Clinical trials: Depressive; Behavioral Disorder
Depressive Symptoms, Diabetes Mellitus
Evaluation of a Diabetes-specific Cognitive Behavioural Treatment for Subthreshold Depression
This work is supported by the "Kompetenznetz Diabetes mellitus (Competence Network for Diabetes mellitus)" funded by the Federal Ministry of Education and Research (FKZ 01GI0809).
- Trial name
- NCT01009138
- Testing
- Diabetes-Specific CBT (DS-CBT), Standard Diabetes Education
- Where
- Germany
- Volunteers
- 214 people
- Sponsor
- Forschungsinstitut der Diabetes Akademie Mergentheim
Depression, Depressive Symptoms
Beating the Blues for Your Heart
The objective of this clinical trial is to evaluate whether a computerized depression treatment, delivered before the onset of heart disease, reduces the risk of heart disease in the future.
- Conditions
- Depression, Depressive Symptoms, Cardiovascular Disease (CVD), Coronary Artery Disease (CAD)
- Trial name
- BtB-Heart (NCT01605552)
- Testing
- Beating the Blues (BtB), Usual Care
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Indiana University
Alcoholism, Depression
Pharmacological Intervention Project (Fluoxetine)
This is a large scale study involving fluoxetine (Prozac) versus a placebo in the treatment of adolescents with alcohol use disorder (AUD) and major depression (MDD).
- Trial name
- FIDAA (NCT00027378)
- Testing
- fluoxetine (Prozac)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pittsburgh
Depression, Melancholia
Antidepressant Treatment of Melancholia in Late Life
The purpose of this study is to compare the safety and effectiveness of a select serotonin re-uptake inhibitor (SSRI, sertraline) and a tricyclic antidepressant (TCA, nortriptyline) in outpatients over the age of 60 who have…
- Trial name
- NCT00000378
- Testing
- Sertraline, Nortriptyline
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- New York State Psychiatric Institute
Major Depressive Disorder, Surgery
Intraoperative Ketamine Versus Saline in Depressed Patients Undergoing Anesthesia for Non-cardiac Surgery
This study evaluates whether ketamine, given as part of an anesthetic, improves depression symptoms in depressed patients undergoing non-cardiac surgery.
- Conditions
- Major Depressive Disorder, Surgery, Orthopedic Disorder
- Trial name
- NCT03861988
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Stanford University
Major Depressive Disorder, Anxiety Disorder
Ketamine Infusion for Adolescent Depression and Anxiety
The purpose of this study is to determine the tolerability and short-term efficacy of a single ketamine infusion for the treatment of adolescents with 1) medication-refractory major depressive disorder (MDD) and/or 2)…
- Trial name
- NCT02579928
- Testing
- Ketamine, Midazolam
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Yale University
Major Depressive Disorder, Post Traumatic Stress Disorder
Positive Processes and Transition to Health
The R61 will be an open trial to determine if Positive Processes and Transition to Health (PATH) engages the proposed targets: unproductive processing, avoidance, and reward deficits in a sample of 45 adults who have experienced…
- Trial name
- PATH (NCT04678232)
- Testing
- Positive Processes and Transition to Health (PATH)
- Where
- 3 sites in United States
- Volunteers
- 45 people
- Sponsor
- Case Western Reserve University
Major Depressive Disorder
Safety and Efficacy of Levomilnacipran ER (F2695 SR) in Adults With Fatigue Associated With Major Depressive Disorder
The purpose of the study is to evaluate the efficacy, safety and tolerability of Levomilnacipran ER for the treatment of fatigue associated with major depressive disorder (MDD).
- Trial name
- NCT01254305
- Testing
- Levomilnacipran ER, Paroxetine, Sertraline, Citalopram or Fluoxetine.
- Where
- 20 sites in United States
- Volunteers
- 262 people
- Sponsor
- Forest Laboratories
Depression, Depressive Disorder
A Clinical Trial of Intravenous (IV) Ganaxolone in Women With Postpartum Depression
This study will evaluate the Safety, Pharmacokinetics and Efficacy of IV Administration of Ganaxolone in Women with Postpartum Depression
- Conditions
- Depression, Depressive Disorder, Depression, Postpartum, Behavioral Symptoms
- Trial name
- NCT03228394
- Testing
- Ganaxolone
- Where
- 16 sites in United States
- Volunteers
- 91 people
- Sponsor
- Marinus Pharmaceuticals
Major Depressive Disorder
Deep Brain Stimulation for Treatment Resistant Depression
The purpose of this study is to test the safety, efficacy and mechanism of action of subgenual cingulate (Cg25) deep brain stimulation (DBS) for major depression in patients who have not responded to prior antidepressant…
- Trial name
- NCT00367003
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Emory University
Depression, Alcoholism
Fluoxetine and Bupropion to Treat Patients With Depression and Alcoholism
We will study patients with a current major depressive episode, comorbid alcoholism and a history of a past suicide attempt. All subjects with alcohol dependence will be evaluated for risk of alcohol withdrawal prior to…
- Conditions
- Depression, Alcoholism, Suicidal Behavior
- Trial name
- NCT00449007
- Testing
- fluoxetine, bupropion
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- New York State Psychiatric Institute
Depressive Disorder, Major
Study of Adjunctive or Monotherapy Rapastinel Treatment in Patients With Major Depressive Disorder (MDD)
Multicenter, open-label, long-term extended access treatment protocol in adult patients with a primary diagnosis of MDD.
- Trial name
- NCT03668600
- Testing
- Rapastinel
- Where
- 74 sites in United States
- Volunteers
- 230 people
- Sponsor
- Naurex, Inc, an affiliate of Allergan plc
Pregnancy Related, Burnout, Professional
The 4th Trimester Initiative: The Impact of Parental Support on Pregnant Trainee Wellbeing
The goal of this clinical trial is to determine the impact of a parental support package for new trainee mothers which focuses on mentorship, lactation, and sleep, and access to perinatal care.
- Conditions
- Pregnancy Related, Burnout, Professional, Wellness, Psychological
- Trial name
- NCT06014892
- Testing
- Snoo smart bassinet, Willow wearable breast pump, Maven Clinic on-demand perinatal consultation
- Where
- 7 sites in United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Fibromyalgia, Chronic Pain
Transcranial Magnetic Stimulation for Treating Women With Chronic Widespread Pain
While acute pain after surgery or trauma comes on suddenly and lasts for a limited amount of time, chronic pain persists and can continue for months and even years.
- Conditions
- Fibromyalgia, Chronic Pain, Depression
- Trial name
- NCT00524420
- Testing
- rTMS
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Washington
Depressive Episodes, Bipolar I Depression
A Clinical Trial to Determine the Long-term Safety and Tolerability of an Investigational Drug in People With Major Depressive Episode Associated With Bipolar I Disorder (Bipolar I Depression).
This is a clinical trial to determine the long-term safety and tolerability of an investigational drug in people with Major Depressive Episode Associated with Bipolar I Disorder (Bipolar I Depression).
- Trial name
- NCT05227209
- Testing
- SEP-4199 CR
- Where
- 69 sites in United States, Bulgaria and 1 more
- Volunteers
- 64 people
- Sponsor
- Sumitomo Pharma America, Inc.
Premenstrual Syndrome, PMS
Treatment of Menstrually Related Disorders With Continuous v. Interrupted Oral Contraceptives
This study will determine whether uninterrupted treatment with birth control pills over several menstrual cycles prevents severe premenstrual syndrome (PMDD).
- Conditions
- Premenstrual Syndrome, PMS, Premenstrual Dysphoric Disorder, PMDD
- Trial name
- NCT00089414
- Testing
- Ethinyl Estradiol/Drospirenone, CDB 2914
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Mental Health (NIMH)
Anxiety Disorder, Depressive Disorder
Feasibility of a Culturally Adapted Emotional-Behavioral Prevention Program for American Indian Children
American Indians (AI) are at greater risk for anxiety and depression early in life. This is concerning given the potential negative effects of these conditions across the lifespan (substance use, suicide).
- Trial name
- NCT05371665
- Testing
- Culturally Adapted Cognitive-Behavioral Prevention and Early Intervention (PEI) Program
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Montana State University
Major Depressive Disorder With Suicidal Ideation With Intent
Study of Efficacy and Safety of MIJ821 in Addition to Comprehensive Standard of Care on the Rapid Reduction of Symptoms of Major Depressive Disorder in Subjects Who Have Suicidal Ideation With Intent
Study of efficacy and safety of MIJ821 in addition to comprehensive standard of care on the rapid reduction of symptoms of Major Depressive Disorder (MDD) in subjects who have suicidal ideation with intent
- Trial name
- NCT04722666
- Testing
- MIJ821 Intravenous Injection
- Where
- 39 sites in United States, Argentina and 12 more
- Volunteers
- 199 people
- Sponsor
- Novartis Pharmaceuticals
Major Depressive Disorder
Synchronized Transcranial Magnetic Stimulation (sTMS) in Major Depressive Disorder
This study is designed to evaluate the safety and efficacy of synchronized transcranial magnetic stimulation (sTMS) using the NeoSync EEG Synchronized TMS device (NEST) in subjects with Major Depressive Disorder.
- Trial name
- NEST-MDD (NCT01370733)
- Testing
- NEST-1 (NeoSync EEG Synchronized TMS)
- Where
- 18 sites in United States
- Volunteers
- 202 people
- Sponsor
- Wave Neuroscience
Depression
Role of Slow-wave Activity and Plasticity in MDD
The hypothesis underlying this proposal is that deficits of synaptic plasticity underlie the slow-wave activity (SWA) abnormalities observed n major depressive disorder (MDD), and that manipulating SWA may serve to circumvent…
- Trial name
- SWIP (NCT04150718)
- Testing
- slow-wave disruption
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania