Clinical trials: Depression in Older Adults
Cerebrovascular Disease
Aerobic Dance Training in Small Vessel Disease
Introduction: Cerebral small vessel disease (SVD) is associated with age-related disabilities including dementia, depression, physical and functional impairment. Chinese are more prone to developing SVD than Caucasians.
- Trial name
- ADTSVD (NCT02730065)
- Testing
- Structured Aerobic Dance Training Group, Stretching plus education
- Where
- 2 sites in Hong Kong
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Dementia, Mild Cognitive Impairment
Virtual Chair Yoga for Older Adults and Caregivers: Randomized Controlled Trial
Over 700,000 Canadians are affected by dementia costing the health care system approximately $10 billion/year. Due to COVID-19, the government has urged individuals over the age of 70 to stay home, putting this population at risk…
- Trial name
- NCT04884529
- Testing
- Chair-yoga program
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Lady Davis Institute
Depression
Memantine Treatment for Improving Rehabilitation Outcomes and Preventing Depression in Older Adults
This study will evaluate the effectiveness of memantine in improving rehabilitation outcomes and preventing major depressive disorder in older adults who have been admitted to a rehabilitation hospital for a hip fracture or…
- Trial name
- NCT00183729
- Testing
- Memantine
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Eric Lenze
Major Depressive Disorder
Trial of Levomilnacipran in Geriatric Depression
The purpose of this study is to examine the effects of levomilnacipran (FETZIMA) compared to placebo for the treatment of depression in older adults.
- Trial name
- LMIL (NCT02466958)
- Testing
- levomilnacipran
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of California, Los Angeles
Critical Illness
Integrated Supportive and Palliative Care for Older Adults in the ICU
The National Academy of Medicine and the National Institutes of Health have called for urgent action to improve the care delivered to the nearly 1,000,000 older Americans who die in intensive care units (ICUs) annually, or…
- Trial name
- ProPACC (NCT04921631)
- Testing
- Early Integration of Specialty Palliative Care with Critical Care
- Where
- United States
- Volunteers
- 1,091 people
- Sponsor
- University of Pittsburgh
Cognitive Changes Due to Organic Disorder (Finding), Dementia
Gerontology Research Programme: The Singapore Longitudinal Ageing Studies (SLAS I & II)
The Gerontology Research Programme (GRP) in the National University Singapore's Department of Psychological Medicine, was formed to coordinate and facilitate the conduct of multi-disciplinary research on in a wide range of…
- Conditions
- Cognitive Changes Due to Organic Disorder (Finding), Dementia, Mild Cognitive Impairment, Frailty
- Trial name
- SLAS (NCT03405675)
- Testing
- SLAS 1, SLAS 2
- Where
- Singapore
- Volunteers
- 6,183 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Insomnia
Eszopiclone Co-Administered With Escitalopram for Insomnia in Elderly Adults With Major Depressive Disorder
Research has established the incidence of insomnia increases with age and the possible causes contributing to sleep problems in the elderly are still being explored and debated.
- Trial name
- NCT00813735
- Testing
- Eszopiclone, Escitalopram
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lehigh Center for Clinical Research
Emotional Distress, Anxiety
Five Session Unified Protocol for Older Adults With Emotional Distress and Reduced Mobility
Research suggests older adults report wide-ranging emotional distress (e.g., symptoms of anxiety, depression) that negatively impacts their physical and mental health and is associated with a reduction in daily activity.
- Conditions
- Emotional Distress, Anxiety, Depression
- Trial name
- NCT04837521
- Testing
- Unified Protocol
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Duke University
Major Depressive Disorder (MDD), Healthy Adult Volunteer
Emotional Cognition: Establishing Constructs and Neural-Behavioral Mechanisms in Older Adults With Depression
This is a cross-sectional pilot study designed to establish hot and cold cognitive functions and underlying neurocircuitry in older adults with MDD. The investigators will study 120 participants aged 21-80 years old with MDD.
- Trial name
- ENSURE (NCT05966532)
- Testing
- Hot Cognitive Task, Cold cognitive tasks, Structural magnetic resonance imaging (sMRI)
- Where
- 2 sites in United States
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Laughter Yoga
Effects of Laughter Yoga in Older Adults
The purpose of this study is to observe the effects of laughter yoga on psychological well-being and depressive symptoms in older adults.
- Trial name
- NCT07421336
- Testing
- Lughter yoga
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ankara University
Older Adults, Hearing Impairment
Effect of an Aural Rehabilitation Program in Hearing-impaired Older Adults
Hearing impairment in older adults is becoming a common health problem as the population ages. The impact of hearing impairment in older adults includes not only physical function and cognitive performance, but also depression…
- Conditions
- Older Adults, Hearing Impairment, Nursing
- Trial name
- NCT05083221
- Testing
- Hear-Talk-Activity audiological program
- Where
- Taiwan
- Volunteers
- 96 people
- Sponsor
- National Taiwan University Hospital
Cognitive Impairment, Mild, Depressive Symptoms
Brain Stimulation and Enhancing Cognition in Older Adults
The aim of the current research is to evaluate the efficacy of a combination of Mindfulness-Based Stress Reduction (MBSR) and transcranial direct current stimulation (tDCS) to improve cognitive function in individuals with…
- Conditions
- Cognitive Impairment, Mild, Depressive Symptoms, Anxiety
- Trial name
- NCT03653351
- Testing
- Active Transcranial Direct Current Stimulation (tDCS)
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Washington University School of Medicine
Mild Cognitive Impairment, Subthreshold Depression
A Trial of Combined Subthreshold Depression in Older Adults With Mild Cognitive Impairment Participating in Art Games
The presence of subthreshold depression accelerates quality of life decline and cognitive impairment in older adults with mild cognitive impairment, increasing the rate of dementia conversion, while the continuous decline in…
- Trial name
- NCT06706739
- Testing
- Online art game intervention group
- Where
- China
- Volunteers
- 87 people
- Sponsor
- Fujian Medical University
Depression, Suicidality
Assessing Improvements in Mood and Sleep Trial
This is a multi-site randomized control trial involving people age 55+ years who have current depression symptoms plus another suicide risk indicator (either current suicidal ideation or a past history of attempt).
- Conditions
- Depression, Suicidality, Sleep
- Trial name
- AIMS (NCT06639477)
- Testing
- Treatment As Usual, Active Condition, Active Comparator
- Where
- 3 sites in United States
- Volunteers
- 420 people
- Sponsor
- University of Pittsburgh
Sleep Disorder, Depressive Disorder
Effects of 12-week Exercise Program on Sleep Quality and Fear of Death in Geriatric Individuals
The aim of this study is to determine the effect of regular aerobic exercise program on tanatophobia and sleep quality in elderly individuals, and to evaluate the relationship between sleep disorder and fear of death.
- Conditions
- Sleep Disorder, Depressive Disorder, Death, Physical Inactivity
- Trial name
- EXDES (NCT05418283)
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Depression in Old Age
Assessment of Depression (iCGI) in Older People, According to Their Presentation in a Wheelchair or an Ordinary Chair.
This study aims to test for a " wheelchair effect ", as a potential impact of stigma, during the evaluation of clinical global impression of depression.Elderly patients will be asked to sit in a wheelchair, or in a regular chair…
- Trial name
- WHEELDEP (NCT04979299)
- Testing
- Wheelchair
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- Hospital Center Guillaume Régnier
Hypertension, Diabetes
Exercise Impact in Elderly With Multimorbidity: HbA1c and Blood Pressure
The main objective of the study is to compare the effect of two different types of physical exercise modalities on glycated hemoglobin and blood pressure in elderly individuals with multimorbidity.
- Conditions
- Hypertension, Diabetes, Osteoarthritis, Depression Disorders
- Trial name
- NCT06879639
- Testing
- Exercise, Control
- Where
- Portugal
- Volunteers
- 63 people
- Sponsor
- Universidade do Porto
Elderly Depression, Sleep Disturbance
Wearable-Based Study of Depression and Sleep in Older Adults
This 4-year study aims to develop a safe and effective management model for late-life depression using wearable technologies. The research will recruit older adults (aged 60 and above) with major depressive disorder, confirmed by…
- Trial name
- NCT07232472
- Testing
- Photobiomodulation
- Where
- United Kingdom
- Volunteers
- 162 people
- Sponsor
- China Medical University Hospital
Cardiovascular Diseases, Hypertension
Impact of Sleep Disordered Breathing in Older Adults
To test the hypothesis that clinically inapparent sleep-disordered breathing was associated with blood pressure elevation, impairment of health-related quality of life, and depression.
- Conditions
- Cardiovascular Diseases, Hypertension, Depression, Sleep Apnea Syndromes
- Trial name
- NCT00005378
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Schizophrenia, Schizoaffective Disorder
Health Care Management and Rehabilitation Skills Training for Treating Serious Mental Illness in Older People
This study will evaluate the effectiveness of a health management and supported rehabilitation intervention in treating serious mental illnesses in older people.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depression
- Trial name
- NCT00169052
- Testing
- Health Care Management and Supported Rehabilitation
- Where
- 3 sites in United States
- Volunteers
- 180 people
- Sponsor
- Dartmouth-Hitchcock Medical Center