Clinical trials: Depressive; Behavioral Disorder
Parkinson Disease
The Efficacy and Safety of Transcutaneous Auricular Vagus Nerve Stimulation for Depression in PD
This study is a double blind comparative study examining the effectiveness of the transcutaneous auricular vagus nerve stimulation treatment on Parkinson's disease patients with depression.
- Trial name
- PD-D-taVNS (NCT07679529)
- Testing
- Active Transcutaneous auricular vagus nerve stimulation
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Depressive Symptoms, Anxiety
Music Therapy's Impact on University Students' Social and Mental Health
In recent years, university education has become more challenging due to increased academic competition. A rising number of university students globally are currently being diagnosed with mental health problems, and previous…
- Conditions
- Depressive Symptoms, Anxiety, Stress
- Trial name
- NCT07024979
- Testing
- Music Therapy Songwriting Intervention
- Where
- Hong Kong
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Depressive Disorder
An Investigation of the Antidepressant Efficacy of the 5-HT2A Antagonist, M100907, in Combination With Citalopram in Treatment Resistant Depression
This study will examine whether a highly specific and powerful 5-hydroxytryptamine 2A (5-HT2A) antagonist, M100907, combined with escitalopram, is responsible for an antidepressant effect.
- Trial name
- NCT00070694
- Testing
- MDL100.907
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depressive Symptoms, Emotion Regulation
Making SPARX Fly in Nunavut: Pilot Testing an E-intervention for Boosting Resilience Against Youth Depression
The goal of this pilot trial was to test SPARX with Inuit youth in Northern Canada. SPARX is an educational video game designed to teach cognitive behavioural therapy strategies and techniques.
- Trial name
- NCT05702086
- Testing
- SPARX (Smart, Positive, Active, Realistic, X-Factor thoughts)
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- York University
Depression
E-Mental Health Adolescent Depression Program (LEAP)
The purpose of this project is to explore the potential value and practicality of an innovative depression intervention for young people. More specifically, the objectives of this project are: 1.
- Trial name
- LEAP (NCT00985686)
- Testing
- LEAP Project
- Where
- Canada
- Volunteers
- 63 people
- Sponsor
- Patricia Steele
Artificial Intelligence (AI)
Identification of Depressive and Anxiety Symptoms Among a Sample of Emergency Department Patients Using Artificial Intelligence (AI) Technology
Behavioral health problems, such as depression and anxiety, are common yet often are not identified by emergency department doctors and nurses.
- Trial name
- NCT06473558
- Testing
- Biometrics (or AI Biomaker)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University Hospitals Cleveland Medical Center
Major Depressive Disorder, Dysthymic Disorder
Mindfulness Based Cognitive Therapy for Chronic Pain and Comorbid Unipolar Depression
The primary aim of this study is to test the feasibility and efficacy of Mindfulness Based Cognitive Therapy (MBCT) training for the treatment of depressive symptoms in patients with chronic pain.
- Conditions
- Major Depressive Disorder, Dysthymic Disorder, Depressive Disorder NOS, Chronic Pain
- Trial name
- NCT01473615
- Testing
- Mindfulness Based Cognitive Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Major Depressive Disorder
Study of Adolescence and Depression
STAND is a research study testing a way to help teens between 12-18 years of age who have symptoms of sadness or depression. The study hopes to learn if teens do better if they get five to nine counseling sessions of cognitive…
- Trial name
- STAND (NCT00523081)
- Testing
- Cognitive Behavioral Therapy (CBT), Active control
- Where
- United States
- Volunteers
- 212 people
- Sponsor
- Kaiser Permanente
Depression, Psychosis
Examining the Effects of Estradiol on Neural and Molecular Response to Reward
This proposal will examine the effects of estradiol administration on perimenopausal-onset (PO) anhedonia and psychosis symptoms as well as on brain function using simultaneous positron emission tomography and functional magnetic…
- Conditions
- Depression, Psychosis, Anhedonia
- Trial name
- PEEPS (NCT05282277)
- Testing
- Transdermal Estradiol, Micronized Progesterone, Raclopride C11
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- University of North Carolina, Chapel Hill
Depressive Disorder, Violence
Text-Message-Based Depression Prevention for High-Risk Youth in the ED
The purpose of this randomized controlled study is to evaluate acceptability and feasibility, and to gather preliminary data about efficacy, of "iDOVE," a brief emergency department introductory session + longitudinal automated…
- Trial name
- iDOVE (NCT02332239)
- Testing
- iDOVE Intervention (ED+text), Control (EUC)
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Rhode Island Hospital
Epilepsy, Major Depressive Disorder (MDD)
Lethargic Depression Study
This is a study of Major Depressive Disorder (MDD) in patients with decreased energy, pleasure and interests.
- Trial name
- NCT00064467
- Testing
- Extended-release bupropion (HCl)
- Where
- 24 sites in United States
- Volunteers
- 268 people
- Sponsor
- GlaxoSmithKline
Depressive Disorders, Anxiety Disorders
A Cognitive-Behavioral Intervention for Depression and Anxiety in COPD
The literature and our preliminary studies found that in COPD patients, psychosocial factors affect quality of life (QOL) and functioning more than would be expected given the severity of their disease.
- Conditions
- Depressive Disorders, Anxiety Disorders, Pulmonary Disease, Chronic Obstructive
- Trial name
- NCT00105911
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 222 people
- Sponsor
- US Department of Veterans Affairs
Seasonal Affective Disorder
Study of Genes in Relation to Seasonal Affective Disorder and Major Depressive Disorder
The investigators are looking for volunteers who have a history of Major Depressive Disorder, the Winter Blues, or Seasonal Affective Disorder or healthy volunteers who do not have a history of these disorders for a research…
- Trial name
- Season605 (NCT01292889)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Major Depressive Disorder
Characterizing Psychological Consequences of Childhood Trauma
This study will characterize the mental health consequences of early-life trauma.
- Trial name
- NCT00209105
- Testing
- DEX-CRF stimulation test, Psychosocial stress induction, Brain imaging of sad mood , self-reference, reward
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Emory University
Behavioral Activation, Major Depressive Disorder
Pharmacogenomics of Selective Serotonin Reuptake Inhibitor (SSRI)-Induced Behavioural Activation
The purpose of this study is to identify and validate a panel of genetic markers associated with selective serotonin reuptake inhibitors (SSRI)-induced behavioural activation in children and youth with major depressive disorder…
- Conditions
- Behavioral Activation, Major Depressive Disorder, Anxiety Disorders, Antidepressant Drug Adverse Reaction
- Trial name
- PGx-SImBA (NCT06763081)
- Testing
- Not applicable- observational study
- Where
- 2 sites in Canada
- Volunteers
- 160 people
- Sponsor
- University of Manitoba
Major Depressive Disorder
The Effects of Videogames on Depression Symptoms and Brain Dynamics
The purpose of the study is to evaluate the effects of a game-based digital-therapeutics (DTx) medical software device on the symptoms of depression in adults with confirmed major depressive disorder.
- Trial name
- NCT05426265
- Testing
- MEL-T01, MEL-S01
- Where
- 6 sites in Finland
- Volunteers
- 1,001 people, healthy volunteers welcome
- Sponsor
- Aalto University
Major Depressive Disorder
Augmentation of Treatment-Resistant Depression With An Analog of the Neuroactive Steroid Allopregnanolone
Major depressive disorder (MDD) is highly prevalent and nearly 70% of individuals with MDD do not respond to standard antidepressant therapies despite adequate dosing.
- Trial name
- NCT02900092
- Testing
- Ganaxolone
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Major Depressive Disorder
Randomised Placebo-controlled Duloxetine-referenced Study of Efficacy and Safety of 5 mg of Vortioxetine (Lu AA21004) in Acute Treatment of Major Depressive Disorder in Elderly Patients
To assess the efficacy of Vortioxetine (5 mg daily) versus placebo in the acute treatment of depression by means of the change from baseline in the 24-item Hamilton Depression Scale (HAM-D24) total score after 8 weeks of…
- Trial name
- NCT00811252
- Testing
- Vortioxetine (Lu AA21004), Duloxetine
- Volunteers
- 453 people
- Sponsor
- H. Lundbeck A/S
Major Depression
Lexapro and Pramipexole and to Treat Major Depression
This study compares the effectiveness of the combination of antidepressants: Lexapro and Pramipexole, with the effectiveness of each antidepressant alone.
- Trial name
- NCT00086307
- Testing
- Pramipexole, Escitalopram
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depressive Disorder, Violence
Intervention to Prevent Peer Violence & Depressive Symptoms Among At-Risk Adolescents
The purpose of this investigation is to test the efficacy of "iDOVE2" (a brief emergency department introductory session and longitudinal automated text-message depression prevention program for high-risk teens), and to determine…
- Trial name
- iDOVE2 (NCT03626103)
- Testing
- + Brief ED Intervention (BI), + Text
- Where
- 2 sites in United States
- Volunteers
- 620 people
- Sponsor
- Rhode Island Hospital
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