Clinical trials: Depressive; Behavioral Disorder
Depression Unipolar
Effects of tDCS-enhanced Cognitive Control Training on Depression
Deficient cognitive control (CC) is one of the central characteristics of major depression (MD). Hypoactivation of the dorsolateral prefrontal cortex (dlPFC) has been linked with this deficit.
- Trial name
- NCT03518749
- Testing
- 1mA tDCS, 2mA tDCS, Cognitive control training
- Where
- Germany
- Volunteers
- 57 people
- Sponsor
- University Hospital Tuebingen
Cannabis Use Disorder, Anxiety
Use of a Generative AI (Gen-AI) Chatbot for Anxiety and Depression Among Persons With Cannabis Use
The goal of this clinical trial is to learn if Therabot-CALM (Cannabis, Anxiety, Low Mood) has acceptability among users and could work to improve the symptoms of persons with cannabis use disorder and anxiety and/or depression.
- Conditions
- Cannabis Use Disorder, Anxiety, Depression, Anxiety, Depression - Major Depressive Disorder
- Trial name
- NCT06920238
- Testing
- Therabot-CALM
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Trustees of Dartmouth College
Major Depressive Disorder
Validating PROMIS Instruments in Depression
The Patient-Reported Outcomes Measurement Information System (PROMIS) is an NIH Roadmap initiative to develop a computerized system measuring patient-reported outcomes in respondents with a wide range of chronic diseases and…
- Trial name
- NCT00784199
- Volunteers
- 115 people
- Sponsor
- University of Pittsburgh
Borderline Personality Disorder (BPD), Treatment-Resistant Major Depressive Disorder
Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT)
The goal of this clinical trial is to learn if intravenous (IV) ketamine with Dialectical Behavioural Therapy (DBT) reduces suicidal ideation in individuals with suicidality who have been diagnosed with Borderline Personality…
- Conditions
- Borderline Personality Disorder (BPD), Treatment-Resistant Major Depressive Disorder, Treatment-resistant Bipolar Depression, Major Depressive Disorder (MDD)
- Trial name
- KET-DBT (NCT07569198)
- Testing
- Ketamine Hydrochloride, Midazolam Hydrochloride, Dialectical Behavioral Therapy (DBT)
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Joshua Rosenblat
Major Depressive Disorder
Safety and Efficacy of Vilazodone in Major Depressive Disorder
Safety and Efficacy of Vilazodone in Major Depressive Disorder
- Trial name
- NCT01573598
- Testing
- Vilazodone
- Where
- 75 sites in United States, Bulgaria and 6 more
- Volunteers
- 1,219 people
- Sponsor
- Forest Laboratories
Major Depressive Disorder, Unipolar Depression
Transcranial Direct Current Stimulation (tDCS) As Treatment for Major Depression
Major depressive disorder (MDD) is a common, recurrent, and frequent chronic disorder. Treatment is often challenging; an estimated 20-40% of patients do not benefit sufficiently from existing antidepressant interventions…
- Conditions
- Major Depressive Disorder, Unipolar Depression, Depression
- Trial name
- DepressionDC (NCT02530164)
- Testing
- Transcranial direct current stimulation (tDCS)
- Where
- Germany
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Major Depression, Depressive Episodes
Primary Care Internet Based Depression Prevention for Adolescents (CATCH-IT) Also Known as Promoting AdolescenT Health
The purpose of this randomized multiple-site clinical study is to determine whether a revised CATCH-IT (Internet-based depression prevention program) is more effective than a general health education Internet intervention (Health…
- Trial name
- CATCH-IT (NCT01893749)
- Testing
- CATCH-IT
- Where
- 7 sites in United States
- Volunteers
- 1,142 people, healthy volunteers welcome
- Sponsor
- Benjamin Van Voorhees, MD, MPH
Stress Disorders, Post-Traumatic, Depressive Symptoms
Mindfulness-based Intervention to Address PTSD in Trauma-exposed, Homeless Women
Posttraumatic stress disorder (PTSD) is a major public health concern that disproportionately effects minorities and those with low-socioeconomic status, such as homeless women, creating a critical health disparity.
- Conditions
- Stress Disorders, Post-Traumatic, Depressive Symptoms, Hydrocortisone, Substance Use
- Trial name
- NCT04605198
- Testing
- Modified Mindfulness-based Stress Reduction, Health Promotion Wellness Classes
- Where
- 2 sites in United States
- Volunteers
- 156 people
- Sponsor
- University of California, Los Angeles
Major Depressive Disorder
Genetic and Neural Predictors of Adolescent Depression
This study aims to examine the relationship between mood and brain activity in adolescent girls in order to better understand the genetic and neural predictors of adolescent depression.
- Trial name
- NCT01743716
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Depression
PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)
Background: Researchers developed [11C]MC1, a radioligand for cyclooxygenase-2 (COX-2). COX-2 is an enzyme induced in the brain during inflammation.
- Trial name
- NCT04582916
- Testing
- 11C-MCI, 11CPS13
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Depression, Pregnancy
Depression Prevention Program for American Indian Adolescents During and After Pregnancy
This study will determine the effectiveness of the "Living in Harmony" depression prevention program in preventing depressive symptoms among pregnant American Indian adolescents during pregnancy and after giving birth.
- Trial name
- NCT00183547
- Testing
- "Living in Harmony" depression prevention program, Depression-prevention education and support
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Depressive Symptoms, Allostatic Load
Rise & Thrive: Community-Engagement Intervention for Stress and Depression in Youth.
American youth and young adults face persistent and chronic stressors, which have contributed to a mental health crisis in the United States.
- Conditions
- Depressive Symptoms, Allostatic Load, Metabolic Syndrome
- Trial name
- R&T (NCT07554326)
- Testing
- Rise Together: Community Engagement Intervention, Adulting 101: Life Skills
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Depressive Disorder, Major
Smartphone App Based CBT Versus Online Group CBT: Randomized, Non-inferiority Clinical Trial
The present research project aims to compare the efficacy and safety of an intervention based on a smartphone application, which uses CBT techniques, to online group cognitive behavioral therapy (CBCT), in improving depressive…
- Trial name
- NCT05450614
- Testing
- Thrive app, TCCG
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Complicated Grief, Prolonged Grief Disorder
Pilot Study of Behavioral Activation for Prolonged Grief
The Institute of Medicine identifies Prolonged Grief (PG) as a critical under-addressed public health problem for which are no empirically supported treatments.
- Conditions
- Complicated Grief, Prolonged Grief Disorder, Major Depressive Disorder, Posttraumatic Stress Disorder
- Trial name
- NCT01556048
- Testing
- Behavioral Activation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Anthony Papa
Depression
Neuronavigation Guided iTBS With Personalized Target for Depression
The study will compare the efficacy of intermittent Theta Burst Stimulation (iTBS) with DLPFC-pgACC personalized target for major depressive disorder (MDD) and explore possible brain network mechanisms.
- Trial name
- NCT05577481
- Testing
- iTBS combined with antidepressants
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Xijing Hospital
Depressive Disorder, Major
The Effect of Mediterranean Diet and Mindfulness Eating on Depression Severity in People With Obesity and Major Depressive Disorder
The present study investigates the effect of Mediterranean Diet and Mindful Eating on depression severity in people with obesity and major depressive disorder.
- Trial name
- MEDIMIND (NCT06621394)
- Testing
- nutritional intervention, Mindful Eating, Attention Control
- Where
- Germany
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Depressive Symptoms, Epilepsy, Temporal Lobe
Effects of tDCS on Depressive Symptoms of Participants With Temporal Lobe Epilepsy
This project was developed to analyze the clinical, biochemical and functional impact of tDCS on depressive symptoms in participants with temporal lobe epilepsy, intending to collaborate directly in the development of new…
- Trial name
- NCT03871842
- Testing
- active tDCS
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Depression, Mania
Impact of Closely Grouped, Iterative Exposures to Suxamethonium During ECT on the Sensitization to NMBA and the Development of Protective Antibodies
Acute per-anesthetic hypersensitivity reaction (HSA-PA) is a rapidly occurring systemic reaction following injection of a drug during anesthesia (mortality between 3 and 9%).
- Conditions
- Depression, Mania, Hallucinations
- Trial name
- SismoSens (NCT05210062)
- Testing
- Iterative exposure to suxamethonium during ECT sessions
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Depression, Intracranial Atherosclerosis
Intracranial Atherosclerosis and Depression After Coronary Artery Bypass Graft
The purpose of the study is to examine if blood flow in the brain before coronary artery bypass graft surgery has an effect on depression after surgery.
- Conditions
- Depression, Intracranial Atherosclerosis, Coronary Artery Disease
- Trial name
- NOAHS (NCT01838356)
- Where
- 2 sites in United States
- Volunteers
- 169 people
- Sponsor
- Yale University
Major Depressive Disorder
Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
The study will evaluate the efficacy of NBI-1065845 compared with placebo as an adjunctive treatment in participants with MDD on improving symptoms of depression.
- Trial name
- NCT06786624
- Testing
- NBI-1065845
- Where
- 18 sites in United States
- Volunteers
- 200 people
- Sponsor
- Neurocrine Biosciences
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