Clinical trials: Depressive; Behavioral Disorder
Major Depressive Disorder, Alcohol Use Disorder
Naltrexone Plus Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use Disorder
To evaluate if naltrexone plus ketamine is effective in reducing depression and alcohol consumption.
- Trial name
- NCT03658330
- Testing
- Ketamine + Naltrexone
- Volunteers
- 5 people
- Sponsor
- VA Connecticut Healthcare System
Depressive Symptoms, Anxiety Disorders and Symptoms
Pregnancy Without Psychosocial Stress
The project is aimed at children who are exposed to the toxic psychosocial stress present in their mothers during pregnancy or after childbirth.
- Conditions
- Depressive Symptoms, Anxiety Disorders and Symptoms, Depression, Postpartum
- Trial name
- NCT04853693
- Testing
- Mom´s Supporting Mom, Enhanced Treatment As Usual
- Where
- Czechia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health, Czech Republic
Anxiety Disorders, Depressive Disorder
Brief Transdiagnostic Group CBT for Adolescents With Internalizing Problems: A Randomized Waitlist Controlled Trial
The investigators will evaluate a brief group-based cognitive-behavioral treatment program for adolescents aged 13-17 years with internalizing problems.
- Conditions
- Anxiety Disorders, Depressive Disorder, Anxiety, Depression
- Trial name
- NCT04716777
- Testing
- Brief Transdiagnostic group-based Cognitive-Behavioral Treatment
- Where
- Iceland
- Volunteers
- 50 people
- Sponsor
- University of Iceland
Anxiety Disorders, Depressive Disorders
Virtual Reality-Based Psychotherapeutic and Psychoeducational Intervention for Anxiety and Depression in Children, Adolescents, and Adults
This study is designed as a non-pharmacological, interventional clinical research project to evaluate the feasibility, safety, and implementation of virtual reality (VR)-based psychoeducational and psychotherapeutic interventions…
- Trial name
- VR-PAD (NCT07250971)
- Testing
- Virtual Reality-Based Psychotherapeutic Program
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul Aydın University
Major Depressive Disorder, Bipolar Disorder
The Role of Dopamine Metabolism in the Antidepressant Effects of Sleep Deprivation and Sertraline in Depressed Patients
This study evaluates the efficacy of sleep deprivation treatment in accelerating antidepressant responses when administered during the first week of medications and augmenting a sustained response with chronobiological…
- Trial name
- NCT00581009
- Testing
- chronobiological augmentation, sertraline, lithium, one night of sleep deprivation and two FDG PET scans
- Where
- 2 sites in United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Major Depressive Disorder, Anxiety Disorders
Sensitivity of Short and Long Allele Carriers of the 5-HTTLPR to Environmental Threat Post Hydrocortisone Administration
The current study will test the causal relationship between elevated levels of cortisol and the serotonin transporter gene (5-HTTLPR) as these factors influence sensitivity to environmental threat.
- Trial name
- 5-HTTLPR (NCT01710202)
- Testing
- Hydrocortisone
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Depression; Major Depressive Disorder
Sleep/Wake Cycle and Depression: An Imaging and Treatment Study
16.2 million American adults are affected by depression each year. The investigators are studying the relationship between sleep/wake cycle and depression.
- Trial name
- NCT04350567
- Testing
- Sleep Deprivation
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Major Depression
Long-term Bilateral Theta Burst Stimulation for the Treatment of Major Depression
Repetitive transcranial magnetic stimulation has been shown to be moderately effective in the treatment of major depression. Theta burst stimulation (TBS) is a new form of rTMS that may exert larger effects.
- Trial name
- TheBuS_D (NCT01153139)
- Testing
- Repetitive Transcranial Magnetic Stimulation (Theta Burst Stimulation, TBS)
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- University Hospital Tuebingen
Major Depressive Disorder
Evaluation of the Safety and Pharmacokinetics of MSI-195 to a Commercial S-Adenosylmethionine
This study was a pharmacokinetic and safety evaluation of the S-adenosylmethionine formulation MSI-195, and a commercial comparator. The study was broken into two stages.
- Trial name
- NCT04623034
- Testing
- Ademetionine
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- MSI Methylation Sciences, Inc.
Depression / Major Depressive Disorder, Conduct Disorders in Children
Optimizing Treatment for Depressed Parents of Children With Emotional and Behavioural Problems
Standard Behavioral Parent Training (BPT) is often less effective for parents experiencing depression. As such, the Addressing Depression and Positive Parenting Techniques (ADAPT) intervention is a novel BPT tailored to address…
- Conditions
- Depression / Major Depressive Disorder, Conduct Disorders in Children, Disruptive Behaviour in Children, Parenting Intervention
- Trial name
- OPTED (NCT07749521)
- Testing
- ADAPT Treatment, Incredible Years Parenting Program (IYPP)
- Where
- Canada
- Volunteers
- 180 people
- Sponsor
- University of Toronto
Obesity, Food Habits
Intervention for Women in Costa Rica
The study develops, implements, and evaluates an intervention focused on alleviating discouragement, food insecurity, and excess weight in women,targeted at the individual, family, and community levels in the Canton Central of…
- Conditions
- Obesity, Food Habits, Mental Depression
- Trial name
- NCT03492619
- Testing
- Intensive Intervention, Non-Intensive Intervention
- Where
- Costa Rica
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
PTSD, Depressive Symptoms
Studying the Effectiveness and Implementation of Sudarshan Kriya Yoga for Canadian Veterans With PTSD
We plan to study the reach, effectiveness, adoption, implementation, and maintenance of the virtually-delivered Sudarshan Kriya Yoga (v-SKY) intervention.
- Conditions
- PTSD, Depressive Symptoms, Anxiety, Pain
- Trial name
- NCT05235828
- Testing
- Sudarshan Kriya Yoga (SKY)
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Mount Sinai Hospital, Canada
Depression
Ethnic Variations in Antidepressant Response
This 11-week study aims to determine how genetic factors affect the way African Americans and Caucasians with major depression respond to antidepressant medication [citalopram (Celexa®)].
- Trial name
- NCT00047671
- Testing
- Citalopram
- Where
- 3 sites in United States
- Volunteers
- 400 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depression, Major Depression
Study of the Effectiveness of Vestibular Stimulation as a Coadjuvant Treatment in Major Depression
Major depression is characterized by vestibular anomalies. The investigators hypothesized that vestibular stimulation will improve depression symptoms in major depression patients.
- Conditions
- Depression, Major Depression, Vestibular Disorders
- Trial name
- NCT01399671
- Testing
- vestibular stimulation
- Where
- Chile
- Volunteers
- 80 people
- Sponsor
- Fuerza Aérea de Chile
Depressive Symptoms in Patients With Epilepsy
Efficacy of taVNS Versus Sham Stimulation in Reduing Depressive Symptoms in Patients With Epilepsy: a Multi-center, Double-blinded, Randomized, 20-week, Parallel-arm, Superiority Study
The purpose of this study is to compare the efficacy of taVNS versus sham stimulation in reduing depressive symptoms in patients with epilepsy.
- Trial name
- TIDES (NCT06794034)
- Testing
- Intervention
- Where
- 5 sites in China
- Volunteers
- 158 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Major Depressive Disorder, Bipolar Depression
Electro-Magnetic Convulsive Therapies for Depression: a Non-inferiority Study
This study aims to compare the efficacy and safety profile of Magnetic Seizure Therapy and Electroconvulsive therapy.
- Trial name
- EMCODE (NCT05054699)
- Testing
- Magnetic Seizure Therapy, Electroconvulsive Therapy
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- University of Sao Paulo
Cancer, Anxiety
My Wellbeing Guide: A Novel Tool for Managing Stress and Improving Quality of Life
The purpose of this study is to examine the implementation and effectiveness of the psychosocial eHealth intervention, My Wellbeing Guide, on the proposed primary outcome, depressive symptoms, in patients diagnosed with cancer…
- Conditions
- Cancer, Anxiety, Depressive Symptoms
- Trial name
- R37 (NCT05369429)
- Testing
- My Wellbeing Guide
- Where
- United States
- Volunteers
- 6,516 people
- Sponsor
- Northwestern University
Post Traumatic Stress Disorder (PTSD), Anxiety
COVID-Impact "Psychological IMPACT of Covid-19 on AP-HP Staff"
The epidemic of coronavirus induces a major influx of patients implying a rapid modification of the organizations, a work overload and a significant stress for the care teams and supports of the hospitals of the Assistance…
- Conditions
- Post Traumatic Stress Disorder (PTSD), Anxiety, Depression, Epidemic Disease
- Trial name
- Covid-Impact (NCT04558437)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 20,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Depressive Symptoms, Mild Traumatic Brain Injury
rTMS for Military TBI-related Depression
The purpose of this study is to investigate the efficacy, safety, and tolerability of two dorsolateral prefrontal cortex (DLPFC) repetitive transcranial magnetic stimulation (rTMS) protocols to alleviate symptoms of depression in…
- Conditions
- Depressive Symptoms, Mild Traumatic Brain Injury, Concussion
- Trial name
- ADEPT (NCT05426967)
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- 3 sites in United States
- Volunteers
- 198 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Depression Moderate, Depression Mild
A Pilot Study Comparing the Efficacy of Traditional Buddhist Mindfulness Training Versus Secular Mindfulness-based Cognitive Therapy for Patients Having Residual Depressive Symptoms
This interventional study is conducted with the goal of comparing the efficacy of traditional Buddhist mindfulness training versus secular mindfulness based cognitive therapy among patients with depressive disorders.
- Trial name
- NCT06456931
- Testing
- Traditional Buddhist mindfulness, secular mindfulness based cognitive therapy
- Where
- Sri Lanka
- Volunteers
- 60 people
- Sponsor
- Anuradha Baminiwatta
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