Clinical trials: Depressive Episodes
Bipolar Disorder, Major Depressive Episode
Ketamine for Suicidality in Bipolar Depression
This study is designed to compare the effectiveness of two medications, Ketamine and Midazolam, for rapidly relieving suicidal thoughts in people suffering from bipolar depression.
- Conditions
- Bipolar Disorder, Major Depressive Episode, Suicidal Ideation
- Trial name
- NCT01944293
- Testing
- Ketamine, Midazolam
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- New York State Psychiatric Institute
Major Depression
Healthy Mood Internet Intervention Research Project
The purpose of the study is: 1. to study whether individuals WHO ARE NOT CURRENTLY SERIOUSLY DEPRESSED will participate in an online study to prevent clinical depression and 2.
- Trial name
- NCT01358487
- Testing
- Online self-help course plus live follow-up if needed, Online + incentives Follow-up Group
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Major Depressive Disorder, Bipolar I and Bipolar II
Bipolar Proteomic Assay Validation Study
The purpose of this study is to validate a set of signatures, based on a panel of proteomic markers, that discriminate BDI, BDII, and MDD in people seeking treatment for a depressive episode.
- Trial name
- NCT02746367
- Testing
- Diagnostic test (LDT)
- Where
- 5 sites in United States
- Volunteers
- 261 people
- Sponsor
- Myriad Genetic Laboratories, Inc.
Bipolar Disorder
Cost- Effectiveness and Quality of Life Assessment in Bipolar Disorder Depressive Episode
To evaluate the effectiveness of an algorithm for Bipolar Disorder depressive episodes (BDD) using medications available in the Brazilian Public Healthcare System (SUS).
- Trial name
- NCT02918097
- Testing
- Lithium Carbonate, Sertraline, Nortriptyline
- Volunteers
- 78 people
- Sponsor
- Federal University of Rio Grande do Sul
Depression, MDD
Feasibility of Home-Based Intermittent 60Hz Light Therapy for Major Depressive Disorder (MDD)
This pilot study evaluates the feasibility, safety, and preliminary efficacy of home-based 60Hz intermittent light therapy in adults with a major depressive episode (MDE).
- Conditions
- Depression, MDD, Major Depressive Disorder, Major Depressive Episode
- Trial name
- NCT07111390
- Testing
- 60Hz Intermittent Light Therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- NYU Langone Health
Depressive Episodes of Bipolar Disorder
A Clinical Study of Light Therapy on Depressive Episodes of Bipolar Disorder
The purpose of this study is to investigate the efficacy and safety of light-emitting diode(LED) light therapy on Chinese patients with Depressive Episodes of Bipolar Disorder and to gather prime research data and application…
- Trial name
- NCT02009371
- Testing
- Bright Light therapy, dim Red Light therapy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University
Depressive Disorder, Major, Major Depressive Disorder (MDD)
Study Of GW679769 In Major Depressive Disorder
This is a placebo-controlled, fixed dose study that will evaluate the efficacy and safety of GW679769 in subjects with major depressive disorder.
- Trial name
- NCT00102492
- Testing
- GW679769
- Where
- 31 sites in United States, Canada
- Volunteers
- 356 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Depression, Unipolar, Bipolar Disorder
Exercise for Depression
A randomized single-blinded prospective study to evaluate the efficacy of an individualized supervised 8-week exercise program in subjects with moderate to severe depressive episodes compared to treatment-as-usual
- Trial name
- EXDEP (NCT02874833)
- Testing
- Exercise
- Where
- 2 sites in Germany
- Volunteers
- 20 people
- Sponsor
- Johannes Gutenberg University Mainz
Major Depressive Episode, Unipolar Depression
Ketamine As an Adjunctive Therapy for Major Depression (2)
Pragmatic, randomised, controlled, parallel-group, superiority trial of ketamine vs. midazolam as an adjunctive therapy for depression.
- Conditions
- Major Depressive Episode, Unipolar Depression, Bipolar Depression
- Trial name
- KARMA-Dep2 (NCT04939649)
- Testing
- Ketamine, Midazolam
- Where
- Ireland
- Volunteers
- 63 people
- Sponsor
- University of Dublin, Trinity College
Major Depressive Episode
Signature Response to Light Therapy in Unipolar and Bipolar Major Depressive Episode (MDE)
Major depressive episode (MDE) are severe and common psychiatric disorders that affect up to 20% of the general population. MDE cause a decrease in psychosocial functioning, quality of life, and is associated with a high rate of…
- Trial name
- SoLuRep (NCT07462637)
- Testing
- Light therapy
- Where
- France
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Suicidal Behavior, Depression
Predictors of Suicidal Behavior in Depression
This study aims at identifying predictors of suicidal behaviors in depressed subjects. Investigators will first compare demographic, clinical, and biological features of depressed recent suicide attempters (within one week) and…
- Conditions
- Suicidal Behavior, Depression, Traumatic Events, Impulsivity Aggression
- Trial name
- SECS (NCT02904005)
- Testing
- Standardized assessment on depressed patients
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- University Hospital, Montpellier
Major Depressive Episode
Validation Study: Mobile DSST on Cognition in Adults With MDD
Objectives The primary objective of this study is to determine the convergent validity of the mobile DSST application with the pencil and paper version of the DSST.
- Trial name
- NCT03999567
- Testing
- Pen and Paper Digit Symbol Substitution Test (DSST), Electronic Digit Symbol Substitution Test (DSST)- (a.k.a. Codebreaker)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Brain and Cognition Discovery Foundation
Major Depressive Disorder (MDD)
Genomics Used to Improve DEpression Decisions
Evaluate the impact of GeneSight Psychotropic on response to psychotropic treatment as judged by the mean change in the 17-item Hamilton Depression (HAM-D17) score from baseline to end of Week 8 of the study.
- Trial name
- GUIDED (NCT02109939)
- Testing
- GeneSight Psychotropic
- Where
- 61 sites in United States
- Volunteers
- 1,398 people
- Sponsor
- Assurex Health Inc.
Depression
Nexalin Therapy for the Treatment of Depressive Symptoms
The primary objectives of this Phase II study are to demonstrate the safety of Nexalin Therapy and to investigate the efficacy of Nexalin Therapy.
- Trial name
- NCT00774813
- Testing
- Nexalin 1.3mA Device, Nexalin 15mA device
- Where
- 2 sites in Russia
- Volunteers
- 120 people
- Sponsor
- Kalaco Scientific, Inc.
Major Depressive Disorder, Bipolar I Disorder
Digital Phenotypes for Predicting Depression_Validation
This 12-month, single-site prospective observational study will prospectively monitor the recurrence of mood episodes while continuously collecting passive digital phenotypes in individuals with and without mood disorders.
- Conditions
- Major Depressive Disorder, Bipolar I Disorder, Bipolar II Disorder, Mood Disorders
- Trial name
- NCT07880015
- Where
- South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Depression - Major Depressive Disorder
Efficacy and Mechanisms of Escitalopram in Drug-Naïve First-Episode Major Depressive Disorder
The goal of this project is to quantify the effectiveness and safety of escitalopram oxalate oral solution in the treatment of first-episode, drug-naïve patients with major depressive disorder, and to explore the mechanisms…
- Trial name
- NCT07480525
- Testing
- Escitalopram (Oral antidepressant)
- Where
- 5 sites in China
- Volunteers
- 200 people
- Sponsor
- Peking University
Depression Chronic, Depression and Quality of Life
Remote Medical Monitoring of Patients With Depression
The goal of this clinical trial is to learn if ThIA Suivi, a digital tool for remote monitoring of patients, can improve the care of adults with depression who are followed by a psychiatrist.
- Conditions
- Depression Chronic, Depression and Quality of Life, Depression, Major Depressive Episode
- Trial name
- TELEMED-DEP (NCT07878754)
- Testing
- Use of ThIA Medical Device
- Where
- 3 sites in France
- Volunteers
- 608 people
- Sponsor
- ThIA Santé Mentale
Long COVID, Major Depressive Disorder
Presynaptic Imaging in Major Depressive Episodes After COVID-19
The goal of this observational study focuses on understanding and addressing a subset of persistent neuropsychiatric symptoms occurring within 3 months after mild to moderate COVID-19 infection (COVID-DNP).
- Conditions
- Long COVID, Major Depressive Disorder, Major Depressive Episode
- Trial name
- PCOV (NCT06086366)
- Testing
- [11C]DTBZ PET scan, [18F]SDM8 PET scan, MRI scan
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Bipolar Disorder
Neuronavigation rTMS to Improve Depressive Episodes of Bipolar Disorder in Adolescent
The purpose of this study is to explore a new stimulation target and protocol for the treatment of depressive episode in adolescents with bipolar disorder through the repetitive transcranial magnetic stimulation(rTMS) under…
- Trial name
- NCT05929183
- Testing
- Repetitive Transcranial magnetic stimulation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Bipolar Disorder I or II With a Major Depressive Episode
ALTO-100 in Bipolar Disorder With Depression (BD-D)
The purpose of this study is to assess antidepressant efficacy differences between ALTO-100 and placebo during the Double-Blind period in patients with bipolar disorder I or II with current major depressive episode, when used…
- Trial name
- NCT06656416
- Testing
- ALTO-100
- Where
- 68 sites in United States, United Kingdom
- Volunteers
- 200 people
- Sponsor
- Alto Neuroscience