Clinical trials: Depressive; Behavioral Disorder
Premenstrual Dysphoric Disorder
Emotion Regulation-based Internet-delivered Cognitive Behavioural Therapy for Premenstrual Dysphoric Disorder
Premenstrual dysphoric disorder (PMDD) is a debilitating cyclic mental disorder affecting about 2-5% of women of reproductive age.
- Trial name
- Premensis-s (NCT06496139)
- Testing
- Therapist-guided internet-delivered cognitive behavioural therapy
- Where
- Sweden
- Volunteers
- 164 people
- Sponsor
- Uppsala University
Depression
Clinical and Biological Markers of Response to Cognitive Behavioural Therapy for Depression
The purpose of this study is to locate clinical markers (for example, interviews, questionnaires, and computer tasks) and biological markers (for example, physiological, blood-based, or electroencephalography measurements) that…
- Trial name
- NCT02883257
- Testing
- Cognitive Behavioral Therapy
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- Centre for Addiction and Mental Health
Major Depression
PUFA Augmentation in Treatment of Major Depression
The purpose of this study is to determine if omega-3 fatty acid EPA will enhance and speed up response to antidepressant therapy with Celexa (Citalopram) in people suffering from Major Depressive Disorder.
- Trial name
- NCT00067301
- Testing
- Polyunsaturated Fatty Acids (PUFA), Citalopram
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Stigma, Social, Mental Health Disorder
Reducing Depression Self-stigma and Increasing Treatment Seeking Intentions Among Youth
Young people with depression, especially those of underserved minority groups, avoid treatment due to stigma and discrimination.
- Conditions
- Stigma, Social, Mental Health Disorder, Depression
- Trial name
- NCT06172075
- Testing
- Brief video intervention (Black Woman), Brief video intervention (Latinx Woman), Brief video intervention (White Woman)
- Where
- United States
- Volunteers
- 1,520 people
- Sponsor
- New York State Psychiatric Institute
Depression - Major Depressive Disorder, Mood
Intern Health Study 2025
The aim of this study is to evaluate the efficacy of using a reinforcement learning algorithm to determine the optimal content of a mobile health intervention (message delivered via smartphone) for improving the mood, physical…
- Conditions
- Depression - Major Depressive Disorder, Mood, Sleep, Physical Activity
- Trial name
- (IHS 2025) (NCT07052357)
- Testing
- Intern Health Study behavioral change mobile notification
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Healthy, Major Depressive Disorder
Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression
The core objective of this study is to enhance the translational potential of this electroencephalogram (EEG) biomarker by using ketamine(KET)-induced gamma potentiation as a prognostic marker of 4-week treatment outcome.
- Conditions
- Healthy, Major Depressive Disorder, Treatment Resistant Depression
- Trial name
- NCT06480201
- Testing
- Ketamine, Saline
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Major Depressive Disorder \(MDD, Depressive Disorder, Major
Electrical Vestibular Nerve Stimulation (VeNS) as a Treatment for Major Depressive Disorder (MDD)
Trial title: A Randomized, Double Blind Sham Controlled Clinical Trial to Evaluate the Efficacy of Electrical Vestibular Nerve Stimulation (VeNS), Compared to a Sham Control for Treatment of Major Depressive Disorder (MDD) …
- Trial name
- NCT06470035
- Testing
- Active VeNS Device
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 170 people
- Sponsor
- Neurovalens Ltd.
Depressive Symptoms, Anxiety
Stay Well at Home: a Text-messaging Study Social Distancing
The investigators have developed supportive text-messages in English and Spanish to help people cope with the stress and anxiety of COVID-19 social distancing.
- Conditions
- Depressive Symptoms, Anxiety, COVID-19
- Trial name
- NCT04473599
- Testing
- Uniform random message delivery, Reinforcement learning message delivery, Mood ratings only
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Major Depressive Disorder
Transcranial Laser Therapy for Major Depressive Disorder
The purpose of this study is to see if using Transcranial LED Therapy (TLT) using the PhotoMedex's Omnilux NEw-U LED helps improve symptoms of major depressive disorder (MDD).
- Trial name
- ELATED (NCT01538199)
- Testing
- Near-infrared radiation via Transcranial LED Therapy
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Paolo Cassano
Major Depressive Disorder
Comparison of Escitalopram Combination in Adult Patients With Major Depressive Disorder
Escitalopram is the S-enantiomer of citalopram. Both escitalopram and citalopram are selective serotonin reuptake inhibitors (SSRIs) and are used to treat depression in adults.
- Trial name
- NCT00109044
- Testing
- Escitalopram
- Where
- 18 sites in United States
- Volunteers
- 540 people
- Sponsor
- Forest Laboratories
Major Depressive Disorder, Bipolar Depression
Electro-Magnetic Convulsive Therapies for Depression: a Non-inferiority Study
This study aims to compare the efficacy and safety profile of Magnetic Seizure Therapy and Electroconvulsive therapy.
- Trial name
- EMCODE (NCT05054699)
- Testing
- Magnetic Seizure Therapy, Electroconvulsive Therapy
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- University of Sao Paulo
Depression / Major Depressive Disorder, Depressed Mood
REM Sleep Disruption and Its Potential Uses in Depression Management
This randomized study evaluated whether brief wrist vibrations delivered through an Apple Watch during algorithm-identified rapid eye movement (REM) sleep could reduce depressive symptoms over approximately four weeks.
- Trial name
- NCT07891806
- Testing
- REM-Contingent Smartwatch Haptic Stimulation, Smartwatch Sleep Monitoring and Smart Alarm
- Where
- 2 sites in Romania
- Volunteers
- 208 people
- Sponsor
- WAKEZ HEALTH TECH ECOSYSTEM SRL
Depressive Symptoms, Anxiety Symptoms
Culturally Adapted i-CBT for Farsi/Dari Speaking Migrants
The aim of this randomized controlled trial (RCT) is to investigate the effectiveness of a culturally adapted internet-based cognitive behavioral therapy (i-CBT) intervention in reducing symptoms of common mental health issues…
- Conditions
- Depressive Symptoms, Anxiety Symptoms, Grief, Psychological Trauma
- Trial name
- i-CBT (NCT06828276)
- Testing
- Culturally adapted i-CBT
- Where
- Sweden
- Volunteers
- 128 people
- Sponsor
- Karolinska Institutet
Depressive Disorder, Major
A 7-year Assessment on Subject Understanding of ZYBAN/ WELLBUTRIN Associated Risks
Branded bupropion hydrochloride products including ZYBAN and WELLBUTRIN range are approved for the treatment of smoking cessation and depressive disorders respectively.
- Trial name
- NCT03001440
- Testing
- KAB survey
- Volunteers
- 1 people
- Sponsor
- GlaxoSmithKline
Depressive Symptoms, Anxiety
Transdiagnostic Treatment for Emotional Disorders
Background and study aims Depression is more prevalent in younger populations. The age of first onset of depression has become younger, yet many adolescents with depressive symptoms remain untreated.
- Conditions
- Depressive Symptoms, Anxiety, Emotional Problem
- Trial name
- UP (NCT04498949)
- Testing
- UP, Treatment as usual
- Where
- Afghanistan
- Volunteers
- 170 people
- Sponsor
- Mohamad hasan yousefi
Anxiety-depressive Patients Mild to Moderate
Anxiety-depressive Disorder in Primary Care and Cognitive-behavioral Treatment
OBJECTIVE: Evaluate the effectiveness of quality of life score, a cognitive-behavioral intervention by psychologists in the field of primary care in anxiety-depressive patients, mild to moderate, compared with usual care.
- Trial name
- PSICCAPAD (NCT01907035)
- Testing
- A cognitive-behavioral intervention, Usual care
- Where
- 3 sites in Spain
- Volunteers
- 246 people
- Sponsor
- Basque Health Service
Refractory Major Depressive Disorder
A Long Term Study of ALKS 5461 in the Treatment of Refractory Major Depressive Disorder (MDD)
This study will assess the long-term safety and tolerability of ALKS 5461 as an adjunctive treatment for refractory MDD.
- Trial name
- NCT03610048
- Testing
- ALKS 5461
- Where
- 34 sites in United States, Australia and 1 more
- Volunteers
- 175 people
- Sponsor
- Alkermes, Inc.
Major Depressive Disorder, Cancer
Vortioxetine for Cancer Patients With Depression: An Observational Study
The purpose of this observational antidepressant study is to determine the efficacy of vortioxetine on depression and cognitive function, and elucidate its potential effects on quality of life in patients with cancer (of any…
- Trial name
- NCT04253678
- Testing
- Vortioxetine
- Where
- 8 sites in Malaysia
- Volunteers
- 140 people
- Sponsor
- University of Malaya
Infertility, Female, Distress, Emotional
Mindful Self-Compassion (MSC) for Infertility Related Distress
This study will test a psychological intervention for the treatment of distress related to infertility. The intervention will pair reading a book "The Mindful Self-Compassion Workbook" by Kristin Neff with guided meditations…
- Conditions
- Infertility, Female, Distress, Emotional, Depressive Symptoms, Anxiety
- Trial name
- NCT05183568
- Testing
- Mindful Self-Compassion
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Regina
Alcohol Drinking Related Problems, Alcohol Use Disorders
Co-occurence of Mental Illness and Problematic Alcohol Use: an Internet-based Cognitive Behavior Therapy Intervention
The goal of this clinical trial is to learn if internet-based cognitive behavior therapy (ICBT ) works to treat co-occurent of problematic alcohol use and mental illness including mild to moderate symptoms of either depression…
- Conditions
- Alcohol Drinking Related Problems, Alcohol Use Disorders, Depressive Disorders, Mental Illness
- Trial name
- CoMiT (NCT06789250)
- Testing
- Internet-based cognitive behavior therapy
- Where
- 2 sites in Sweden
- Volunteers
- 240 people
- Sponsor
- Linkoeping University
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