Clinical trials: Depression in Old Age
Cardiovascular Diseases, Non-communicable Disease
Effects of Primary Prevention in Elderly People-The Healthy Aging Initiative
The number of elderly will increase rapidly in Europe in the next 30 years, which affects the country's economic and social development, welfare, health care, and also the individuals.
- Trial name
- HAI (NCT03312439)
- Testing
- Given advice
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Region Västerbotten
Fractures in the Elderly
Post-operative Anxiety and Depression Among Older Adults Who Undergo Surgery for Fragility Fractures
Patients who present with falls and fractures can experience increased symptoms of depression and anxiety due to the trauma of falling, hospitalisation and surgery.
- Trial name
- FFAD (NCT06724484)
- Testing
- Surgical management of fracture, No intervention
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Southampton
Depressive Disorder, Major
Neuropsychological Factors Associated With Vulnerability to Suicidal Behavior in Depressed Elderly Patients
The main objective of this study is to confirm the existence of risky decision making in a non strategic situation (Iowa Gambling Task) and a deficit of decision making in social situations, linked to greater sensitivity to…
- Trial name
- SPAD (NCT02737540)
- Where
- 2 sites in France
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Depression
Effectiveness of a Depression Care Management Initiative in Home Healthcare
Depression in older home healthcare patients occurs very often, is typically not treated appropriately, and leads to poor health outcomes.
- Trial name
- NCT01979302
- Testing
- Depression CAREPATH, Usual Care
- Where
- United States
- Volunteers
- 310 people
- Sponsor
- Weill Medical College of Cornell University
Depression
Safety and Efficacy of Venlafaxine XR in Elderly Patients With Major Depression
This research study is to evaluate the safety and usefulness of venlafaxine-XR in the treatment of major depression in the elderly.
- Trial name
- NCT00177528
- Testing
- venlafaxine-XR
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Pittsburgh
Depressive Disorder, Major
Major Depressive Disorder In The Elderly
This is a placebo-controlled study evaluating the effectiveness of medication in elderly subjects with Major Depressive Disorder (MDD).
- Trial name
- NCT00093288
- Testing
- bupropion XL
- Where
- 16 sites in Australia, Belgium and 4 more
- Volunteers
- 364 people
- Sponsor
- GlaxoSmithKline
Depression in Old Age
Protocol for a Feasibility Cluster Randomised Controlled Trial of a Home-based Depression Care for Older People Delivered by Lay Providers in Nigeria
The aim of this hybrid (Effectiveness-Implementation) cluster randomised controlled clinical trial is to test the feasibility of implementing an age-appropriate electronic version of the WHO Mental Health Gap Action Programme…
- Trial name
- INDIGO (NCT06125899)
- Testing
- emhGAP-Age
- Volunteers
- 110 people
- Sponsor
- University of Ibadan
Old Age, Depressive Disorder, Treatment-Resistant
Neuromodulation in the Elderly Depressed: a Brain Imaging Pilot Study
To evaluate safety and efficacy of an accelerated deep brain Transcranial Magnetic stimulation (adTMS) and transcutaneous direct current stimulation (tDCS) protocol in an elderly depressed patient population
- Trial name
- NCT04783103
- Testing
- a Magstim Rapid2 Plus1 Magnetic Stimulator connected to a Brainsway H1 coil
- Where
- Belgium
- Volunteers
- 44 people
- Sponsor
- Universitair Ziekenhuis Brussel
Elderly Depression, Sleep Disturbance
Wearable-Based Study of Depression and Sleep in Older Adults
This 4-year study aims to develop a safe and effective management model for late-life depression using wearable technologies. The research will recruit older adults (aged 60 and above) with major depressive disorder, confirmed by…
- Trial name
- NCT07232472
- Testing
- Photobiomodulation
- Where
- United Kingdom
- Volunteers
- 162 people
- Sponsor
- China Medical University Hospital
Depression, Depression in Old Age
Trial to Test Effectiveness of Depression Intervention for Mistreated Older Adults
The investigators developed EM/PROTECT, a behavioral intervention for depressed EM (elderly mistreatment) victims, to work in synergy with EM mistreatment resolution services that provide safety planning, support services, and…
- Conditions
- Depression, Depression in Old Age, Elder Abuse, Anxiety
- Trial name
- NCT04258579
- Testing
- PROTECT with Technology Augmentation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Weill Medical College of Cornell University
Elderly Person
Gardening Activities for the Elderly Psychological Well-Being and Depression
Purpose of the Study: This research will be conducted to determine the effects of gardening activities applied to the elderly in nursing homes on psychological well-being and depression.
- Trial name
- NCT05256680
- Testing
- Gardening Activities
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Ordu University
Depression
Sleep Deprivation Plus Paroxetine for Treating Major Depression in Elderly Individuals
This study will determine the effectiveness of total sleep deprivation (TSD) for one night plus paroxetine versus either TSD plus placebo or paroxetine alone in inducing rapid symptom resolution of major depression in the elderly.
- Trial name
- NCT00178035
- Testing
- paroxetine, One night of Total Sleep Deprivation
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- University of Pittsburgh
Healthy Elderly
Effects of Exercise on Depression Symptoms, Physical Function, and Quality of Life in Community-Dwelling Elderly
The purpose of this study was to investigate the effects of 8-week exercise training on depression symptoms, physical functions, and quality of life in the community-dwelling elderly.
- Trial name
- NCT00931814
- Testing
- exercise training
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Resilience, Anxiety
Development and Relationship Between Resilience and Anxiety and Depression in Elderly Gastric Cancer Survivors
This study will explore the dynamic interaction between mental resilience, anxiety and depression in elderly patients with gastric cancer 1 year after surgery, in order to better understand the role of these two factors in…
- Conditions
- Resilience, Anxiety, Depression
- Trial name
- NCT06033716
- Testing
- Measurement correlation variable
- Where
- China
- Volunteers
- 412 people
- Sponsor
- Nanjing Medical University
Depression in Old Age
Improving Adult Protective Services Client Outcomes: A Stepped-Care Social and Mental Health Engagement Program
The purpose of this study is to ascertain the feasibility and effectiveness of an 8-week social engagement program aimed at reducing depression and increasing social engagement among seniors who are transitioning out of Adult…
- Trial name
- NCT06257095
- Testing
- Stepped-care social and mental health engagement, APS Usual care
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Depressive Disorder, Treatment-Resistant
A Study to Evaluate the Efficacy, Safety, and Tolerability of Intranasal Esketamine Plus an Oral Antidepressant in Elderly Participants With Treatment-resistant Depression
The purpose of this study is to evaluate the efficacy and safety of switching elderly participants with treatment-resistant depression (TRD) from a prior antidepressant treatment (to which they have not responded) to either…
- Trial name
- TRANSFORM-3 (NCT02422186)
- Testing
- Esketamine, Duloxetine (Oral Antidepressant), Escitalopram (Oral Antidepressant)
- Where
- 69 sites in United States, Belgium and 10 more
- Volunteers
- 139 people
- Sponsor
- Janssen Research & Development, LLC
Depression in Old Age, Depression, Anxiety
Internet Delivered Psychotherapy for Older Adults
The goal of this mixed-methods, single-arm intervention study is to develop and evaluate a new internet-delivered psychotherapy option called Ger-iPST in older adults with symptoms of depression.
- Trial name
- NCT05739370
- Testing
- Problem-Solving Therapy for Older Adults
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Frail Elderly Syndrome
A Machine Learning Algorithm to Predict Health Clinical Situations in Primary Healthcare for Frail Older Adults.
Introduction: We developed a machine learning algorithm to predict the risk of emergency hospitalization within the new 7 to 14 days with a good predictive performance (AUC=0.85).
- Trial name
- NCT06013709
- Testing
- PRESAE CARE
- Volunteers
- 1,478 people
- Sponsor
- Presage
Major Depressive Disorder
Treatment of Patients With Major Depressive Disorder With MK0869 (0869-068)(COMPLETED)
A clinical study to determine the efficacy and safety of an investigational medication (MK0869) in the treatment of depression.
- Trial name
- NCT00035048
- Testing
- aprepitant
- Volunteers
- 540 people
- Sponsor
- Merck Sharp & Dohme LLC
Late Life Depression
Explore the Neural Mechanism of Mindfulness Training to Reduce Loneliness in Depressed Older Adults
Perceived loneliness causes a global health burden on older adults. Mindfulness training may be a feasible solution. Through our study, we expect that comprehensive and convincing neuroscientific evidence may support the efficacy…
- Trial name
- NCT05620511
- Testing
- Mindfulness based stress reduction
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- Chang Gung Memorial Hospital