Clinical trials: Depressive Disorder, completed
Depressive Disorder, Major, Depression
Individualized Functional Connectivity Targeting in aiTBS for Depression
The goal of this clinical trial is to estimate the importance of neuroimaging in accelerated intermittent theta burst stimulation (aiTBS) for depression.
- Conditions
- Depressive Disorder, Major, Depression, Mood Disorders, Mental Disorder
- Trial name
- AINT (NCT05680727)
- Testing
- transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brigham and Women's Hospital
Psychosis, Schizophrenia
CBTpro: Scaling up CBT for Psychosis Using Simulated Patients and Spoken Language Technologies
The primary objective of this grant is to develop and evaluate an Artificial Intelligence-based clinical training tool--CBTpro--to support high-quality skills training in CBT for psychosis (CBTp).
- Conditions
- Psychosis, Schizophrenia, Schizo Affective Disorder, Bipolar Disorder
- Trial name
- CBTpro (NCT05127837)
- Testing
- CBTpro
- Where
- 13 sites in United States
- Volunteers
- 601 people
- Sponsor
- University of Washington
Schizophrenia, Schizoaffective Disorder
Impact of Medication Education on Adherence and Side Effects
Severe mental disorders such as schizophrenia, bipolar disorder, and psychotic depression often require long-term or lifelong medication treatment.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder With Psychotic Features, Major Depressive Disorder With Psychotic Features
- Trial name
- MED-ADHERE (NCT07374588)
- Testing
- Medication Education Program, Routine Psychiatric Inpatient Care
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Cumhuriyet University
Depressive Disorder
Effect of Adapted Physical Activity on Emotion Regulation in People With Depressive Disorders
Depression is associated with difficulties in emotion regulation. Adapted physical activity (APA) may help improve emotional regulation in people with depressive disorders.
- Trial name
- REAPAD (NCT07780695)
- Testing
- Classical Adapted Physical Activity Program, Adapted Physical Activity Program
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier Georges Mazurelle
Depressive Symptoms, Anxiety
A Trial of a Positive Psychology Intervention for Older Adults (RESET)
The heightened vulnerability to COVID-19 of African American older adults in Detroit, Michigan and other marginalized communities is linked to systemic racism experienced over the life course.
- Conditions
- Depressive Symptoms, Anxiety, Chronic Pain, Fatigue
- Trial name
- NCT05451589
- Testing
- RESET, Wellness Check Control
- Where
- United States
- Volunteers
- 457 people
- Sponsor
- University of Michigan
Major Depressive Disorder, Inflammatory Bowel Diseases
Trial of Mirtazapine for Depression in IBD
This study will test whether it is feasible to conduct a clinical trial of mirtazapine (an antidepressant tablet) in patients who have both depression and inflammatory bowel disease (IBD).
- Trial name
- MDIBD (NCT06309472)
- Testing
- Mirtazapine
- Where
- 4 sites in United Kingdom
- Volunteers
- 76 people
- Sponsor
- King's College London
Chronic Pain, Persistent Pain
Physiotherapy Intervention Program for Chronic Pain Associated With Depressive Disorder
This prospective longitudinal pre-post intervention study aims to evaluate the effects of an 8-week physiotherapy program combining face-to-face and asynchronous tele-rehabilitation sessions in individuals with chronic persistent…
- Conditions
- Chronic Pain, Persistent Pain, Depressive Disorder
- Trial name
- NCT07764848
- Testing
- Hybrid Physiotherapy Program
- Where
- Spain
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Sanitaria Aragón
Major Depressive Disorder
A Study of the Efficacy and Safety of SP-624 in the Treatment of Adults With Major Depressive Disorder
This is a Phase 2B clinical study evaluating the effectiveness and safety of SP-624 as compared to placebo in the treatment of adults with Major Depressive Disorder.
- Trial name
- NCT06254612
- Testing
- SP-624
- Where
- 50 sites in United States
- Volunteers
- 497 people
- Sponsor
- Sirtsei Pharmaceuticals, Inc.
Depression - Major Depressive Disorder, Transcranial Alternating Current Stimulation
Individualized Non-invasive Brain Stimulation for the Treatment of Major Depressive Disorder
The purpose of this research study is to study a closed-loop transcranial alternating current stimulation (tACS) device to evaluate feasibility of the product in a clinical trial and collect preliminary data on potential effects…
- Trial name
- CL-tACS RCT (NCT06874374)
- Testing
- Closed-loop tACS
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Pulvinar Neuro, LLC
Major Depressive Disorder, Post-Traumatic Stress Disorder
Examination of Glutamate and mGluR5 in Psychiatric Disorders
This research study is designed to look at the involvement of the glutamate system in depression. Each subject will undergo a screening appointment to determine study eligibility.
- Conditions
- Major Depressive Disorder, Post-Traumatic Stress Disorder, Bipolar Disorder
- Trial name
- NCT02727972
- Testing
- Cognitive Testing, MRI, PET
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Yale University
Depressive Disorder, Major
A Study to Test How Well Different Doses of BI 1569912 Are Tolerated and How Well They Work in People With Depression Who Take Anti-depressive Medication
This study is open to adults between 18 and 65 years of age who have depression (major depressive disorder). People with a current depressive episode lasting between 2 months and one and a half years can join the study.
- Trial name
- NCT04937829
- Testing
- 5 mg BI 1569912, 20 mg BI 1569912
- Where
- 10 sites in United States
- Volunteers
- 59 people
- Sponsor
- Boehringer Ingelheim
Major Depressive Disorder
Impact of Transcutaneous Vagal Nerve Stimulation on Stress Response in Major Depression
This study will identify the sex-dependent impact of expiratory-gated transcutaneous vagus nerve stimulation (tVNS) on the modulation of the stress response circuitry and associated physiology in major depressive disorder (MDD).
- Trial name
- tVNS_MDD_Sex (NCT04448327)
- Testing
- active tVNS
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Massachusetts General Hospital
Suicide, Mental Health Disorder
Optimizing a Just-in-time Adaptive Intervention for Suicide Safety Planning in Adolescents
Despite efforts to prevent suicide, US rates are climbing, and suicide is the second leading cause of death amongst youth. Digital tools, especially personal smartphones, are promising avenues to address these issues and can be…
- Conditions
- Suicide, Mental Health Disorder, Anhedonia
- Trial name
- NCT06665620
- Testing
- ViraBrite nudges
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Ksana Health
Depressive Symptoms, Remited Major Depressive Disorder
Cognitive Control Emotion Training to Prevent Major Depression in Youth At-Risk
The goal of this clinical trial is to learn if intervention of positive emotion working memory (PEWM), or negative emotion working memory (NEWM), or positive attention bias training (PABT) can prevent major depressive disorder…
- Trial name
- CTE 2019 (NCT04346784)
- Testing
- positive emotion working memory(PEWM) training, negative emtion working memory(NEWM) training, PABT
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Hunan Normal University
Treatment Resistant Depression
Efficacy, Safety, and Tolerability of COMP360 in Participants With TRD
Efficacy, Safety, and Tolerability of a single administration of COMP360 in participants with treatment-resistant depression (TRD)
- Trial name
- NCT05624268
- Testing
- Psilocybin
- Where
- 40 sites in United States
- Volunteers
- 258 people
- Sponsor
- COMPASS Pathways
Treatment-Resistant Depression, Depressive Disorder
Stereotactic Radiotherapy Treatment for Treatment-Resistant Depression
This study is an clinical trial aimed at evaluating the effectiveness and safety of stereotactic radiotherapy for treatment-resistant depression
- Trial name
- NCT07274917
- Testing
- ZAP-X
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Capital Medical University
Late Life Depression, Cognitive Decline
Dopaminergic Dysfunction in Late-Life Depression
Late-Life Depression (LLD), or depression in older adults, often presents with motivational deficits, deficits in performance in cognitive domains including processing speed and executive dysfunction, and mobility impairments.
- Conditions
- Late Life Depression, Cognitive Decline, Depressive Disorder, Treatment-Resistant, Levodopa
- Trial name
- D3 (NCT04469959)
- Testing
- L-Dopa
- Where
- 2 sites in United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Depressive Disorder
Depressed Mood Improvement Through Nicotine Dosing 3
Deficits in cognitive control are core features of late-life depression (LLD), contributing both to emotion dysregulation and problems with inhibiting irrelevant information, conflict detection, and working memory.
- Trial name
- DepMIND3 (NCT05746273)
- Testing
- Transdermal Nicotine Patch
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Depressive Disorder
Depressed Mood Improvement Through Nicotine Dosing-3 (Depressed MIND3) Extension
Deficits in cognitive control are core features of late-life depression (LLD), contributing both to emotion dysregulation and problems with inhibiting irrelevant information, conflict detection, and working memory.
- Trial name
- NCT05746546
- Testing
- Transdermal Nicotine patch
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Vanderbilt University Medical Center
Major Depressive Disorder (MDD), Female
Gottman Couple Therapy Program in Treatment of Depressed Female Partners
This study aimed to evaluate the effect of Gottman couple therapy program targeted for discordant couples struggling with the negative impact of depression of the female partner and compare between the outcome in case of usual…
- Trial name
- NCT07748845
- Testing
- Gottman couple therapy, treatment as usual for depression
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Tanta University