Clinical trials: Depression Symptom
Depression
Exploration of the Relationship Between Inflammation and Integrity of the Blood-Brain Barrier in Suicidal Behaviour
Recent studies have revealed an association between history of suicide attempt and inflammatory markers in both the cerebrospinal fluid and the plasma.
- Trial name
- IBIS (NCT04137458)
- Testing
- Biological analysis
- Where
- France
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Major Depressive Disorder
Does Dual Therapy Hasten Antidepressant Response?
This study will utilize a randomized double-blind design to evaluate whether initial treatment with two anti-depressant medications (escitalopram and bupropion) results in more rapid remission and greater over-all remission rates…
- Trial name
- NCT00519428
- Testing
- escitalopram, bupropion extra long (XL), escitalopram + bupropion
- Where
- 2 sites in United States, Canada
- Volunteers
- 245 people
- Sponsor
- New York State Psychiatric Institute
Anxiety, Depression
Transdiagnostic Behavioral Therapy for Anxiety and Depression in Autistic Adolescents
This study tests the effectiveness of a transdiagnostic cognitive behavioral therapy for autistic youth with anxiety and/or depression.
- Conditions
- Anxiety, Depression, Emotional Disorder, Autism
- Trial name
- NCT05738967
- Testing
- Transdiagnostic cognitive behavioral therapy (CBT), Treatment as usual
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Baylor College of Medicine
Cardiovascular Diseases, Coronary Artery Disease
Supporting Methods in Cardiovascular Diseases Rehabilitation
The study evaluates how various therapeutic approaches perform in addressing depression, anxiety symptoms, and stress levels among patients in the second stage of cardiac rehabilitation.
- Conditions
- Cardiovascular Diseases, Coronary Artery Disease, Mood Disorders, Depressive Symptoms
- Trial name
- NCT06241534
- Testing
- Cardiac rehabilitation, Relaxation-therapeutic recordings, Virtual reality therapy
- Where
- Poland
- Volunteers
- 45 people
- Sponsor
- Wroclaw University of Health and Sport Sciences
Depression, Pregnancy
Patient Decision Aid for Antidepressant Use in Pregnancy
The proposed study is a pilot randomized controlled trial (RCT) of an electronic patient decision aid (PDA) for antidepressant use in pregnancy.
- Trial name
- NCT02492009
- Testing
- Standard Resource Sheet, Patient Decision Aid
- Where
- United Kingdom
- Volunteers
- 51 people
- Sponsor
- King's College London
Anxiety, Depression
Growth, Empowerment, and Mindfulness (GEM): A Mindfulness-based Intervention to Address Mental Health in Young Adults With Early Life Adversity
The goal of this clinical trial (single-arm feasibility study) is to examine the feasibility, acceptability, and preliminary efficacy of a mindfulness-based, app-delivered intervention to address mental health and emotion…
- Trial name
- NCT07546799
- Testing
- Growth, Empowerment, and Mindfulness (GEM)
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Brown University
Depression
Brain Connectivity in Depression
This study originally included 140 subjects with medication-refractory depression undergoing 10 Hz transcranial magnetic stimulation (10Hz-TMS) to the left dorsal lateral prefrontal cortex (DLPFC), with the goal of having 60…
- Trial name
- NCT03276793
- Testing
- MRI scan, Behavioral testing
- Where
- 4 sites in United States
- Volunteers
- 260 people
- Sponsor
- Brigham and Women's Hospital
Depression, Thyroid Cancer
Study on the Mechanism of Ganoderma Lucidum Spore Powder in the Treatment of Depression
To clarify the clinical effect of Ganoderma lucidum spore powder intervention on postoperative depressive symptoms of papillary thyroid carcinoma ; to elucidate the antidepressant mechanism of Ganoderma lucidum spore powder.
- Trial name
- NCT06429514
- Testing
- Ganoderma lucidum spore powder
- Where
- China
- Volunteers
- 298 people
- Sponsor
- Ling Zhiqiang
Depression
Standardized Versus Tailored Implementation of Measurement Based Care for Depression
Depression remains among the nation's top 10 chronic illnesses, costing over $80 billion annually; however, Measurement Based Care (MBC) is a relatively simple evidence-based intervention framework that has been shown to improve…
- Trial name
- iMBC (NCT02266134)
- Testing
- Tailored Implementation of Measurement Based Care, Standard Implementation of Measurement Based Care
- Where
- 6 sites in United States
- Volunteers
- 382 people
- Sponsor
- Indiana University
Depression - Major Depressive Disorder, Resilience
Evaluating The Impact of A Mental Health App on Depression and Resilience Among Medical Students
This randomized controlled trial aims to determine whether access to a mental health app improves resilience and reduces depressive symptoms among medical students over a three-month period.
- Trial name
- NCT07397299
- Testing
- Full digital mental health intervention, Basic digital mental health intervention
- Where
- Malaysia
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Major Depressive Disorder
Antidepressant Incomplete Response Depression
Observational, non-interventional, longitudinal, prospective,multicenter, open label (No treatment is involved). 3 assessment will be carried out .
- Trial name
- DRIA (NCT00782964)
- Where
- 48 sites in Spain
- Volunteers
- 364 people
- Sponsor
- AstraZeneca
Menopausal Depression, Menopause Hot Flashes
Transcranial Electrical Stimulation for Noninvasive Study of Menopausal/Perimenopausal Symptoms
Participants are being invited to a research study. This research aims to assess the tolerability of transcranial electrical stimulation of the brain, and explore the response of TES on menopausal/perimenopausal symptoms…
- Conditions
- Menopausal Depression, Menopause Hot Flashes, Menopause, Menopause Related Conditions
- Trial name
- NCT07375732
- Testing
- Transcranial Electrical Stimulation
- Volunteers
- 50 people
- Sponsor
- Carnegie Mellon University
Depression, Anxiety
Mindfulness Based Cognitive Therapy (MBCT) for Primary Care Patients
This study is done to evaluate the effects of Mindfulness Based Cognitive Therapy (MBCT) for primary care patients that have mild to moderate symptoms of depression and anxiety.
- Trial name
- NCT03272516
- Testing
- Mindfulness based cognitive therapy (MBCT), Treatment as usual (TAU)
- Where
- 2 sites in Iceland
- Volunteers
- 120 people
- Sponsor
- University of Iceland
Mild Cognitive Impairment (MCI), Depression
Brain Aging and Treatment Response in Geriatric Depression
The proposed project will evaluate the role of neuroimaging biomarkers of brain aging (i.e., neurodegenerative and vascular brain changes) and mild cognitive impairment in the patterns of treatment response to memantine combined…
- Trial name
- NCT01902004
- Testing
- Escitalopram, Memantine
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- University of California, Los Angeles
Health Care Utilization, Depression
Health and Health Care Utilization Effects of Medical Debt Forgiveness
The goal of this study is to estimate the direct, causal impact of medical debt on health care utilization, mental health, and wellbeing of patients.
- Conditions
- Health Care Utilization, Depression, Anxiety, Subjective Wellbeing
- Trial name
- NCT04835012
- Testing
- Medical debt forgiveness
- Where
- United States
- Volunteers
- 15,008 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Ischemic Stroke, Depressive Symptoms
Combined tDCS and Cognitive Neurorehabilitation in Post-Stroke Depression
This study evaluates a multimodal intervention pathway for affective and cognitive symptoms after ischemic stroke. Patients undergo an initial screening of depressive symptoms, cognitive function, and quality of life.
- Trial name
- CACTUS (NCT07848919)
- Testing
- Active transcranial direct current stimulation, Cognitive neurorehabilitation using Guttmann NeuroPersonalTrainer
- Where
- Spain
- Volunteers
- 33 people
- Sponsor
- Institut de Recerca Biomèdica de Lleida-Fundació Dr. Pifarré (IRBLleida)
Heart Failure
Depression and Heart Failure Disease Progression
Heart failure is the most costly diagnosis in the Medicare population. Clinical depression is strikingly common in heart failure patients, and not only diminishes their quality of life, but also is associated with a markedly…
- Trial name
- NCT02131428
- Where
- United States
- Volunteers
- 186 people
- Sponsor
- Duke University
Covid19, Neurocognitive Dysfunction
Long-term Neurocognitive and Psychiatric Consequences in Severe COVID-19 Survivors.
Long-term neurocognitive and psychiatric consequences of COVID-19 remain mostly unknown to date. It has been reported that coronaviruses cause direct central nervous system infection (Needham et al. 2020).
- Trial name
- NPQCOVID (NCT05019300)
- Testing
- Exposure: COVID-19 severity
- Where
- Chile
- Volunteers
- 80 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Post Intensive Care Syndrome, Narrative Medicine
Effect of Pediatric Intensive Care Unit Diaries on PICS-p
When children become very sick and need to stay in a Pediatric Intensive Care Unit (PICU), it can have a big impact on their recovery and their family's well-being.
- Conditions
- Post Intensive Care Syndrome, Narrative Medicine, Post Traumatic Stress Disorder, Anxiety
- Trial name
- PICS-p (NCT06310109)
- Testing
- PICU diary
- Where
- Italy
- Volunteers
- 110 people
- Sponsor
- Bambino Gesù Children's Hospital IRCCS
Pregnancy, Pre-eclampsia
Oxfordshire Women and Their Children's Health
The aim of this feasibility study is to test recruitment of participants into Phase 1 of the study and then the re-recruitment and retention of participants in Phase 2 of the study.
- Conditions
- Pregnancy, Pre-eclampsia, Gestational Diabetes, Depression
- Trial name
- OxWATCH (NCT02419898)
- Where
- United Kingdom
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
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