Clinical trials: Depressive; Behavioral Disorder
Insomnia, Depressive Disorder, Major
Cannabinoids as a Treatment for Insomnia in Major Depression
This single-site study is a pilot, three-armed, double-blinded, placebo-controlled randomized controlled trial (RCT) that will determine the feasibility of a definitive RCT investigating the use of cannabis oil as a treatment for…
- Conditions
- Insomnia, Depressive Disorder, Major, Sleep Disorder, Depression
- Trial name
- CANMDD (NCT05041647)
- Testing
- 25:1 CBD/THC, 5:1 CBD/THC
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Major Depressive Disorder, Depressive Symptoms
A Randomised Controlled Clinical Trial of Memory Specificity Training (MEST) for Depression
Depression involves the tendency to recall overgeneral personal memories, a phenomenon which has been linked to numerous adverse psychological outcomes.
- Trial name
- MEST (NCT01882452)
- Testing
- Memory Specificity Training, Education and Support
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- Medical Research Council
Molecular Mechanisms of Pharmacological Action, Depression
Citalopram and Self Emotional Processing
This study is investigating the effect of an acute dose of citalopram on emotional processing about the self. Using a parallel-group double-blind design, participants will be randomised to receive either an acute dose of…
- Conditions
- Molecular Mechanisms of Pharmacological Action, Depression, Depressive Disorder, Mental Disorder
- Trial name
- NCT04169230
- Testing
- Citalopram
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Depression, Unipolar, Depression, Bipolar
IM Ketamine vs Midazolam for Suicidal ER Patients
Rising US suicide rates and the increased risk of suicide among persons who visit an emergency department (ED) for suicidality make the ED an important site for interventions to prevent suicide.
- Conditions
- Depression, Unipolar, Depression, Bipolar, Suicidal Ideation
- Trial name
- NCT04640636
- Testing
- Ketamine hydrochloride injection, Midazolam injection
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- New York State Psychiatric Institute
Stress, Resilience
Virtual Reality (VR) for Stress Management
This is a randomized pilot trial that aims to examine the impact of smartphone-based Virtual Reality (VR) intervention, MindCo Relief, in reducing stress levels and perceived anxiety, depression, and quality of life among young…
- Conditions
- Stress, Resilience, Quality of Life, Depressive Symptoms
- Trial name
- NCT06970652
- Testing
- virtual reality
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- City University of New York, School of Public Health
Depressive Disorder, Major
Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) In The Treatment Of Major Depressive Disorder
The primary purpose of this study is to evaluate the efficacy and safety of two doses of DVS SR (50 and 100 mg/day) in the treatment of adults with Major Depressive Disorder.
- Trial name
- NCT00384033
- Testing
- Desvenlafaxine Succinate Sustained-Release (DVS SR), Duloxetine 60 mg/day
- Where
- 22 sites in United States
- Volunteers
- 638 people
- Sponsor
- Pfizer
Major Depressive Disorder
Open Label Optimization Study
The goal of this observational study is to demonstrate effectiveness in the treatment of Major Depressive Disorder The primary objective is to assess the effectiveness in the treatment of Major Depressive Disorder using the CGI-I…
- Trial name
- OLO (NCT05819021)
- Testing
- SAINT® Neuromodulation System (NMS)
- Where
- 7 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Magnus Medical
Depression, Postpartum
The Impact of Creative Interventions on Symptoms of Postnatal Depression (Cohort Study)
Post-natal depression (PND) is anticipated to affect 12.9% of new mothers with at least 75,000 cases per year in the UK alone. However, despite this, there is currently a worrying lack of support for new mothers, with data…
- Trial name
- NCT02526433
- Where
- United Kingdom
- Volunteers
- 2,558 people, healthy volunteers welcome
- Sponsor
- Royal College of Music
Major Depressive Disorder, Depression
Incomplete Response in Late-Life Depression: Getting to Remission With Buprenorphine
The Investigators are conducting a research study to learn about the safety and benefit of using a medication called buprenorphine for patient with difficult to treat depression .
- Trial name
- (IRLGREY-B) (NCT02263248)
- Testing
- venlafaxine, buprenorphine
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- Centre for Addiction and Mental Health
Depression / Major Depressive Disorder
Adjunctive Probiotic Therapy in Major Depressive Disorder (ProMOOD)
A double-blind, randomized controlled trial (RCT) aimed at evaluating the efficacy of probiotic supplementation in patients undergoing concurrent antidepressant therapy.
- Trial name
- ProMOOD (NCT07786285)
- Testing
- OMNi-BiOTiC® STRESS Repair
- Where
- Slovenia
- Volunteers
- 200 people
- Sponsor
- University Maribor
Major Depressive Disorder
Multimodal MRI Characteristics of Psychotherapy Response in Late Life Depression
The specific focus of this study is to gather data regarding the effects of a psychological therapy known as Problem Solving Therapy (PST) on cerebral blood flow (CBF), cortical gray matter (GM) atrophy, subcortical white matter…
- Trial name
- PRS (NCT02440815)
- Testing
- Problem Solving Therapy
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
PTSD, Post Traumatic Stress Disorder, Major Depressive Disorder
Ketamine Treatment for PTSD and MDD in TBI
The goal of this clinical trial is to examine the use of sedative ketamine to treat depression and post-traumatic stress disorder (PTSD) in Veterans with mild to moderate traumatic brain injury (TBI).
- Conditions
- PTSD, Post Traumatic Stress Disorder, Major Depressive Disorder, Traumatic Brain Injury
- Trial name
- NCT06228391
- Testing
- IV ketamine, Midazolam
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Depressive Disorder, Major
Self Neuro-modulation Therapy for Major Depressive Disorder (MDD) With Anhedonia
The purpose of this research is to learn more about a new treatment for individuals with Major Depressive Disorder (MDD) with heightened symptoms of anhedonia (i.e. loss of pleasure or interest in activities).
- Trial name
- NCT06982820
- Testing
- Prism Training
- Where
- 3 sites in United States, Israel
- Volunteers
- 170 people
- Sponsor
- GrayMatters Health Ltd.
Major Depressive Disorder
Transcranial Alternating Current Stimulation (tACS) on Serotonin-1A Receptor in Depression
This study will apply a comprehensive tools that integrates neuroimaging, psychological evaluation, and sleep monitoring through 18F-MPPF PET/MR, neuropsychological tests, and polysomnography (PSG) to explore the neurobiological…
- Trial name
- NCT06211140
- Testing
- tACS, Control
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Major Depressive Disorder, Cancer
Vortioxetine for Cancer Patients With Depression: An Observational Study
The purpose of this observational antidepressant study is to determine the efficacy of vortioxetine on depression and cognitive function, and elucidate its potential effects on quality of life in patients with cancer (of any…
- Trial name
- NCT04253678
- Testing
- Vortioxetine
- Where
- 8 sites in Malaysia
- Volunteers
- 140 people
- Sponsor
- University of Malaya
Depressive Disorder
Study In Patients With Depression Not Responding to Selective Serotonin Re-uptake Inhibitors
This study is designed to evaluate the efficacy and safety in depressive patients who did not respond sufficiently to selective serotonin re-uptake inhibitors (SSRI).
- Trial name
- NCT00296517
- Testing
- 323U66 (Bupropion Hydrochloride Sustained Release)
- Where
- 62 sites in Japan
- Volunteers
- 325 people
- Sponsor
- GlaxoSmithKline
Fibromyalgia, Depressive Symptoms
Psychological Treatment of Depression in Women With Fibromyalgia
The purpose of this study is to perform an efficacy study of Personal Construct Therapy, which focuses on the construction of self and others, for women diagnosed with fibromyalgia who have also comorbid depressive symptoms.
- Trial name
- PCTFORDEPFM (NCT02711020)
- Testing
- Cognitive Behavioral Therapy, Personal Construct Therapy
- Where
- 4 sites in Spain
- Volunteers
- 110 people
- Sponsor
- University of Barcelona
Pain, Depressive Symptoms
Assessing Pain as a Mediator of Behavior Change in Post-coronary Angioplasty Patients
The focus of this secondary data analysis is to determine whether pain due to a combination of both cardiac and non cardiac sources operates as a mediator of behavior change, an area that has not been previously evaluated.
- Conditions
- Pain, Depressive Symptoms, Quality of Life
- Trial name
- NCT01469780
- Where
- United States
- Volunteers
- 660 people
- Sponsor
- Weill Medical College of Cornell University
Major Depression
Efficacy and Safety Curcumin in Depression
Antidepressants generally do not lead to an immediate relief of symptoms. Most people will not see a significant improvement for at least 4 weeks.
- Trial name
- NCT01750359
- Testing
- curcumin
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Vladimir Lerner
Major Depressive Disorder, Treatment Resistant Depression
Antidepressant Effects of Nitrous Oxide
To evaluate the acute and sustained antidepressant effects of nitrous oxide in people with major depressive disorder; and further evaluate these effects by identifying the optimal dose and regimen to guide current practice, and…
- Trial name
- NCT05357040
- Testing
- Nitrous oxide gas for inhalation
- Where
- 2 sites in United States, Australia
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Chicago
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