Clinical trials: Depressive Episode, active
Moderate Depression, Severe Depressive Episode Without Psychotic Symptoms
A Randomized Clinical Trial Comparing Active Versus Sham T-PEMF Headband Treatment for Depression
An 8-week, two-armed, randomized-controlled trial that examines the antidepressant effect of treatment with transcranial pulsed electromagnetic fields (T-PEMF) in patients diagnosed with moderate to severe depression using using…
- Conditions
- Moderate Depression, Severe Depressive Episode Without Psychotic Symptoms, Recurrent Depressive Disorder, Current Episode Moderate, Recurrent Depressive Disorder, Current Episode Severe Without Psychotic Symptoms
- Trial name
- NCT06005103
- Testing
- Treatment with MoodHeadBand (T-PEMF treatment)
- Where
- Denmark
- Volunteers
- 117 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Major Depressive Disorder (MDD), Depressive Episodes
Effectiveness of Clustered Versus Tapered Repetitive Transcranial Magnetic Stimulation (rTMS) as Maintenance Therapy Following Successful Acute rTMS Treatment in Patients With Depressive Syndrome
The goal of this clinical trial is to compare two maintenance transcranial magnetic stimulation (rTMS) strategies following successful acute theta burst stimulation (TBS) treatment in adults with depressive syndrome.
- Conditions
- Major Depressive Disorder (MDD), Depressive Episodes, Depressive Syndrome
- Trial name
- ERTE (NCT07727005)
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS), Theta Burst Stimulation
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Technical University of Munich
Major Depressive Episode
Signature Response to Light Therapy in Unipolar and Bipolar Major Depressive Episode (MDE)
Major depressive episode (MDE) are severe and common psychiatric disorders that affect up to 20% of the general population. MDE cause a decrease in psychosocial functioning, quality of life, and is associated with a high rate of…
- Trial name
- SoLuRep (NCT07462637)
- Testing
- Light therapy
- Where
- France
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Major Depressive Disorder (MDD) With Insomnia
Efficacy of Chronotherapeutic Combination for Major Depressive Episode With Insomnia
Major Depressive Disorder (MDD) affects 5% of the global population and is the second leading cause of disability worldwide. Despite the widespread use of antidepressants, 50-60% of patients do not respond adequately after 8…
- Trial name
- CombiChronoS (NCT07120880)
- Testing
- AD + SHR + active LT and extended-release melatonin 2mg
- Where
- France
- Volunteers
- 184 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Major Depressive Episode (MDE), Beliefs
Belief Update: The Effects of Depression and Antidepressants in Older People
People in good health do not perceive the future in the same way as those suffering from depression. This difference in perception affects behaviour and emotions and warrants further investigation, both before and after treatment…
- Conditions
- Major Depressive Episode (MDE), Beliefs, Beliefs About Future, Depression
- Trial name
- OLDBELIEFS (NCT07681492)
- Testing
- Response to questionnaire
- Where
- 2 sites in France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Hospital Center Guillaume Régnier
Patients With Major Depressive Disorder
Cognitive Behavior Therapy Among Patients With Major Depressive Disorder-Multiple Episodes.
The main purpose of this study to teach the patients how to manage their depression, generalized Anxiety symptoms, mental health seeking attitude, motivation and attitude toward changing health, to improve the quality of life…
- Trial name
- NCT07300527
- Testing
- Cognitive Behavior Therapy, treatment as usual (TAU) (Control Group)
- Where
- Pakistan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Government College University Faisalabad
Bipolar Disorder (BD), Major Depressive Episode (MDE)
Validation of a Composite Medical Device Using a Blood Biomarker-based Algorithm and MDQ for the Diagnosis of Bipolar Disorder
The goal of this interventional clinical trial is to assess the diagnostic performance of a composite diagnostic medical devise based on blood-based in vitro diagnostic device and Mood Disorder Questionnaire (MDQ) in identifying…
- Conditions
- Bipolar Disorder (BD), Major Depressive Episode (MDE), Primary Care, Major Depression
- Trial name
- BIPOVITE (NCT07031817)
- Testing
- Venous blood sample for measuring blood biomarkers related to bipolar disorder, Standardized psychiatric assessment tools
- Where
- France
- Volunteers
- 623 people
- Sponsor
- University Hospital, Montpellier
Depression - Major Depressive Disorder, Depressive Episodes
TDM-Guided Treatment With SSRIs in Hospitalized Adults and Children
Depression in childhood and adolescence is a serious and increasing public-health problem associated with profound short- and long-term consequences, including impaired social and educational functioning, increased risk of…
- Trial name
- NCT07478796
- Testing
- Fluoxetine, Escitalopram, Sertralin
- Where
- Poland
- Volunteers
- 180 people
- Sponsor
- Poznan University of Medical Sciences
Depression - Major Depressive Disorder
Efficacy and Safety of Transcranial Alternating Current Stimulation (tACS) in Adolescents With First-episode Depression Who Are Drug-naive: A Randomized, Double-blind, Controlled Pilot Study
To evaluate the efficacy of tACS treatment.To determine whether tACS can accelerate symptom remission, improve clinical response rates, and facilitate the recovery of emotional and cognitive functions through standardized…
- Trial name
- NCT07185464
- Testing
- tACS
- Where
- China
- Volunteers
- 30 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP)
French Minds Cohort: a French Longitudinal and Multimodal Cohort of Patients With Major Mood Disorders, Psychotic Disorders, Autism Spectrum Disorders, and Healthy Controls
The goal of this study is to learn whether people living with severe psychiatric disorders can be grouped into more homogeneous subgroups, across usual diagnostic categories, based on two key dimensions: social withdrawal and…
- Conditions
- Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP), Bipolar Disorder (BD), Major Depressive Disorder (MDD
- Trial name
- FRENCH-MINDS (NCT07881016)
- Testing
- 3T Brain MRI, Biological Sampling, Clinical, Cognitive and Digital Assessments
- Where
- 17 sites in France
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Fondation FondaMental
Major Depressive Episode, Risk Reduction
The Impact of Coach-guided Risk Communication on the Risk of Major Depression
Depression is a highly prevalent and disabling mental health problem. One way of preventing depression is to stop it before it happens through effective self-management.
- Conditions
- Major Depressive Episode, Risk Reduction, Self Efficacy
- Trial name
- NCT06619366
- Testing
- coach-guided personalized depression risk communication, depression risk information
- Where
- Canada
- Volunteers
- 1,000 people
- Sponsor
- Dalhousie University
Long COVID, Major Depressive Disorder
Presynaptic Imaging in Major Depressive Episodes After COVID-19
The goal of this observational study focuses on understanding and addressing a subset of persistent neuropsychiatric symptoms occurring within 3 months after mild to moderate COVID-19 infection (COVID-DNP).
- Conditions
- Long COVID, Major Depressive Disorder, Major Depressive Episode
- Trial name
- PCOV (NCT06086366)
- Testing
- [11C]DTBZ PET scan, [18F]SDM8 PET scan, MRI scan
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Depression Disorder
Estimation of Control Before and After Treatment of a Depressive Episode With Serotonin Reuptake Inhibitors
The goal of this observational study is to better understand cognitive and affective processes involved in depression, in particular how individuals estimate their perception of control over events in their environment, as well…
- Trial name
- APTE-Sero (NCT07716982)
- Testing
- Selective Serotonin Reuptake Inhibitors (SSRIs) or serotonergic antidepressants, Experimental tasks
- Where
- France
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier
Bipolar Depression
Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients
This is a multicenter, randomized, double-blind, placebo-controlled study in pediatric patients who are experiencing major depressive episodes (MDEs) associated with a primary diagnosis of bipolar I or bipolar II disorder as…
- Trial name
- NCT06372964
- Testing
- Lumateperone
- Where
- 68 sites in United States, Colombia and 2 more
- Volunteers
- 384 people
- Sponsor
- Intra-Cellular Therapies, Inc.
Bipolar Disorder, Bipolar Depression
A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disorder (Bipolar Depression)
X-CEED is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of azetukalner in adult participants diagnosed with bipolar I or II disorder who are currently in a…
- Conditions
- Bipolar Disorder, Bipolar Depression, Bipolar I Disorder, Bipolar II Disorder
- Trial name
- X-CEED (NCT07172516)
- Testing
- Azetukalner
- Where
- 44 sites in United States, Bulgaria and 2 more
- Volunteers
- 400 people
- Sponsor
- Xenon Pharmaceuticals Inc.
Major Depressive Disorder, Major Depressive Disorder, Recurrent
Accelerated Intermittent Theta-Burst Stimulation Ameliorate Major Depressive Disorder by Regulating CAMKII Pathway
Major depressive disorder(MDD) is a complex and heterogeneous mental disorder. Repeated transcranial magnetic stimulation (rTMS), as a non-invasive neuroregulatory technique, has shown a promising function in the treatment of…
- Trial name
- NCT05913960
- Testing
- accelerated intermittent theta burst stimulation, high frequency stimulation
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Depression
rTMS Response Trajectories in Depression
Notwithstanding the cumulative evidence on the safety and efficacy of transcranial magnetic stimulation in depression care, the non-response rate to transcranial magnetic stimulation (TMS) amongst treatment-resistant depression…
- Trial name
- NCT03348761
- Testing
- rTMS group
- Where
- Hong Kong
- Volunteers
- 70 people
- Sponsor
- Chinese University of Hong Kong
Major Depression Moderate, Major Depression Severe
EEG Microstate Parameters and Neuroinflammatory Biomarkers in Patients With Treatment-Resistant Major Depressive Disorder Receiving ECT
This study aims to investigate the neurophysiological and inflammatory changes associated with electroconvulsive therapy (ECT) in patients diagnosed with Major Depressive Disorder who are resistant to at least two antidepressant…
- Conditions
- Major Depression Moderate, Major Depression Severe, Major Depression With Comorbid Anxiety Symptoms, Major Depression With Panic Attacks
- Trial name
- NCT07748091
- Testing
- Electroconvulsive Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Depression, MDD
Feasibility of Home-Based Intermittent 60Hz Light Therapy for Major Depressive Disorder (MDD)
This pilot study evaluates the feasibility, safety, and preliminary efficacy of home-based 60Hz intermittent light therapy in adults with a major depressive episode (MDE).
- Conditions
- Depression, MDD, Major Depressive Disorder, Major Depressive Episode
- Trial name
- NCT07111390
- Testing
- 60Hz Intermittent Light Therapy
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- NYU Langone Health
Major Depressive Disorder
Effective of Transcranial Magnetic Stimulation (TMS) vs Treatment as Usual for First-Episode Depression in Adults
This clinical trial aims to assess the effectiveness of Transcranial Magnetic Stimulation (TMS) compared to Treatment as Usual (TAU) in adult patients experiencing their first or second episode of unipolar major depressive…
- Trial name
- NCT06644833
- Testing
- Transcranial magnetic stimulation, Antidepressant
- Volunteers
- 120 people
- Sponsor
- Sultan Qaboos University