Clinical trials: Depression Symptom
Parental Anxiety Following Premature Birth
Impact of Preterm Birth on Symptoms of Anxiety and Depression in Parents, and on the Precursors of Cognition, Including Social Cognition in Their Child
In 2018, the World Health Organization (WHO) counted no less than 15 million preterm births each year worldwide, or more than one in ten children.
- Trial name
- PréDANPa (NCT05734768)
- Testing
- State-Trait Anxiety Inventory - Y ou STAI-Y
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
COPD, Anxiety
Intervention Strategy in Chronic Obstructive Pulmonary Disease With Anxiety and Depression
Anxiety and depression have negative effect on outcomes of chronic obstructive pulmonary disease (COPD). Intervention strategy including behavioral-cognitive therapy and pulmonary rehabilitation are promising in improving life…
- Conditions
- COPD, Anxiety, Depression
- Trial name
- NCT03187249
- Testing
- Cognitive Behavioral Therapy, Pulmonary Rehabilitation Therapy, Combined Therapy
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Adjunctive Treatment of Major Depressive Disorder (MDD)
A Study of CLE-100 (Oral Esketamine) as an Adjunctive Treatment to Standard Antidepressants for Major Depressive Disorder
The study is a Phase 2, double-blind, randomized, placebo-controlled study in Major Depressive Disorder (MDD) participants with an inadequate response to standard antidepressants The objective of the study is to assess CLE-100…
- Trial name
- SOLEO (NCT06340958)
- Testing
- CLE-100
- Where
- 23 sites in United States
- Volunteers
- 99 people
- Sponsor
- Clexio Biosciences Ltd.
Insomnia, Depression
Acute Psychological Sleep Stabilisation for Patients Hospitalised With Depression
Disturbed sleep occurs in almost all patients in psychiatric inpatient care, and although it is well known that comorbid sleep disorders in depression often persist after treatment of depression and also increase the risk of new…
- Trial name
- NCT06145555
- Testing
- Acute psychological sleep stabilization, Sleep hygiene education
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Depression, Anxiety
Treatment of Psoriasis With Depression and/or Anxiety With Methotrexate vs Combined Methotrexate and Antidepressant
This randomized controlled trial aims to compare the efficacy of methotrexate (MTX) monotherapy versus combined methotrexate and selective serotonin reuptake inhibitor (SSRI) therapy in patients with psoriasis and comorbid…
- Conditions
- Depression, Anxiety, Psoriasis
- Trial name
- NCT07432815
- Testing
- Combination of methotrexate and escitalopram in treatment of psoriasis patients with depression and/or anxiety, Methotrexate
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Hyperhydrosis, Depression
Excessive Sweating Caused by Antidepressants: Measurement and Treatment With Glycopyrrolate (AIDES-G)
The study consists of measurement of antidepressant-induced excessive sweating and its treatment with an experimental medication, glycopyrrolate (approved to treat ulcers), which will be added to the antidepressant.
- Trial name
- AIDES-G (NCT01588717)
- Testing
- Glycopyrrolate
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Thomas Jefferson University
Drug Use Disorders, Drug Abuse
Evaluation of a Health Plan Initiative to Mitigate Chronic Opioid Therapy Risks
Background: Sixty million American adults suffer from moderate to severe chronic pain. Of these, 5 to 8 million currently use opioids long-term.
- Conditions
- Drug Use Disorders, Drug Abuse, Drug Addiction, Drug Dependence
- Trial name
- CARE (NCT02224508)
- Volunteers
- 1,588 people
- Sponsor
- Kaiser Permanente
Doomscrolling, Cyberchondriac Behavior
4-STEP-Training Program for Doomscrolling, Cyberchondriac Behavior and Psychiatric Symptoms (4-STEP-TPS) Among Individuals With Social Media Addiction
The goal of this clinical trial is to evaluate the effectiveness of the 4-Step Training Program for Social Media Addiction (4-STEP-TPS) in reducing social media addiction, doomscrolling, cyberchondriac behavior, depressive…
- Conditions
- Doomscrolling, Cyberchondriac Behavior, Social Media Addiction
- Trial name
- (4-STEP-TPS) (NCT07663708)
- Testing
- 4-STEP-Training Program for Social Media Addiction (4-STEP-TPS)
- Where
- Pakistan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Government College University Faisalabad
Depression
Immediate Effects of DLPFC tDCS on Attention Bias
This research is being done to test if the investigators can modify or reduce negative attention bias in depression following a single session of transcranial direct current stimulation (tDCS) over the left anodal dorsolateral…
- Trial name
- NCT05263440
- Testing
- Transcranial direct current stimulation (tDCS)
- Sponsor
- Johns Hopkins University
Depression - Major Depressive Disorder, Cognition Disorders in Old Age
Real-world Clinical Response to Trazodone in Italy, Poland, and Romania
TRACOMDD study is a study with the intention to describe the real-world use of trazodone and the clinical response in a sub-group of patients affected by Major Depressive Disorder and Mild Cognitive impairment, by collecting data…
- Trial name
- NCT07377682
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Aziende Chimiche Riunite Angelini Francesco S.p.A
Depressed Mood, Young Adults
Heat and Mental Health - PART 2
The goal of this clinical trial is to learn how hot indoor temperatures affect mood in young adults with depression, with or without anxiety.
- Conditions
- Depressed Mood, Young Adults, Heat Stress, Sleep
- Trial name
- NCT07903896
- Testing
- Heat/Humidity Exposure Condition, Thermoneutral Condition
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Hartford Hospital
Depression
Testing Scalable, Single-Session Interventions for Adolescent Depression in the Context of COVID-19
Most mental health problems emerge by age 14, often leading to chronic impairments and adverse impacts for individuals, families, and societies.
- Trial name
- NCT04634903
- Testing
- Supportive Therapy SSI, Behavioral Activation SSI, Growth Mindset SSI
- Where
- United States
- Volunteers
- 2,452 people
- Sponsor
- Stony Brook University
Breast Neoplasm Female, Symptom Cluster
Effects of a Traditional Chinese Exercise Program on Symptom Cluster in Breast Cancer Patients
The Medical Research Council Framework for Developing and Evaluating Complex Interventions (MRC Framework) will be utilized to develop and evaluate an evidence-based tai chi intervention for managing the symptom cluster of…
- Conditions
- Breast Neoplasm Female, Symptom Cluster, Tai ji
- Trial name
- NCT04190342
- Testing
- control group, tai chi group
- Where
- 2 sites in China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Charles Darwin University
Healthy Participants, Anxiety Disorders (With High Anxiety Symptoms)
tVNS and Approach-Avoidance Behavior in Anhedonia and Anxiety
This study investigates if anhedonia and anxiety symptoms are associated with alterations in reinforcement learning, effort trade-offs for wins vs. punishments, and foraging behavior under threat.
- Conditions
- Healthy Participants, Anxiety Disorders (With High Anxiety Symptoms), Depressive Disorders (With High Anhedonia Symptoms), Comorbid Depression and Anxiety Disorder (With High Anhedonia and High Anxiety Symptoms)
- Trial name
- NCT07476469
- Testing
- tVNS
- Where
- Germany
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Dr. Nils B. Kroemer
Depression, Suicidal Ideation
UH3 Pragmatic Suicide Prevention Trial
This pragmatic clinical trial will evaluate the effectiveness of two population-based outreach programs for preventing suicide attempts among patients identified as at-risk.
- Trial name
- SPOT (NCT02326883)
- Testing
- Care Management, Skills Training, Usual Care
- Volunteers
- 18,882 people
- Sponsor
- Kaiser Permanente
Loneliness, Well-Being, Psychological
A Randomized Controlled Trial of Robotic Support for Enhanced Later Life (RoSELL)
The purpose of this study is to compare the efficacy of a personalized, co-designed robot interaction against a standardized, fixed robot interaction for reducing loneliness, depression, as well as improving self-agency and…
- Conditions
- Loneliness, Well-Being, Psychological, Depression - Major Depressive Disorder
- Trial name
- RoSELL (NCT07102017)
- Testing
- Co-Design LOVOT Intervention, Standard LOVOT Intervention
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Depression, Depressive Disorder, Major
An Expert System to Reduce Depression in Primary Care
The purpose of this study is to determine whether a home-based intervention matched to stage of change (readiness) for using effective methods to prevent or reduce depression can improve depression outcomes in primary care.
- Trial name
- NCT00497874
- Testing
- Computer-tailored intervention
- Where
- 2 sites in United States
- Volunteers
- 902 people
- Sponsor
- Pro-Change Behavior Systems
Childhood Depression
Neural Mechanisms of Family-Focused Treatment for Youth Depression
The goal of this interventional study is to compare the baseline neural mechanisms and parenting in depressed and non-depressed children and to examine baseline neural mechanisms and parenting as predictors of Family-Focused…
- Trial name
- NCT06289010
- Testing
- Family-Focused Treatment for Childhood-Depression (FFT-CD)
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Major Depressive Disorder
Follow-up Study of Transcranial Direct Current Stimulation to Treat Major Depressive Disorder
The investigators purpose is to follow remitted patients from their previous study using transcranial direct current stimulation (tDCS); as to verify whether this treatment prevents relapse.
- Trial name
- NCT01149213
- Testing
- transcranial direct current stimulation
- Where
- Brazil
- Volunteers
- 42 people
- Sponsor
- University of Sao Paulo
Depression, Anxiety
Virtual Mindfulness Intervention RCT
Mindfulness-based interventions (MBIs) have emerged as clinically effective interventions for anxiety, depression, and general distress.
- Trial name
- NCT05374213
- Testing
- Mindfulness-Based Intervention
- Where
- Canada
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
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