Clinical trials: Depressive; Behavioral Disorder
Depressive Disorder
A 24-52-week Study to Evaluate the Long-term Efficacy and Safety of Saredutant in Patients With Depression (MAGENTA)
The purpose of the study is to evaluate the long-term efficacy and safety of Saredutant in patients with depression. The primary objective is to evaluate the efficacy and safety of Saredutant 100 mg once daily compared to placebo…
- Trial name
- NCT00336713
- Testing
- Saredutant (SR48968C)
- Where
- United States
- Volunteers
- 430 people
- Sponsor
- Sanofi
Depression, Depressive Disorder
Effects of Therapist Behavior on the Treatment of Depressed Adolescents
The purpose of this study is to identify and evaluate therapist behaviors that affect how well and how long adolescent patients stay in treatment for depression.
- Conditions
- Depression, Depressive Disorder, Dysthymic Disorder
- Trial name
- NCT00073359
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Denver
Treatment-Resistant Depression
Focal Electrically Administered Seizure Therapy for the Treatment of Depression
The purpose of this study is to determine the efficacy and any possible side effects of focal electrically administered seizure therapy (FEAST) as a treatment intervention for patients with recurrent and treatment resistant…
- Trial name
- FEAST (NCT02462551)
- Testing
- Focal Electrically Administered Seizure Therapy
- Where
- Lebanon
- Volunteers
- 30 people
- Sponsor
- Ziad Nahas
Post Traumatic Stress Disorder (PTSD), Depressive Symptoms
The Norwegian Stepped-Care TF-CBT Study
Every day, a significant number of children and young people in Norway experience violence, abuse, or other potentially traumatizing events.
- Conditions
- Post Traumatic Stress Disorder (PTSD), Depressive Symptoms, Parental Stress, Health Related Quality of Life
- Trial name
- NCT04073862
- Testing
- Stepped-Care TF-CBT
- Where
- Norway
- Volunteers
- 82 people
- Sponsor
- Norwegian Center for Violence and Traumatic Stress Studies
Postpartum Depression (PPD), Pregnancy
A Study of a Test for Postpartum Depression at Home
The study will seek to prospectively validate the Enlighten Device for prediction of PPD by examining true/false positive and negative rates of the test using PPD outcomes collected through 3 months postpartum; compare the…
- Trial name
- BRAVE (NCT07186309)
- Testing
- Diagnostic Test: Enlighten
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Major Depressive Disorder, Bipolar, Depression
Jump Step - A Participatory Approach to Physical Activity & Mental Wellness
The WHO, the Pan American Health Organization, the EU Council of Ministers, the World Federation of Mental Health, and the UK Royal College of Psychiatrists all agree -"there can be no health without mental health".
- Trial name
- JumpStep (NCT02549547)
- Testing
- Group Medical Visits
- Where
- 3 sites in Canada
- Volunteers
- 80 people
- Sponsor
- University of British Columbia
Depressive Symptoms, Mental Health Wellness 1
Mindfulness and Intercare Based Intervention for Medicine Students (MIIM)
The effects of Coronavirus Disease (COVID-19) pandemic on health, economy and social network has an impact on mental health, specially students.
- Conditions
- Depressive Symptoms, Mental Health Wellness 1, Anxiety
- Trial name
- MIIM (NCT05011955)
- Testing
- Mindfulness, compassion and intercare based Intervention, Psychoeducational based intervention, General curricular intervention
- Where
- Chile
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University Diego Portales
Major Depressive Disorder
Rise Study for Depression
This study will examine the efficacy of digital CBT versus waitlist in improving symptoms for adults with Major Depressive Disorder.
- Trial name
- NCT06003361
- Testing
- Digital CBT, Waitlist
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Big Health Inc.
Major Depressive Disorder
Behavioral Activation for Depression and Habitual Rumination
Depressive rumination, a negative thinking style characterized by repetitive and passive thoughts about the causes, meanings, and consequences of one's feelings and distress, is often described as being a habitual response…
- Trial name
- MoodHab (NCT06322420)
- Testing
- Behavioural Activation (BA)
- Where
- Iceland
- Volunteers
- 120 people
- Sponsor
- University of Iceland
Major Depressive Disorder, Menopausal Staging and Vasomotor Symptoms (for Females)
Desvenlafaxine Succinate (DVS) for Major Depressive Disorder (MDD) in Midlife Men and Women
The main objective of this study is to characterize a range of brain activation symptoms associated with depression and response to treatment in midlife men and women with MDD, using MRI and functional MRI.
- Trial name
- DVS (NCT00888862)
- Testing
- Desvenlafaxine Succinate
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Depression, Bipolar, Depression, Unipolar
The Effect of S-ketamine for Patients Undergoing Electroconvulsive Therapy (ECT)
This study will determine the effectiveness and safety of S-Ketamine in depression patients undergoing electroconvulsive therapy.
- Conditions
- Depression, Bipolar, Depression, Unipolar, Major Depressive Disorder, Manic-Depressive - Now Depressed
- Trial name
- ECT (NCT04399070)
- Testing
- S-ketamine, ketamine, saline
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Yan Qiu
Cognitive Decline, Dementia
Group Reminiscence Therapy for Elderly People With Cognitive Decline in Institutional Context
The project presented here respond to this emerging need by implementing a Reminiscence Therapy program dedicated to elderly people in an institutional context.
- Conditions
- Cognitive Decline, Dementia, Cognitive Impairment
- Trial name
- NCT03370796
- Testing
- Reminiscence Therapy Program
- Where
- Portugal
- Volunteers
- 50 people
- Sponsor
- Escola Superior de Enfermagem de Coimbra
Treatment-Resistant Depression
Functional and Neurochemical Correlates of Treatment Response in Major Depressive Disorder
This is an ancillary study to a clinical trial that is being conducted at Massachusetts General Hospital. Investigators at MGH are conducting a clinical trial to test the efficacy of ziprasidone together with escitalopram for…
- Trial name
- NCT01598324
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mclean Hospital
Depression, Major Depressive Disorder
Stress Generation and Recurrent Depression: The Role of Differential Treatment Response
Depression affects over one million people in Canada, resulting in $14.4 billion per year in costs to Canadian society. In order to prevent this often lifelong disorder, it is critically important to identify risk factors for the…
- Trial name
- NCT00745017
- Testing
- Cognitive Behavioral Therapy, Interpersonal Therapy, Antidepressant medication
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- Centre for Addiction and Mental Health
Depression, Anxiety, Healthy
Integrins and Protocadherins in Glutamatergic Circuits: Identification of Common Signaling Pathways and Molecular Targets in Anxiety and Major Depressive Disorders (GAPsy)
The aim of this study is to identify biologically viable targets for the treatment of major depressive disorder (MDD) and anxiety disorder (AD) with the ultimate goal of guiding physicians' therapeutic strategies and identifying…
- Trial name
- GAPsy (NCT06167590)
- Testing
- GAPsy protocol
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Depression
B Vitamins in MTHFR Positive Patients With Major Depression: A Post Hoc Analysis of Findings
A randomized double-blind placebo controlled study of reduced B vitamins in patients with major depression who were positive for one or both of the common MTHFR polymorphisms was conducted between 8/1/2014 and 4/3/2015.
- Trial name
- BVMD (NCT02709668)
- Testing
- Enlyte
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- High Point Regional Health Systems
Osteoarthritis, Knee, Depressive Symptoms
Study on Brain Structure and Function of Pain-related Emotion Disorder
By the method of multi-mode Magnetic Resonance Imaging, 5 patients with knee osteoarthritis are selected in this trial to observe the possible differences in the brain structure and function from the 5 healthy volunteers.
- Conditions
- Osteoarthritis, Knee, Depressive Symptoms, Anxiety State
- Trial name
- NCT03912610
- Testing
- Functional magnetic resonance examination
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Zhoujie
Psoriasis, Depressive Symptoms
Smart Phone Delivered Cognitive Behavioral Therapy for Adults With Psoriasis and Co-Morbid Depression Symptoms
A single arm, pilot study in which all eligible participants will be enrolled in an 8-week coach-guided smartphone delivered CBT program. The full duration of the program, with follow-up interview, will be 9 weeks.
- Trial name
- NCT06216691
- Testing
- Coach-guided smartphone delivered CBT program.
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Brigham and Women's Hospital
Major Depressive Disorder
Mechanisms of Emotion Regulation Underlying Successful CBT in Depression
This research aims to elucidate mechanisms through which change occurs during cognitive behavior therapy (CBT) for depression. Assessing meta-cognitive processes of self-knowledge (top-down), electrophysiological and behavioral…
- Trial name
- NCT04328103
- Testing
- Cognitive Behavior Therapy (CBT), Nonspecific Supportive Therapy (PBO)
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- New York State Psychiatric Institute
Seasonal Affective Disorder (SAD), Winter Depression
Cognitive-behavioral Therapy vs. Light Therapy for Preventing SAD Recurrence
Major depression is a highly prevalent, chronic, and debilitating mental health problem with significant social cost that poses a tremendous economic burden.
- Conditions
- Seasonal Affective Disorder (SAD), Winter Depression, Major Depressive Disorder, Recurrent, With Seasonal Pattern
- Trial name
- NCT01714050
- Testing
- Cognitive-Behavioral Therapy (CBT), Light Therapy (LT)
- Where
- United States
- Volunteers
- 177 people
- Sponsor
- University of Vermont
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