Clinical trials: Depressive; Behavioral Disorder
Low Mood, Depressive Symptoms
The Effects of Bifidobacterium Longum 1714® in a Population With Low Mood
A randomised, double-blind, placebo-controlled clinical trial to evaluate the effect of 8 weeks of supplementation with Bifidobacterium longum 1714® strain on Beck's Depression Inventory-II Score in adults who experience low mood.
- Trial name
- NCT04925440
- Testing
- Bifidobacterium longum 1714® strain
- Where
- Ireland
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- PrecisionBiotics Group Ltd.
Postpartum Depression
The Effects of Motherly on Postpartum Depression
Investigators will be test the efficacy of Motherly, a smartphone application (app) to treat depression in women with postpartum Depression.
- Trial name
- NCT05055674
- Testing
- Motherly app, COMVC app
- Volunteers
- 264 people
- Sponsor
- University of Sao Paulo
Depression, Depressive Disorder
Near-infrared Transcranial Laser Therapy in Subjects With Major Depressive Disorder
Major depressive disorder (MDD) is a leading cause of disability worldwide, and many patients do not achieve adequate benefit from current treatments.
- Conditions
- Depression, Depressive Disorder, Depressive Disorder, Major
- Trial name
- ELATED-4 (NCT06934135)
- Testing
- Bilateral Near-Infrared Transcranial Photobiomodulation (tPBM)
- Where
- 2 sites in Peru
- Volunteers
- 50 people
- Sponsor
- NeuroThera DE
Post Traumatic Stress Disorder, Major Depressive Disorder
Accelerated TMS to a Novel Brain Target in MDD and PTSD
This is a Clinical Trial designed to evaluate novel transcranial magnetic stimulation (TMS) methods for treating depression/PTSD. TMS is an FDA-approved procedure for treatment-resistant depression.
- Trial name
- NCT03114891
- Testing
- Transcranial Magnetic Stimulation (TMS), Task, fMRI-guided TMS target
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pennsylvania
Major Depressive Disorder in Patients Taking PrEP
Mental Health and PreP
According to ANSM, by June 2023, almost 85,000 people living in France had initiated medical monitoring for HIV PrEP since 2016.
- Trial name
- SAM-P (NCT06944691)
- Testing
- Major depressive disorder scale
- Volunteers
- 600 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Depressive Disorder
Study of the Antidepressant Efficacy of a Combination Herbal Drug Preparation (NEURAPAS Balance)
The efficacy and tolerability of Neurapas® balance was compared against placebo in this single-centre, controlled, double-blind study in patients with a mild depressive episode.
- Trial name
- NCT00997490
- Testing
- Neurapas® balance (Herbal combination out of hypericum, valerian, passionflower), film-coated sugar-pill
- Where
- Germany
- Volunteers
- 67 people
- Sponsor
- Pascoe Pharmazeutische Praeparate GmbH
Post Partum Depression
Sensing Technologies for Maternal Depression Treatment in Low-Resource Settings
In certain low- and middle- income country settings, there is a disproportionate level of untreated postpartum depression that presents both acute and long-term risks to a mother's well-being.
- Trial name
- StandStrong (NCT06253676)
- Testing
- Problem Management Plus (PM+)
- Where
- Nepal
- Volunteers
- 121 people
- Sponsor
- George Washington University
Colorectal Cancer Patients and Their Partners
Sexual Dysfunction and the Quality of Sexual Life in Patients With Colorectal Cancer and Their Partners.
In this project the main focus is on assessing sexual functioning and the quality of sexual life after the treatment of colorectal cancer in patients and their partners.
- Trial name
- NCT01234246
- Where
- 4 sites in Netherlands
- Volunteers
- 1,371 people
- Sponsor
- Tilburg University
Cancer Diagnosis, Non-Metastatic Neoplasm
PRISM for Depression and Anxiety in Young Adults With Cancer
This research study is being done to test the feasibility of an existing supportive program (PRISM) to address psychological symptoms (i.e., depressive and anxiety symptoms) that young adult participants diagnosed with cancer or…
- Conditions
- Cancer Diagnosis, Non-Metastatic Neoplasm, Anxiety, Anxiety Disorders
- Trial name
- PRISM (NCT06502483)
- Testing
- Promoting Resilience in Stress Management Program
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Dana-Farber Cancer Institute
Depression
Evaluating the Effectiveness of Escitalopram to Prevent Depression in Head and Neck Cancer Patients Receiving Treatment
This study will evaluate the effectiveness of escitalopram to prevent depression in head and neck cancer patients receiving treatment.
- Trial name
- PROTECT (NCT00536172)
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- University of Nebraska
Depression, Executive Dysfunction
The Antidepressant Effect of Intermittent Theta Burst Stimulation (iTBS)
The present study is a randomized placebo-controlled trial examining the effect of intermittent theta burst stimulation (iTBS) on unipolar depression. iTBS is a form of transcranial magnet stimulation.
- Trial name
- NCT05516095
- Testing
- Transcranial magnet stimulation
- Where
- Norway
- Volunteers
- 73 people
- Sponsor
- University Hospital of North Norway
Stress, Physiological, Stress, Psychological
Autonomic Modulation Training for Police Exposed to Post-Traumatic Stress Injuries
Police officers are exposed to hazardous, disturbing events that impose stress and long-term trauma. Upwards of 15-26% of public safety personnel (PSP) report one or more mental health symptoms.
- Trial name
- AMT (NCT05521360)
- Testing
- Autonomic Modulation Training
- Where
- Canada
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Depression, Depression, Postpartum
Clinician Managed Interpersonal Psychotherapy
This 12-week study will evaluate the effectiveness of Clinician-Managed Interpersonal Psychotherapy (CM-IPT) in treating postpartum depression and will compare CM-IPT to standard IPT.
- Trial name
- NCT00043602
- Testing
- Standard interpersonal psychotherapy (IPT), Clinician managed interpersonal psychotherapy (CM-IPT)
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Depressive Symptoms
Group- Versus Individual-Mindfulness-Based Cognitive Therapy: a Randomized Trial
The purpose of this study is to determine whether both group and individual mindfulness-based cognitive therapy (MBCT) are effective in reducing depressive symptoms in patients with a chronic somatic disease.
- Trial name
- G/I-MBCT (NCT02314390)
- Testing
- Group-Mindfulness-Based Cognitive Therapy, Individual-Mindfulness-Based Cognitive Therapy
- Volunteers
- 56 people
- Sponsor
- University Medical Center Groningen
Bipolar, Depressive Symptoms
"Mindfulness vs Psychoeducation in Bipolar Disorder"
This is a parallel 3-group, multicenter, prospective, randomized, single-blind (evaluator) controlled pilot trial, with a 38- week follow-up.
- Trial name
- BI-MIND (NCT02133170)
- Testing
- Mindfulness Based Cognitive Therapy (MBCT), Psychoeducation, Standard treatment
- Where
- 2 sites in Spain
- Volunteers
- 140 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Major Depressive Disorder
Characterizing Psychological Consequences of Childhood Trauma
This study will characterize the mental health consequences of early-life trauma.
- Trial name
- NCT00209105
- Testing
- DEX-CRF stimulation test, Psychosocial stress induction, Brain imaging of sad mood , self-reference, reward
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Emory University
Postpartum Depression, Emotional Regulation
Prenatal Affective Cognitive Training to Reduce the Risk of Postpartum Depression (PACT)
Many pregnant women face the risk of experiencing depression after giving birth, especially if they've previously dealt with depression.
- Conditions
- Postpartum Depression, Emotional Regulation, Cognitive Function 1, Social, Pregnancy Related
- Trial name
- PACT (NCT06046456)
- Testing
- Prenatal Affective CogntiiveTraining
- Where
- Denmark
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Depressive Disorder, Major
A Study to Evaluate the Efficacy of Sage-217 in the Treatment of Adult Participants With Major Depressive Disorder (MDD)
The purpose of this study to evaluate the efficacy of SAGE-217 in the treatment of participants with MDD.
- Trial name
- NCT04442490
- Testing
- SAGE-217
- Where
- 39 sites in United States
- Volunteers
- 543 people
- Sponsor
- Biogen
Depression, Stroke
Electroacupuncture Combined With Antidepressants for Post-stroke Depression
This is a randomized, assessor-blind, placebo controlled study in post stroke depression patients. Subjects receiving antidepressant drug would be assigned to either active or placebo scalp electro-acupuncture treatment, on the…
- Trial name
- NCT01174394
- Testing
- DCEAS (Hwato®/ Dongbang®), Body electro-acupuncture (Hwato®/ Dongbang®), n-CEA (Strietberger®)
- Where
- 3 sites in Hong Kong
- Volunteers
- 43 people
- Sponsor
- The University of Hong Kong
Treatment Resistant Depression
Psilocybin for Treatment-Resistant Depression
The purpose of this study is to see if psilocybin, an investigational drug, is safe and well tolerated. Researchers also want to know if psilocybin can improve symptoms of depression.
- Trial name
- NCT05029466
- Testing
- Psilocybin
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Brain and Cognition Discovery Foundation
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