Clinical trials: Depression in Adolescence
Cystic Fibrosis
Prevalence and Impact of Depression and Anxiety in Cystic Fibrosis
The Impact of cystic fibrosis (CF) on psychological and emotional functioning has been the focus of several studies over the past 20 years.
- Trial name
- ADMPE-2 (NCT03424486)
- Testing
- Questionnaires
- Where
- 8 sites in France
- Volunteers
- 108 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anxiety, Depression
Reducing Depression and Anxiety Among Teens
The objective of this clinical trial is to assess the efficacy of the Early Adolescent Skills for Emotions (EASE) program, a school-based, non-specialist psychosocial intervention developed by the WHO for LMICs, in alleviating…
- Trial name
- NCT06155838
- Testing
- "Early Adolescent Skills for Emotions (EASE)
- Where
- Pakistan
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Depression, Depressive Disorder
Manual-based Art Therapy for Adolescents With Depression
There is a need to evaluate different interventions in order to meet young people's needs of treatment. The study's goal is to find out if manual-based art therapy is a useful method for young people with depression and thus…
- Trial name
- NCT04603235
- Testing
- Manual-based Art Therapy
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Vastra Gotaland Region
Insomnia
Effectiveness of eCBT-I on Improving Mental Health in Chinese Youths With Insomnia
This study aims to conduct a randomized control trial to validate the treatment effect of e-based cognitive behavioral therapy for Insomnia (e-CBT-I) on insomnia disorder, and explore whether e-CBT-I could prevent depression and…
- Trial name
- NCT04069247
- Testing
- e-CBT-I, e-HE
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 708 people
- Sponsor
- Chinese University of Hong Kong
Anorexia Nervosa
Microbiome Shifts in Adolescent Anorexia Nervosa
The aim of this study is to evaluate the effect of starvation and recovery in adolescent anorexia nervosa patients in regard to microbiome activity and composition and to elucidate potential connections between weight gain…
- Trial name
- MaAN (NCT02962726)
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Depression in Adolescence, Antidepressant Activity in Healthy Volunteers
Fluoxetine and Understanding Social Experiences
Adolescence is a critical developmental period marked by significant social, cognitive, and emotional changes. Unfortunately, it is also a time when the risk of depression and anxiety rises dramatically.
- Conditions
- Depression in Adolescence, Antidepressant Activity in Healthy Volunteers, Healthy Adult Participants
- Trial name
- FUSE (NCT07456501)
- Testing
- Fluoxetine
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Type 1 Diabetes
Resilience Promotion in Teens With Type 1 Diabetes: Preventing Negative Outcomes
Adolescents with type 1 diabetes are at increased risk for depressive symptoms, poor coping and problem-solving skills, poor regimen adherence, and negative diabetes-specific health outcomes.
- Trial name
- NCT01490619
- Testing
- Healthy Thinking In Teens, Advanced Diabetes Education.
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Major Depressive Disorder, Dysthymic Disorder
The Efficacy of Parent Involvement in the Treatment of Adolescent Depression
The primary aim of this study is to examine whether adolescent depression and the family context in which it develops is best treated using an individual adolescent intervention or an intervention that includes both the…
- Conditions
- Major Depressive Disorder, Dysthymic Disorder, Depressive Disorder NOS, Adjustment Disorder
- Trial name
- NCT00883519
- Testing
- Interpersonal Psychotherapy for Depressed Adolescents, Interpersonal Psychotherapy for Depressed Adolescents and Parents
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- New York State Psychiatric Institute
HIV-1-infection, Adherence, Medication
Social Media for ART Adherence and Retention in Adolescents and Young Adults: the Vijana-SMART Study
The goal of this study is to investigate whether a virtual peer support group improves ART knowledge, adherence, and mental health in youth living with HIV in Kenya.
- Conditions
- HIV-1-infection, Adherence, Medication, Depression
- Trial name
- NCT05634265
- Testing
- Vijana-SMART
- Where
- Kenya
- Volunteers
- 55 people
- Sponsor
- University of Washington
Suicide, Mental Health Disorder
A Just-in-time Adaptive Intervention for Suicide Safety Planning in Adolescents
Despite efforts to prevent suicide, US rates are climbing, and suicide is the second leading cause of death amongst youth. Digital tools, especially personal smartphones, are promising avenues to address these issues and can be…
- Conditions
- Suicide, Mental Health Disorder, Anhedonia
- Trial name
- ViraSafeRCT (NCT07348666)
- Testing
- ViraSafe: Treatment pushes, BRITE
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Ksana Health
Unipolar Depression, Dysthymia
A Clinical Trial of IPT-A to Prevent Suicide in Depressed Adolescents With Suicidal Behavior
The investigators are adapting Interpersonal Psychotherapy (IPT-A) for adolescents who are referred to emergency services either for a suicide attempt or for being evaluated as high risk for suicidal behavior.
- Trial name
- IPT-A-CSP (NCT01447602)
- Testing
- IPT-A
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- New York State Psychiatric Institute
Mental Disorder, Depressive Symptoms
Module-Based Psychological (MBP) for Community Youths
This waitlist, randomised controlled trial (RCT) aims to examine the effectiveness of the Module-Based Psychological (MBP) intervention in reducing mental distress for youths aged 12-30 years in Hong Kong.
- Conditions
- Mental Disorder, Depressive Symptoms, Anxiety Symptoms
- Trial name
- MBP_RCT (NCT06005961)
- Testing
- Module-Based Psychological (MBP) Intervention
- Where
- Hong Kong
- Volunteers
- 400 people
- Sponsor
- The University of Hong Kong
Depression
Addressing Mental Health in African American Job Training Adolescents and Young Adults
This project's focus is twofold-to change the culture of an employment training program for adolescents and young adults (Youth Opportunities, or "YO") to more fully address the many mental health issues faced by its participants…
- Trial name
- NCT00979524
- Testing
- Comprehensive Mental Health Services and Supports
- Where
- United States
- Volunteers
- 782 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Depression
Hypericum vs Fluoxetine for Mild to Moderate Adolescent Depression
The study is a pilot study where adolescents 12 - 18 years of age with mild to moderate depression will be randomized to receive either hypericum 250mg twice daily or fluoxetine 10mg daily increased to 20mg daily after 1 week and…
- Trial name
- NCT00557427
- Testing
- hypericum, fluoxetine
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Rafa Laboratories
Depressive Disorder
Efficacy and Safety of Peropirone Hydrochloride Tablets in the Treatment of Adolescent Bipolar Disorder Depression
Bipolar disorder, a type of mood disorder that occurs in various forms, such as depression, mania, hypomania or irregularity.According to the World Health Organization mental health survey, the lifetime prevalence of bipolar…
- Trial name
- NCT04826510
- Testing
- Perospirone hydrochloride tablets, Lithium carbonate + perospirone hydrochloride, Lithium Carbonate Pill
- Where
- China
- Volunteers
- 189 people
- Sponsor
- Shanghai Mental Health Center
Depression in Adolescence, Suicidal Ideation
Stratified Care Intervention for Suicidal Ideation, Depression, and Non-Suicidal Self-Injury in Adolescents (Reframe-IT+ & CARIBOU)
The aim of this study is to evaluate the acceptability, feasibility, and fidelity of implementing a stratified care intervention for adolescents with suicidal ideation and depressive symptoms, and to preliminarily explore its…
- Conditions
- Depression in Adolescence, Suicidal Ideation, Non Suicidal Self Injury
- Trial name
- NCT07780084
- Testing
- Reframe-IT and CARIBOU
- Where
- Chile
- Volunteers
- 90 people
- Sponsor
- Universidad de los Andes, Chile
Depressive Disorder, Major
A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adolescents With Major Depressive Disorder Who Have an Inadequate Response to Selective Serotonin Reuptake Inhibitor (SSRI) and Psychotherapy
The purpose of this study is to assess the safety and tolerability of Seltorexant as adjunctive therapy to an antidepressant in adolescents with major depressive disorder (MDD) in the short-term compared with placebo.
- Trial name
- NCT04951609
- Testing
- Seltorexant
- Where
- 23 sites in United States, Italy and 2 more
- Volunteers
- 31 people
- Sponsor
- Janssen Research & Development, LLC
Anxiety, Anxiety Disorders
Randomized Feasibility Trial of Mind My Mind
In this feasibility RCT of the modular and flexible cognitive and behavioural therapy (Mind My Mind, MMM) compared with treatment as usual, the overall research aim was to explore the trial design and the acceptability of the…
- Conditions
- Anxiety, Anxiety Disorders, Depressive Symptoms, Depressive Disorder
- Trial name
- MindMyMind (NCT03448809)
- Testing
- Mind My Mind, TAU (Treatment as Usual)
- Volunteers
- 150 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Social Anxiety, Major Depression Mild
Transdiagnostic REBT Prevention Program for Adolescents
Anxiety and depressive disorders are common in adolescents, however they are often unrecognized. Rational emotive behavioral therapy (REBT), a form of cognitive behavioral therapy (CBT) is efficient for children and adolescents.
- Conditions
- Social Anxiety, Major Depression Mild, Panic Disorder, Specific Phobia
- Trial name
- NCT02756507
- Testing
- video-based transdiagnostic REBT, Wait list
- Where
- Romania
- Volunteers
- 381 people, healthy volunteers welcome
- Sponsor
- Babes-Bolyai University
Major Depressive Disorder (MDD), Adolescent Depression
Predictors of rTMS and Group Therapy Efficacy in Adolescent Depression
This study aims to identify baseline predictors of treatment efficacy in adolescents with Major Depressive Disorder (MDD) undergoing a combined intervention of repetitive transcranial magnetic stimulation (rTMS) and group…
- Trial name
- NCT07283419
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS), Group Cognitive Behavioral Therapy (CBT)
- Where
- China
- Volunteers
- 163 people
- Sponsor
- The First Hospital of Hebei Medical University