Clinical trials: Depressive; Behavioral Disorder
Migraine
Nutritional Intervention in Migraine
Migraine is a common medical condition. Several studies suggest that obesity and/or weight gain are risk factors for aggravating migraine course, especially increase the frequency of headache episodes.
- Trial name
- NCT02703129
- Testing
- Nutritional intervention
- Where
- Brazil
- Volunteers
- 52 people
- Sponsor
- Federal University of Minas Gerais
HIV Infections
Effects of a Nurse-delivered Cognitive Behaviour Therapy on Adherence and Depressive Symptoms in HIV Infected Persons of South Korea
Cognitive behaviour therapy (CBT) has repeatedly been found to effectively treat depression in adult populations, and CBT for adherence and depression (CBT-AD) is an effective treatment for improving depressive symptoms and…
- Trial name
- NCT03823261
- Testing
- Cognitive Behavioral Therapy
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Yonsei University
Postpartum Depression, Posttraumatic Stress Disorder
Intervention for IPV-exposed Pregnant Women
The overarching goal of the proposed project is to evaluate a randomized clinical trial of the Pregnant Moms' Empowerment Program aimed at detecting its effects on maternal mental health, re-victimization, parenting sensitivity…
- Conditions
- Postpartum Depression, Posttraumatic Stress Disorder, Infant Behavior, Violence
- Trial name
- NCT04068662
- Testing
- Pregnant Moms' Empowerment Program, Nondirective Support Group
- Where
- 2 sites in United States
- Volunteers
- 424 people
- Sponsor
- University of Notre Dame
Major Depressive Disorder
Pharmacogenomic Testing in Major Depressive Disorder
This is a two-arm double-blind prospective randomized controlled trial (RCT) to evaluate clinical impact of pharmacogenomic testing on the treatment of major depressive disorder.
- Trial name
- NCT03228953
- Testing
- Pharmacogenomic testing
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Columbia University
Depression, Major Depressive Disorder
Single Session of tACS in a Depressive Episode
Purpose: Investigating the effects of non-invasive transcranial alternating current stimulation (tACS) on healthy participants and participants with mood disorders.
- Conditions
- Depression, Major Depressive Disorder, Premenstrual Dysphoric Disorder, Depressive Episode
- Trial name
- SSDE (NCT03449979)
- Testing
- XCSITE100 Stimulator tACS
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Depression, Obesity
Research Aimed at Improving Both Mood and Weight
The RAINBOW study is an NIH R01-funded randomized controlled trial to evaluate the clinical and cost effectiveness and implementation potential of a primary care integrated multicondition intervention program to help improve mood…
- Trial name
- RAINBOW-ENGAGE (NCT02246413)
- Testing
- RAINBOW Intervention Program
- Where
- 2 sites in United States
- Volunteers
- 409 people
- Sponsor
- Palo Alto Medical Foundation
Depression, Major Depressive Disorder
Incorporating Stepped Care Approach Into e-CBT for Depression
This randomized trial intervention will provide e-CBT for MDD through the Online Psychotherapy Tool (OPTT), a secure, cloud-based, digital mental health platform.
- Conditions
- Depression, Major Depressive Disorder, Depressive Symptoms
- Trial name
- NCT04747873
- Testing
- e-CBT, Stepped Care
- Where
- Canada
- Volunteers
- 79 people
- Sponsor
- Dr. Nazanin Alavi
Depressive Disorder
Depressed Mood Improvement Through Nicotine Dosing 3
Deficits in cognitive control are core features of late-life depression (LLD), contributing both to emotion dysregulation and problems with inhibiting irrelevant information, conflict detection, and working memory.
- Trial name
- DepMIND3 (NCT05746273)
- Testing
- Transdermal Nicotine Patch
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Depression
Treatment of Mild and Subthreshold Depressive Disorders
The purpose of this study is to determine the efficacy of a SSRI, cognitive-bahavioral-therapy and a free choice between SSRI and CBT in a sample of primary care patients suffering from mild to moderate depression.
- Trial name
- NCT00226642
- Testing
- Sertralin, Cognitive-behavioral therapy, Non-specific supporting group therapy
- Where
- Germany
- Volunteers
- 369 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Anxiety Symptoms, Perceived Stress
The Effects of Probiotic Supplementation on State and Trait Stress, Anxiety, and Depression Symptoms in Stressed Adults
The goal of this randomized controlled trial is to learn if supplementation with the probiotic Lactobacillus reuteri DSM 17938 can reduce levels of trait and state perceived stress, anxiety, and depressive symptoms compared to a…
- Conditions
- Anxiety Symptoms, Perceived Stress, Depressive Symptoms
- Trial name
- NCT07216729
- Testing
- Lactobacillus reuteri DSM 17938
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Colorado, Boulder
Childhood Traumatic Grief, Post Traumatic Stress
Randomized Controlled Trial of Trauma-focused CBT in Tanzania and Kenya
The primary goal is to study the effectiveness of Trauma-focused Cognitive Behavioral Therapy (TF-CBT) in treating traumatic grief and traumatic stress for orphaned children and young adolescents in two East African sites with…
- Conditions
- Childhood Traumatic Grief, Post Traumatic Stress, Post Traumatic Stress Disorder, Depressive Symptoms
- Trial name
- NCT01822366
- Testing
- Trauma-focused Cognitive Behavioral Therapy
- Where
- 3 sites in United States, Kenya and 1 more
- Volunteers
- 1,280 people
- Sponsor
- Duke University
Lung Cancer
Sleep and Immune Checkpoint Inhibitors
Sleep disturbances are prevalent in cancer patients and linked to levels of fatigue and depressive symptoms with a major impact on quality of life.
- Trial name
- NCT04070651
- Where
- Denmark
- Volunteers
- 49 people
- Sponsor
- Aarhus University Hospital
Depression, Psychological Stress
Online Positive Emotion Skills Intervention for Symptoms of Depression
Major depressive disorder affects over 120 million people worldwide. Only 50% of Americans with depression receive adequate treatment, and one-third of those receiving treatment do not benefit.
- Conditions
- Depression, Psychological Stress, Affect
- Trial name
- MARIGOLD (NCT02861755)
- Testing
- Positive Affect Skills Training, 5-week Emotion Reporting
- Where
- United States
- Volunteers
- 677 people
- Sponsor
- Northwestern University
Depression, Major Depressive Disorder
Stress Generation and Recurrent Depression: The Role of Differential Treatment Response
Depression affects over one million people in Canada, resulting in $14.4 billion per year in costs to Canadian society. In order to prevent this often lifelong disorder, it is critically important to identify risk factors for the…
- Trial name
- NCT00745017
- Testing
- Cognitive Behavioral Therapy, Interpersonal Therapy, Antidepressant medication
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- Centre for Addiction and Mental Health
Major Depressive Disorder
Assessing Symptomatic Clinical Episodes in Depression
Randomized, Double-Blind, Active-Controlled Study of AXS-05 for MDD.
- Trial name
- ASCEND (NCT03595579)
- Testing
- AXS-05, Bupropion
- Where
- 4 sites in United States
- Volunteers
- 97 people
- Sponsor
- Axsome Therapeutics, Inc.
Treatment-Resistant Major Depressive Disorder
Understanding Music and Mindfulness Preferences in Psilocybin-Assisted Psychotherapy
The goal of this pilot clinical trial is to learn whether it is feasible to individually tailor psilocybin-assisted psychotherapy (PAP) for people with treatment-resistant depression (TRD) based on their personal preferences.
- Trial name
- PPP (NCT07373535)
- Testing
- Psilocybin 25mg, Music-centered psilocybin-assisted therapy, Mindfulness-centered psilocybin-assisted therapy
- Where
- 2 sites in Canada
- Volunteers
- 16 people
- Sponsor
- Kyle Greenway
Perinatal Depression, Post Partum Depression
Characterizing the Neural Substrates of Irritability in Women: an Experimental Neuroendocrine Model
The proposed study involves experimentally manipulating reproductive hormones in nonpregnant, euthymic women to create a scaled down version of the changes that occur during pregnancy and the postpartum period.
- Conditions
- Perinatal Depression, Post Partum Depression, Depression, Postpartum, Depression
- Trial name
- NCT04051320
- Testing
- Leuprolide Acetate 3.75 MG/ML, Estradiol 2 Mg tablet, Micronized progesterone
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Depression NOS, Major Depressive Disorder
Meditation to Reduce Caregiver Stress
The purpose of this study is to determine whether meditation will reduce stress and depressive of adult caregivers of a person with dementia.
- Conditions
- Depression NOS, Major Depressive Disorder, Anxiety NOS
- Trial name
- Meditation (NCT01537679)
- Testing
- Kirtan Kriya meditation, Relaxation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, Los Angeles
Depression, Anxiety
A Mechanistic Study to Assess a Single Dose of CYB003 in Participants With Depression and Anxiety
The goal of this study is to learn how psychedelics may help symptoms of depression and anxiety. Participants with major depressive disorder experiencing symptoms of depression and anxiety will receive one dose of either a drug…
- Conditions
- Depression, Anxiety, Major Depressive Disorder
- Trial name
- NCT06820723
- Testing
- CYB003
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ohio State University
Depression, Depressive Disorder
Metformin as Adjunct Therapy in Depression-obesity Comorbidity: Clinical and Genetic Evaluation
The patients with depression and obesity will receive add-on metformin with antidepressant therapy, which may result in greater improvement in depressive symptoms and BMI reduction compared to antidepressant monotherapy.
- Conditions
- Depression, Depressive Disorder, Overweight or Obesity, Depressive Symptoms
- Trial name
- NCT07654179
- Testing
- Metformin, Antidepressant Therapy
- Where
- 2 sites in Pakistan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Riphah International University
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