on patients affected by xerostomia caused by drugs.
- Conditions
- Xerostomia, Depression, Hypertension
- Trial name
- NCT01652001
- Testing
- Malic Acid
- Where
- Spain
- Volunteers
- 185 people
- Sponsor
- Universidad de Granada
Smoking, Bipolar Disorder
Varenicline in Bipolar Depressed Patients
Patients with bipolar disorder have one of the highest rates of nicotine dependence and one of the lowest quit rates. Varenicline has been shown in previous trials to be effective for smoking cessation, but has not been studied…
- Conditions
- Smoking, Bipolar Disorder, Depression
- Trial name
- Varenicline (NCT00813800)
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Mark Frye
Depression
Circadian Effects of Escitalopram
The goal of the study is to obtain preliminary data that will test whether the antidepressant medication escitalopram resets the body clock: a collection of nerve cells in the brain that control the timing of many body processes.
- Trial name
- NCT01214044
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Oregon Health and Science University
Major Depressive Disorder (MDD)
Study to Evaluate the Efficacy, Safety and Tolerability of an Oral Aripiprazole/Escitalopram Combination Therapy in Participants With Major Depressive Disorder (MDD)
This will be a multicenter, randomized, double-blind study designed to assess the efficacy, safety and tolerability of an oral Aripiprazole/Escitalopram combination therapy in participants with MDD who have demonstrated an…
- Trial name
- NCT01111565
- Testing
- Escitalopram, Aripiprazole
- Where
- 53 sites in United States, Canada and 9 more
- Volunteers
- 137 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Depression, Stress, Psychological
Rural Dementia Caregiver Project
Rural caregivers face challenges of geographic isolation and lower health care access and quality. Many rural dementia caregivers experience serious health consequences due to caregiving responsibilities that can limit their…
- Conditions
- Depression, Stress, Psychological, Self Efficacy, Loneliness
- Trial name
- NCT04428112
- Testing
- Building Better Caregivers Workshop, Attention Control
- Where
- United States
- Volunteers
- 418 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Depression
Optimizing the Effectiveness of Selective Serotonin Reuptake Inhibitors (SSRIs) in Treatment-Resistant Depression
This study will determine the effectiveness of adding S-adenosyl methionine to antidepressant drug treatment in reducing depressive symptoms in depressed people who have not responded to antidepressants alone.
- Trial name
- NCT00093847
- Testing
- S-adenosyl methione (SAMe)
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Massachusetts General Hospital
Depressive Disorder, Major
A Study of Psilocybin for Major Depressive Disorder (MDD)
One hundred participants, ages 21 to 65, who meet Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria for major depressive disorder (MDD) will be stratified by study site and randomized with a 1-to-1 allocation…
- Trial name
- NCT03866174
- Testing
- Psilocybin, Niacin, Set and Setting (SaS) Protocol
- Where
- 11 sites in United States
- Volunteers
- 347 people
- Sponsor
- Usona Institute
Distress, Cancer
POEM (Practice Of Embracing Each Moment) STUDY
A cancer diagnosis is extremely stressful, emotionally challenging, and often life-altering for both patients and their loved ones.
- Conditions
- Distress, Cancer, Chemotherapy Effect
- Trial name
- POEM (NCT03078608)
- Testing
- Mindfulness meditation program (administered via mobile app), Progressive muscle relaxation (via mobile app)
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Burnout, Professional, Anxiety
Feasibility of a Yoga- and Mindfulness-Based Intervention for Resident Physicians
The investigators aim to initiate and complete the first investigation of the effect of a yoga-based program on resident physicians' psychological health using a randomized controlled trial to assess feasibility of the program in…
- Conditions
- Burnout, Professional, Anxiety, Depression, Stress
- Trial name
- NCT03687450
- Testing
- RISE yoga-based program
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Depression
Enhancing the Effectiveness of Electroconvulsive Therapy in Severe Depression
Electroconvulsive therapy (ECT) is the most powerful antidepressant treatment available and is often life-saving. There are concerns, however, that standard bitemporal ECT (the most commonly used form of ECT worldwide) causes…
- Trial name
- EFFECT-Dep (NCT01907217)
- Testing
- ECT Mecta 5000M, Methohexitone, Suxamethonium
- Where
- Ireland
- Volunteers
- 138 people
- Sponsor
- St Patrick's Hospital, Ireland
Depression, Anxiety
Low Intensity Family Support for Refugees in an LMIC
The rapidly growing scale of humanitarian crises requires new response capabilities geared towards addressing populations with prolonged high vulnerability to mental health consequences and little to no access to mental health…
- Conditions
- Depression, Anxiety, PTSD, Family Dynamics
- Trial name
- NCT03978533
- Testing
- Family Support Group
- Where
- 6 sites in Turkey (Türkiye)
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
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