Clinical trials: Depressive State
Depression
Bayesian Sequential Single Case Methods to Personalize Low-Intensity Psychological Interventions: Initial Pilot Work
The study is an initial investigation of the feasibility of applying Bayesian sequential analyses to individual participant single-case data for rapid detection of whether or not the individual is benefitting from a low-intensity…
- Trial name
- NCT04779437
- Testing
- Imagery Cognitive Bias Modification, Cognitive Control Training
- Where
- Germany
- Volunteers
- 7 people
- Sponsor
- Ruhr University of Bochum
Labor Pain, Pregnancy Outcomes
The Association Between Epidural Labor Analgesia and Pregnancy Outcomes
Labor analgesia can alleviate intrapartum pain, in the importance of the delivery is very obvious.But some researches think labor analgesia may affect the progress of labor, increase the cesarean section rate.This research adopts…
- Conditions
- Labor Pain, Pregnancy Outcomes, Psychological Disorder
- Trial name
- NCT03381495
- Testing
- Ropivacaine Hydrochloride, Sufentanil
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Deng Dongrui
Cardiovascular Diseases, Heart Diseases
Epidemiology of Depression and Heart Failure in Aging
To understand how depression leads to congestive heart failure (CHF) in older adults.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Heart Failure, Heart Failure, Congestive
- Trial name
- NCT00241761
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Depression, Anxiety
Depressive and Anxiety Disorders in Patients With Chronic Liver Diseases
The aim of this observational study is to learn about the prevalence of depressive and anxiety disorders among patients with chronic liver diseases
- Trial name
- NCT06113029
- Testing
- The Hamilton Rating Scale for Anxiety, The Beck Depression inventory, Rand SF-36 Questionnaire
- Where
- Egypt
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Assiut University
Chronic Major Depressive Disorder
A Comparison of Cognitive Behavioral Analysis System of Psychotherapy (CBASP) and System of Supportive Psychotherapy (SYSP) for Early Onset Chronic Depression
The purpose of this study is to compare the efficacy of the Cognitive Behavioural Analysis System of Psychotherapy (CBASP) with the non-specific System of Supportive Psychotherapy (SYSP)in early onset chronically depressives.
- Trial name
- NCT00970437
- Testing
- Cognitive Behavioral Analysis System of Psychotherapy, System of Supportive Psychotherapy
- Where
- Germany
- Volunteers
- 268 people
- Sponsor
- University Hospital Freiburg
Bipolar Disorder, Schizophrenia
Comparison of Physical Fitness, Physical Activity Level in Patients With Bipolar Disorder and Schizophrenia
According to the World Health Organization; Bipolar disorder ranks in the top 20 causes of disability among all medical conditions and 6th among mental disorders worldwide.
- Trial name
- NCT05936983
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Yeditepe University
Postoperative Depression
Ketamine for Postoperative Avoidance of Depressive Symptoms: The K-PASS Feasibility Trial
This protocol describes a feasibility trial that will evaluate the feasibility of conducting a full-scale phase 3 trial testing the hypothesis that a postoperative sustained, low-dose ketamine infusion can prevent postoperative…
- Trial name
- K-PASS (NCT05233566)
- Testing
- Ketamine, Normal saline
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Washington University School of Medicine
Depression, Selective Serotonin Reuptake Inhibitor
Impact of Depression on Thermoregulation
The purpose of this study is to determine if, compared to non-depressed adults, differences exist in skin blood flow and sweating responses to passive heat stress in adults with clinically diagnosed depression, those with…
- Trial name
- NCT06805851
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Penn State University
Bipolar Depression
The Safety and Effectiveness of Probiotic Supplementation on Bipolar Depression
This is an 8-week randomized, double-blind placebo-controlled proof of concept study assessing the combination of a mood stabilizer + Align in the treatment of participants with a bipolar depressive episode.
- Trial name
- ALIGN (NCT02155972)
- Testing
- Bifidobacterium infantis
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Women's College Hospital
MDD
Take-home Functional Electrical Stimulation for MDD
The purpose of this study is to learn whether Functional Electrical Stimulation (FES) of the facial muscles is effective in treating major depressive disorder (MDD) and to develop a model for take-home delivery.
- Trial name
- NCT06261177
- Testing
- Functional Electrical Stimulation (FES)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Unity Health Toronto
Adolescent Behavior, Psychosocial Functioning
Intervention to Enhance Coping and Help-seeking Among Youth in Foster Care
This study will deploy a scalable secondary prevention program that leverages existing foster youth transition services to improve mental health functioning and service use before and after exiting foster care.
- Conditions
- Adolescent Behavior, Psychosocial Functioning, Coping Behavior, Help-Seeking Behavior
- Trial name
- NCT06019377
- Testing
- Stronger Youth Networks and Coping (SYNC)
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Portland State University
Depression Anxiety Disorder, Self-criticism
Compassionate Mind Training for Teachers (CMT-T)
Literature has reported the emergence of various mental disorders in teachers at this level, including common mental disorders (CMDs) such as depression and anxiety, leading to increased job turnover and detrimental to the…
- Trial name
- UFSergipe (NCT07716657)
- Testing
- Compassionate Mind Training for Teachers (CMT-T)
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Universidade Federal de Sergipe
Major Depression
Randomized Trial of Psychotherapy for Persistently Depressed Primary Care Patients
This is a pilot study. The purpose of this study is to determine whether adding 4 months of behavioral therapy to primary care physician medication treatment(relative to medication treatment alone) improves outcomes for…
- Trial name
- NCT00541957
- Testing
- behavior therapy, Medication prescribed by PCP
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Butler Hospital
Heart Failure, Mental Health
Improving Care and Mental Well-Being for Adults With Heart Failure
Heart failure is a high-risk, chronic condition that impacts patients' mental health. Approximately 50% of heart failure patients experience comorbid mental health conditions, such as stress, depression and anxiety, which affect…
- Conditions
- Heart Failure, Mental Health, Stress, Anxiety
- Trial name
- NCT07313657
- Testing
- Heart Failure and Mental Health Intervention (FRAME)
- Where
- 9 sites in Canada
- Volunteers
- 7,300 people
- Sponsor
- Bruyère Health Research Institute.
Depressive Disorder, Major, Depression
Altering Default Mode Network Activity With Transcranial Focused Ultrasound to Reduce Depressive Symptoms
Depression is a leading cause of disability worldwide, affecting roughly 21 million adults. Repetitive Negative Thought (RNT) has been identified as a potential maintaining factor in depression, such that those who exhibit higher…
- Trial name
- DMNtFUS (NCT06320028)
- Testing
- Non-Invasive Transcranial Focused Ultrasound
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Arizona
Symptoms of Depression and Anxiety
Mindfulness Intervention Using Virtual Reality in Older Adults With Symptoms of Anxiety and Depression in Ecuador
The availability of affordable hardware and rapidly growing content that can be freely accessed in the public domain raises the possibility of VR being used across the world globally and, in a very broad range of settings…
- Trial name
- NCT06219642
- Testing
- Mindfulness using virtual reality
- Where
- Ecuador
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Universidad San Francisco de Quito
Oral Lichen Planus
The Regulatory Role of Immune Response in Oral Lichen Planus
Oral lichen planus (OLP) is a common chronic inflammatory disease of Oral mucosa. The pathogenesis of OLP is not clear, and there is no effective method to cure it.
- Trial name
- NCT05997173
- Testing
- Control, Non erosive OLP, Erosive OLP
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Depression
Deep Brain Stimulation for Treatment-Refractory Major Depression
This study will investigate the use of deep brain stimulation (DBS) to reduce symptom severity and enhance the quality of life for patients with treatment-refractory major depression.
- Trial name
- NCT00122031
- Testing
- Deep Brain Stimulation with Medtronic Activa Neurostimulator
- Where
- Germany
- Volunteers
- 13 people
- Sponsor
- University Hospital, Bonn
Psychological Distress, Anxiety
Acceptance and Commitment Therapy for Older Adults
Title: Acceptance and Commitment Therapy for older adults experiencing psychological distress: A hermeneutic single case efficacy design (HSCED) series.
- Conditions
- Psychological Distress, Anxiety, Depression
- Trial name
- NCT04280445
- Testing
- Psychological therapy
- Where
- United Kingdom
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Lincoln
Loneliness, Depression
Mindful Response to Adversity: A Brief Stress Resilience Training
The investigators will conduct an intervention study with the aim of improving stress resilience and mental health outcomes in at-risk freshman students.
- Trial name
- NCT04064372
- Testing
- Mindful response to adversity brief training, Strengths-based response to adversity brief training
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Carnegie Mellon University
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