Clinical trials: Depression Symptom
Parkinson Disease
Non-motor Symptoms (Depressive Symptoms) of Parkinson's Disease and Their Course Under Pramipexole Treatment
The objective of this PMS study is the evaluation of depressive symptoms measured with Unified Parkinson's Disease Rating Scale (UPDRS) Part I (mentation, behavior and mood) and with Hospital Anxiety and Depression Scale…
- Trial name
- NCT00651183
- Testing
- Pramipexole immediate release
- Where
- 57 sites in Austria
- Volunteers
- 286 people
- Sponsor
- Boehringer Ingelheim
Depression, Depressive Disorder, Major
Comparing the Efficacy of fMRI-Guided vs. Standard iTBS in Treating Depression
In this triple-blind randomized controlled trial, we ask if targeting intermittent theta burst stimulation (iTBS) based on individual resting state connectivity improves treatment outcomes in major depressive disorder (MDD).
- Conditions
- Depression, Depressive Disorder, Major, Depressive Episode
- Trial name
- NCT06152705
- Testing
- repetitive Transcranial Magnetic Stimulation
- Where
- Canada
- Volunteers
- 210 people
- Sponsor
- The Royal Ottawa Mental Health Centre
Major Depressive Disorder
Efficacy and Safety of SR58611A in Patients With Major Depressive Disorder
To evaluate the efficacy of a fixed dose of SR58611A(350 mg q12) compared to placebo in patients with MajorDepressive Disorder (MDD) using escitalopram (10 mgqd) as positive control.
- Trial name
- ORION (NCT00252356)
- Testing
- SR58611A
- Where
- 2 sites in United States, Canada
- Volunteers
- 468 people
- Sponsor
- Sanofi
Depression Disorder
The Effects of Chiropractic on Adults With Depression
The goal of this clinical trial is to evaluate the feasibility of the study design in preparation for a future clinical trial examining chiropractic care for adults with mild to moderate depression.
- Trial name
- DEP (NCT07260045)
- Testing
- Chiropractic Care
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Life University
Diabetes, Hypertension
Pharmacy Interventions to Improve Chronic Disease Medication Refill
Compare the effectiveness of 3 strategies by pharmacists to decrease the time to refill of prescriptions for common chronic diseases (diabetes, hypertension, hyperlipidemia, heart failure, depression, psychoses).
- Conditions
- Diabetes, Hypertension, Hyperlipidemia, Heart Diseases
- Trial name
- NCT00469365
- Testing
- pharmacist contact with the patient via telephone, Pharmacist contact with the patient's physician via fax, Usual care
- Where
- United States
- Volunteers
- 3,048 people
- Sponsor
- Medical University of South Carolina
Major Depressive Disorder
A Placebo- and Paroxetine-controlled Study of the Efficacy, Safety and Tolerability of Agomelatine (25 or 50 mg) in the Treatment of Major Depressive Disorder (MDD)
This study will evaluate the efficacy, safety and tolerability of agomelatine 25 mg or 50 mg per day and will compare agomelatine and paroxetine tolerability.
- Trial name
- NCT00463242
- Testing
- Agomelatine, paroxetine
- Where
- 47 sites in United States, Puerto Rico
- Volunteers
- 501 people
- Sponsor
- Novartis
Major Depression
Single Day of Ultra-accelerated TMS With a Single Dose of NRX-101
In this pilot study, investigators aim to combine D-cycloserine, lurasidone, and single-day repeated intermittent Theta Burst Stimulation (iTBS) to preliminarily assess clinical improvement in an open-label cohort and monitor for…
- Trial name
- SPARC-LI (NCT07785102)
- Testing
- TMS, NRX-101
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mclean Hospital
Depression - Major Depressive Disorder, Anhedonia
Elucidating the Relevance of the Psychedelic Experience to Psilocybin's Anti-Anhedonic Effects
The goal of this clinical trial is to systematically categorize potential prohedonic effects of psilocybin in patients with anhedonia in depression. The main questions it aims to answer are: Primary Objectives 1.
- Trial name
- NCT07490353
- Testing
- Psilocybin (Usona Institute), Risperidone 1 MG, MRI
- Where
- Austria
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Depression, Migraine
Vortioxetine in Depression and Concomitant Migraine
Depression and migraine are among the most prevalent conditions in the general population, and many research shows they are closely related.
- Trial name
- VORTIX (NCT07579481)
- Where
- Italy
- Volunteers
- 31 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Depression
Mobile Technology to Engage and Link Patients and Providers in Antidepressant Treatment (MedLink)
The goal of this project is to develop and pilot a mobile smartphone delivered intervention that will improve antidepressant medication care by providing medication adherence monitoring and support to the patient, feedback on…
- Trial name
- NCT02583230
- Testing
- MedLink System
- Volunteers
- 11 people
- Sponsor
- Northwestern University
Depression
Effectiveness of Case Management Versus Case Management Plus Problem-solving Therapy to Treat Depression in Low-income Elders
This study will compare the effectiveness of case management combined with problem-solving therapy (CM-PST) versus case management (CM) alone for assisting elderly people with depression.
- Trial name
- NCT00540865
- Testing
- Problem-solving therapy (PST), Case management (CM)
- Where
- 2 sites in United States
- Volunteers
- 187 people
- Sponsor
- Weill Medical College of Cornell University
Depression
E-mental Health Support for Rural Areas
In the treatment of depression, primary care team play an important role, but they are most effective when inserted into a collaborative model of disease management.
- Trial name
- NCT02200367
- Testing
- e-mental health collaborative programme, Usual Care
- Volunteers
- 254 people
- Sponsor
- University of Chile
Major Depressive Disorder
Do Antidepressants Induce Metabolic Syndromes METADAP Study
Since antidepressants and antipsychotics have common receptorial mechanisms of action (H1 antagonism, 5HT2 antagonism), the impact of antidepressants in terms of metabolic syndromes is a matter of concern.
- Trial name
- METADAP (NCT00526383)
- Testing
- Tricyclic antidepressants
- Where
- France
- Volunteers
- 624 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Metabolic Syndrome
Effects of a Zumba Dance Program for Postmenopausal Women With Metabolic Syndrome
The aim of this study is to examine the effects of a 12-week Zumba dance intervention on fitness, anthropometric and psychometric parameters and eating behavior.
- Trial name
- ZumBeat (NCT02384694)
- Testing
- Zumba dance
- Where
- Switzerland
- Volunteers
- 17 people
- Sponsor
- University of Basel
Chronic Pain, Depression
Mindfulness-based Cognitive Therapy vs the Health Enhancement Program for Chronic Pain and Depression; The Quiet Focus Study
The goal of this clinical trial is to pilot a randomized controlled trial comparing an adaptation of mindfulness-based cognitive therapy to the health enhancement program for chronic pain and depression.
- Trial name
- NCT07118722
- Testing
- Quiet Focus, Health Enhancement Program
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Expectant Couples
"Becoming Parents": A Hospital-community Partnership
The proposed of this study is to determine if an intervention, known as the "Becoming Parents" programme, is more effective in improving the mental health, marital relationship and parental competence of expectant couples in a…
- Trial name
- NCT01383551
- Testing
- "Becoming Parents" intervention
- Where
- Hong Kong
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Major Depressive Disorder, Mood Disorders
Can Genetics Predict Treatment Response to a Computerized Self-help Program for Depression?
The goal of this project is to determine whether genetic information can be used to predict response to an internet-based treatment of depression.
- Trial name
- NCT01818453
- Testing
- Computerized self-help program for depression
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Texas at Austin
Bipolar Depression, Suicidal Ideation
NRX100 vs. Placebo for Rapid Stabilization of Acute Suicidal Ideation and Behavior in Bipolar Depression
NMDA antagonist drugs have increasingly been demonstrated to reduce symptoms of depression and suicidal ideation. NeuroRx has developed a sequential therapy consisting of IV NRX-100 (ketamine HCL) for rapid stabilization of…
- Trial name
- SevereBD (NCT03396601)
- Testing
- Ketamine Hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- NeuroRx, Inc.
Major Depressive Disorder
NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
The study will evaluate the efficacy of NBI-1065845 compared with placebo as an adjunctive treatment in participants with MDD on improving symptoms of depression.
- Trial name
- NCT06911112
- Testing
- NBI-1065845
- Where
- 39 sites in United States, Bulgaria and 3 more
- Volunteers
- 200 people
- Sponsor
- Neurocrine Biosciences
Depression, Quality of Life
Impact of Breathing Exercises and Meditation on Quality of Life in Dry Eye Disease Patients: A Pilot Study
People staring at computer screens for long hours, blinking less frequently, or having long-term contact lens wear are prone to dry eye disease (DED).
- Conditions
- Depression, Quality of Life, Dry Eye, Anxiety
- Trial name
- NCT03345381
- Testing
- SKY + ASTM + usual care, Usual care
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
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