Clinical trials: Depressive Episodes
Depressive Episode, Major Depressive Disorder
Pre-mapping Networks for Brain Stimulation 2
The investigators compare the primary and secondary outcome measures using accelerated intermittent theta burst stimulation (aiTBS, 20 sessions active and 20 sessions sham in a counterbalanced crossover design) to treat…
- Trial name
- PreNeSt2 (NCT05260086)
- Testing
- Neuronavigated aiTBS
- Where
- Germany
- Volunteers
- 92 people
- Sponsor
- University Medical Center Goettingen
Major Depressive Episode
Predictors of the Response and Relapse/Recurrence After ECT for Depressed Patients
Objective: Psychiatrists have long sought a quantifiable biomarker of electroconvulsive therapy (ECT) response. Although ECT is highly effective for treatment of patients with major depressive episode, a high rate of…
- Trial name
- NCT02032576
- Testing
- ECT for depressed patients
- Where
- Taiwan
- Volunteers
- 170 people
- Sponsor
- Kaohsiung Kai-Suan Psychiatric Hospital
Schizoaffective Disorders, Bipolar Disorder With Psychotic Features
Transition Care for FEP
This study is testing a new approach to help people with first episode psychosis transition successfully from the hospital to outpatient mental health care.
- Conditions
- Schizoaffective Disorders, Bipolar Disorder With Psychotic Features, Schizophrenia Disorders, Major Depressive Disorder With Psychotic Features
- Trial name
- TCT FEP (NCT07713849)
- Testing
- Transition Care Team
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- University of Chicago
Depressive Disorder, Major, Borderline Personality Disorder
Treatment of Acute Mood Depressive Episode in Borderline Personality Disorder With rTMS
This study evaluates the antidepressant effects of an accelerated schedule of theta-burst stimulation, termed accelerated intermittent theta-burst stimulation (aiTBS), in individuals with borderline personality disorder (BPD) or…
- Trial name
- NCT04870255
- Testing
- Left Dorsolateral Prefrontal Cortex (L-DLPFC), Dorsomedial Prefrontal Cortex (DMPFC)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Stanford University
Depressive Symptoms, Hypomania Nos Single Episode or Unspecified
A Study of Aerobic Exercise for Adolescents With Subthreshold Mood Syndromes
This study will investigate the effects of aerobic exercise on mental states, cognition, and long-term outcomes in adolescents with subthreshold depressive and/or hypomanic syndromes and in non-clinical school children
- Trial name
- NCT03300778
- Testing
- aerobic exercise
- Where
- China
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Guangzhou Psychiatric Hospital
Major Depression Moderate, Major Depression Severe
EEG Microstate Parameters and Neuroinflammatory Biomarkers in Patients With Treatment-Resistant Major Depressive Disorder Receiving ECT
This study aims to investigate the neurophysiological and inflammatory changes associated with electroconvulsive therapy (ECT) in patients diagnosed with Major Depressive Disorder who are resistant to at least two antidepressant…
- Conditions
- Major Depression Moderate, Major Depression Severe, Major Depression With Comorbid Anxiety Symptoms, Major Depression With Panic Attacks
- Trial name
- NCT07748091
- Testing
- Electroconvulsive Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Depressive Disorders
Acute, Affective, Organic Disorders.
The purpose of the study is to investigate whether patients with brief depressive periods together with other fluctuating psychiatric symptoms, have this condition due to epilepsy or an other organic brain disorder.
- Trial name
- NCT00201474
- Where
- Norway
- Volunteers
- 32 people
- Sponsor
- Norwegian University of Science and Technology
Treatment Resistant Depression, Major Depressive Episode
University of Iowa Interventional Psychiatry Service Patient Registry
The purpose of this study is to examine the effects of interventional/procedural therapies for treatment-resistant depression (TRD) and Obsessive-Compulsive Disorder (OCD).
- Conditions
- Treatment Resistant Depression, Major Depressive Episode, Major Depression, Major Depressive Disorder
- Trial name
- NCT04480918
- Testing
- Electroconvulsive Therapy (ECT), Transcranial Magnetic Stimulation (TMS), Ketamine
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Mark Niciu
Major Depressive Episode
Pain Perception in Suicidal Behavior Vulnerability
In France, almost 1 death on 50 is a suicide. The suicide occurs in unbearable psychic pain where mental trouble has a major influence. It is classified as preventable mortality.
- Trial name
- DOCS (NCT02915679)
- Testing
- Blood sample for genetic purpose, psychiatric assessment and pain investigation
- Where
- France
- Volunteers
- 167 people
- Sponsor
- University Hospital, Montpellier
Major Depressive Episode
Personalized High-Definition Transcranial Direct Current Stimulation (HD-tDCS) Treatment for Major Depressive Episode
Adolescents with mood disorders experiencing major depressive episode have poor efficacy of medication treatment. High-Definition Transcranial Direct Current Stimulation (HD-tDCS) has been proven adjuvant efficacy in patients…
- Trial name
- PRHDTDCSTMDE (NCT05498441)
- Testing
- High-Definition Transcranial Direct Current Stimulation (HD-tDCS), Antipsychotics, mood stabilizers, etc.
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Jiangsu Province Nanjing Brain Hospital
Bipolar Disorder, Bipolar Depression
A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disorder (Bipolar Depression)
X-CEED is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of azetukalner in adult participants diagnosed with bipolar I or II disorder who are currently in a…
- Conditions
- Bipolar Disorder, Bipolar Depression, Bipolar I Disorder, Bipolar II Disorder
- Trial name
- X-CEED (NCT07172516)
- Testing
- Azetukalner
- Where
- 44 sites in United States, Bulgaria and 2 more
- Volunteers
- 400 people
- Sponsor
- Xenon Pharmaceuticals Inc.
Acute Depressive Episode
Efficacy and Safety of Ramelteon Sublingual in Adult Patients With Acute Depressive Episodes Associated With Bipolar I Disorder
The purpose of this study is to determine the efficacy and safety of Ramelteon, once daily (QD), sublingual (SL), in adult participants with acute depressive episodes associated with Bipolar I disorder.
- Trial name
- NCT01467700
- Testing
- Ramelteon SL
- Where
- 161 sites in United States, Argentina and 3 more
- Volunteers
- 490 people
- Sponsor
- Takeda
Depressive Disorder, Major
A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder
This study evaluates the safety and efficacy of brenipatide when administered with standard of care (SoC) compared to placebo plus SoC in delaying the return of major depressive symptoms.
- Trial name
- RENEW-MDD- 2 (NCT07775300)
- Testing
- Brenipatide
- Where
- 170 sites in United States, Australia and 13 more
- Volunteers
- 1,000 people
- Sponsor
- Eli Lilly and Company
Depressive Disorder, Major
European Deep Brain Stimulation (DBS) Depression Study
To evaluate the effects of two different programming settings of deep brain stimulation (DBS) in the subgenual white matter (Brodmann Area 25 WM) as an adjunctive treatment for treatment resistant Major Depressive Disorder…
- Trial name
- NCT01331330
- Testing
- Deep Brain Stimulation
- Where
- 5 sites in France, Israel and 1 more
- Volunteers
- 9 people
- Sponsor
- Abbott Medical Devices
Bipolar II Disorder, Bipolar II Disorder, Most Recent Episode Major Depressive
Closed-Loop Deep Brain Stimulation for Treatment-Resistant Bipolar Depression
Neurons are specialized types of cells that are responsible for carrying out the functions of the brain. Neurons communicate with electrical signals. In diseases such as major depression this electrical communication can go awry.
- Trial name
- PReSiDio-BP (NCT07127913)
- Testing
- Device: Stimulation-ON, Device: Stimulation-OFF, Device: Stimulation -ON Active Control
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Andrew Krystal
Bipolar Disorder Depression
Scopolamine in Bipolar Depression
This is a single-site, randomised, double-blind, placebo-controlled, parallel, phase IIb clinical trial. The primary objective of the SCOPE-BD study is to investigate the efficacy and safety of IV Scopolamine, compared to…
- Trial name
- SCOPE-BD (NCT04211961)
- Testing
- Scopolamine
- Where
- Ireland
- Volunteers
- 55 people
- Sponsor
- Dr. Brian Hallahan
Depression, Depressive Disorder, Major
Comparing the Efficacy of fMRI-Guided vs. Standard iTBS in Treating Depression
In this triple-blind randomized controlled trial, we ask if targeting intermittent theta burst stimulation (iTBS) based on individual resting state connectivity improves treatment outcomes in major depressive disorder (MDD).
- Conditions
- Depression, Depressive Disorder, Major, Depressive Episode
- Trial name
- NCT06152705
- Testing
- repetitive Transcranial Magnetic Stimulation
- Where
- Canada
- Volunteers
- 210 people
- Sponsor
- The Royal Ottawa Mental Health Centre
Major Depressive Disorder
An Eight-week Study of Saredutant and Escitalopram as Combination Treatment for Major Depressive Disorder
The main purpose of this study is to evaluate the efficacy of saredutant 100mg once daily in combination with escitalopram 10mg once daily compared to saredutant placebo in combination with escitalopram 10mg once daily in…
- Trial name
- NCT00531622
- Testing
- saredutant (SR48968), escitalopram
- Where
- 6 sites in United States, Argentina and 4 more
- Volunteers
- 643 people
- Sponsor
- Sanofi
Schizophrenia, Major Depressive Disorder (MDD)
A Study of SEP-380135 in Adults With Schizophrenia or Major Depressive Episode
The purpose of this study is to assess the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of multiple dose oral administration of SEP-380135 in participants with schizophrenia or with a major depressive…
- Conditions
- Schizophrenia, Major Depressive Disorder (MDD), Bipolar Disorder
- Trial name
- NCT07549581
- Testing
- SEP-380135
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Major Depressive Disorder (MDD), Depressive Episodes
Effectiveness of Clustered Versus Tapered Repetitive Transcranial Magnetic Stimulation (rTMS) as Maintenance Therapy Following Successful Acute rTMS Treatment in Patients With Depressive Syndrome
The goal of this clinical trial is to compare two maintenance transcranial magnetic stimulation (rTMS) strategies following successful acute theta burst stimulation (TBS) treatment in adults with depressive syndrome.
- Conditions
- Major Depressive Disorder (MDD), Depressive Episodes, Depressive Syndrome
- Trial name
- ERTE (NCT07727005)
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS), Theta Burst Stimulation
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Technical University of Munich