Clinical trials: Depression Symptom
Depression, Dysthymic Disorder
Duloxetine Treatment in Elderly With Dysthymia
Dysthymic disorder (DD) denotes chronic depression with fewer symptoms than major depressive disorder (MDD), and it affects ~ 2-4 % of adults with a similar prevalence in the elderly.
- Trial name
- NCT01852383
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- New York State Psychiatric Institute
Health Care Utilization
Modifying Treatment Expectations in Depression: the Role of Social Learning
Research has shown that treatment expectations play a major role in the course of mental disorders and that positive expectations have a beneficial impact on treatment outcomes.
- Trial name
- NCT05245370
- Testing
- Control video, Rationale video, Clinician testimonial
- Where
- Germany
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Anxiety, Depression
Stress Levels and Mental Well-Being Among Students During e-Learning
Introducing restrictions on human contact has been effective in preventing the uncontrolled spread of COVID-19, however, it appears to have negatively impacted mental health.
- Trial name
- NCT04926441
- Testing
- Stress Levels and Mental Well-Being assessment
- Where
- 8 sites in Lithuania, Poland and 1 more
- Volunteers
- 4,870 people, healthy volunteers welcome
- Sponsor
- The Opole University of Technology
Depression
Telehealth Depression Treatments for Older Adults
This study aims to find an effective and sustainable approach to reducing disparities in accessing mental health services for an underserved and growing population group of low-income, racially diverse, homebound older adults.
- Trial name
- NCT02600754
- Testing
- IT-PST, IT-SCM
- Where
- United States
- Volunteers
- 277 people
- Sponsor
- University of Texas at Austin
Depression, Suicidal Ideation
A Double-Blind Study of Buprenorphine Treatment of Acute Suicidality
The acutely suicidal patient presents a complex and dangerous clinical dilemma. Many suicidal patients receive antidepressant medications, but the onset of action of these medications is at least three weeks, and despite their…
- Conditions
- Depression, Suicidal Ideation, Suicidal Action
- Trial name
- NCT00863291
- Testing
- buprenorphine
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Abarbanel Mental Health Center
Depression
Antiglucocorticoid Augmentation of antiDepressants in Depression
Depression is one of the most common mental health problems, with at least one in six adults suffering from this at some time in their life. It can become long-lasting and frequently recurs.
- Trial name
- ADD (NCT01375920)
- Testing
- Metyrapone
- Where
- 11 sites in United Kingdom
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Jane Barnes
Depression, Substance Use Disorders
BA Trial for Co-Occurring Depression and Substance Use
A large proportion of people seeking treatment for drug and alcohol issues also have clinically significant depression symptoms.
- Trial name
- NCT03661580
- Testing
- Behavioural Activation, Treatment as Usual
- Where
- United Kingdom
- Volunteers
- 34 people
- Sponsor
- University of Sheffield
Depression/Depressed State
Drug Use Investigation Of Effexor (SECONDARY DATA COLLECTION STUDY; SAFETY AND EFFICACY OF EFFEXOR.UNDER JAPANESE MEDICAL PRACTICE)
SECONDARY DATA COLLECTION STUDY; SAFETY AND EFFICACY OF EFFEXOR.UNDER JAPANESE MEDICAL PRACTICE
- Trial name
- NCT02958527
- Testing
- venlafaxine
- Volunteers
- 1,408 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Major Depressive Disorder
Melatonin Agonist Effects of Tasimelteon Versus Placebo in Patients With Major Depressive Disorder
The purpose of this study is to evaluate the safety and efficacy of an 8-week double-masked treatment of tasimelteon or placebo in male and female subjects with Major Depressive Disorder.
- Trial name
- MAGELLAN (NCT01428661)
- Testing
- tasimelteon
- Where
- 40 sites in United States
- Volunteers
- 507 people
- Sponsor
- Vanda Pharmaceuticals
Comfort Theory, AI-Assisted Group Music Intervention
Applying Comfort Theory to an AI-Assisted Group Music Intervention: Psychosocial and Physiological Outcomes and Feasibility in Long-Term Care Residents.
The research design adopts a sequential two-phase framework. The study will be conducted in three residential LTC facilities located in Taichung City or Changhua County, with a total planned enrollment of 60 residents.
- Conditions
- Comfort Theory, AI-Assisted Group Music Intervention, Long-Term Care Residents, Loneliness
- Trial name
- NCT07882979
- Testing
- Group music intervention, AI-assisted monitoring system
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yu Chia Chang
Psychological Distress, Psychological Well-being
Two Sessions of Coach-Delivered Core Transformation for Distress and Well-Being
The goal of this study is to learn if Core Transformation, a guided coaching process, lowers psychological distress in adults. It will also look at well-being, daily functioning, and whether any changes last over time.
- Trial name
- NCT07879196
- Testing
- Core Transformation Process
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Andreas NLP (Legal Entity - Real People Press)
Colorectal Cancer Patients and Their Partners
Sexual Dysfunction and the Quality of Sexual Life in Patients With Colorectal Cancer and Their Partners.
In this project the main focus is on assessing sexual functioning and the quality of sexual life after the treatment of colorectal cancer in patients and their partners.
- Trial name
- NCT01234246
- Where
- 4 sites in Netherlands
- Volunteers
- 1,371 people
- Sponsor
- Tilburg University
Major Depressive Disorder, Depression
Treatment for Adolescents With Depression Study (TADS)
TADS is designed to compare the effectiveness of established treatments for teenagers suffering from major depressive disorder (MDD).
- Trial name
- NCT00006286
- Testing
- Fluoxetine, Psychotherapy
- Where
- 12 sites in United States
- Volunteers
- 432 people
- Sponsor
- National Institute of Mental Health (NIMH)
Diabetes Mellitus, Type 2, Depression
Treatment Adherence Intervention in Patients With Type 2 Diabetes and Comorbid Depression
Patients with diabetes have higher depression rates, impaired QOL and increased mortality rates due to complications and comorbid depression.
- Trial name
- TELE-DD (NCT04097483)
- Testing
- Telephone Intervention Group
- Volunteers
- 428 people
- Sponsor
- Alicia Monreal Bartolomé
Depression
Chatbot-based Mindfulness Programme for Depressive University Students: Pilot Intervention Study
The goal of this study is to evaluate the feasibility, acceptability, safety and preliminary efficacy of a chatbot-based mindfulness-based stress reduction (MBSR) intervention for university students with depressive symptoms.
- Trial name
- NCT06440941
- Testing
- chatbot-based mindfulness-based stress reduction
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- The Hong Kong Polytechnic University
Major Depressive Disorder, Depression
A Positron Emission Topographic (PET) Study on Depression Patient With Electroacupuncture
This is a randomized, assessor-blind, placebo controlled study in major depressive disorder (MDD) patients. Subjects receiving antidepressant drug (FLX) would be assigned to receive either 18 sham / active DCEAS for in 6 weeks.
- Trial name
- NCT01479920
- Testing
- Fluoxetine, DCEAS (Hwato®/ Dongbang®), n-CEA (Strietberger®)
- Where
- 4 sites in China, Hong Kong
- Volunteers
- 36 people
- Sponsor
- The University of Hong Kong
Depression
Pilot Randomized Trial of BA-GSH in VA PC-MHI
Symptoms of depression are highly prevalent among Veterans. However, fewer than 30% of individuals with these symptoms receive any psychotherapy in the Veterans Health Administration (VHA).
- Trial name
- NCT07541482
- Testing
- Behavioral Activation-Guided Self-Help
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- VA Office of Research and Development
Ocular Hypertension, Sleep Disturbance
Ocular Hypertension And Yoga Study
The investigators aim to pilot test the efficacy of a yoga intervention designed specifically for individuals with ocular hypertension.
- Conditions
- Ocular Hypertension, Sleep Disturbance, Stress, Anxiety
- Trial name
- OHAYS (NCT01446588)
- Testing
- Yoga Intervention
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Type 2 Diabetes, Hyperlipidemia
Using Learning Teams for Reflective Adaptation for Diabetes and Depression
The study will randomize 54 primary care practices to two intervention and a comparison groups. Both interventions will involve an on-site Improvement Facilitator who will assist the practice in forming an Improvement Team, using…
- Conditions
- Type 2 Diabetes, Hyperlipidemia, Hypertension, Depression
- Trial name
- ULTRA-DM/MDD (NCT00414986)
- Testing
- Standard CQI intervention, Chronic Care Improvement (CCI) Intervention, Self-directed practice comparison
- Where
- United States
- Volunteers
- 1,565 people
- Sponsor
- University of Colorado, Denver
Depression
Adding Exercise to Antidepressant Medication Treatment for Depression
This study will assess the effectiveness of an exercise program in improving antidepressant medication treatment for individuals with major depressive disorder (MDD).
- Trial name
- TREAD (NCT00076258)
- Testing
- SSRI + LD, SSRI + PHD
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- University of Texas Southwestern Medical Center
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