Clinical trials: Depression in Older Adults
Lung Cancer
Lung Cancer and Aging: Improving Well-being for Older Adults With Lung Cancer
The purpose of this study is to develop a brief assessment and need-based behavioral intervention for addressing aging-specific concerns in older adults with lung cancer.
- Trial name
- LuCA (NCT06636721)
- Testing
- LuCA Behavioral Intervention
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Duke University
Depression
A Long Term Effect of Collaborative Care on Depression Treatment in a Community Dwelling Elderly
Suicide is a significant cause of death in Korea. According to the report compiled by the Korea National Statistical Office, 24.8 victims of every 100,000 in 2007 (Korea National Statistical Office, 2008), which is higher…
- Trial name
- NCT01817244
- Testing
- care management
- Where
- South Korea
- Volunteers
- 82 people
- Sponsor
- National Clinical Research Coordination Center, Seoul, Korea
Mental Health Care, Depression Anxiety Disorder
Effectiveness of Exercise, Walking, and Education on Mental Health, Mobility and Quality of Life in Elderly Residents of Nursing Homes
Clinical Trial This clinical trial aims to determine the impact of physiotherapy interventions on mental health, quality of life, and spinal mobility in older adults.
- Conditions
- Mental Health Care, Depression Anxiety Disorder, Quality of Life
- Trial name
- NCT07236424
- Testing
- Physiotherapy
- Where
- Bosnia and Herzegovina
- Volunteers
- 44 people
- Sponsor
- University of Mostar
Depression
Exercise Training Versus Drug Therapy for Treating Depression in Older Adults
This study will evaluate the effectiveness of both center-based and home-based exercise versus the antidepressant drug sertraline in treating depression in middle-aged and older adults.
- Trial name
- NCT00331305
- Testing
- Supervised Exercise, Home-Based Exercise, Sertraline (Zoloft)
- Where
- United States
- Volunteers
- 457 people
- Sponsor
- Duke University
Bipolar Depression
CoQ10 in Geriatric Bipolar Depression
We propose to study and compare measures of brain energy metabolism in geriatric bipolar individuals and healthy older adults. We would also like to investigate changes in brain energy metabolites and in vivo creatine kinase (CK)…
- Trial name
- CoQ10 (NCT00720369)
- Testing
- CoEnzyme Q10
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Depression, Anxiety
Postoperative Anxiety and Depression Among Chinese Elderly Patients
The goal of this observational study is to learn about the prevalence of postoperative anxiety and depression symptoms and identify the related risk factors in elderly patients aged 65 and older who undergo non-cardiac surgery in…
- Trial name
- NCT07532122
- Where
- China
- Volunteers
- 7,568 people
- Sponsor
- Chinese PLA General Hospital
Alcoholism, Depression
Treating Alcohol Use In Older Adults With Depression
The purpose of this study is to test the efficacy combining a treatment for depression with a treatment for alcohol dependence.
- Trial name
- NCT00018824
- Testing
- NALTREXONE
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- US Department of Veterans Affairs
Older Adults Institutionalized in Residential Homes
A Virtual Reality Program for Nursing Home Residents With Physical Disabilities
This project will evaluate how well the immersive virtual reality psychological program works in residential care homes and how it can be used in everyday practice.
- Trial name
- NCT07879677
- Testing
- Psychological intervention
- Volunteers
- 400 people
- Sponsor
- Tung Wah College
Functional Disability, Dementia
Aspirin in Reducing Events in the Elderly
ASPREE-XT is a post-treatment, longitudinal observational follow-up study of ASPREE participants [ASPREE Investigator Group, 2013; www.aspree.org; McNeil et al 2017].
- Conditions
- Functional Disability, Dementia, Heart Disease, Stroke
- Trial name
- ASPREE (NCT01038583)
- Testing
- 100 mg enteric-coated aspirin
- Where
- 47 sites in United States, Australia
- Volunteers
- 19,114 people, healthy volunteers welcome
- Sponsor
- Hennepin Healthcare Research Institute
Depression in Old Age
Efficacy of Metacognitive Training in Older Adults With Depression
Effective pharmacological and psychological treatments for depression are available. However, treatment modalities are not accessible to all patients diagnosed with depression.
- Trial name
- NCT06042283
- Testing
- Metacognitive Training-Silver
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University - Cerrahpasa
Depression, Dementia
Prognosis of Depression in the Elderly (PRODE). A Multicentre, Longitudinal Study of Elderly Depressed Patients.
PRODE is a Norwegian multicentre study investigating the prognosis of depression in the elderly. The study has included 169 patients who will be followed with assessments after one and three years.
- Trial name
- PRODE (NCT01952366)
- Where
- Norway
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Sykehuset Innlandet HF
Critical Illness
Integrated Supportive and Palliative Care for Older Adults in the ICU
The National Academy of Medicine and the National Institutes of Health have called for urgent action to improve the care delivered to the nearly 1,000,000 older Americans who die in intensive care units (ICUs) annually, or…
- Trial name
- ProPACC (NCT04921631)
- Testing
- Early Integration of Specialty Palliative Care with Critical Care
- Where
- United States
- Volunteers
- 1,091 people
- Sponsor
- University of Pittsburgh
Brain Fog, Cognitive Impairment
Cognitive Task-Based Walking Effects on Cognition, Mood, Sleep, and Quality of Life in Older Adults With Brain Fog
This randomized controlled trial aims to investigate the effects of cognitive task-based walking exercise on cognitive function, depressive symptoms, sleep quality, and quality of life in older adults experiencing brain fog.
- Conditions
- Brain Fog, Cognitive Impairment, Geriatric Population
- Trial name
- NCT07396779
- Testing
- Cognitive Task-Based Walking Exercise, Walking-Only Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Medipol University
Major Depression
Predictors of the Outcome of Late Life Depression
Predictors of response to pharmacological treatment of major depressive disorder will be investigated. One hundred and twenty patients will be included in a naturalistic clinical trial.
- Trial name
- NCT02441387
- Testing
- Antidepressant, Psychoeducation, Treatment as usual (only pharmacological treatment).
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- University of Sao Paulo General Hospital
Bipolar Depression
Lamotrigine Therapy in Geriatric Bipolar Depression
We propose to study the efficacy and tolerability of lamotrigine in the treatment of older adults with bipolar depression and to compare measures of brain energy metabolism between older subjects with bipolar depression and…
- Trial name
- NCT00720473
- Testing
- Lamotrigine
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
DEPRESSION
rTMS in Elderly Depressed:Neuronavegated Study
This double-blind, controlled and randomized study intents to investigate the antidepressive response of rTMS on the elderly population.This is the first neuronavegated pulse intensity corrected study of rTMS in elderly depressed…
- Trial name
- NCT01255072
- Testing
- Transcranial Magnetic Stimulation, Repetitive Transcranial Magnetic Stimulation
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo General Hospital
Functionally-Impaired Elderly, Caregivers
Impact on Family or Care-givers of Very Old ICU-survivors, Trajectories and 6 Months' Outcome in the Very Old.
It is known from extensive documentation that second victims in critical illness often are the care givers of the patients: family, friends or other persons.
- Conditions
- Functionally-Impaired Elderly, Caregivers, PTSD, Depression, Anxiety
- Trial name
- VIP2 (NCT03138278)
- Testing
- Telephone support on demand
- Sponsor
- University of Bergen
Major Depressive Disorder (MDD), Healthy Adult Volunteer
Emotional Cognition: Establishing Constructs and Neural-Behavioral Mechanisms in Older Adults With Depression
This is a cross-sectional pilot study designed to establish hot and cold cognitive functions and underlying neurocircuitry in older adults with MDD. The investigators will study 120 participants aged 21-80 years old with MDD.
- Trial name
- ENSURE (NCT05966532)
- Testing
- Hot Cognitive Task, Cold cognitive tasks, Structural magnetic resonance imaging (sMRI)
- Where
- 2 sites in United States
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Major Depression
TBS Over DLPFC in Elderly Refractory Depression
The study aim to examine the effect of Thea-burst stimulation over bilateral dorsolateral prefrontal cortex (DLPFC) among patients with LLD on mood condition and relevant biomarkers.
- Trial name
- NCT04872465
- Testing
- TBS
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Depressive Symptoms
Metacognitive Training in the Older Adults With Depressive Symptoms (MCT-Silver)
Depression is one of the most common mental disorders in older adults and a major cause of years lived with disability. Depression does not always respond to antidepressants, and non-pharmacological interventions are recommended…
- Trial name
- NCT05640492
- Testing
- Metacognitive Training for Depression in Later Life (MCT-Silver)
- Where
- Portugal
- Volunteers
- 120 people
- Sponsor
- University of Évora