Clinical trials: Depressive Disorder, Major, open to volunteers
Major Depressive Disorder
NMDA Modulation in Major Depressive Disorder
Most of the current antidepressants for major depressive disorder (MDD) are based upon the monoamine hypothesis which cannot fully explain the etiology of depression.
- Trial name
- NCT04637620
- Testing
- NMDAE, Sertraline
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- China Medical University Hospital
Major Depressive Disorder
NMDA Modulation in Antidepressant Nonresponders With Major Depressive Disorder
Most of the current antidepressants for major depressive disorder (MDD) are based upon the monoamine hypothesis which cannot fully explain the etiology of depression.
- Trial name
- NCT05136755
- Testing
- NMDAE
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- China Medical University Hospital
Major Depression
Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression
The purpose of this multi-site randomized controlled trial is to evaluate the efficacy and risks of psilocybin for the treatment of depression in U.S.
- Trial name
- PIVOT (NCT07226232)
- Testing
- Psilocybin
- Where
- 5 sites in United States
- Volunteers
- 240 people
- Sponsor
- VA Office of Research and Development
Major Depressive Disorder
A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)
A Phase 3 Double-blind, Placebo-controlled Study (Part A) with an Open-label Extension (Part B) Evaluating DT120 Compared to Placebo in Major Depressive Disorder - Ascend
- Trial name
- NCT07592689
- Testing
- DT120
- Where
- 30 sites in United States
- Volunteers
- 165 people
- Sponsor
- Definium Therapeutics US, Inc.
Major Depression, Generalized Anxiety
Neural Mechanisms of Real-world Emotions and Internalizing
This study utilizes mobile health methods, including smartphone technology, subjective self-reports measures of emotion, behavioral tasks, functional Magnetic Resonance Imaging (fMRI), physiological measures of attention and…
- Conditions
- Major Depression, Generalized Anxiety, Emotions
- Trial name
- NCT07891624
- Testing
- Academic Performance Feedback
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Miami
Depression - Major Depressive Disorder
Effect of Neurofeedback and TMS
The goal of this clinical trial is to is to learn whether adding EEG neurofeedback (NFB) to repetitive transcranial magnetic stimulation (rTMS) is safe and feasible for adults with major depressive disorder (MDD).
- Trial name
- NCT07892287
- Testing
- Repetitive Transcranial Magnetic Stimulation, Alpha-down EEG Neurofeedback
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Depression
Characterization and Treatment of Adolescent Depression
This research study seeks to find causes and treatments of depression in teenagers. The study goals are to increase our knowledge of treatments for depression and understand how the brain changes when teenagers have depression.
- Trial name
- NCT03388606
- Testing
- Growth Mindset
- Where
- 3 sites in United States
- Volunteers
- 4,100 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Late Life Depression (LLD), Depression - Major Depressive Disorder
Accelerated vs. Conventional Theta Burst Stimulation for Late-life Depression
The purpose of this trial is to compare the treatment efficacy (improvement in depressive symptoms) of accelerated TBS protocol (where participants receive multiple TBS treatments daily) to conventional TBS protocol (where…
- Conditions
- Late Life Depression (LLD), Depression - Major Depressive Disorder, Depressive Disorder, Treatment-Resistant, Mood Disorders
- Trial name
- ACT-LLD (NCT06854367)
- Testing
- TBS
- Where
- 2 sites in Canada
- Volunteers
- 280 people
- Sponsor
- Centre for Addiction and Mental Health
Major Depressive Disorder
A Study to Evaluate the Maintenance Effect of Osavampator as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
The primary objective of this study is to evaluate the efficacy of osavampator (previously NBI-1065845) compared with placebo as an adjunctive treatment in delaying relapse of depressive symptoms (maintenance of effect) in…
- Trial name
- NCT07196501
- Testing
- Osavampator
- Where
- 61 sites in United States, Australia and 9 more
- Volunteers
- 550 people
- Sponsor
- Neurocrine Biosciences
Insomnia, Depression - Major Depressive Disorder
Enhancing Operational Readiness With Digital Self-Managed Cognitive Behavioral Therapy for Insomnia (CBTI)
The goal of this pilot clinical trial is to evaluate the effectiveness and delivery method of a CBTI self-managed digital mobile application in service members. The main questions it aims to answer are: RQ1.
- Conditions
- Insomnia, Depression - Major Depressive Disorder, PTSD
- Trial name
- NCT07335276
- Testing
- Cognitive Behavioral Therapy for Insomnia
- Volunteers
- 144 people
- Sponsor
- Madigan Army Medical Center
MDD, Severe Depression
Sensation Seeking and TMS Response in TRD
his real-world observational study examines whether sensation-seeking personality traits influence the clinical response to transcranial magnetic stimulation (TMS) in patients with treatment-resistant depression (TRD).
- Conditions
- MDD, Severe Depression, Major Depressive Episode
- Trial name
- NCT07889739
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Technical University of Munich
Depression - Major Depressive Disorder, Psychological Distress
Testing a Non-Deceptive Placebo Intervention for Subclinical Depressive Symptoms
Subclinical depression - depressive symptoms that fall below the threshold for major depressive disorder - is common in young adults and predicts later depressive episodes, yet it often goes untreated.
- Conditions
- Depression - Major Depressive Disorder, Psychological Distress, Depression / Major Depressive Disorder
- Trial name
- NDP_CCG (NCT07889908)
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Miami University
Major Depressive Disorder
Regulated Stimulation for Optimized Network Activity and Therapeutic Equilibrium
The objective of this study is to evaluate the safety, tolerability, and preliminary efficacy of the Motif eXternally powered Cortical Stimulation (XCS) System when used as indicated for treatment-resistant depression (TRD).
- Trial name
- RESONATE (NCT07594483)
- Testing
- Motif XCS System
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Motif Neurotech, Inc.
Major Depressive Disorder (MDD)
Temporal Interference Transcranial Alternating Current Stimulation for Major Depressive Disorder
This multi-center, double-blind study, randomized controlled trial aims to evaluate the efficacy and safety of Temporal Interference transcranial Alternating Current Stimulation (TI-tACS) in patients with major depressive…
- Trial name
- NCT07712159
- Testing
- Temporal Interference transcranial Alternating Current Stimulation (TI-tACS)
- Volunteers
- 102 people
- Sponsor
- Central South University
Depressive Disorder, Major Depressive Disorder, Suicidal Ideation
Evaluation of a Multi-Layered Digital Phenotyping, Digital Safety Plan, and Pharmacogenomic Intervention for Suicide Prevention in Adults With Depression
The goal of this clinical trial is to learn if a multi-layered digital and pharmacogenomic intervention works to prevent suicide re-attempts in adults with depression.
- Conditions
- Depressive Disorder, Major Depressive Disorder, Suicidal Ideation, Suicide, Attempted, Suicide Prevention
- Trial name
- SMARTomicS (NCT07885722)
- Testing
- Digital Monitoring (Active/Passive EMA), Ecological Momentary Intervention (EMI) via Digital Safety Plan, Pharmacogenetic-Guided Care and Therapeutic Drug Monitoring
- Where
- Spain
- Volunteers
- 525 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Healthy Volunteer, Major Depressive Disorder
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder
Background: Most medications that treat depression take weeks or months to work. Researchers want to develop fast-acting treatments. One dose of ketamine has a rapid antidepressant effect.
- Conditions
- Healthy Volunteer, Major Depressive Disorder, Depression
- Trial name
- NCT03065335
- Testing
- Ketamine, Cobot TS MV robotic arm for TMS, NeurOptics PLRTM-30000 Pupillometer
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Depression, Anxiety
A Mechanistic Study to Assess a Single Dose of CYB003 in Participants With Depression and Anxiety
The goal of this study is to learn how psychedelics may help symptoms of depression and anxiety. Participants with major depressive disorder experiencing symptoms of depression and anxiety will receive one dose of either a drug…
- Conditions
- Depression, Anxiety, Major Depressive Disorder
- Trial name
- NCT06820723
- Testing
- CYB003
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ohio State University
Major Depressive Disorder (MDD)
Evaluation of the Acceptability, Feasibility and Exploration of the Efficacy of an Integrated Care Pathway CARIBOU
Problem statement. Major Depressive Disorder (MDD) is a significant concern among adolescents, characterized by episodes of mood changes, cognitive symptoms, and neurovegetative dysfunction, often lasting months or even years…
- Trial name
- CARIBOU-FR (NCT07806825)
- Testing
- CARIBOU Integrated Care Pathway, Treatment as Usual (TAU)
- Where
- Chile
- Volunteers
- 72 people
- Sponsor
- Universidad de los Andes, Chile
Post Traumatic Stress Disorder, Depression - Major Depressive Disorder
Mindfulness-based Psilocybin Therapy for PTSD
The goal of this study is to learn how psilocybin delivered with mindfulness-based therapy may help symptoms of posttraumatic stress disorder (PTSD).
- Trial name
- NCT07104916
- Testing
- Psilocybin + MBCT therapy, Active Comparator: Psilocybin with Support Only
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Anthony P King
Depression - Major Depressive Disorder
Dual Neuromodulation for Depression: Boosting TMS With tES
Major depressive disorder (MDD) is a common and disabling condition. Transcranial magnetic stimulation (TMS) is an established non-invasive neuromodulation treatment for depression, but clinical response varies considerably…
- Trial name
- DUAL MOD (NCT07879924)
- Testing
- Transcranial Magnetic Stimulation, Transcranial Alternating Current Stimulation
- Where
- 2 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- Mersey Care NHS Trust