Clinical trials: Depressive; Behavioral Disorder
Depressive Disorder
Psilocybe Cubensis Mushrooms With or Without Fluoxetine for Refractory Depression
This Phase 2a pilot, exploratory, randomized, double-blind, placebo-controlled, parallel-group trial will estimate whether concurrent fluoxetine alters the antidepressant effect, acute psychedelic experience, or safety of a…
- Trial name
- COGUNILA (NCT06898606)
- Testing
- Psilocybin and Psilocyn, Psychotherapy-assisted session, Fluoxetine
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Federal University of Latin American Integration
Depression - Major Depressive Disorder
iPath for CP Pilot
Depression is a significant problem in care partners of people living with dementia; despite the expansion of options for accessing evidence-based treatments, most care partners of people living with dementia are not screened for…
- Trial name
- care partners (NCT07631247)
- Testing
- depression app for care partners of persons with dementia
- Volunteers
- 15 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Depression, Postpartum Depression
Is Vitamin D Insufficiency and Deficiency Associated With Antepartum and Postpartum Depression?
Our primary aim is to evaluate whether Vitamin D deficiency causes depressive symptoms in antepartum and postpartum depression and whether early correction of Vitamin D deficiency improves these symptoms.
- Trial name
- NCT02272387
- Testing
- Vitamin D3 (Cholecalciferol)
- Where
- United States
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Major Depressive Disorder, Persistent Depressive Disorder
Transdiagnostic Psychotherapy for Veterans With Mood and Anxiety Disorders
Cognitive behavioral therapy (CBT) is a brief, efficient, and effective psychotherapy for individuals with depressive and anxiety disorders.
- Conditions
- Major Depressive Disorder, Persistent Depressive Disorder, Posttraumatic Stress Disorder, Panic Disorder
- Trial name
- TBT-RCT (NCT01947647)
- Testing
- Transdiagnostic Behavior Therapy, Behavioral Activation Therapy
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- VA Office of Research and Development
Depression
Effectiveness of Web-based Treatment for Depression in Patients With Neurologic Disorders
200 persons (100 with multiple sclerosis and 100 with epilepsy) with depressive symptoms are recruited via the multiple sclerosis clinics of the University Medical Center Hamburg-Eppendorf and the epilepsy centre Alsterdorf and…
- Trial name
- NCT01663649
- Testing
- Deprexis, Wait-list
- Where
- 2 sites in Germany
- Volunteers
- 180 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Major Depressive Disorder, Post-Traumatic Stress Disorder (PTSD)
PET Imaging of mGLuR5 With Drug Challenge
This study is designed to look at that involvement of a process in the brain called the glutamate system in depression. Participants will undergo a screening session, up to two functional Magnetic Resonance Imaging (fMRI) scans…
- Trial name
- NCT01691092
- Testing
- Ketamine
- Where
- 3 sites in United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Yale University
Constipation - Functional, Depressive Symptoms
FMT Treating Constipation Patients With Depression and/or Anxiety Symptoms - Clinical Efficacy and Potential Mechanisms
Constipated patients often have mental problems such as depression and anxiety due to difficult defecation. Our previous studies have proved the efficacy of FMT treating constipation.
- Conditions
- Constipation - Functional, Depressive Symptoms, Anxiety Symptoms, Gut-Brain Disorders
- Trial name
- NCT03233100
- Testing
- FMT
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Jianfeng Gong
Major Depressive Disorder (MDD), Breast Cancer Survivor
Moving on After Breast Cancer Trial for Depressed Breast Cancer Survivors in Pakistan
Breast cancer is the most common cancer among women worldwide, and many survivors experience comorbid mental health conditions such as depression and anxiety, which can significantly worsen health outcomes and increase mortality.
- Trial name
- Moving On ABC (NCT07015944)
- Testing
- Non-specialist delivered Low intensity guided self-help (Khushi and Khatoon), Moving on After Breast Cancer (ABC) plus, Standardised pharmacological treatment (antidepressants)
- Where
- Pakistan
- Volunteers
- 26,376 people
- Sponsor
- Pakistan Institute of Living and Learning
Major Depressive Episode
Depressive Symptoms and Subjective Stress in the Course of the Menstrual Cycle - an Ambulatory Assessment Study.
Background: Major changes in female sex hormone concentrations influence the development of depressive symptoms in women. This hypothesis has been thoroughly investigated with regard to the menopause, the postpartal phase and…
- Trial name
- DepCy (NCT04086316)
- Where
- Germany
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Freie Universität Berlin
Mental Health, Neurodevelopment
Investigating the Impacts of Early Life Experience on the Brain & Behaviour
The aim of this study is to learn more about how early life experience influences the brain, behaviour, and the immune system later in life.
- Conditions
- Mental Health, Neurodevelopment, ADHD, Autism
- Trial name
- NCT06823492
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Depression, Treatment Resistant Depression
Studying the Health of Asians to Advance Knowledge, Treatments, and Interventions for Depression
SHAKTI (from the Sanskrit word for "power") is a 5-year natural history, longitudinal, prospective study of a cohort of 6,000 participants that will help uncover the socio-demographic, lifestyle, clinical, psychological, and…
- Conditions
- Depression, Treatment Resistant Depression, Mood Disorders, Bipolar Disorder
- Trial name
- SHAKTI (NCT06002204)
- Testing
- Observational Study
- Where
- United States
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Treatment Resistant Depression (TRD), Chronic Pain
Ketamine-Assisted Psychotherapy for Treatment-Resistant Depression
The goal of this clinical trial is to understand the effect of ketamine on the brain in people with treatment-resistant depression (TRD).
- Trial name
- NCT07247006
- Testing
- Ketamine hydrochloride injection
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Rochester
Depressive Disorder, Depression
Magnetic Stimulation Therapy for Treating Vascular Depression
This 12-week study will evaluate the effectiveness of repetitive transcranial magnetic stimulation (rTMS) of the brain, followed by citalopram (Celexa®), for treatment of depression associated with small vascular lesions in the…
- Trial name
- rtms (NCT00044798)
- Testing
- Repetitive transcranial magnetic stimulation (rTMS), Citalopram
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- University of Iowa
Depression, Treatment Resistant Depression
Investigational TMS Treatment for Depression
This study is aimed to help us learn about the effects of Transcranial Magnetic Stimulation at the forehead versus the left side of the head for treatment of Treatment Resistant Depression.
- Trial name
- NCT03175887
- Testing
- TMS
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- White River Junction Veterans Affairs Medical Center
End Stage Renal Disease
The Routine Use of SSRI's at the Initiation of End-stage Renal Disease Treatment (RoSIE)
In this study the investigators hypothesize that antidepressant therapy may improve the overall welling of patients with acute or chronic kidney disease when given around the time of starting chronic dialysis therapy.
- Trial name
- RoSIE (NCT02407821)
- Testing
- Escitalopram
- Where
- 3 sites in Canada
- Volunteers
- 25 people
- Sponsor
- University Health Network, Toronto
Major Depressive Disorder
African American Depression Intervention Trial (AADI)
Primary Aim 1: Examine effectiveness of the Oh Happy Day Class (OHDC) compared to the Coping With Depression (CWD)in increasing retention, adherence, engagement, satisfaction, and treatment-seeking.
- Trial name
- AADI (NCT01342536)
- Testing
- Coping with Depression Course (CWD) and Oh Happy Day Class (OHDC)
- Where
- 2 sites in United States
- Volunteers
- 160 people
- Sponsor
- University of Wisconsin, Madison
Major Depressive Disorder
Neuroimaging Studies of Reward Processing in Depression
This study investigates stress-related signaling of glutamate and dopamine within the reward-processing circuit in Major Depressive Disorder (MDD), and whether they can be used to predict depressive symptoms in the future.
- Trial name
- NCT03026036
- Testing
- PET Scan with Raclopride
- Where
- United States
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Depression - Major Depressive Disorder
Integrating Digital Phenotypes and AI-Driven Cognitive-Behavioral Therapy: Advancing Precision Medicine in Depression Through Digital Medicine
This project aims to integrate digital phenotyping and AI-driven iCBT into a comprehensive platform for MDD diagnosis and treatment in Taiwan.
- Trial name
- NCT07500714
- Testing
- Internet Cognitive-Behavioral Therapy
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Science and Technology Council, Taiwan
Depressive Symptoms, Remited Major Depressive Disorder
Cognitive Control Emotion Training to Prevent Major Depression in Youth At-Risk
The goal of this clinical trial is to learn if intervention of positive emotion working memory (PEWM), or negative emotion working memory (NEWM), or positive attention bias training (PABT) can prevent major depressive disorder…
- Trial name
- CTE 2019 (NCT04346784)
- Testing
- positive emotion working memory(PEWM) training, negative emtion working memory(NEWM) training, PABT
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Hunan Normal University
Depressive Disorder, Major Depressive Disorder, Healthy Volunteer
Exploring the Role of the Prefrontal Cortex in Decision-Making
The goal of this study is to examine whether high-definition transcranial direct current stimulation (HD-tDCS) can influence decision-making for emotionally valenced content in younger and older adults, with or without major…
- Conditions
- Depressive Disorder, Major Depressive Disorder, Healthy Volunteer, Aging
- Trial name
- NCT07080489
- Testing
- Active high-definition transcranial direct current stimulation (HD-tDCS) - anodal F3/F4, Active high-definition transcranial direct current stimulation (HD-tDCS) - anodal F3/ kathodal F4
- Where
- Switzerland
- Volunteers
- 444 people, healthy volunteers welcome
- Sponsor
- University of Bern
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