Clinical trials: Depression Symptom
Depression
Sequence Towards Remission in Depression
In this study the investigators use clinical, biological and imaging markers to develop predictive markers for remission from depression.
- Trial name
- STRIDE (NCT01628783)
- Testing
- escitalopram 10 mg
- Where
- Finland
- Volunteers
- 90 people
- Sponsor
- Jesper Ekelund
Behavior Problems, Oppositional Defiant Disorder
The Effectiveness of Parent-Child Interaction Therapy (PCIT)
The purpose of this study was to investigate whether a type of parent-based intervention, Parent-Child Interaction Therapy will lower symptoms of behavior problems in young children more than treatment as usual.
- Conditions
- Behavior Problems, Oppositional Defiant Disorder, Conduct Disorder
- Trial name
- NCT01085305
- Testing
- Parent-Child Interaction Therapy, TAU
- Where
- 2 sites in Norway
- Volunteers
- 63 people
- Sponsor
- Norwegian University of Science and Technology
Depression, Anxiety, Palliative Care
Problem-Solving Therapy for Cancer Caregivers in Outpatient Palliative Care
This study is a randomized clinical trial of a problem-solving therapy intervention for family caregivers of individuals with cancer receiving outpatient palliative care.
- Conditions
- Depression, Anxiety, Palliative Care, Caregivers, Cancer
- Trial name
- NCT04867122
- Testing
- Problem-Solving Therapy, Attention-matched Control, In-depth interviews
- Where
- 3 sites in United States
- Volunteers
- 532 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Fear of Childbirth, Anxiety
The MOTIVE (Multiparas Overcoming Childbirth Fear Through Intervention and Empowerement) Feasibility Trial
The purpose of the study is to develop and pilot an intervention for the treatment of fear of childbirth for multiparas and to evaluate the feasibility of the intervention in the treatment of fear of childbirth in multiparas.
- Conditions
- Fear of Childbirth, Anxiety, Depression
- Trial name
- MOTIVE (NCT05766202)
- Testing
- An group intervention for multiparas with fear of childbirth
- Where
- Finland
- Volunteers
- 19 people
- Sponsor
- Tampere University
Depression, Pregnancy Related
Treatment of Intrapartum Depression Using Non-invasive Photobiomodulation
Depression during pregnancy can cause fetal and maternal problems such as growth restriction, preterm labor, low birthweight, poor compliance and suicide.
- Conditions
- Depression, Pregnancy Related, Intrapartum Depression
- Trial name
- NCT04404231
- Testing
- Delivery of infrared light to the head, No Infrared treatment
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Type 2 Diabetes, Acute Coronary Event
Tailored Support for Type 2 Diabetes Patients With an Acute Coronary Event After Discharge From Hospital
Background: In type 2 diabetes mellitus patients, an acute coronary event (ACE) may result in a decreased quality of life and increased distress.
- Trial name
- Diacourse (NCT01801631)
- Testing
- Home visits, Consultation by telephone
- Where
- 13 sites in Netherlands
- Volunteers
- 201 people
- Sponsor
- UMC Utrecht
Depression, Suicide
A Study to Decrease Suicidal Thinking Using Ketamine
Depression treatment typically is slow acting. Patients presenting with acute suicidality have few immediate treatment options. However, sub-anesthetic doses of ketamine have been now widely tested as a rapid-acting treatment for…
- Trial name
- NCT02418702
- Testing
- 0.2 mg/kg ketamine
- Where
- United States
- Sponsor
- United States Naval Medical Center, San Diego
Temperament, Anxiety
Effect of Temperament, Anxiety and Depression on Immuninity in Colorectal Cancer Patients. Effetti Del Temperamento, Dell'Ansia e Della Depressione Sulla Sopravvivenza Globale e Sulla Risposta Immunitaria Del Paziente Affetto da Adenocarcinoma Colo-Rettale.
Aim of the study is to evaluate if Temperament, Anxiety and Depression can affect Immunity and influence Survival in Colorectal Cancer Patients
- Conditions
- Temperament, Anxiety, Depression, Colorectal Cancer
- Trial name
- NCT01433146
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- University of Roma La Sapienza
Major Depressive Disorder (MDD)
Open-label Brexpiprazole fMRI Trial in Adults With Major Depressive Disorder and Anxiety
The purpose of this study is to use fMRI to evaluate the effects of brexpiprazole as add-on therapy to antidepressants on brain connectivity in individuals with MDD and symptoms of anxiety, aged 18 to 65.
- Trial name
- NCT05504486
- Testing
- Brexpiprazole
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Anxiety Disorder, Colorectal Cancer
Moderate Physical Activity in Helping Patients Recover Physically and Emotionally From Stage II Or Stage III Colorectal Cancer
RATIONALE: Physical activity may prevent or lessen depression and anxiety and improve quality of life and immune function in patients with colorectal cancer.
- Conditions
- Anxiety Disorder, Colorectal Cancer, Depression, Psychosocial Effects of Cancer and Its Treatment
- Trial name
- NCT00373022
- Testing
- exercise intervention, flow cytometry, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Arizona
Depression, Burnout, Professional
Health cAre woRkers exposeD to COVID-19
Health care workers working in hospital or nursing home for elderly people involved in the coronavirus epidemic are facing several challenges such as direct exposure and involvement in the resolution of major public health…
- Conditions
- Depression, Burnout, Professional, Post Traumatic Stress Disorder
- Trial name
- HARD-COVID19 (NCT04570202)
- Testing
- EMDR
- Where
- 2 sites in France
- Volunteers
- 900 people
- Sponsor
- University Hospital, Tours
Depression, Depressive Disorder
Improving Retention of Hispanics Receiving Antidepressant Therapy
This study will develop an intervention that will increase the retention of Hispanics with major depression in antidepressant therapy.
- Trial name
- NCT00057642
- Testing
- Sertraline, Venlafaxine Extended Release
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- New York State Psychiatric Institute
Depression
Preliminary Study to Investigate the Effect of rTMS and SSRI Antidepressants on Leukocyte Expression of the C-FOS and DUSP1 Genes in Patients Treated for Depression
Low frequency rTMS (repetitive Transcranial Magnetic Stimulation) for the treatment of patients with depression, is responsible for a decrease in the expression of the C-FOS and DUSP1 genes in peripheral blood leukocytes.
- Trial name
- TMSFOS (NCT02042573)
- Testing
- rTMS, SSRI (SEROPLEX ou ZOLOFT), Genetic samples
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Depression, Mood Disorders
Functional MRI Before and After Treatment for Depression
The purpose of this study is to help us understand how depression changes brain activity and how this relates to mood, anxiety, and cognitive functions like memory.
- Conditions
- Depression, Mood Disorders, Depressive Disorder
- Trial name
- NCT00896441
- Testing
- Citalopram
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Stanford University
Major Depression, Bipolar Disorder
Longitudinal Study of People Presenting for First Treatment of a Mood Disorder
The goal of this project is to study the course and outcome of illness in individuals who present with a first episode of depression or mania, or who have a recurrent disorder but have never received treatment.
- Trial name
- NCT01529905
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- McMaster University
Low Back Pain
Low Back Pain in Mothers of Children With Disabilities
This is a cross-sectional study that aims to determine the prevalence of low back pain in mothers of children with disabilities following the COVID-19 pandemic and to describe its relationship with exposure to the virus, handgrip…
- Trial name
- NCT07106905
- Testing
- Measurements
- Where
- Turkey (Türkiye)
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Selvin BALKİ
Depressive Disorder, Major
An Eight-week Study of Saredutant and Paroxetine as Combination Treatment for Major Depressive Disorder
The main purpose of this study is to evaluate the efficacy of saredutant 100mg or 30mg once daily in combination with paroxetine 20mg once daily compared to saredutant placebo in combination with paroxetine 20mg once daily in…
- Trial name
- COMPASS (NCT00629551)
- Testing
- saredutant (SR48968), paroxetine
- Where
- 8 sites in United States, Chile and 6 more
- Volunteers
- 825 people
- Sponsor
- Sanofi
Infant, Newborn, Hypoxia, Brain
Preemie Hypothermia for Neonatal Encephalopathy
This study is a randomized, controlled trial to assess safety and effectiveness of whole body hypothermia for 72 hours in preterm infants 33-35 weeks gestational age (GA) who present at <6 hours postnatal age with moderate to…
- Conditions
- Infant, Newborn, Hypoxia, Brain, Hypoxia-Ischemia, Brain, Encephalopathy, Hypoxic-Ischemic
- Trial name
- NCT01793129
- Testing
- Hypothermia, Normothermic Control
- Where
- 18 sites in United States
- Volunteers
- 168 people
- Sponsor
- NICHD Neonatal Research Network
Coronary Disease, Myocardial Infarction
Chronical Illness-related Limitations of the Ability to Cope with Rising Temperatures: an Observational Study, 2nd Wave
The CLIMATE-II Observational Study examines to what extent chronically ill patients experience adverse health effects because of heat and whether the patients' specific health behavior, somatosensory amplification, risk and…
- Conditions
- Coronary Disease, Myocardial Infarction, Heart Failure, Arrhythmias, Cardiac
- Trial name
- CLIMATE-II (NCT06407154)
- Where
- Germany
- Volunteers
- 578 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Depression
High-frequency vs. Low-frequency vs. Sham DMPFC-rTMS for Major Depression
This trial will compare the efficacy and tolerability of 20 Hz vs. 1 Hz vs. sham repetitive transcranial magnetic stimulation targeting the dorsomedial prefrontal cortex, delivered twice daily over 15 days, in patients with a…
- Trial name
- NCT02702154
- Testing
- High-frequency rTMS, Low-frequency rTMS
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
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