Clinical trials: Depression Symptom
Depression
A Comparative Trial of TMS Approaches to Treating Depression
Trancranial Magnetic Stimulation (TMS) is a non-drug and non-invasive treatment for depression and has been investigated for the treatment of psychiatric illness for over 15 years.
- Trial name
- NCT01906905
- Testing
- Transcranial Magnetic Stimulation
- Where
- Australia
- Sponsor
- The University of New South Wales
Pregnancy Related, Depression
Effects of Digitally Delivered and Group-based CBT-I in Pregnant Women With Comorbid Insomnia and Depression
Major depressive disorder (MDD) is a debilitating and recurrent illness associated with a constellation of grave consequences and is among the most common psychiatric disorders during the pregnancy and postpartum periods.
- Conditions
- Pregnancy Related, Depression, Insomnia
- Trial name
- NCT06054256
- Testing
- Group CBT-I, App-based CBT-I, Health related psychoeducation
- Where
- Hong Kong
- Volunteers
- 144 people
- Sponsor
- The University of Hong Kong
Suicidal Ideation, Depression
Gamified VR Sports for Elderly Suicidal Ideation
Detailed Description: This quasi-experimental study investigates the effectiveness of a gamified sports exercise intervention delivered through virtual reality (VR) to improve mental health and life expectancy in elderly…
- Conditions
- Suicidal Ideation, Depression, Mental Health Issue
- Trial name
- VR-LIFE-SI (NCT06856083)
- Testing
- Gamified Virtual Reality Sports Exercise Program, Traditional Sports Exercise Program for Elderly Individuals with Suicidal Thoughts
- Where
- Iran
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj
Intrinsic Capacity, Frailty
Project ICOPE Brazil: Assessment of Intrinsic Capacity in Brazilian Older Adults
The ICOPE Brazil study aims to understand aging trajectories in Brazil, especially healthy aging trends based on intrinsic capacity, a collective of mental and physical capacities one may have to maintain their functional ability…
- Conditions
- Intrinsic Capacity, Frailty, Aging, Healthy Aging
- Trial name
- ICOPE-BR (NCT06968702)
- Volunteers
- 3,838 people
- Sponsor
- University of Sao Paulo
Schizophrenia, Depression
Body Movement Imitation and Perspective Perception Among Psychiatric Patients
The ability to understand the other's perspective and respond accordingly is the most important normal process of daily social life and is probably one of the foundations of human existence.
- Trial name
- NCT01375894
- Testing
- imitation assessment using the 5-dt "data glove".
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Shalvata Mental Health Center
Major Depressive Disorder
Transcranial Alternating Current Stimulation (tACS) on Serotonin-1A Receptor in Depression
This study will apply a comprehensive tools that integrates neuroimaging, psychological evaluation, and sleep monitoring through 18F-MPPF PET/MR, neuropsychological tests, and polysomnography (PSG) to explore the neurobiological…
- Trial name
- NCT06211140
- Testing
- tACS, Control
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Cancer Pain, Oncology
Randomized Controlled Trial of Virtual Reality Assisted Guided Imagery (VRAGI) for Pain in Advanced Cancer Patients.
Introduction Patients with advanced cancer often experience high levels of debilitating pain and pain-related psychological distress.
- Conditions
- Cancer Pain, Oncology, Virtual Reality, Depression, Anxiety
- Trial name
- NCT05348174
- Testing
- Virtual Reality Assisted Guided Imagery (VRAGI)
- Where
- 3 sites in United States
- Volunteers
- 41 people
- Sponsor
- Prisma Health-Upstate
Depression
A Study to Evaluate the Efficacy, Safety and Tolerability of Fixed Doses of Intranasal Esketamine in Japanese Participants With Treatment Resistant Depression
The purpose of this study is to evaluate the efficacy of fixed dosed intranasal esketamine compared to intranasal placebo, as an add-on to an oral antidepressant in Japanese participants with treatment-resistant depression (TRD)…
- Trial name
- NCT02918318
- Testing
- Intranasal esketamine (28 mg), Intranasal esketamine (56 mg), Intranasal esketamine (84 mg)
- Where
- 43 sites in Japan
- Volunteers
- 202 people
- Sponsor
- Janssen Pharmaceutical K.K.
Anxiety, Depression
An Internet-administered, Mindfulness Training Program for the Treatment of Anxiety
The purpose of this study is to examine the effects of a 10 week mindfulness training program -- without therapist-support -- as treatment of anxiety.
- Conditions
- Anxiety, Depression, Insomnia
- Trial name
- NCT01577290
- Testing
- Internet-administered Mindfulness Training Program, Discussion group
- Where
- Sweden
- Volunteers
- 91 people
- Sponsor
- Umeå University
Depression, Depressive Disorder
Study to Evaluate TNX-601 ER Monotherapy Versus Placebo in Patients With Major Depressive Disorder (MDD)
This is a Phase 2, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy, safety, and tolerability of TNX-601 ER monotherapy versus placebo in patients with Major Depressive Disorder (MDD).
- Conditions
- Depression, Depressive Disorder, Depressive Symptoms, Depressive Disorder, Major
- Trial name
- UPLIFT (NCT05686408)
- Testing
- TNX-601 ER
- Where
- 27 sites in United States
- Volunteers
- 132 people
- Sponsor
- Tonix Pharmaceuticals, Inc.
Type 2 Diabetes Mellitus (T2DM), Health-related Quality of Life
Psychological Well-Being, Depression, and Health-Related Quality of Life in Adults With Type 2 Diabetes: A Cross-Sectional Study
This prospective cross-sectional observational study aims to explore the relationships among psychological well-being, depression, and quality of life in patients with type 2 diabetes attending the outpatient metabolic clinic at…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Health-related Quality of Life, Depressive Symptoms, Psychological Well-being
- Trial name
- PWDQ-T2D (NCT07241325)
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- National Taiwan University Hospital
Disorder; Mental, Sedative, Depressed Level of Consciousness
Use of Bispectral Index Monitoring to Detect Deep Sedation in Mechanically Ventilated Patients: Validity Study
In the previous study, the investigators obtained the cutoff value of Bispectral Index to detect early deep sedation in patients with mechanical ventilation.
- Conditions
- Disorder; Mental, Sedative, Depressed Level of Consciousness, Mechanical Ventilation Complication, Psychosis Associated With Intensive Care
- Trial name
- NCT02439840
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Capital Medical University
Anxiety, Depression
Internet-delivered Cognitive Behavioural Therapy in Arabic for Anxiety and Depression
The purpose of this study is to evaluate the efficacy of a culturally adapted internet-administrated cognitive behaviour therapy (ICBT) in Arabic for anxiety and depression
- Trial name
- NCT03496350
- Testing
- Internet-delivered CBT
- Where
- Sweden
- Volunteers
- 59 people
- Sponsor
- Linkoeping University
Depression
The Efficacy of a Depression Intervention for Adolescents With Depression and Sleep Disturbances
The focus of this study is on identifying how Interpersonal Psychotherapy for Adolescents (IPT-A) with depression works to change sleep and related biological markers found in saliva, namely cortisol and pro-inflammatory cytokine…
- Trial name
- NCT02429674
- Testing
- TranS-C and IPT-A
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- New York State Psychiatric Institute
Depressive Symptoms
Omega-3 Supplementation and Depression Clinical Trial
Fish oil omega-3 supplements provide essential nutrients for brain health and functioning. These nutrients have been proven to be effective in reducing depressive symptoms.
- Trial name
- NCT01614249
- Testing
- Soybean oil soft gels, Fish oil omega-3 EPA-rich soft gels
- Where
- Kenya
- Volunteers
- 216 people
- Sponsor
- University of Nairobi
Dysautonomia, Anxiety
Implementation of Transdx Group for POTS
The proposed intervention is focused on developing and implementing a psychological approach incorporated into a group-based outpatient intervention for pediatric autonomic dysfunction.
- Conditions
- Dysautonomia, Anxiety, Depression
- Trial name
- NCT03185247
- Testing
- Transdiagnostic Group-Based Treatment
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Bipolar Disorder (BD)
Pramipexole vs Placebo Treatment in Bipolar Disorder With Anhedonic Depression
Among psychiatric disorders, bipolar disorder stands out due to its alarmingly high suicide rates. This condition presents unique management challenges, especially during its depressive phase, which carries the highest risk of…
- Trial name
- B-HAPPI (NCT07664852)
- Testing
- Pramipexole
- Where
- Sweden
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Daniel Lindqvist
Common Mental Disorders and/or Stress Related Symptoms
Stress and Mental Ill-health in the Workplace: Evaluation of an Intervention for the Prevention of Sick Leave
Purpose Common mental disorders (CMD:s) are the leading cause of sick-leave spells in Sweden, resulting in suffering for the individual and financial costs for the employer as well as for society at large.
- Trial name
- NCT02563743
- Testing
- Problem-solving based intervention, Treatment as usual
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Erectile Dysfunction, Depression
Depression, Illness Perception, and Erectile Dysfunction Outcomes
The goal of this observational study is to evaluate the impact of illness perception and depressive symptoms on treatment outcomes in adult male patients diagnosed with erectile dysfunction (ED).
- Conditions
- Erectile Dysfunction, Depression, Perception and Beliefs
- Trial name
- NCT06996925
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Haseki Training and Research Hospital
Depressive Disorder, Fatigue Syndrome, Chronic
Glucocorticoid Effects on Cellular Cytokine Release
A variety of hormones and immune system processes are responsible for how the body responds to illness. This study concentrates on how the hormone cortisol effects the release of immune system factors called cytokines.
- Conditions
- Depressive Disorder, Fatigue Syndrome, Chronic, Fibromyalgia, Healthy
- Trial name
- NCT00001415
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
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