Clinical trials: Depressive; Behavioral Disorder
Major Depressive Disorder
Flexible Dose Titration Add-on Study to Treat Major Depressive Disorder
Depressed patients will receive 6 weeks of citaloprma (20-40mg) therapy. Subjects who have an inadequate response (partial or non-responder) will be randomized to receive either mecamylamine (5-10mg) or placebo added to their…
- Trial name
- NCT00593879
- Testing
- Mecamylamine
- Volunteers
- 450 people
- Sponsor
- Targacept Inc.
Systemic Lupus Erythematosus
Telehealth CBT for Adolescents and Young Adults With Childhood-onset Systemic Lupus Erythematosus
This study aims to investigate the feasibility and effectiveness of a remotely delivered psychological intervention for youth with cSLE.
- Trial name
- cSLE (NCT04335643)
- Testing
- TEACH
- Where
- 2 sites in United States, Canada
- Volunteers
- 65 people
- Sponsor
- Michigan State University
Depression, End Stage Renal Disease
A Trial of Sertraline vs. CBT for End-stage Renal Disease Patients With Depression {ASCEND}
Patients whose kidneys fail generally require dialysis treatments to sustain life. The ability of patients to make major adjustments in their lives for dialysis is hampered by depression that affects almost one-quarter of such…
- Trial name
- ASCEND (NCT02358343)
- Testing
- Engagement Interview, Cognitive Behavioral Therapy, Antidepressant Drug Therapy
- Where
- 3 sites in United States
- Volunteers
- 184 people
- Sponsor
- University of Washington
Depression
Repetitive Transcranial Magnetic Stimulation Compared or Associated With Venlafaxine for Depressive Disorder
The purpose of this study is to treat participants with a diagnosis of depressive disorder to assess the efficacy of repetitive Transcranial Magnetic Stimulation (rTMS) and venlafaxine in the treatment of depressive disorders…
- Trial name
- NCT01370304
- Testing
- active rTMS and active Venlafaxine
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital
Cancer-related Problem/Condition, Depressive Symptoms
Ketamine-Assisted PsychoTherapy ViAbility in Treating Cancer-related Emotional Distress
The present study will investigate if ketamine-assisted psychotherapy during palliative radiation therapy is safe, feasible, and effective at reducing psychological distress.
- Conditions
- Cancer-related Problem/Condition, Depressive Symptoms, Anxiety Disorders
- Trial name
- KAPTIVATED (NCT05344625)
- Testing
- Ketamine 100 MG/ML
- Sponsor
- Northwell Health
Cigarette Smoking, Schizophrenia
Integrated Smoking Cessation Treatment for Smokers With Serious Mental Illness
The overall aim of this study is to test the effect of academic detailing (i.e. provider-level educational intervention focused on evidence-based smoking cessation treatment for those with psychiatric illness) and community…
- Conditions
- Cigarette Smoking, Schizophrenia, Bipolar Disorder, Depressive Disorder, Major
- Trial name
- NCT02845440
- Testing
- Academic Detailing, Community Health Worker, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 1,165 people
- Sponsor
- Massachusetts General Hospital
Treatment-resistant Depression
Action of Ketamine in Treatment-Resistant Depression
Depression carries the largest burden of all medical disorders in middle to high income countries, as determined by the World Health Organization.
- Trial name
- NCT01945047
- Testing
- Ketamine, Midazolam
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- University of Ottawa
Major Depressive Disorder
Phase IV:Safety and Efficacy of EMSAM in Adolescents With Major Depression
The primary purpose of your participation in this study is to help answer the following research question: Whether 12-week administration of EMSAM (selegiline transdermal system) is safe and effective for the treatment of…
- Trial name
- NCT00531947
- Testing
- Selegiline Transdermal System
- Where
- 20 sites in United States
- Volunteers
- 308 people
- Sponsor
- Somerset Pharmaceuticals
Major Depressive Disorder
Neural Components Underlying the Treatment of Adolescent Depression
The goal of the study is to examine how cognitive behavioral therapy (CBT), a common treatment for adolescent depression, affects brain functioning.
- Trial name
- NCT01717508
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Microbial Colonization
Comparing Impacts of Donor Human Milk to Formula Supplementation on the Gut Microbiome of Full-term Infants
The goal of this pilot randomized controlled trial (RCT) is to examine donor human milk (DHM) as a clinical intervention targeted at achieving beneficial microbiome signatures in full-term infants who are exposed to intrapartum…
- Trial name
- PPDHM (NCT05815433)
- Testing
- Donor Human Milk - Nutritional Replacement
- Where
- Canada
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Stress, Anxiety
Comparing the Effects of Mindfulness-Based and Cognitive Behavioral-Based Stress Reduction in Medical Students
We aimed to compare the effects of the Mindfulness-Based Stress Reduction (MBSR) and the Cognitive Behavioural Stress Reduction (CBSR) group interventions on depression and anxiety symptoms and perceived stress of medical…
- Conditions
- Stress, Anxiety, Depressive Symptoms
- Trial name
- NCT06156852
- Testing
- Mindfulness-based stress reduction group, Cognitive behavioral-based stress reduction group
- Where
- Turkey (Türkiye)
- Volunteers
- 253 people, healthy volunteers welcome
- Sponsor
- Gazi University
Major Depressive Disorder, Childhood Trauma
RESET-medication Glucocorticoid Receptor (GR) Blockade As Disease Modifying Treatment for Depression with Childhood Trauma
Depression is a recurrent debilitating psychiatric disorder with a lifetime prevalence of 20%. Even though antidepressants and psychotherapy are often effective, a substantial proportion of patients does not respond to currently…
- Trial name
- RESET-m (NCT05217758)
- Testing
- Mifepristone
- Where
- Netherlands
- Volunteers
- 158 people
- Sponsor
- Amsterdam UMC, location VUmc
Anesthesia, Analgesia
The Efficacy and Safety of S-ketamine in Elective Cesarean Section
During the past years, a large number of clinical trials have investigated the use of the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist racemic ketamine as an adjunct to local anaesthetics, opioids, or other…
- Conditions
- Anesthesia, Analgesia, Depression, Cesarean Section
- Trial name
- ES-CS (NCT04657107)
- Testing
- S-ketamine, normal saline
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- Beijing Obstetrics and Gynecology Hospital
Traumatic Brain Injury, Concussion, Mild
fMRI-neuronavigated rTMS Treatment for Symptoms of Depression Associated With Concussive TBI in the Military Population
This study aims to investigate the efficacy and tolerability of fMRI-targeted repetitive transcranial magnetic stimulation (rTMS) in the treatment of depressive symptoms in service members with a history of concussive traumatic…
- Conditions
- Traumatic Brain Injury, Concussion, Mild, Depressive Symptoms
- Trial name
- NCT03523507
- Testing
- Active: rTMS
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Depressive Disorder, Anxiety
An Efficacy, Safety and Tolerability Study of JNJ-42165279 in Participants With Major Depressive Disorder With Anxious Distress
The purpose of this study is to evaluate the efficacy and safety and tolerability of JNJ-42165279 in participants with major depressive disorder (MDD) with anxiety symptoms who have had inadequate response to treatment with a…
- Trial name
- NCT02498392
- Testing
- JNJ-42165279
- Where
- 32 sites in United States, Moldova and 4 more
- Volunteers
- 161 people
- Sponsor
- Janssen Research & Development, LLC
Depressive Disorder, Major
Major Depressive Disorder: Early Prediction of Non-response to Antidepressant Therapy Via a Mobile Digital Scale
Major Depressive Disorder (MDD) is a debilitating disease characterized by a depressed mood, diminished interests, impaired cognitive function and vegetative symptoms, such as disturbed sleep or appetite.
- Trial name
- REDRESS (NCT03872492)
- Testing
- Digital Assessment on mobile
- Where
- 10 sites in France
- Volunteers
- 92 people
- Sponsor
- Ad scientiam
Depression
Sertraline for the Prevention of Recurrent Postpartum Depression
This study will determine the effectiveness of taking sertraline within 24 hours of giving birth in preventing a recurrence of postpartum depression.
- Trial name
- NCT00276900
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Depression
A Safety and Efficacy Study of JNJ26489112 in Patients With Treatment-Resistant Major Depressive Disorder
The purpose of this study is to evaluate the effectiveness and safety of JNJ26489112 compared with an active control (Venlafaxine XR) and placebo in patients with Treatment-Resistant Major Depressive Disorder.
- Trial name
- NCT01114698
- Testing
- Venlafaxine XR, JNJ26489112
- Where
- 14 sites in United States
- Volunteers
- 12 people
- Sponsor
- Janssen Research & Development, LLC
Condition: Major Depressive Disorder (MDD)
The Modulatory Role of Communicated Treatment Rationale on Treatment Expectation Effects in Depression.
Placebo groups in clinical trials on depression show impressive improvements. Yet, there is little research on the mechanism underlying this effect.
- Trial name
- NCT04719663
- Testing
- Biological illness and treatment rationale, Psychological illness and treatment rationale
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Philipps University Marburg
Breast Feeding, Parenting
Doula Home Visiting Randomized Trial
The purpose of this randomized controlled trial is to examine whether evidence-based home visiting programs enhanced by doula services have effects on positive parenting practices, breastfeeding, and child and maternal health…
- Conditions
- Breast Feeding, Parenting, Child Development, Depression, Postpartum
- Trial name
- NCT01947244
- Testing
- Doula Home Visiting, Case management
- Volunteers
- 312 people
- Sponsor
- University of Chicago
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