Clinical trials: Depression in Adolescence
Depression, Anxiety
Community Study of Outcome Monitoring for Emotional Disorders in Teens
This study is being done to compare three types of talk therapies for youth who struggle with emotional and behavioral problems (e.g., anxiety, sadness, worries) in Community Mental Health Clinics in Connecticut (CT) and Florida…
- Trial name
- COMET (NCT02567266)
- Testing
- Unified Protocol for Adolescents (UP-A), Youth Outcomes Questionnaire, Treatment as Usual
- Where
- 2 sites in United States
- Volunteers
- 196 people
- Sponsor
- University of Miami
Major Depression
Chicago Urban Resiliency Building (CURB)
The purpose of the study is to determine whether a culturally tailored, low-cost, primary care/internet based depression prevention intervention (CURB) is superior to wait-list control for African American and Hispanic youth in…
- Trial name
- CURB (NCT01571011)
- Testing
- CURB
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Benjamin Van Voorhees, MD, MPH
Depression, Post-traumatic Stress Disorder
Evaluating Implementation Strategies to Scale-up Transdiagnostic Evidence-based Mental Health Care in Zambia
This study utilizes a Hybrid Type 1 multi-arm parallel group randomized control design to compare the effectiveness of an evidence-based treatment (CETA) delivered either in-person or via telephone, compared with a treatment as…
- Conditions
- Depression, Post-traumatic Stress Disorder, Anxiety, Substance Abuse
- Trial name
- NCT03458039
- Testing
- In-person CETA, Telephone CETA, Treatment as Usual (TAU)
- Where
- Zambia
- Volunteers
- 456 people, healthy volunteers welcome
- Sponsor
- Centre for Infectious Disease Research in Zambia
Depression in Adolescence
Mechanisms of Depression and Anhedonia in Adolescents: Linking Sleep to Reward- and Stress-Related Brain Function
This research will use biobehavioral approaches to generate understanding about the linkages between sleep duration and timing, stressful life events, and depressive symptoms in adolescents, with a long-term aim of developing…
- Trial name
- MoDA (NCT05691439)
- Testing
- Sleep extension and advance, Regular sleep duration and timing
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Oregon
Well-Being, Psychological, Depressive Symptoms
e-Intervention Enhancing Mental Health in Adolescents
The e-Intervention Enhancing Mental Health in Adolescents (IMPROVA) study will co-design, test, evaluate, and facilitate the upscaling of a modular eHealth intervention platform that aims to improve mental health and wellbeing…
- Conditions
- Well-Being, Psychological, Depressive Symptoms, Social Isolation
- Trial name
- IMPROVA (NCT06556576)
- Testing
- IMPROVA Platform
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Fundació Sant Joan de Déu
Depressive Disorder, Major Depressive Disorder
Study Evaluating Desvenlafaxine Succinate Sustained-Release Tablets (DVS SR) In The Treatment Of Child and Adolescent Outpatients With Major Depressive Disorder
The primary purpose of this study is to evaluate the long-term safety and tolerability of Desvenlafaxine Succinate Sustained-Release (DVS SR) in child and adolescent outpatients with major depressive disorder.
- Trial name
- NCT00669110
- Testing
- Desvenlafaxine Succinate Sustained-Release Tablets (DVS SR)
- Where
- 9 sites in United States
- Volunteers
- 40 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Major Depression
Computerized Information-Processing Bias Retraining in Depressed Adolescents
This study will examine how well a novel four-session computerized program, designed to help adolescents learn to interpret ambiguous situations less negatively, reduces symptoms of depression and decreases negative…
- Trial name
- NCT01147913
- Testing
- Computerized Information-Processing Bias Retraining, Attention Control Training
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Massachusetts General Hospital
Depression
Hormone and Sleep Response to Antidepressant Treatment in Adolescents and Adults With Depression
This study will determine whether there are age-related differences in the body systems controlling sleep and stress hormone patterns.
- Trial name
- NCT00106197
- Testing
- Bupropion
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Uma Rao
Depression
iTBS for Adolescent Depression: An Open Label Study Evaluating Safety and Efficacy of Treatment
This is an open label, pilot, feasibility study evaluating effects of Intermittent Theta Burst Transcranial Magnetic Stimulation (iTBS) on 5 eligible adolescents for the treatment of depression.
- Trial name
- NCT04485455
- Testing
- iTBS Device/Motor Threshold Coil, iTBS Device/Treatment Coil
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of North Carolina, Chapel Hill
Adolescent Depression
Bone Mineral Content and Bone Metabolism in Adolescents on Antipsychotic Therapy
We hypothesize that antipsychotic induced hyperprolactinemia can decrease bone mineral accrual and decrease bone mineral content (BMC) in adolescents on antipsychotic therapy. Specifics Aims 1.
- Trial name
- NCT00399776
- Testing
- Bone Density Test
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Creighton University
Depression, Suicidal Ideation
Engaging Black Youth in Depression and Suicide Prevention Treatment Within Urban Schools
Completing evidence-based treatments for depression has been shown to be particularly problematic for Black adolescents. If Black adolescents' depression treatment needs are to be met, the engagement challenges and the factors…
- Trial name
- NCT03940508
- Testing
- Making Connections Intervention, IPT-A
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- New York University
Depression, Depression in Children
Evaluation of a Training Course for Educational Professionals
The aim of this study is to evaluate the efficacy of a two-hour online training course on depression and mental health in childhood and adolescence in educational professionals to improve depression and mental health literacy.
- Conditions
- Depression, Depression in Children, Depression in Adolescence
- Trial name
- NCT06387108
- Testing
- training course
- Where
- Germany
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Depression, Anxiety, Trauma
Psychoeducation, Relaxation, PrOblem Solving, Activation, Cognitive Coping Therapy for Adolescents and Youth in HIV Care
The proposed PROACT study will test the effectiveness of a mental health intervention (psychotherapy) for multiple common mental health conditions (depressive, anxiety and trauma symptoms) among adolescents and youth with HIV in…
- Conditions
- Depression, Anxiety, Trauma, HIV-1-infection
- Trial name
- PROACT (NCT06247527)
- Testing
- Psychoeducation, Relaxation, PrOblem solving, Activation, Cognitive coping Therapy, Standard of care
- Where
- Kenya
- Volunteers
- 600 people
- Sponsor
- University of Nairobi
Depressive Symptoms
High- vs Low-Frequency Exercise for Depression in Adolescents
This research project aims to examine the antidepressant effects of different exercise routines on adolescent depression, which has risen significantly in recent years.
- Trial name
- HFEDA (NCT06677723)
- Testing
- physical activity
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Je Bouge Pour Mon Moral
Mental Disorder in Adolescence, Behavioral Symptoms
Effects of Web-Based Training on HbA1c, Quality of Life and Depression Levels in Adolescents With Type 1 Diabetes
Objective: This study was conducted to determine the effect of diabetes training on HbA1c, levels of depression and quality of life of Type 1 Diabetes Mellitus adolescents by using the Web-Based Watson Human Care Model.
- Conditions
- Mental Disorder in Adolescence, Behavioral Symptoms, Problem Behavior
- Trial name
- NCT04888780
- Testing
- The web-based Watson's Human Care Theory oriented training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Gaziantep Islam Science and Technology University
Depression
Reboxetine Treatment in Depressed Children and Adolescents an 8-Week, Open Study
The aim of the present study is to prospectively assess the anti-depressant effectiveness of reboxetine in children and adolescents, as compared with fluoxetine, in a randomized controlled open-label trial.
- Trial name
- NCT00426946
- Testing
- Reboxetine
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Geha Mental Health Center
Type2 Diabetes, Type 2 Diabetes Mellitus
Depression & Insulin Sensitivity in Adolescents
There has been a rise in type 2 diabetes (T2D) rates in adolescents, disproportionately in girls from disadvantaged racial/ethnic groups.
- Conditions
- Type2 Diabetes, Type 2 Diabetes Mellitus, Insulin Sensitivity, Insulin Resistance
- Trial name
- NCT03263351
- Testing
- Cognitive-behavioral therapy group, Health education group
- Where
- United States
- Volunteers
- 147 people
- Sponsor
- Colorado State University
Childhood Depression, Childhood Anxiety
Integrative Coping Group for Children
The purpose of this study is to examine whether an integrative group-based intervention will help children experiencing psychological and physical distress.
- Conditions
- Childhood Depression, Childhood Anxiety, Pediatric Pain, Migraines
- Trial name
- ToPSY (NCT01813669)
- Testing
- Integrative Coping Group
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Duke University
Bipolar Depression
Pediatric Bipolar Depression
The purpose of this study is to determine if quetiapine fumarate extended-release (quetiapine XR or SEROQUEL® XR) 150 to 300 mg/day taken by itself is effective and safe in treating children or adolescents aged 10 to 17 with…
- Trial name
- NCT00811473
- Testing
- Quetiapine XR
- Where
- 48 sites in United States, Colombia and 5 more
- Volunteers
- 193 people
- Sponsor
- AstraZeneca
Depression, Anxiety
Effectiveness of School-Based Cognitive Behavioral Therapy in Preventing Depression in Young Adolescents
This study will evaluate the effectiveness of the Penn Resiliency Program, a school-based cognitive behavioral depression prevention program for young adolescents.
- Trial name
- NCT00360451
- Testing
- Adolescent only Penn Resiliency Program (Adolescent PRP), Parent Penn Resiliency Program (Parent PRP)
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania