Clinical trials: Depression Symptom
Emotional Disorder
Cost-effectiveness of a Transdiagnostic Psychological Treatment for Emotional Disorders in Primary Care
The aim of this study is to test the cost-effectiveness and cost-utility of adding a transdiagnostic group cognitive-behavioural therapy (TD-CBT) to treatment as usual (TAU) for emotional disorders in primary care .
- Trial name
- PsicAP-Costs2 (NCT05314920)
- Testing
- Transdiagnostic cognitive-behavioral therapy (TD-CBT), Bernstein and Borkovec progressive muscle relaxation (PMR)
- Where
- 4 sites in Spain
- Volunteers
- 300 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Psychological Distress (Depression, Anxiety and Stress) Cancer
Efficacy of an Integrated Psychological Interventions Combined With Ar_Rahman Listening for Reducing Psychological Distress and Enhancing Hope and Quality of Life Among Cancer Patients: A Randomized Controlled Trial
This is a randomized control trial(RCT ID:25142101) to evaluate the efficacy of psychological intervention combined with listening to surah Ar- RAhman for reducing psychological distress and improving cancer patients' hope and…
- Trial name
- NCT07833982
- Testing
- supportive psychotherapy plus QURAN recitation9Surah Ar -Rahman
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Shaheed Zulfikar Ali Bhutto Institute of Science and Technology (SZABIST) University
Stress, Anxiety
Effects of Coherent Breathing Breathwork on Health
The investigators are conducting a randomised-controlled trial comparing coherent breathing at ~5.5 breath cycles per minute-bcpm (with equal inhalation/exhalation durations of ~5.5secs each) to a well-designed placebo (paced…
- Conditions
- Stress, Anxiety, Depressive Symptoms, Wellbeing
- Trial name
- NCT05676658
- Testing
- Coherent breathing
- Where
- United Kingdom
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Sussex
Depressive Symptoms, Anxiety
Strategies for Coping With Negative Thoughts
The primary objective of this study is to assess the impact of two strategies for coping with negative automatic thoughts (positive thinking and cognitive restructuring) on one's belief in negative thoughts and one's affect.
- Conditions
- Depressive Symptoms, Anxiety, Negative Thinking
- Trial name
- NCT05566691
- Testing
- Positive thinking, Positive thinking + Mood induction, Thought reevaluation
- Where
- United States
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Temporomandibular Disorder (TMD)
Marine Lipids Ease Painful TMD
The ADAPT study is a single-site, Phase 2b, randomized, quadruple-masked, placebo-controlled trial evaluating an omega-3 dietary supplement enriched with specialized pro-resolving mediator (SPM) precursors in adults with chronic…
- Trial name
- ADAPT (NCT07437313)
- Testing
- SPM Precursor-Enriched Marine Lipid Supplement, Medium-Chain Triglyceride Supplement
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of North Carolina, Chapel Hill
Internet Treatment, Active Control
ICBT for Depression in Older Adults
The study was a randomized controlled trial investigating treatment effects against an active control condition. 101 self-recruited participants, aged 65 to 88 years, were included.
- Trial name
- ALM (NCT05269524)
- Testing
- Internet-delivered tailored cognitive behavior therapy
- Where
- Sweden
- Volunteers
- 101 people
- Sponsor
- Linkoeping University
Obstetric Anal Sphincter Injury, Episiotomy Wound
Mediolateral Episiotomy and Obstetric Anal Sphincter Injuries in Instrumental Delivery
Literature is contradictory about the impact of mediolateral episiotomy during operative vaginal delivery in obstetric anal sphincter injuries prevention explaining the absence of international guidelines.
- Conditions
- Obstetric Anal Sphincter Injury, Episiotomy Wound, Anal Incontinence, Pelvic Floor Disorders
- Trial name
- INSTRUMODA (NCT04446780)
- Testing
- Mediolateral episiotomy
- Where
- France
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Depression
Repeated Partial Sleep Deprivation to Augment SSRI Response in Depression
The purpose of the study is to determine whether changing sleep patterns improves response to an antidepressant medication.
- Trial name
- NCT01545843
- Testing
- Sleep scheduling, Fluoxetine
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Michigan
Schizophrenia, Autism Spectrum Disorder
Cerebellar Stimulation and Cognitive Control
The purpose of this study is to examine whether cerebellar stimulation can be used to improve cognitive deficits and mood in patients with schizophrenia, autism, bipolar disorder, Parkinson's disease, and major depression.
- Conditions
- Schizophrenia, Autism Spectrum Disorder, Bipolar Disorder, Depression
- Trial name
- NCT03217110
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Krystal Parker, PhD
Depression
A Novel Individualized Connectome-guided Approach for Precision Intermittent Theta Burst Stimulation for Depression
The Investigators propose to carry out a randomized, double-blind trial to compare the clinical efficacy of an individualized connectome-guided accelerated iTBS vs an anatomically-guided (Beam F3) accelerated iTBS.
- Trial name
- NCT06385223
- Testing
- Beam F3 targeted accelerated iTBS, Individualized connectome-guided accelerated iTBS
- Where
- Singapore
- Volunteers
- 70 people
- Sponsor
- Institute of Mental Health, Singapore
Anxiety Disorders, Depression
Process and Outcomes in CBT for Anxious and Depressed Youth
The current study will evaluate the predictors, mediators, outcomes, and critical therapy processes associated with manual-based psychological therapies for 400 youth (ages 7-16 years) with anxiety and/or depression seeking…
- Trial name
- NCT03100279
- Testing
- Coping Cat/CAT Project, Primary and Secondary Coping Enhancement Therapy
- Where
- United States
- Volunteers
- 247 people
- Sponsor
- Rutgers University
Bipolar Disorder
Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
A long-term study of current treatments for bipolar disorder, including medications and psychosocial therapies.
- Trial name
- NCT00012558
- Testing
- lithium, valproate, bupropion
- Where
- 11 sites in United States
- Volunteers
- 5,000 people
- Sponsor
- National Institute of Mental Health (NIMH)
Hematologic Malignancy, Anxiety
Cognitive-behavioural Intervention for Anxiety, Depression and Quality of Life Among Children Receiving Chemotherapy.
The diagnosis and treatment of paediatric cancer is the most stressful experience for children and their families. Nearly all paediatric cancer patients are presented with at least one psychosocial problem, of which, anxiety and…
- Conditions
- Hematologic Malignancy, Anxiety, Depression, Quality of Life
- Trial name
- NCT05270655
- Testing
- Cognitive-behavioural intervention
- Where
- 2 sites in Ethiopia
- Volunteers
- 76 people
- Sponsor
- Chinese University of Hong Kong
Major Depressive Disorder, Inflammation
The Relations Among Endotoxin, Inflammatory Cytokines, Cognitive Markers and Brain MRI Changes in Subjects With Depressive Disorder
Major depressive disorder (MDD) is a chronic mental illness, with 60% lifetime risk of recurrence after the first MDD episode. Despite available treatment options for MDD, only about half to two-thirds of patients respond to…
- Conditions
- Major Depressive Disorder, Inflammation, Cognitive Dysfunction, Endotoxemia
- Trial name
- NCT06203015
- Testing
- The Cambridge Neuropsychological Test Automated Battery., Venous blood samples, brain MRI
- Where
- 2 sites in Lithuania
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Mild to Moderate Depression
EMI Therapy for Depression in Hong Kong
To determine if a two-week ecological momentary intervention (two EMA + one EMI daily) as augmentation to treatment as usual would reduce depressive symptoms, rumination levels, and functioning in subjects with mild to moderate…
- Trial name
- NCT06430476
- Testing
- EMI, EMA
- Where
- Hong Kong
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Anxiety, Depression
High-Intensity Interval Training and Mental Health in Psychiatric Inpatients: A Pilot Study
The goal of this pilot clinical trial is to investigate the feasibility of conducting a high-intensity interval training intervention among adult inpatients in a psychiatric care setting and to explore changes in mental health…
- Conditions
- Anxiety, Depression, Mental Health, Psychiatric Inpatients
- Trial name
- NCT07864324
- Testing
- High-Intensity Interval Training (1 × 4)
- Where
- Norway
- Volunteers
- 10 people
- Sponsor
- University Hospital of North Norway
Acute Stress Disorder, Anxiety
GASA-CIR Trail (Guidance and the Symptoms of Acute Stress and Anxiety in Critically Ill Patients Relatives in Intensive Care Unit)
A randomized clinical trial 1:1 among relatives of patients admitted to an intensive care unit, the intervention group will be composed by family members who receive a printed brochure and will be encouraged to visit a website…
- Conditions
- Acute Stress Disorder, Anxiety, Depression
- Trial name
- GASA-CIR (NCT03812458)
- Testing
- website and brochure
- Where
- Brazil
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Depression, Adolescent Behavior
Volunteering as an Intervention to Reduce Depression Among Adolescents
The purpose of the present study is to test in a preliminary manner an innovative strategy for treating depression among adolescents (alongside existing therapy) using community volunteerism.
- Conditions
- Depression, Adolescent Behavior, Depressive Symptoms
- Trial name
- NCT03816215
- Testing
- Volunteer experience
- Where
- 3 sites in United States
- Volunteers
- 9 people
- Sponsor
- Wake Forest University Health Sciences
Post Intensive Care Syndrome, Depression
Companion Dog Walking for ICU Survivor Health
The goal of this clinical trial is to determine the feasibility and acceptability of a randomized controlled trial comparing a pet dog walking intervention to an attention control education intervention in adult intensive care…
- Conditions
- Post Intensive Care Syndrome, Depression, Anxiety, Quality of Life
- Trial name
- POOCH (NCT05820308)
- Testing
- Companion Dog Walking, Attention Control Group
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- University of Missouri, Kansas City
Bipolar Depression
Magnetic Resonance Imaging Study of Lisdexamfetamine for Bipolar Depression
There have been reports that stimulants may be effective for bipolar depression without triggering mania. This study will examine whether lisdexamfetamine can improve depressive symptoms over the course of eight weeks.
- Trial name
- NCT01051440
- Testing
- Lisdexamfetamine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Steward St. Elizabeth's Medical Center of Boston, Inc.
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