Clinical trials: Depressive
Depression - Major Depressive Disorder, Behavioral Activation
VR-Based Behavioral Activation in Adults
Study Overview This study aims to evaluate the effectiveness of a newly developed Virtual Reality (VR) behavioral activation software program for individuals experiencing symptoms of depression.
- Conditions
- Depression - Major Depressive Disorder, Behavioral Activation, Virtual Reality Therapy, Behavioral Inhibition
- Trial name
- VR-Dep (NCT07703397)
- Testing
- Virtual Reality Behavioral Activation Software, Waitlist Control and Psychoeducation
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- KTO Karatay University
Postpartum Depression
Early Diagnosis of PPD Through Self-portraits
the target of the research is development of a predictive tool for early identification of women which are at higher risk for development of postpartum depression.
- Trial name
- ppd (NCT03791021)
- Testing
- draw a person (DAP), Edinburgh Postnatal Depression Scale (EPDS), Beck Depression Inventory- II (BDI-II)
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Depression, Unipolar
Whole-body Hyperthermia for Moderate to Severe Depressive Disorder
The primary aim of this study is to investigate the effectiveness of whole-body hyperthermia in addition to standard medical care in comparison to standard medical care alone on depressive symptom severity in patients with…
- Trial name
- HYPE2 (NCT03906149)
- Testing
- Whole-body hyperthermia + standard medical care, Standard medical care
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- Universität Duisburg-Essen
Major Depressive Disorder
Transcranial Direct Current Stimulation (tDCS) in the Treatment of Major Depressive Disorder (MDD)
The project will investigate the use of a novel neuromodulatory technique, transcranial direct current stimulation (tDCS) in the treatment of patients with major depressive disorder.
- Trial name
- NCT01078948
- Testing
- transcranial direct current stimulation (tDCS)
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Centre for Addiction and Mental Health
Major Depressive Disorder
Comparison of Anodal Transcranial Direct Current Stimulation (t-DCS) and Sham Stimulation in Patients With Treatment-resistant Depression
Major depressive disorder (MDD) is a significant public health problem. Existing treatment modalities are not always sufficient to alleviate this disorder. Treatment refractoriness is a common clinical problem.
- Trial name
- NCT02141776
- Testing
- Transcranial direct current stimulation (t-DCS)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Florida
Insomnia, Depression - Major Depressive Disorder
Enhancing Operational Readiness With Digital Self-Managed Cognitive Behavioral Therapy for Insomnia (CBTI)
The goal of this pilot clinical trial is to evaluate the effectiveness and delivery method of a CBTI self-managed digital mobile application in service members. The main questions it aims to answer are: RQ1.
- Conditions
- Insomnia, Depression - Major Depressive Disorder, PTSD
- Trial name
- NCT07335276
- Testing
- Cognitive Behavioral Therapy for Insomnia
- Volunteers
- 144 people
- Sponsor
- Madigan Army Medical Center
Anxiety Disorders, Major Depressive Disorder
Acquisition and Analysis of Relationships Between Longitudinal Emotional Signals Produced by an Artificial Intelligence Algorithm and Self-questionnaires Used in the Psychiatric Follow-up of Patients With Mood and/or Anxiety Disorders: a Real-Environment Study.
The worldwide prevalence of anxiety and depression increased massively during the pandemic, with a 25% rise in the number of patients suffering from psychological distress.
- Trial name
- EMOACQ-1 (NCT05988840)
- Testing
- Acquisition and analysis of relationships between Longitudinal Emotional Signals produced by a software and Self-questionnaires.
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Emobot
Psychosis, Bipolar and Related Disorders
A Mental Health Services Engagement Program for Racial and Ethnic Minority Young Adults
Researchers aim to test a brief culturally-responsive young adult orientation program for community mental health services. They will conduct a 24-month randomized trial with 80 young adults from racial and ethnic minority groups…
- Conditions
- Psychosis, Bipolar and Related Disorders, Depressive Disorder
- Trial name
- NCT06508450
- Testing
- Just Do You, Component A, Component B
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- New York University
Postnatal Depression
Behavioural Activation (BA) for Postnatal Depression in Blackpool
Is Behavioural Activation feasible, acceptable and potentially effective for mothers experiencing post natal depression in Blackpool? Phase 1: A series of single case studies which aim to examine and refine a) the appropriateness…
- Trial name
- BA (NCT04183582)
- Testing
- Behavioural Activation
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- National Society for the Prevention of Cruelty to Children
Depressive Episode
Characterisation of Fundamental Decision Making in People Suffering From a Characterised Depressive Episode
The investigators will include patients suffering from Major Depressive Disorder (MDD), in episode. The patients will undertake neuropsychological tasks evaluating executive function and clinical assessment related to depressive…
- Trial name
- MINDDE (NCT05654948)
- Testing
- computerised cognitive performance test : MindPulse
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Tours
Depression, Anxiety
Digital Cognitive Behavioral Therapy for Depressive Disorders
This study aims to explore the effectiveness of digital interventions combined with medication in the treatment of patients with depressive disorders.
- Trial name
- NCT06423443
- Testing
- Digital Cognitive Behavioral Therapy, Health Education, TAU
- Sponsor
- Adai Technology (Beijing) Co., Ltd.
Postpartum Anxiety, Postpartum Depression
Postpartum Screening for Anxiety and Comorbid Conditions
The goal of this project is to facilitate the design of individualized postpartum anxiety (PPA) screening strategies in British Columbia (BC), Canada.
- Conditions
- Postpartum Anxiety, Postpartum Depression, Postpartum Disorder, Postoperative Pain
- Trial name
- PPA (NCT06242717)
- Where
- Canada
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Depressive Symptoms, Stress Disorder, Acute
Neurophysiological Mechanisms of Accelerated Resolution Therapy (ART)
In brief, ART is an innovative "mind-body" (body-centric) psychotherapy that makes use of established core components of trauma-focused therapy including imaginal exposure and imagery rescripting to promote memory…
- Conditions
- Depressive Symptoms, Stress Disorder, Acute, Prolonged Grief Disorder, Alcohol Abuse
- Trial name
- M-ART (NCT04121884)
- Testing
- Accelerated Resolution Therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of South Florida
Depressive Symptoms
Effectiveness of a CBT Based Mobile Application
This research aims to explore the effect of a mobile application designed on the basis of cognitive behavioral therapy on college students suffering from depression in terms of their symptoms, suicidal thoughts, and other…
- Trial name
- NCT05188950
- Testing
- depression screening test App
- Where
- Taiwan
- Volunteers
- 91 people
- Sponsor
- National Taiwan University Hospital
Major Depressive Disorder
Study of Aripiprazole as an Adjunctive Therapy in Patients With Major Depressive Disorder
To examine the efficacy and safety of aripiprazole versus placebo as an adjunctive therapy co-administered with either an selective serotonin reuptake inhibitor (SSRI) or a serotonin-norepinephrine reuptake inhibitor (SNRI) in…
- Trial name
- NCT00876343
- Testing
- Aripiprazole (Fixed dose), Aripiprazole (Titrated dose)
- Where
- 8 sites in Japan
- Volunteers
- 586 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Major Depressive Disorder (MDD), Cognitive Dysfunction
Cognitive Rehabilitation for Veterans With MDD-related Cognitive Functioning Deficits
Individuals with depression often describe difficulties with memory, attention, concentration, and overall cognitive functioning, which can persist even after mood episodes get better, and can affect treatment and health…
- Trial name
- NCT06728774
- Testing
- Motivationally Enhanced Compensatory Cognitive Training for Major Depressive Disorder (ME-CCT-MDD), Goal-focused Supportive Contact
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Portland VA Medical Center
Major Depressive Disorder
Sensory Synchronized Imaging and Neuromodulation
The purpose of this research study is to better understand the relationship between the type of brain stimulation used and how it changes brain activity in adult military Veterans.
- Trial name
- NCT06548113
- Testing
- TMS
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Major Depressive Disorder
Linking Affective Dynamics in Response to Daily Stress to Peripheral Vascular Function in Working Age Adults
The objective of this proposal is to determine whether heightened negative affective responsivity (NA-R) to daily stressors is related to blunted nitric oxide (NO)-mediated endothelium-dependent dilation (EDD) in working age…
- Trial name
- NCT06860724
- Testing
- NG-nitro-L-arginine methyl ester (L-NAME)
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Major Depressive Disorder
SPD489 in Combination With an Antidepressant in the Treatment of Adults With Major Depressive Disorder
This study will examine SPD489 in subjects aged 18-65 with major depressive disorder (MDD) who are taking certain types of antidepressants but continue to have residual depression symptoms.
- Trial name
- NCT01435759
- Testing
- Antidepressant + SPD489 (Lisdexamfetamine dimesylate) 10 mg, Antidepressant + SPD489 (Lisdexamfetamine dimesylate) 30 mg, Antidepressant + SPD489 (Lisdexamfetamine dimesylate) 50 mg
- Where
- 82 sites in United States, Argentina and 3 more
- Volunteers
- 1,197 people
- Sponsor
- Shire
Malignant Neoplasm
Talking Pictures Social Media Intervention in Reducing Depressive Symptoms and Improving Spiritual Well-Being and Quality of Life in Adolescent and Young Adult Cancer Patients
This clinical trial studies how well Talking Pictures social media intervention works in reducing depressive symptoms and improving spiritual well-being and quality of life in adolescent and young adult cancer patients.
- Trial name
- NCT03679585
- Testing
- Internet-Based Intervention, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Roswell Park Cancer Institute